Protein Info for Rru_A0207 in Rhodospirillum rubrum S1H

Annotation: Cobalt chelatase, CobT subunit (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 633 PF06213: CobT" amino acids 15 to 280 (266 residues), 222 bits, see alignment E=1.2e-69 PF11775: CobT_C" amino acids 399 to 616 (218 residues), 330.2 bits, see alignment E=6.5e-103

Best Hits

KEGG orthology group: K09883, cobaltochelatase CobT [EC: 6.6.1.2] (inferred from 100% identity to rru:Rru_A0207)

Predicted SEED Role

"Aerobic cobaltochelatase CobT subunit (EC 6.6.1.2)" in subsystem Coenzyme B12 biosynthesis or Conenzyme B12 related Hypothetical: Clusters with cobST (EC 6.6.1.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.6.1.2

Use Curated BLAST to search for 6.6.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RXY3 at UniProt or InterPro

Protein Sequence (633 amino acids)

>Rru_A0207 Cobalt chelatase, CobT subunit (NCBI) (Rhodospirillum rubrum S1H)
MTRIPVPGAGGRANEPQEALKNVTSATLRAVAGRPGLVVSYTPGGAALIGGQARLPLPPR
KLDPGQITRLRGTADSLALKLRHHDITIQAGLEPTGIEAREVFSALEQARYETLGAGRMA
GVAANIAGAVEERLAGEGYDKATDPGQIPLGEAVRLLALERFGKVAPGPVTRHVLDLARQ
VLPESAQAALERMIAEVGDQKRFARSTRELLDEMGLEDFDPTQADRSDDETRSGESEPEA
GEGAEDSPPEGISSPGPESDMQMAPGEGESGEGEEEGSAQQATLPGEGGEDPAGEGDPSR
RRNSVDEDDDVDRYKVFSRTHDQVVGALDLCDPEELTRLRAQLDMQLSPLQGVVTRIANR
LQRRLMAQQTRSWEFDLEEGLLDVSRLARMVANPTYTLSYKQEKEMEFRDTVVSLLIDNS
GSMRGRPISVAAVSADILARTLERCGVKVEILGFTTSAWKGGKAREDWVAAGKPPLPGRL
NDLRHIIYKEADVPWRRARRALGLMLKEGILKENIDGEALLWAHSRLVGRPEARRILMVI
SDGAPVDDSTLSANTGNYLEKHLREVIALIQDRSPAQLVAIGIGHDVTRYYQRAVTINDP
EDLGGTMMRQLLELFEEPSAPNRRWRKADRLAL