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  • Top cofit genes for MMP_RS05265 from Methanococcus maripaludis S2

    2-isopropylmalate synthase
    SEED: (R)-citramalate synthase (EC 2.3.1.182)
    KEGG: D-citramalate synthase

    Rank Hit Name Description Conserved? Cofitness  
    1 MMP_RS05930 3-isopropylmalate dehydratase large subunit 0.69 0.84
    2 MMP_RS03035 4-hydroxy-tetrahydrodipicolinate synthase no 0.81
    3 MMP_RS06270 TIGR00300 family protein no 0.77
    4 MMP_RS07730 pyruvate synthase subunit beta no 0.69
    5 MMP_RS07845 LL-diaminopimelate aminotransferase 0.70 0.68
    6 MMP_RS05500 2-isopropylmalate synthase no 0.67
    7 MMP_RS04500 adenosylmethionine--8-amino-7-oxononanoate transaminase no 0.66
    8 MMP_RS03435 ketol-acid reductoisomerase no 0.66
    9 MMP_RS06370 biotin synthase BioB no 0.66
    10 MMP_RS01830 tRNA-Val no 0.65
    11 MMP_RS01700 dihydroxy-acid dehydratase 0.58 0.65
    12 MMP_RS01455 nickel pincer cofactor biosynthesis protein LarC no 0.65
    13 MMP_RS04215 nickel pincer cofactor biosynthesis protein LarB no 0.64
    14 MMP_RS08095 dethiobiotin synthase no 0.64
    15 MMP_RS03450 glycine synthesis protein GlyXS (from data) no 0.62
    16 MMP_RS06375 ATP-dependent sacrificial sulfur transferase LarE no 0.62
    17 MMP_RS04685 DUF126 domain-containing protein no 0.62
    18 MMP_RS06730 phosphopantothenate/pantothenate synthetase no 0.62
    19 MMP_RS02345 GTP-dependent dephospho-CoA kinase family protein no 0.62
    20 MMP_RS08105 6-carboxyhexanoate--CoA ligase no 0.62

    Or look for negative cofitness