Experiment: D-Glucose
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt 16S_rrna and murI are separated by 376 nucleotides murI and btuB overlap by 56 nucleotides
NIAGMN_11270: 16S_rrna - 16S ribosomal RNA, at 2,224,256 to 2,225,797
_rrna
NIAGMN_11275: murI - glutamate racemase, at 2,226,174 to 2,227,031
murI
NIAGMN_11280: btuB - TonB-dependent vitamin B12 receptor BtuB, at 2,226,976 to 2,228,820
btuB
Position (kb)
2226
2227
2228 Strain fitness (log2 ratio)
-3
-2
-1
0
1
2
3 at 2226.181 kb on - strand at 2226.181 kb on - strand at 2227.044 kb on - strand at 2227.154 kb on + strand at 2227.160 kb on + strand at 2227.160 kb on + strand at 2227.160 kb on + strand at 2227.160 kb on + strand at 2227.160 kb on + strand at 2227.160 kb on + strand at 2227.161 kb on - strand, within btuB at 2227.161 kb on - strand, within btuB at 2227.161 kb on - strand, within btuB at 2227.161 kb on - strand, within btuB at 2227.161 kb on - strand, within btuB at 2227.170 kb on - strand, within btuB at 2227.181 kb on + strand, within btuB at 2227.192 kb on + strand, within btuB at 2227.193 kb on - strand, within btuB at 2227.193 kb on - strand, within btuB at 2227.196 kb on + strand, within btuB at 2227.196 kb on + strand, within btuB at 2227.196 kb on + strand, within btuB at 2227.197 kb on - strand, within btuB at 2227.197 kb on - strand, within btuB at 2227.197 kb on - strand, within btuB at 2227.197 kb on - strand, within btuB at 2227.202 kb on + strand, within btuB at 2227.202 kb on + strand, within btuB at 2227.202 kb on + strand, within btuB at 2227.202 kb on + strand, within btuB at 2227.202 kb on + strand, within btuB at 2227.203 kb on - strand, within btuB at 2227.203 kb on - strand, within btuB at 2227.203 kb on - strand, within btuB at 2227.206 kb on + strand, within btuB at 2227.206 kb on + strand, within btuB at 2227.206 kb on + strand, within btuB at 2227.206 kb on + strand, within btuB at 2227.206 kb on + strand, within btuB at 2227.206 kb on + strand, within btuB at 2227.206 kb on + strand, within btuB at 2227.206 kb on + strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.207 kb on - strand, within btuB at 2227.226 kb on + strand, within btuB at 2227.226 kb on + strand, within btuB at 2227.226 kb on + strand, within btuB at 2227.227 kb on - strand, within btuB at 2227.227 kb on - strand, within btuB at 2227.227 kb on - strand, within btuB at 2227.227 kb on - strand, within btuB at 2227.263 kb on + strand, within btuB at 2227.264 kb on - strand, within btuB at 2227.264 kb on - strand, within btuB at 2227.274 kb on - strand, within btuB at 2227.313 kb on + strand, within btuB at 2227.313 kb on + strand, within btuB at 2227.313 kb on + strand, within btuB at 2227.314 kb on - strand, within btuB at 2227.314 kb on - strand, within btuB at 2227.319 