Experiment: m.b.  D-Cycloserine 0.064 mg/ml 
Only strains with sufficient reads to estimate fitness are shown,
                   but the strain fitness values are still rather noisy and may be biased towards zero.
                   Strains near the edge of a gene are not shown as being associated with that
                   gene (they are in grey).
                   Strains in the central 10-90% of a gene are color coded by the insertion's strand.
                   Usually, "+" means that the selectable marker is encoded on the forward strand,
                   i.e., transcribed rightward. 
    
        
         
     
    
        
         
     
    
        
         
     
    
        
         
     
    
         
     
     
 
500 nt Echvi_1099 and Echvi_1100 are separated by 184 nucleotides Echvi_1100 and Echvi_1101 are separated by 202 nucleotides Echvi_1101 and Echvi_1102 are separated by 39 nucleotides  
        
        Echvi_1099: Echvi_1099 - hypothetical protein, at 1,259,316 to 1,260,587 
         
        _1099 
         
        
        Echvi_1100: Echvi_1100 - cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases, at 1,260,772 to 1,261,485 
         
        _1100 
         
        
        Echvi_1101: Echvi_1101 - N-acetylglutamate synthase and related acetyltransferases, at 1,261,688 to 1,262,170 
         
        _1101 
         
        
        Echvi_1102: Echvi_1102 - cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases, at 1,262,210 to 1,262,776 
         
