Negative cofitness for Ga0059261_2052 from Sphingomonas koreensis DSMZ 15582

siroheme synthase, N-terminal domain
SEED: Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)
KEGG: uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase

Computing cofitness values with 166 experiments...

Genes with the strongest negative cofitness:

Rank Hit Name Description Cofit  
1 Ga0059261_4022 Signal transduction histidine kinase -0.76
2 Ga0059261_0209 His Kinase A (phospho-acceptor) domain/Response regulator receiver domain/Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase -0.74
3 Ga0059261_0657 Uncharacterized protein conserved in bacteria -0.69
4 Ga0059261_2504 ribosome silencing factor RsfS/YbeB/iojap -0.65
5 Ga0059261_0225 polyphosphate kinase 1 -0.62
6 Ga0059261_3652 phosphate transport system regulatory protein PhoU -0.60
7 Ga0059261_0285 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] -0.60
8 Ga0059261_3698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain -0.60
9 Ga0059261_1127 Alginate export -0.59
10 Ga0059261_1846 Xaa-Pro aminopeptidase -0.59
11 Ga0059261_2227 aminodeoxychorismate synthase, component I, bacterial clade -0.59
12 Ga0059261_1561 Signal transduction histidine kinase -0.58
13 Ga0059261_3748 ribosomal protein L15, bacterial/organelle -0.58
14 Ga0059261_2698 N-acetylmuramoyl-L-alanine amidase -0.58
15 Ga0059261_4199 asparagine synthase (glutamine-hydrolyzing) -0.57
16 Ga0059261_1236 Methylase of chemotaxis methyl-accepting proteins -0.57
17 Ga0059261_1420 Protein of unknown function (DUF2490) -0.57
18 Ga0059261_1505 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) -0.56
19 Ga0059261_1312 amino acid/peptide transporter (Peptide:H+ symporter), bacterial -0.56
20 Ga0059261_4065 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases -0.56

Or look for positive cofitness