kb on + strand, within btuB at 2227.319 kb on + strand, within btuB at 2227.319 kb on + strand, within btuB at 2227.320 kb on - strand, within btuB at 2227.320 kb on - strand, within btuB at 2227.320 kb on - strand, within btuB at 2227.320 kb on - strand, within btuB at 2227.320 kb on - strand, within btuB at 2227.320 kb on - strand, within btuB at 2227.329 kb on + strand, within btuB at 2227.330 kb on - strand, within btuB at 2227.330 kb on - strand, within btuB at 2227.330 kb on - strand, within btuB at 2227.330 kb on - strand, within btuB at 2227.377 kb on + strand, within btuB at 2227.400 kb on + strand, within btuB at 2227.403 kb on + strand, within btuB at 2227.556 kb on + strand, within btuB at 2227.556 kb on + strand, within btuB at 2227.557 kb on - strand, within btuB at 2227.581 kb on + strand, within btuB at 2227.581 kb on + strand, within btuB at 2227.582 kb on - strand, within btuB at 2227.582 kb on - strand, within btuB at 2227.582 kb on - strand, within btuB at 2227.582 kb on - strand, within btuB at 2227.582 kb on - strand, within btuB at 2227.582 kb on - strand, within btuB at 2227.582 kb on - strand, within btuB at 2227.582 kb on - strand, within btuB at 2227.582 kb on - strand, within btuB at 2227.583 kb on + strand, within btuB at 2227.583 kb on + strand, within btuB at 2227.583 kb on + strand, within btuB at 2227.583 kb on + strand, within btuB at 2227.583 kb on + strand, within btuB at 2227.583 kb on + strand, within btuB at 2227.583 kb on + strand, within btuB at 2227.583 kb on + strand, within btuB at 2227.583 kb on + strand, within btuB at 2227.583 kb on + strand, within btuB at 2227.584 kb on - strand, within btuB at 2227.584 kb on - strand, within btuB at 2227.584 kb on - strand, within btuB at 2227.584 kb on - strand, within btuB at 2227.584 kb on - strand, within btuB at 2227.584 kb on - strand, within btuB at 2227.584 kb on - strand, within btuB at 2227.584 kb on - strand, within btuB at 2227.584 kb on - strand, within btuB at 2227.584 kb on - strand, within btuB at 2227.584 kb on - strand, within btuB at 2227.584 kb on - strand, within btuB at 2227.584 kb on - strand, within btuB at 2227.613 kb on + strand, within btuB at 2227.739 kb on + strand, within btuB at 2227.739 kb on + strand, within btuB at 2227.740 kb on - strand, within btuB at 2227.740 kb on - strand, within btuB at 2227.740 kb on - strand, within btuB at 2227.740 kb on - strand, within btuB at 2227.749 kb on + strand, within btuB at 2227.752 kb on + strand, within btuB at 2227.752 kb on + strand, within btuB at 2227.753 kb on - strand, within btuB at 2227.763 kb on + strand, within btuB at 2227.774 kb on - strand, within btuB at 2227.778 kb on + strand, within btuB at 2227.778 kb on + strand, within btuB at 2227.778 kb on + strand, within btuB