        _1102 
         Position (kb)  
1260 
 
1261 
 
1262 Strain fitness (log2 ratio)  
-3 
 
-2 
 
-1 
 
0 
 
1 
 
2 
 
3 
 
4 at 1259.805 kb on - strand, within Echvi_1099 at 1259.805 kb on - strand, within Echvi_1099 at 1259.857 kb on + strand, within Echvi_1099 at 1259.857 kb on + strand, within Echvi_1099 at 1259.858 kb on - strand, within Echvi_1099 at 1259.858 kb on - strand, within Echvi_1099 at 1259.861 kb on - strand, within Echvi_1099 at 1259.874 kb on + strand, within Echvi_1099 at 1259.875 kb on - strand, within Echvi_1099 at 1259.875 kb on - strand, within Echvi_1099 at 1259.895 kb on + strand, within Echvi_1099 at 1259.895 kb on + strand, within Echvi_1099 at 1259.895 kb on + strand, within Echvi_1099 at 1259.937 kb on - strand, within Echvi_1099 at 1260.016 kb on + strand, within Echvi_1099 at 1260.017 kb on - strand, within Echvi_1099 at 1260.029 kb on + strand, within Echvi_1099 at 1260.030 kb on - strand, within Echvi_1099 at 1260.030 kb on - strand, within Echvi_1099 at 1260.031 kb on + strand, within Echvi_1099 at 1260.032 kb on - strand, within Echvi_1099 at 1260.042 kb on + strand, within Echvi_1099 at 1260.043 kb on - strand, within Echvi_1099 at 1260.048 kb on - strand, within Echvi_1099 at 1260.048 kb on - strand, within Echvi_1099 at 1260.050 kb on - strand, within Echvi_1099 at 1260.073 kb on - strand, within Echvi_1099 at 1260.073 kb on - strand, within Echvi_1099 at 1260.073 kb on - strand, within Echvi_1099 at 1260.073 kb on - strand, within Echvi_1099 at 1260.107 kb on + strand, within Echvi_1099 at 1260.109 kb on + strand, within Echvi_1099 at 1260.121 kb on - strand, within Echvi_1099 at 1260.121 kb on - strand, within Echvi_1099 at 1260.224 kb on + strand, within Echvi_1099 at 1260.229 kb on + strand, within Echvi_1099 at 1260.229 kb on + strand, within Echvi_1099 at 1260.229 kb on + strand, within Echvi_1099 at 1260.229 kb on + strand, within Echvi_1099 at 1260.353 kb on + strand, within Echvi_1099 at 1260.354 kb on - strand, within Echvi_1099 at 1260.377 kb on + strand, within Echvi_1099 at 1260.378 kb on - strand, within Echvi_1099 at 1260.378 kb on - strand, within Echvi_1099 at 1260.381 kb on + strand, within Echvi_1099 at 1260.398 kb on + strand, within Echvi_1099 at 1260.399 kb on - strand, within Echvi_1099 at 1260.399 kb on - strand, within Echvi_1099 at 1260.399 kb on - strand, within Echvi_1099 at 1260.400 kb on + strand, within Echvi_1099 at 1260.401 kb on - strand, within Echvi_1099 at 1260.401 kb on - strand, within Echvi_1099 at 1260.409 kb on + strand, within Echvi_1099 at 1260.409 kb on + strand, within Echvi_1099 at 1260.410 kb on - strand, within Echvi_1099 at 1260.502 kb on - strand at 1260.515 kb on + strand at 1260.533 kb on + strand at 1260.555 kb on + strand at 1260.575 kb on - strand at 1260.625 kb on - strand at 1260.648 kb on + strand at 1260.657 kb on + strand at 1260.677 kb on + strand at 1260.677 kb on + strand at 1260.678 kb on - strand at 1260.678 kb on - strand at 1260.701 kb on + strand at 1260.742 kb on + strand at 1260.743 kb on - strand at 1260.754 kb on - strand at 1260.754 kb on - strand at 1260.773 kb on + strand at 1260.788 kb on + strand at 1260.932 kb on - strand, within Echvi_1100 at 1260.952 kb on + strand, within Echvi_1100 at 1260.952 kb on + strand, within Echvi_1100 at 1260.953 kb on - strand, within Echvi_1100 at 1260.953 kb on - strand, within Echvi_1100 at 1260.953 kb on - strand, within Echvi_1100 at 1260.990 kb on + strand, within Echvi_1100 at 1260.990 kb on + strand, within Echvi_1100 at 1260.991 kb on - strand, within Echvi_1100 at 1260.991 kb on - strand, within Echvi_1100 at 1260.991 kb on - strand, within Echvi_1100 at 1260.993 kb on + strand, within Echvi_1100 at 1260.993 kb on + strand, within Echvi_1100 at 1260.993 kb on + strand, within Echvi_1100 at 1261.011 kb on + strand, within Echvi_1100 at 1261.065 kb on + strand, within Echvi_1100 at 1261.083 kb on - strand, within Echvi_1100 at 1261.105 kb on + strand, within Echvi_1100 at 1261.105 kb on + strand, within Echvi_1100 at 1261.106 kb on - strand, within Echvi_1100 at 1261.106 kb on - strand, within Echvi_1100 at 1261.123 kb on + strand, within Echvi_1100 at 1261.123 kb on + strand, within Echvi_1100 at 1261.124 kb on - strand, within Echvi_1100 at 1261.196 kb on + strand, within Echvi_1100 at 1261.197 kb on - strand, within Echvi_1100 at 1261.197 kb on - strand, within Echvi_1100 at 1261.297 kb on + strand, within Echvi_1100 at 1261.297 kb on + strand, within Echvi_1100 at 1261.297 kb on + strand, within Echvi_1100 at 1261.297 kb on + strand, within Echvi_1100 at 1261.314 kb on + strand, within Echvi_1100 at 1261.319 kb on + strand, within