Protein Info for Rru_A0288 in Rhodospirillum rubrum S1H

Annotation: 2,5-didehydrogluconate reductase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00248: Aldo_ket_red
  • amino acids 14 to 256 (243 residues), 200.2 bits, E=2e-63

Best Hits

Swiss-Prot: 43% identical to DKGB_ECO57: 2,5-diketo-D-gluconic acid reductase B (dkgB) from Escherichia coli O157:H7

KEGG orthology group: K05885, 2,5-diketo-D-gluconate reductase [EC: 1.1.1.274] (inferred from 100% identity to rru:Rru_A0288)

MetaCyc: 42% identical to methylglyoxal reductase DkgB (Escherichia coli K-12 substr. MG1655)
Aryl-alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.91]; RXN0-7020 [EC: 1.1.1.91, 1.1.1.346]; Aldehyde reductase. [EC: 1.1.1.91, 1.1.1.346, 1.1.1.21]

Predicted SEED Role

No annotation

MetaCyc Pathways

• methylglyoxal degradation III (1/2 steps found)
• D-arabinose degradation V (1/3 steps found)
• superpathway of methylglyoxal degradation (4/8 steps found)
• L-ascorbate biosynthesis VIII (engineered pathway) (3/7 steps found)
• ketogluconate metabolism (3/8 steps found)
• detoxification of reactive carbonyls in chloroplasts (4/10 steps found)
• superpathway of pentose and pentitol degradation (9/42 steps found)

KEGG Metabolic Maps

• Fructose and mannose metabolism
• Galactose metabolism
• Glycerolipid metabolism
• Pentose and glucuronate interconversions
• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.21 or 1.1.1.274 or 1.1.1.346 or 1.1.1.91

Sequence Analysis Tools

See Q2RXQ2 at UniProt or InterPro

Protein Sequence (274 amino acids)

>Rru_A0288 2,5-didehydrogluconate reductase (NCBI) (Rhodospirillum rubrum S1H)
MHRVSANGIAIPALGFGTWQIEGDDARVAVAEALALGYRHIDTARAYGNEAQVGAGIAQS
GVPRGDIFLTTKIWTSEFKPEALTAALADSLAKLGTDYVDLTLLHWPNPEVPLADSLGAL
AALQQEGLTLAIGVSNFPVALVEEAVAVCGRPLAVNQVEYHPFLDQSKVIEACRRHGMAV
EAYSPLARGKVMEDATLRRIAEIYGRTPGQVALRWLIQQDGVIALPKAVRPEHAKANLGA
LDFALSQSEMAEISALARPDGRLINPSWAPAWDD