Experiment: m.b. Paraquat dichloride 0.00390625 mg/ml
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt B158DRAFT_0259 and B158DRAFT_0260 are separated by 26 nucleotides B158DRAFT_0260 and B158DRAFT_0261 are separated by 58 nucleotides B158DRAFT_0261 and B158DRAFT_0262 are separated by 363 nucleotides
B158DRAFT_0259: B158DRAFT_0259 - shikimate 5-dehydrogenase, at 264,608 to 265,402
_0259
B158DRAFT_0260: B158DRAFT_0260 - Putative protein-S-isoprenylcysteine methyltransferase, at 265,429 to 265,890
_0260
B158DRAFT_0261: B158DRAFT_0261 - catalase/peroxidase HPI, at 265,949 to 268,180
_0261
B158DRAFT_0262: B158DRAFT_0262 - hypothetical protein, at 268,544 to 269,149
_0262
Position (kb)
265
266
267
268
269 Strain fitness (log2 ratio)
-4
-3
-2
-1
0
1
2
3 at 264.956 kb on + strand, within B158DRAFT_0259 at 264.998 kb on + strand, within B158DRAFT_0259 at 264.998 kb on + strand, within B158DRAFT_0259 at 264.998 kb on + strand, within B158DRAFT_0259 at 264.998 kb on + strand, within B158DRAFT_0259 at 264.998 kb on + strand, within B158DRAFT_0259 at 264.998 kb on + strand, within B158DRAFT_0259 at 264.998 kb on + strand, within B158DRAFT_0259 at 264.998 kb on + strand, within B158DRAFT_0259 at 265.006 kb on - strand, within B158DRAFT_0259 at 265.006 kb on - strand, within B158DRAFT_0259 at 265.006 kb on - strand, within B158DRAFT_0259 at 265.006 kb on - strand, within B158DRAFT_0259 at 265.017 kb on + strand, within B158DRAFT_0259 at 265.034 kb on + strand, within B158DRAFT_0259 at 265.056 kb on + strand, within B158DRAFT_0259 at 265.056 kb on + strand, within B158DRAFT_0259 at 265.064 kb on - strand, within B158DRAFT_0259 at 265.064 kb on - strand, within B158DRAFT_0259 at 265.064 kb on - strand, within B158DRAFT_0259 at 265.064 kb on - strand, within B158DRAFT_0259 at 265.080 kb on - strand, within B158DRAFT_0259 at 265.291 kb on + strand, within B158DRAFT_0259 at 265.299 kb on - strand, within B158DRAFT_0259 at 265.316 kb on + strand, within B158DRAFT_0259 at 265.350 kb on + strand at 265.351 kb on - strand at 265.358 kb on - strand at 265.493 kb on + strand, within B158DRAFT_0260 at 265.501 kb on - strand, within B158DRAFT_0260 at 265.521 kb on + strand, within B158DRAFT_0260 at 265.576 kb on - strand, within B158DRAFT_0260 at 265.623 kb on - strand, within B158DRAFT_0260 at 265.832 kb on - strand, within B158DRAFT_0260 at 265.839 kb on + strand, within B158DRAFT_0260 at 266.044 kb on + strand at 266.129 kb on + strand at 266.129 kb on + strand at 266.129 kb on + strand at 266.129 kb on + strand at 266.129 kb on + strand at 266.129 kb on + strand at 266.129 kb on + strand at 266.129 kb on + strand at 266.129 kb on + strand at 266.129 kb on + strand at 266.136 kb on + strand at 266.137 kb on - strand at 266.137 kb on - strand at 266.137 kb on - strand at 266.137 kb on - strand at 266.137 kb on - strand at 266.137 kb on - strand at 266.137 kb on - strand at 266.137 kb on - strand at 266.137 kb on - strand at 266.137 kb on - strand at 266.137 kb on - strand at 266.144 kb on - strand at 266.213 kb on + strand, within B158DRAFT_0261 at 266.221 kb on - strand, within B158DRAFT_0261 at 266.228 kb on - strand, within B158DRAFT_0261 at 266.228 kb on - strand, within B158DRAFT_0261 at 266.228 kb on - strand, within B158DRAFT_0261 at 266.248 kb on + strand, within B158DRAFT_0261 at 266.256 kb on - strand, within B158DRAFT_0261 at 266.264 kb on + strand, within B158DRAFT_0261 at 266.264 kb on + strand, within B158DRAFT_0261 at 266.269 kb on + strand, within B158DRAFT_0261 at 266.320 kb on + strand, within B158DRAFT_0261 at 266.320 