at 2227.778 kb on + strand, within btuB at 2227.778 kb on + strand, within btuB at 2227.778 kb on + strand, within btuB at 2227.778 kb on + strand, within btuB at 2227.778 kb on + strand, within btuB at 2227.778 kb on + strand, within btuB at 2227.778 kb on + strand, within btuB at 2227.779 kb on - strand, within btuB at 2227.779 kb on - strand, within btuB at 2227.779 kb on - strand, within btuB at 2227.779 kb on - strand, within btuB at 2227.779 kb on - strand, within btuB at 2227.779 kb on - strand, within btuB at 2227.874 kb on + strand, within btuB at 2227.874 kb on + strand, within btuB at 2227.875 kb on - strand, within btuB at 2227.875 kb on - strand, within btuB at 2227.875 kb on - strand, within btuB at 2227.875 kb on - strand, within btuB at 2227.875 kb on - strand, within btuB at 2227.910 kb on + strand, within btuB at 2227.911 kb on - strand, within btuB at 2227.911 kb on - strand, within btuB at 2227.919 kb on + strand, within btuB at 2227.931 kb on + strand, within btuB at 2227.931 kb on + strand, within btuB at 2227.931 kb on + strand, within btuB at 2227.931 kb on + strand, within btuB at 2227.931 kb on + strand, within btuB at 2227.932 kb on - strand, within btuB at 2227.932 kb on - strand, within btuB at 2227.932 kb on - strand, within btuB at 2227.932 kb on - strand, within btuB at 2227.932 kb on - strand, within btuB at 2227.932 kb on - strand, within btuB at 2227.938 kb on - strand, within btuB at 2227.938 kb on - strand, within btuB at 2227.947 kb on + strand, within btuB at 2227.953 kb on + strand, within btuB at 2227.953 kb on + strand, within btuB at 2227.953 kb on + strand, within btuB at 2227.954 kb on - strand, within btuB at 2227.954 kb on - strand, within btuB at 2227.955 kb on + strand, within btuB at 2227.955 kb on + strand, within btuB at 2227.955 kb on + strand, within btuB at 2227.955 kb on + strand, within btuB at 2227.955 kb on + strand, within btuB at 2227.956 kb on - strand, within btuB at 2227.956 kb on - strand, within btuB at 2227.956 kb on - strand, within btuB at 2227.956 kb on - strand, within btuB at 2227.956 kb on - strand, within btuB at 2227.963 kb on - strand, within btuB at 2227.977 kb on + strand, within btuB at 2227.978 kb on - strand, within btuB at 2227.978 kb on - strand, within btuB at 2227.993 kb on - strand, within btuB at 2227.993 kb on - strand, within btuB at 2227.994 kb on + strand, within btuB at 2227.994 kb on + strand, within btuB at 2228.022 kb on + strand, within btuB at 2228.023 kb on - strand, within btuB at 2228.023 kb on - strand, within btuB at 2228.023 kb on - strand, within btuB at 2228.024 kb on + strand, within btuB at 2228.024 kb on + strand, within btuB at 2228.024 kb on + strand, within btuB at 2228.031 kb on + strand, within btuB
Per-strain Table
