Conservation of cofitness between b0335 and b4350 in Escherichia coli BW25113

4 genomes with putative orthologs of both genes

Organism	Ratio1	Gene1	Name1	Description1	Ratio2	Gene2	Name2	Description2	Cofit	Rank
Escherichia coli BW25113	1.0	b0335	prpE	predicted propionyl-CoA synthetase with ATPase domain (NCBI)	1.0	b4350	hsdR	endonuclease R (RefSeq)	0.23	5
Escherichia coli BL21	0.99	ECD_00289		propionate--CoA ligase	0.99	ECD_04216		endonuclease R Type I restriction enzyme	0.45	7
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868	0.91	GFF4266		Propionate--CoA ligase (EC 6.2.1.17)	0.91	GFF1002		Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)	low	> 78
Shewanella sp. ANA-3	0.40	Shewana3_1675		AMP-dependent synthetase and ligase (RefSeq)	0.33	Shewana3_2963	hsdR	type I restriction enzyme EcoKI subunit R (RefSeq)	low	> 73
Alteromonas macleodii MIT1002	0.40	MIT1002_01463		Acetyl-coenzyme A synthetase	0.33	MIT1002_03395		Type-1 restriction enzyme R protein	low	> 70

Not shown: 48 genomes with orthologs for b0335 only; 3 genomes with orthologs for b4350 only