Echvi_1100 at 1261.351 kb on - strand, within Echvi_1100 at 1261.386 kb on + strand, within Echvi_1100 at 1261.386 kb on + strand, within Echvi_1100 at 1261.386 kb on + strand, within Echvi_1100 at 1261.386 kb on + strand, within Echvi_1100 at 1261.386 kb on + strand, within Echvi_1100 at 1261.386 kb on + strand, within Echvi_1100 at 1261.386 kb on + strand, within Echvi_1100 at 1261.387 kb on - strand, within Echvi_1100 at 1261.387 kb on - strand, within Echvi_1100 at 1261.387 kb on - strand, within Echvi_1100 at 1261.387 kb on - strand, within Echvi_1100 at 1261.400 kb on - strand, within Echvi_1100 at 1261.452 kb on + strand at 1261.459 kb on - strand at 1261.459 kb on - strand at 1261.461 kb on - strand at 1261.632 kb on + strand at 1261.642 kb on + strand at 1261.642 kb on + strand at 1261.643 kb on - strand at 1261.648 kb on - strand at 1261.653 kb on + strand at 1261.653 kb on + strand at 1261.653 kb on + strand at 1261.654 kb on - strand at 1261.697 kb on + strand at 1261.698 kb on - strand at 1261.704 kb on + strand at 1261.709 kb on - strand at 1261.732 kb on + strand at 1261.732 kb on + strand at 1261.737 kb on + strand, within Echvi_1101 at 1261.737 kb on + strand, within Echvi_1101 at 1261.875 kb on + strand, within Echvi_1101 at 1261.887 kb on - strand, within Echvi_1101 at 1261.931 kb on + strand, within Echvi_1101 at 1261.931 kb on + strand, within Echvi_1101 at 1261.932 kb on - strand, within Echvi_1101 at 1261.946 kb on + strand, within Echvi_1101 at 1261.946 kb on + strand, within Echvi_1101 at 1261.946 kb on + strand, within Echvi_1101 at 1261.947 kb on - strand, within Echvi_1101 at 1261.948 kb on + strand, within Echvi_1101 at 1261.948 kb on + strand, within Echvi_1101 at 1261.949 kb on - strand, within Echvi_1101 at 1261.961 kb on + strand, within Echvi_1101 at 1261.961 kb on + strand, within Echvi_1101 at 1261.962 kb on - strand, within Echvi_1101 at 1261.992 kb on + strand, within Echvi_1101 at 1261.992 kb on + strand, within Echvi_1101 at 1261.993 kb on - strand, within Echvi_1101 at 1262.040 kb on + strand, within Echvi_1101 at 1262.041 kb on - strand, within Echvi_1101 at 1262.041 kb on - strand, within Echvi_1101 at 1262.041 kb on - strand, within Echvi_1101 at 1262.041 kb on - strand, within Echvi_1101 at 1262.163 kb on + strand at 1262.168 kb on + strand at 1262.173 kb on + strand at 1262.173 kb on + strand at 1262.173 kb on + strand at 1262.173 kb on + strand at 1262.173 kb on + strand at 1262.173 kb on + strand at 1262.173 kb on + strand at 1262.173 kb on + strand at 1262.173 kb on + strand at 1262.173 kb on + strand at 1262.173 kb on + strand at 1262.173 kb on + strand at 1262.173 kb on + strand at 1262.173 kb on + strand at 1262.173 kb on + strand at 1262.174 kb on - strand at 1262.174 kb on - strand at 1262.174 kb on - strand at 1262.174 kb on - strand at 1262.174 kb on - strand at 1262.174 kb on - strand at 1262.174 kb on - strand at 1262.174 kb on - strand at 1262.174 kb on - strand at 1262.174 kb on - strand at 1262.174 kb on - strand at 1262.174 kb on - strand at 1262.174 kb on - strand at 1262.174 kb on - strand at 1262.177 kb on + strand at 1262.184 kb on + strand at 1262.333 kb on - strand, within Echvi_1102 at 1262.346 kb on - strand, within Echvi_1102 at 1262.346 kb on - strand, within Echvi_1102 at 1262.346 kb on - strand, within Echvi_1102 at 1262.378 kb on + strand, within Echvi_1102 at 1262.381 kb on + strand, within Echvi_1102 at 1262.381 kb on + strand, within Echvi_1102 at 1262.381 kb on + strand, within Echvi_1102 at 1262.381 kb on + strand, within Echvi_1102 at 1262.381 kb on + strand, within Echvi_1102 at 1262.382 kb on - strand, within Echvi_1102 at 1262.382 kb on - strand, within Echvi_1102 at 1262.382 kb on - strand, within Echvi_1102 at 1262.383 kb on + strand, within Echvi_1102 at 1262.383 kb on + strand, within Echvi_1102 at 1262.384 kb on - strand, within Echvi_1102 at 1262.473 kb on + strand, within Echvi_1102 at 1262.474 kb on - strand, within Echvi_1102 at 1262.474 kb on - strand, within Echvi_1102 at 1262.474 kb on - strand, within Echvi_1102 at 1262.474 kb on - strand, within Echvi_1102 at 1262.474 kb on - strand, within Echvi_1102 at 1262.474 kb on - strand at 1262.477 kb on + strand, within Echvi_1102 at 1262.478 kb on - strand, within Echvi_1102 at 1262.478 kb on - strand, within Echvi_1102 at 1262.478 kb on - strand, within Echvi_1102 at 1262.478 kb on - strand, within Echvi_1102 at 1262.478 kb on - strand, within Echvi_1102 at 1262.478 kb on - strand, within Echvi_1102 at 1262.478 kb on - strand, within Echvi_1102 at 1262.479 kb on + strand, within Echvi_1102 at 1262.479 kb on + strand, within Echvi_1102  
 
