Protein Info for Rru_A0635 in Rhodospirillum rubrum S1H

Annotation: Na+/solute symporter (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 559 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 42 to 62 (21 residues), see Phobius details amino acids 83 to 105 (23 residues), see Phobius details amino acids 111 to 130 (20 residues), see Phobius details amino acids 157 to 177 (21 residues), see Phobius details amino acids 189 to 211 (23 residues), see Phobius details amino acids 220 to 240 (21 residues), see Phobius details amino acids 272 to 294 (23 residues), see Phobius details amino acids 306 to 332 (27 residues), see Phobius details amino acids 364 to 392 (29 residues), see Phobius details amino acids 413 to 432 (20 residues), see Phobius details amino acids 438 to 459 (22 residues), see Phobius details amino acids 470 to 492 (23 residues), see Phobius details amino acids 505 to 524 (20 residues), see Phobius details TIGR00813: transporter, solute:sodium symporter (SSS) family" amino acids 71 to 478 (408 residues), 206.3 bits, see alignment E=4.2e-65 PF00474: SSF" amino acids 71 to 478 (408 residues), 404.5 bits, see alignment E=2.6e-125

Best Hits

Swiss-Prot: 71% identical to ACTP_PECAS: Cation/acetate symporter ActP (actP) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K14393, cation/acetate symporter (inferred from 100% identity to rru:Rru_A0635)

MetaCyc: 70% identical to acetate/glycolate:cation symporter (Escherichia coli K-12 substr. MG1655)
RXN0-1981; RXN0-5111; TRANS-RXN0-576

Predicted SEED Role

"Acetate permease ActP (cation/acetate symporter)" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RWQ6 at UniProt or InterPro

Protein Sequence (559 amino acids)

>Rru_A0635 Na+/solute symporter (NCBI) (Rhodospirillum rubrum S1H)
MDRLRHSRAAAAAFLAPLAFPALALAAPAVEGPVEKQAVNVTAIAMFVAFVIGTLFITYW
AARRTKSAKDFYAAGGGITGFQNGLAIAGDYMSAASFLGIAGLVFTSGFDGLIYSIGFLV
GWPVIMFLVAERLRNLGKYTFADVASFRLGQGPIRSMAASGTLVVVILYLIAQMVGAGKL
IELLFGLDYSTAVVLVGVLMVSYVMFGGMLATTWVQIIKAVLLLSGASFMAIMVLVSFGF
SPEALFAKAVEVHAKKTLLMAPGGLVSDPIDAISLGIALMFGTAGLPHILMRFFTVSDAK
EARKSVFYATGFIGYFYILTFIIGFGAIVMVLNQPEFMAADGKGIAGGSNMAAIHLAHAV
GGNIFLGFISAVAFATILAVVSGLTLSGASAVSHDLYASVWRKGRVSERDEIRVSKITTV
GLGVVAILLGIAFESQNIAFMVGLAFAIAASANFPILFMSMFWKGLTTRGAFIGGFAGLI
SATVLVILGPPIWKTVLGHPEAIFPYSNPAIFSMPLAFLVTWLVSKADSSMGSRSEAIAF
EDQYVRSQTGLGAEGAADH