Position Strand Gene LocusTag Fraction D-Glucose remove 2,226,181 - +1.2 2,226,181 - +0.1 2,227,044 - +0.6 2,227,154 + +2.0 2,227,160 + +1.5 2,227,160 + -0.5 2,227,160 + -0.3 2,227,160 + -1.9 2,227,160 + +1.0 2,227,160 + -0.8 2,227,161 - btuB NIAGMN_11280 0.10 +0.2 2,227,161 - btuB NIAGMN_11280 0.10 -1.2 2,227,161 - btuB NIAGMN_11280 0.10 +0.0 2,227,161 - btuB NIAGMN_11280 0.10 -1.8 2,227,161 - btuB NIAGMN_11280 0.10 +0.4 2,227,170 - btuB NIAGMN_11280 0.11 -0.4 2,227,181 + btuB NIAGMN_11280 0.11 +0.6 2,227,192 + btuB NIAGMN_11280 0.12 +0.3 2,227,193 - btuB NIAGMN_11280 0.12 +0.3 2,227,193 - btuB NIAGMN_11280 0.12 -1.0 2,227,196 + btuB NIAGMN_11280 0.12 +1.0 2,227,196 + btuB NIAGMN_11280 0.12 -0.8 2,227,196 + btuB NIAGMN_11280 0.12 -0.4 2,227,197 - btuB NIAGMN_11280 0.12 +1.5 2,227,197 - btuB NIAGMN_11280 0.12 -2.1 2,227,197 - btuB NIAGMN_11280 0.12 -0.1 2,227,197 - btuB NIAGMN_11280 0.12 +0.0 2,227,202 + btuB NIAGMN_11280 0.12 -2.2 2,227,202 + btuB NIAGMN_11280 0.12 -0.8 2,227,202 + btuB NIAGMN_11280 0.12 -0.2 2,227,202 + btuB NIAGMN_11280 0.12 -0.9 2,227,202 + btuB NIAGMN_11280 0.12 -0.2 2,227,203 - btuB NIAGMN_11280 0.12 +0.3 2,227,203 - btuB NIAGMN_11280 0.12 +1.8 2,227,203 - btuB NIAGMN_11280 0.12 -0.2 2,227,206 + btuB NIAGMN_11280 0.12 -0.3 2,227,206 + btuB NIAGMN_11280 0.12 +1.2 2,227,206 + btuB NIAGMN_11280 0.12 +0.6 2,227,206 + btuB NIAGMN_11280 0.12 -0.0 2,227,206 + btuB NIAGMN_11280 0.12 +0.6 2,227,206 + btuB NIAGMN_11280 0.12 -0.0 2,227,206 + btuB NIAGMN_11280 0.12 -1.0 2,227,206 + btuB NIAGMN_11280 0.12 -2.2 2,227,207 - btuB NIAGMN_11280 0.13 -0.4 2,227,207 - btuB NIAGMN_11280 0.13 +1.4 2,227,207 - btuB NIAGMN_11280 0.13 -0.7 2,227,207 - btuB NIAGMN_11280 0.13 -0.8 2,227,207 - btuB NIAGMN_11280 0.13 -0.3 2,227,207 - btuB NIAGMN_11280 0.13 -1.5 2,227,207 - btuB NIAGMN_11280 0.13 +0.9 2,227,207 - btuB NIAGMN_11280 0.13 -3.4 2,227,207 - btuB NIAGMN_11280 0.13 +0.7 2,227,207 - btuB NIAGMN_11280 0.13 -1.2 2,227,207 - btuB NIAGMN_11280 0.13 +1.3 2,227,207 - btuB NIAGMN_11280 0.13 +1.7 2,227,207 - btuB NIAGMN_11280 0.13 -1.8 2,227,207 - btuB NIAGMN_11280 0.13 +0.1 2,227,207 - btuB NIAGMN_11280 0.13 +1.7 2,227,226 + btuB NIAGMN_11280 0.14 -0.1 2,227,226 + btuB NIAGMN_11280 0.14 -2.2 2,227,226 + btuB NIAGMN_11280 0.14 -2.5 2,227,227 - btuB NIAGMN_11280 0.14 +0.7 2,227,227 - btuB NIAGMN_11280 0.14 -0.6 2,227,227 - btuB NIAGMN_11280 0.14 +0.7 2,227,227 - btuB NIAGMN_11280 0.14 -2.6 2,227,263 + btuB NIAGMN_11280 0.16 +0.1 2,227,264 - btuB NIAGMN_11280 0.16 +0.3 2,227,264 - btuB NIAGMN_11280 0.16 -0.6 2,227,274 - btuB NIAGMN_11280 0.16 +0.6 2,227,313 + btuB NIAGMN_11280 0.18 +0.9 2,227,313 + btuB NIAGMN_11280 0.18 +0.0 2,227,313 + btuB NIAGMN_11280 0.18 -1.4 2,227,314 - btuB NIAGMN_11280 0.18 -2.6 2,227,314 - btuB NIAGMN_11280 0.18 +0.3 2,227,319 + btuB