 
 
Per-strain Table 
Position  Strand  Gene  LocusTag  Fraction   m.b.  D-Cycloserine 0.064 mg/ml             remove   1,259,805   -    Echvi_1099   0.38  -0.7   1,259,805   -    Echvi_1099   0.38  -0.1   1,259,857   +    Echvi_1099   0.43  +0.4   1,259,857   +    Echvi_1099   0.43  +1.6   1,259,858   -    Echvi_1099   0.43  +2.5   1,259,858   -    Echvi_1099   0.43  +0.6   1,259,861   -    Echvi_1099   0.43  +0.1   1,259,874   +    Echvi_1099   0.44  +1.2   1,259,875   -    Echvi_1099   0.44  +1.2   1,259,875   -    Echvi_1099   0.44  +0.5   1,259,895   +    Echvi_1099   0.46  +0.9   1,259,895   +    Echvi_1099   0.46  +0.5   1,259,895   +    Echvi_1099   0.46  +0.2   1,259,937   -    Echvi_1099   0.49  -1.5   1,260,016   +    Echvi_1099   0.55  +1.5   1,260,017   -    Echvi_1099   0.55  +0.1   1,260,029   +    Echvi_1099   0.56  +0.5   1,260,030   -    Echvi_1099   0.56  +0.5   1,260,030   -    Echvi_1099   0.56  -0.2   1,260,031   +    Echvi_1099   0.56  +2.5   1,260,032   -    Echvi_1099   0.56  +0.5   1,260,042   +    Echvi_1099   0.57  -1.3   1,260,043   -    Echvi_1099   0.57  +3.7   1,260,048   -    Echvi_1099   0.58  +0.2   1,260,048   -    Echvi_1099   0.58  +1.5   1,260,050   -    Echvi_1099   0.58  +1.0   1,260,073   -    Echvi_1099   0.60  -2.4   1,260,073   -    Echvi_1099   0.60  -2.1   1,260,073   -    Echvi_1099   0.60  +0.8   1,260,073   -    Echvi_1099   0.60  +1.4   1,260,107   +    Echvi_1099   0.62  -2.5   1,260,109   +    Echvi_1099   0.62  +1.3   1,260,121   -    Echvi_1099   0.63  +1.1   1,260,121   -    Echvi_1099   0.63  +0.2   1,260,224   +    Echvi_1099   0.71  -1.9   1,260,229   +    Echvi_1099   0.72  +0.6   1,260,229   +    Echvi_1099   0.72  -2.9   1,260,229   +    Echvi_1099   0.72  -0.2   1,260,229   +    Echvi_1099   0.72  -0.9   1,260,353   +    Echvi_1099   0.82  +0.9   1,260,354   -    Echvi_1099   0.82  -0.9   1,260,377   +    Echvi_1099   0.83  -1.1   1,260,378   -    Echvi_1099   0.83  +0.3   1,260,378   -    Echvi_1099   0.83  +0.2   1,260,381   +    Echvi_1099   0.84  +0.0   1,260,398   +    Echvi_1099   0.85  -1.8   1,260,399   -    Echvi_1099   0.85  -0.1   1,260,399   -    Echvi_1099   0.85  -1.0   1,260,399   -    Echvi_1099   0.85  -0.3   1,260,400   +    Echvi_1099   0.85  -2.2   1,260,401   -    Echvi_1099   0.85  -2.9   1,260,401   -    Echvi_1099   0.85  -0.2   1,260,409   +    Echvi_1099   0.86  -2.5   1,260,409   +    Echvi_1099   0.86  -2.4   1,260,410   -    Echvi_1099   0.86  -0.3   1,260,502   -        -1.3   1,260,515   +        +1.4   1,260,533   +        +1.9   1,260,555   +        +1.6   1,260,575   -        -1.4   1,260,625   -        +0.3   1,260,648   +        -0.1   1,260,657   +        -0.1   1,260,677   +        -1.1   1,260,677   +        +1.7   1,260,678   -        +1.2   1,260,678   -        -0.8   1,260,701   +        +0.6   1,260,742   +        +0.6   1,260,743   -        -2.7   1,260,754   -        -0.1   1,260,754   -        -2.2   1,260,773   +        +0.7   