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  • Top cofit genes for Rv0939 from Mycobacterium tuberculosis H37Rv

    Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase
    SEED: Fumarylacetoacetase (EC 3.7.1.2)

    Rank Hit Name Description Conserved? Cofitness  
    1 Rv0813c Conserved protein no 0.26
    2 Rv2527 Possible toxin VapC17 no 0.26
    3 Rv3731 Possible ATP-dependent DNA ligase LigC (polydeoxyribonucleotide synthase [ATP]) (polynucleotide ligase [ATP]) (sealase) (DNA repair protein) (DNA joinase) no 0.25
    4 Rv1077 Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) no 0.25
    5 Rv0843 Probable dehydrogenase no 0.25
    6 Rv3705c Conserved protein no 0.24
    7 Rv2296 Probable haloalkane dehalogenase no 0.23
    8 Rv2336 Hypothetical protein no 0.23
    9 Rv1470 Probable thioredoxin TrxA no 0.23
    10 Rv2491 Conserved hypothetical protein no 0.23
    11 Rv3711c Probable DNA polymerase III (epsilon subunit) DnaQ no 0.23
    12 Rv2667 Possible ATP-dependent protease ATP-binding subunit ClpC2 no 0.23
    13 Rv2141c Conserved protein no 0.23
    14 Rv3641c Possible cell filamentation protein Fic no 0.22
    15 Rv2030c Conserved protein no 0.22
    16 Rv2184c Conserved hypothetical protein no 0.22
    17 Rv2022c Conserved protein no 0.21
    18 Rv2854 Unknown protein no 0.21
    19 Rv2622 Possible methyltransferase (methylase) no 0.21
    20 Rv2639c Probable conserved integral membrane protein no 0.21

    Or look for negative cofitness