NIAGMN_11280 0.19 +0.1 2,227,319 + btuB NIAGMN_11280 0.19 +0.2 2,227,319 + btuB NIAGMN_11280 0.19 +1.2 2,227,320 - btuB NIAGMN_11280 0.19 +0.1 2,227,320 - btuB NIAGMN_11280 0.19 -0.5 2,227,320 - btuB NIAGMN_11280 0.19 -0.2 2,227,320 - btuB NIAGMN_11280 0.19 -0.6 2,227,320 - btuB NIAGMN_11280 0.19 -0.2 2,227,320 - btuB NIAGMN_11280 0.19 +1.1 2,227,329 + btuB NIAGMN_11280 0.19 -0.5 2,227,330 - btuB NIAGMN_11280 0.19 -0.9 2,227,330 - btuB NIAGMN_11280 0.19 -1.1 2,227,330 - btuB NIAGMN_11280 0.19 +0.3 2,227,330 - btuB NIAGMN_11280 0.19 +0.5 2,227,377 + btuB NIAGMN_11280 0.22 +0.9 2,227,400 + btuB NIAGMN_11280 0.23 +0.3 2,227,403 + btuB NIAGMN_11280 0.23 -0.1 2,227,556 + btuB NIAGMN_11280 0.31 +0.5 2,227,556 + btuB NIAGMN_11280 0.31 -0.1 2,227,557 - btuB NIAGMN_11280 0.31 +0.2 2,227,581 + btuB NIAGMN_11280 0.33 +0.4 2,227,581 + btuB NIAGMN_11280 0.33 +0.5 2,227,582 - btuB NIAGMN_11280 0.33 -0.8 2,227,582 - btuB NIAGMN_11280 0.33 +1.1 2,227,582 - btuB NIAGMN_11280 0.33 -0.4 2,227,582 - btuB NIAGMN_11280 0.33 -2.2 2,227,582 - btuB NIAGMN_11280 0.33 -1.4 2,227,582 - btuB NIAGMN_11280 0.33 -1.6 2,227,582 - btuB NIAGMN_11280 0.33 -1.3 2,227,582 - btuB NIAGMN_11280 0.33 +0.2 2,227,582 - btuB NIAGMN_11280 0.33 -0.5 2,227,583 + btuB NIAGMN_11280 0.33 +1.0 2,227,583 + btuB NIAGMN_11280 0.33 -1.2 2,227,583 + btuB NIAGMN_11280 0.33 -1.1 2,227,583 + btuB NIAGMN_11280 0.33 +0.1 2,227,583 + btuB NIAGMN_11280 0.33 -1.6 2,227,583 + btuB NIAGMN_11280 0.33 +0.2 2,227,583 + btuB NIAGMN_11280 0.33 -0.2 2,227,583 + btuB NIAGMN_11280 0.33 -3.0 2,227,583 + btuB NIAGMN_11280 0.33 -0.0 2,227,583 + btuB NIAGMN_11280 0.33 -0.4 2,227,584 - btuB NIAGMN_11280 0.33 -0.6 2,227,584 - btuB NIAGMN_11280 0.33 +1.0 2,227,584 - btuB NIAGMN_11280 0.33 -0.6 2,227,584 - btuB NIAGMN_11280 0.33 -0.4 2,227,584 - btuB NIAGMN_11280 0.33 +0.0 2,227,584 - btuB NIAGMN_11280 0.33 -0.1 2,227,584 - btuB NIAGMN_11280 0.33 +0.3 2,227,584 - btuB NIAGMN_11280 0.33 +0.1 2,227,584 - btuB NIAGMN_11280 0.33 +0.7 2,227,584 - btuB NIAGMN_11280 0.33 -0.2 2,227,584 - btuB NIAGMN_11280 0.33 +0.4 2,227,584 - btuB NIAGMN_11280 0.33 +2.2 2,227,584 - btuB NIAGMN_11280 0.33 +0.7 2,227,613 + btuB NIAGMN_11280 0.35 -0.6 2,227,739 + btuB NIAGMN_11280 0.41 +1.2 2,227,739 + btuB NIAGMN_11280 0.41 -0.4 2,227,740 - btuB NIAGMN_11280 0.41 -0.2 2,227,740 - btuB NIAGMN_11280 0.41 +1.3 2,227,740 - btuB NIAGMN_11280 0.41 -0.1 2,227,740 - btuB NIAGMN_11280 0.41 -0.3 2,227,749 + btuB NIAGMN_11280 0.42 +0.5 2,227,752 + btuB NIAGMN_11280 0.42 -0.8 2,227,752 + btuB NIAGMN_11280 0.42 -0.2 2,227,753 - btuB NIAGMN_11280 0.42 -0.2 2,227,763 + btuB NIAGMN_11280 0.43 +3.3 2,227,774 - btuB NIAGMN_11280 0.43 -0.6 2,227,778 + btuB NIAGMN_11280 0.43 -0.8 2,227,778 + btuB NIAGMN_11280 0.43 -0.4 2,227,778 + btuB NIAGMN_11280 0.43 -0.5 2,227,778 + btuB NIAGMN_11280 0.43 -0.1 2,227,778 + btuB NIAGMN_11280 0.43 +0.6 2,227,778 + btuB NIAGMN_11280 0.43 +1.3 2,227,778 + btuB NIAGMN_11280 0.43 -1.1 2,227,778 + btuB NIAGMN_11280 0.43 +0.8 2,227,778 + btuB NIAGMN_11280 0.43 -0.1 2,227,778 + btuB NIAGMN_11280 0.43 +0.0 2,227,779 - btuB NIAGMN_11280 0.44 -0.2 2,227,779 - btuB NIAGMN_11280 0.44 -1.5 2,227,779 - btuB NIAGMN_11280 0.44 +0.7 2,227,779 - btuB NIAGMN_11280 0.44 +0.4 2,227,779 - btuB NIAGMN_11280 0.44 -1.1 2,227,779 - btuB NIAGMN_11280 0.44 -0.5 2,227,874 + btuB NIAGMN_11280 0.49 +0.2 2,227,874 + btuB NIAGMN_11280 0.49 +0.3 2,227,875 - btuB NIAGMN_11280 0.49 +0.5 2,227,875 - btuB NIAGMN_11280 0.49 +1.7 2,227,875 - btuB NIAGMN_11280 0.49 -0.3 2,227,875 - btuB NIAGMN_11280 0.49 -0.6 2,227,875 - btuB NIAGMN_11280 0.49 -0.8 2,227,910 + btuB NIAGMN_11280 0.51 -0.2 2,227,911 - btuB NIAGMN_11280 0.51 -0.5 2,227,911 - btuB NIAGMN_11280 0.51 -0.3 2,227,919 + btuB NIAGMN_11280 0.51 -1.7 2,227,931 + btuB NIAGMN_11280 0.52 -0.7 2,227,931 + btuB NIAGMN_11280 0.52 +1.0 2,227,931 + btuB NIAGMN_11280 0.52 -1.3 2,227,931 + btuB NIAGMN_11280 0.52 -2.1 2,227,931 + btuB NIAGMN_11280 0.52 +0.1 2,227,932 - btuB NIAGMN_11280 0.52 -0.0 2,227,932 - btuB NIAGMN_11280 0.52 -0.4 2,227,932 - btuB NIAGMN_11280 0.52 +0.1 2,227,932 - btuB NIAGMN_11280 0.52 +0.5 2,227,932 - btuB NIAGMN_11280 0.52 +1.0 2,227,932 - btuB NIAGMN_11280 0.52 -2.2 2,227,938 - btuB NIAGMN_11280 0.52 -0.5 2,227,938 - btuB NIAGMN_11280 0.52 -1.2 2,227,947 + btuB NIAGMN_11280 0.53 +0.1 2,227,953 + btuB NIAGMN_11280 0.53 -1.1 2,227,953 + btuB NIAGMN_11280 0.53 +0.8 2,227,953 + btuB NIAGMN_11280 0.53 -1.8 2,227,954 - btuB NIAGMN_11280 0.53 -0.8 2,227,954 - btuB NIAGMN_11280 0.53 -0.5 2,227,955 + btuB NIAGMN_11280 0.53 +0.0 2,227,955 + btuB NIAGMN_11280 0.53 -0.5 2,227,955 + btuB NIAGMN_11280 0.53 -1.4 2,227,955 + btuB NIAGMN_11280 0.53 +0.8 2,227,955 + btuB NIAGMN_11280 0.53 +0.3 2,227,956 - btuB NIAGMN_11280 0.53 -1.7 2,227,956 - btuB NIAGMN_11280 0.53 -1.8 2,227,956 - btuB NIAGMN_11280 0.53 -0.6 2,227,956 - btuB NIAGMN_11280 0.53 -0.3 2,227,956 - btuB NIAGMN_11280 0.53 +0.2 2,227,963 - btuB NIAGMN_11280 0.53 +1.0 2,227,977 + btuB NIAGMN_11280 0.54 +0.8 2,227,978 - btuB NIAGMN_11280 0.54 -0.2 2,227,978 - btuB NIAGMN_11280 0.54 +0.2 2,227,993 - btuB NIAGMN_11280 0.55 -0.9 2,227,993 - btuB NIAGMN_11280 0.55 -0.4 2,227,994 + btuB NIAGMN_11280 0.55 -0.5 2,227,994 + btuB NIAGMN_11280 0.55 +0.7 2,228,022 + btuB NIAGMN_11280 0.57 -0.3 2,228,023 - btuB NIAGMN_11280 0.57 -1.9 2,228,023 - btuB NIAGMN_11280 0.57 -1.0 2,228,023 - btuB NIAGMN_11280 0.57 -0.6 2,228,024 + btuB NIAGMN_11280 0.57 -0.9 2,228,024 + btuB NIAGMN_11280 0.57 +0.6 2,228,024 + btuB NIAGMN_11280 0.57 +1.6 2,228,031 + btuB NIAGMN_11280 0.57 +0.2
Or see this region's nucleotide sequence