1,260,788   +        +1.6   1,260,932   -    Echvi_1100   0.22  +0.5   1,260,952   +    Echvi_1100   0.25  -1.2   1,260,952   +    Echvi_1100   0.25  +0.9   1,260,953   -    Echvi_1100   0.25  +1.7   1,260,953   -    Echvi_1100   0.25  -1.8   1,260,953   -    Echvi_1100   0.25  +1.0   1,260,990   +    Echvi_1100   0.31  +1.7   1,260,990   +    Echvi_1100   0.31  +1.9   1,260,991   -    Echvi_1100   0.31  -0.7   1,260,991   -    Echvi_1100   0.31  -1.5   1,260,991   -    Echvi_1100   0.31  -0.8   1,260,993   +    Echvi_1100   0.31  +0.2   1,260,993   +    Echvi_1100   0.31  -1.2   1,260,993   +    Echvi_1100   0.31  +1.2   1,261,011   +    Echvi_1100   0.33  -1.6   1,261,065   +    Echvi_1100   0.41  -0.5   1,261,083   -    Echvi_1100   0.44  +1.5   1,261,105   +    Echvi_1100   0.47  -1.9   1,261,105   +    Echvi_1100   0.47  +1.4   1,261,106   -    Echvi_1100   0.47  +1.0   1,261,106   -    Echvi_1100   0.47  +0.7   1,261,123   +    Echvi_1100   0.49  +0.3   1,261,123   +    Echvi_1100   0.49  +2.0   1,261,124   -    Echvi_1100   0.49  -1.9   1,261,196   +    Echvi_1100   0.59  +2.2   1,261,197   -    Echvi_1100   0.60  +1.4   1,261,197   -    Echvi_1100   0.60  +1.0   1,261,297   +    Echvi_1100   0.74  -1.8   1,261,297   +    Echvi_1100   0.74  +1.7   1,261,297   +    Echvi_1100   0.74  +0.5   1,261,297   +    Echvi_1100   0.74  +2.4   1,261,314   +    Echvi_1100   0.76  -1.8   1,261,319   +    Echvi_1100   0.77  -3.1   1,261,351   -    Echvi_1100   0.81  -0.5   1,261,386   +    Echvi_1100   0.86  -1.6   1,261,386   +    Echvi_1100   0.86  -1.6   1,261,386   +    Echvi_1100   0.86  -3.1   1,261,386   +    Echvi_1100   0.86  -1.1   1,261,386   +    Echvi_1100   0.86  +0.2   1,261,386   +    Echvi_1100   0.86  +1.7   1,261,386   +    Echvi_1100   0.86  -1.3   1,261,387   -    Echvi_1100   0.86  -0.9   1,261,387   -    Echvi_1100   0.86  +1.7   1,261,387   -    Echvi_1100   0.86  -1.1   1,261,387   -    Echvi_1100   0.86  +0.8   1,261,400   -    Echvi_1100   0.88  -0.5   1,261,452   +        -0.2   1,261,459   -        -1.5   1,261,459   -        -0.3   1,261,461   -        -0.6   1,261,632   +        -0.5   1,261,642   +        -1.8   1,261,642   +        +1.2   1,261,643   -        +1.1   1,261,648   -        -1.8   1,261,653   +        -1.4   1,261,653   +        +1.1   1,261,653   +        -1.6   1,261,654   -        -0.1   1,261,697   +        -3.2   1,261,698   -        +1.2   1,261,704   +        -0.4   1,261,709   -        +1.6   1,261,732   +        +0.5   1,261,732   +        +0.3   1,261,737   +    Echvi_1101   0.10  +2.4   1,261,737   +    Echvi_1101   0.10  -2.4   1,261,875   +    Echvi_1101   0.39  -1.2   1,261,887   -    Echvi_1101   0.41  +0.7   1,261,931   +    Echvi_1101   0.50  +0.4   1,261,931   +    Echvi_1101   0.50  -3.0   1,261,932   -    Echvi_1101   0.51  +2.0   1,261,946   +    Echvi_1101   0.53  -0.5   1,261,946   +    Echvi_1101   0.53  +1.4   1,261,946   +    Echvi_1101   0.53  -0.1   1,261,947   -    Echvi_1101   