Negative cofitness for SMc00008 from Sinorhizobium meliloti 1021

riboflavin biosynthesis protein RibA
SEED: 3,4-dihydroxy-2-butanone 4-phosphate synthase (EC 4.1.99.12) / GTP cyclohydrolase II (EC 3.5.4.25)
KEGG: 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II

Computing cofitness values with 243 experiments...

Genes with the strongest negative cofitness:

Rank	Hit	Name	Description	Cofit
1	SMc00761		oxidoreductase	-0.39
2	SMc02112		hypothetical protein	-0.36
3	SMc02057		preprotein translocase subunit SecD/SecF	-0.36
4	SMc04454		ABC transporter ATP-binding protein	-0.36
5	SMc00622		ribonuclease D protein	-0.35
6	SMc00727		3-hydroxybutyryl-CoA dehydrogenase	-0.35
7	SMc00877		transcriptional regulator	-0.35
8	SMc02577		ATP-dependent protease ATP-binding subunit HslU	-0.33
9	SMc00482		hypothetical protein	-0.33
10	SM_b21197		oligopeptide uptake ABC transporter permease	-0.33
11	SMa0742		hypothetical protein	-0.33
12	SMc00788		peptide ABC transporter permease	-0.33
13	SM_b20684		hypothetical protein	-0.32
14	SMc04382		beta-(1,2)-glucan production associated transmembrane protein	-0.32
15	SMc02716		hypothetical protein	-0.32
16	SMc04444		NAD-dependent formate dehydrogenase subunit alpha protein	-0.32
17	SMc02695		GTP-dependent nucleic acid-binding protein EngD	-0.31
18	SMc03015		transcriptional regulator	-0.31
19	SMc04000		hypothetical protein	-0.31
20	SMc02659		GTP pyrophosphokinase (ATP:GTP 3'-pyrophosphotransferase) protein	-0.31

Or look for positive cofitness