Protein Info for Rru_A0612 in Rhodospirillum rubrum S1H

Annotation: Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1061 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 296 to 318 (23 residues), see Phobius details PF00989: PAS" amino acids 329 to 431 (103 residues), 46.5 bits, see alignment E=1.2e-15 amino acids 508 to 618 (111 residues), 50.2 bits, see alignment E=8.5e-17 TIGR00229: PAS domain S-box protein" amino acids 330 to 430 (101 residues), 53.3 bits, see alignment E=3e-18 amino acids 507 to 628 (122 residues), 86.1 bits, see alignment E=2.1e-28 PF13188: PAS_8" amino acids 331 to 386 (56 residues), 29.5 bits, see alignment 1.9e-10 PF08448: PAS_4" amino acids 336 to 432 (97 residues), 28.2 bits, see alignment E=6.9e-10 amino acids 513 to 623 (111 residues), 39.6 bits, see alignment E=1.9e-13 PF13426: PAS_9" amino acids 341 to 433 (93 residues), 51.6 bits, see alignment E=3.6e-17 amino acids 518 to 620 (103 residues), 54.2 bits, see alignment E=5.2e-18 PF08447: PAS_3" amino acids 530 to 613 (84 residues), 36.2 bits, see alignment E=2.2e-12 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 630 to 791 (162 residues), 131.6 bits, see alignment E=2.3e-42 PF00990: GGDEF" amino acids 632 to 788 (157 residues), 160.9 bits, see alignment E=8.3e-51 PF00563: EAL" amino acids 810 to 1043 (234 residues), 228.1 bits, see alignment E=3.6e-71

Best Hits

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A0612)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RWS9 at UniProt or InterPro

Protein Sequence (1061 amino acids)

>Rru_A0612 Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) (NCBI) (Rhodospirillum rubrum S1H)
MPMKRWVLAFLILELFVSCVLFLQFREERQRLFAAHVDRTLLAWEAARESRLDLQRIIQG
ALLADGRIASLLSQALATPADRRAPLRTALADRFAPSRPALLAHGITMTQVLLADGATFF
RLNNPQRSNAVEPIPRPALREVLASARPVAAVETTSRATALRLISPVFHDARLVGVLETA
VPLAEMPALLDHLDKTRRHSLLGPLPAGESGGRLALAPLPPGAGAAPDPETARLVAALGD
LGQPLADGHPFARSLAGADADRVITIVPISDYSGESHGYLMANAVEPALETIRRSLIISA
TVTAFLLLAALLLLAQLVNSRRALLREREDMRAITDTMGEGLYILDNEGLIAFVNRSAET
MLGYSREDLLGAKAHSLFHSHDGDGRPQDADACAILRAMRERRHFTSSDEAFIRSNGTRF
PVEVRCAPLTADDPLLKALAHQAPPGGPGGRLAARLRAAMGNRPRLSVALSRLFGHADAL
LLPTNPRASVITFVDITERKASEAALRKLSRAVEQSPASVIITDARGTIEYVNPQFEKST
GYRSWEVIGANPRILKSGHIAEATYAEMWKTLNEGREWRGELHNRRKDGTLYWEYASLSP
VKDRRGRTTHLLAVKEDITARKETENRLIRQANFDELTDLPNRSLCYSRLKEAIVEAEAT
ASIVGVLFIDLDHFKNVNDSLGHAVGDKLLTAVAQRLREVARPGDTLSRQGGDEFLMLLP
DLNGSEAGHGVAQAILTALAPPFSIDGREIYMAASIGITFFPRDGRSAAELLRNADSAMY
TAKESGRNAICFFSPEMEIRAAQRLAIEGALRQALAHEELRVAYQPLVRTSDARPIGAEA
LLRWTSPTLGEVSPTEFIKVAEETGLIVPIGAWVLDQAVAEAARLRAEGYGAFQIAVNVS
VRQFRGGDLAGLVSDTLKRHDFPAAGLELELTESLLLDVTPAITTTLQSLSALGVRLSLD
DFGTGYSALSYLKTFPFDILKVDRSFIRDISSAPDSGALARAIIAMARGLGLATIVEGVE
TEEQCAFARAEDCDIMQGFLFGKAMTPADLRRMLDEKAAAE