0.54  +0.5   1,261,948   +    Echvi_1101   0.54  +1.2   1,261,948   +    Echvi_1101   0.54  -0.5   1,261,949   -    Echvi_1101   0.54  -1.7   1,261,961   +    Echvi_1101   0.57  -0.5   1,261,961   +    Echvi_1101   0.57  -0.6   1,261,962   -    Echvi_1101   0.57  +1.9   1,261,992   +    Echvi_1101   0.63  -0.5   1,261,992   +    Echvi_1101   0.63  -2.2   1,261,993   -    Echvi_1101   0.63  -1.1   1,262,040   +    Echvi_1101   0.73  -2.1   1,262,041   -    Echvi_1101   0.73  +1.0   1,262,041   -    Echvi_1101   0.73  -1.3   1,262,041   -    Echvi_1101   0.73  -0.3   1,262,041   -    Echvi_1101   0.73  +2.1   1,262,163   +        +0.2   1,262,168   +        -1.9   1,262,173   +        +0.2   1,262,173   +        +0.5   1,262,173   +        -1.2   1,262,173   +        -1.6   1,262,173   +        +2.4   1,262,173   +        +1.8   1,262,173   +        -0.6   1,262,173   +        +0.9   1,262,173   +        -0.3   1,262,173   +        +0.2   1,262,173   +        -1.1   1,262,173   +        +0.8   1,262,173   +        -0.6   1,262,173   +        +0.9   1,262,173   +        +1.1   1,262,174   -        -0.2   1,262,174   -        -1.6   1,262,174   -        +0.7   1,262,174   -        -1.4   1,262,174   -        +0.5   1,262,174   -        +0.1   1,262,174   -        +1.3   1,262,174   -        +0.8   1,262,174   -        +0.6   1,262,174   -        -0.3   1,262,174   -        -1.9   1,262,174   -        -0.9   1,262,174   -        -1.5   1,262,174   -        +0.2   1,262,177   +        -1.8   1,262,184   +        -0.8   1,262,333   -    Echvi_1102   0.22  -0.6   1,262,346   -    Echvi_1102   0.24  +2.7   1,262,346   -    Echvi_1102   0.24  +0.6   1,262,346   -    Echvi_1102   0.24  -1.3   1,262,378   +    Echvi_1102   0.30  +0.5   1,262,381   +    Echvi_1102   0.30  +1.1   1,262,381   +    Echvi_1102   0.30  +0.2   1,262,381   +    Echvi_1102   0.30  +1.9   1,262,381   +    Echvi_1102   0.30  -1.7   1,262,381   +    Echvi_1102   0.30  -2.2   1,262,382   -    Echvi_1102   0.30  +0.9   1,262,382   -    Echvi_1102   0.30  -0.8   1,262,382   -    Echvi_1102   0.30  +0.5   1,262,383   +    Echvi_1102   0.31  -0.1   1,262,383   +    Echvi_1102   0.31  -0.5   1,262,384   -    Echvi_1102   0.31  -0.2   1,262,473   +    Echvi_1102   0.46  +2.3   1,262,474   -    Echvi_1102   0.47  +0.4   1,262,474   -    Echvi_1102   0.47  +0.2   1,262,474   -    Echvi_1102   0.47  -0.3   1,262,474   -    Echvi_1102   0.47  -0.1   1,262,474   -    Echvi_1102   0.47  -3.1   1,262,474   -        +4.1   1,262,477   +    Echvi_1102   0.47  -2.2   1,262,478   -    Echvi_1102   0.47  -1.6   1,262,478   -    Echvi_1102   0.47  -1.9   1,262,478   -    Echvi_1102   0.47  +0.5   1,262,478   -    Echvi_1102   0.47  -0.6   1,262,478   -    Echvi_1102   0.47  -2.4   1,262,478   -    Echvi_1102   0.47  +0.9   1,262,478   -    Echvi_1102   0.47  -1.2   1,262,479   +    Echvi_1102   0.47  -3.7   1,262,479   +    Echvi_1102   0.47  -0.1 
 
Or see this region's nucleotide sequence