kb on + strand, within B158DRAFT_0261 at 266.320 kb on + strand, within B158DRAFT_0261 at 266.320 kb on + strand, within B158DRAFT_0261 at 266.320 kb on + strand, within B158DRAFT_0261 at 266.320 kb on + strand, within B158DRAFT_0261 at 266.320 kb on + strand, within B158DRAFT_0261 at 266.320 kb on + strand, within B158DRAFT_0261 at 266.328 kb on + strand, within B158DRAFT_0261 at 266.328 kb on - strand, within B158DRAFT_0261 at 266.328 kb on - strand, within B158DRAFT_0261 at 266.328 kb on - strand, within B158DRAFT_0261 at 266.328 kb on - strand, within B158DRAFT_0261 at 266.328 kb on - strand, within B158DRAFT_0261 at 266.351 kb on - strand, within B158DRAFT_0261 at 266.351 kb on - strand, within B158DRAFT_0261 at 266.351 kb on - strand, within B158DRAFT_0261 at 266.403 kb on + strand, within B158DRAFT_0261 at 266.410 kb on + strand, within B158DRAFT_0261 at 266.477 kb on - strand, within B158DRAFT_0261 at 266.477 kb on - strand, within B158DRAFT_0261 at 266.482 kb on - strand, within B158DRAFT_0261 at 266.574 kb on + strand, within B158DRAFT_0261 at 266.576 kb on + strand, within B158DRAFT_0261 at 266.618 kb on + strand, within B158DRAFT_0261 at 266.685 kb on - strand, within B158DRAFT_0261 at 266.767 kb on - strand, within B158DRAFT_0261 at 266.861 kb on + strand, within B158DRAFT_0261 at 266.928 kb on + strand, within B158DRAFT_0261 at 266.936 kb on - strand, within B158DRAFT_0261 at 266.936 kb on - strand, within B158DRAFT_0261 at 266.985 kb on - strand, within B158DRAFT_0261 at 267.028 kb on + strand, within B158DRAFT_0261 at 267.071 kb on - strand, within B158DRAFT_0261 at 267.071 kb on - strand, within B158DRAFT_0261 at 267.071 kb on - strand, within B158DRAFT_0261 at 267.121 kb on + strand, within B158DRAFT_0261 at 267.121 kb on + strand, within B158DRAFT_0261 at 267.129 kb on - strand, within B158DRAFT_0261 at 267.143 kb on + strand, within B158DRAFT_0261 at 267.151 kb on - strand, within B158DRAFT_0261 at 267.179 kb on + strand, within B158DRAFT_0261 at 267.179 kb on + strand, within B158DRAFT_0261 at 267.187 kb on - strand, within B158DRAFT_0261 at 267.187 kb on - strand, within B158DRAFT_0261 at 267.187 kb on - strand, within B158DRAFT_0261 at 267.219 kb on + strand, within B158DRAFT_0261 at 267.219 kb on + strand, within B158DRAFT_0261 at 267.227 kb on - strand, within B158DRAFT_0261 at 267.262 kb on - strand, within B158DRAFT_0261 at 267.313 kb on + strand, within B158DRAFT_0261 at 267.318 kb on + strand, within B158DRAFT_0261 at 267.329 kb on + strand, within B158DRAFT_0261 at 267.329 kb on - strand, within B158DRAFT_0261 at 267.331 kb on + strand, within B158DRAFT_0261 at 267.331 kb on + strand, within B158DRAFT_0261 at 267.331 kb on + strand, within B158DRAFT_0261 at 267.336 kb on + strand, within B158DRAFT_0261 at 267.339 kb on - strand, within B158DRAFT_0261 at 267.339 kb on - strand, within B158DRAFT_0261 at 267.339 kb on - strand, within B158DRAFT_0261 at 267.348 kb on - strand, within B158DRAFT_0261 at 267.388 kb on - strand, within B158DRAFT_0261 at 267.412 kb on + strand, within B158DRAFT_0261 at 267.462 kb on + strand, within B158DRAFT_0261 at 267.462 kb on + strand, within B158DRAFT_0261 at 267.470 kb on - strand, within B158DRAFT_0261 at 267.477 kb on - strand, within B158DRAFT_0261 at 267.502 kb on - strand, within B158DRAFT_0261 at 267.502 kb on - strand, within B158DRAFT_0261 at 267.502 kb on - strand, within B158DRAFT_0261 at 267.503 kb on + strand, within B158DRAFT_0261 at 267.511 kb on - strand, within B158DRAFT_0261 at 267.530 kb on - strand, within B158DRAFT_0261 at 267.543 kb on + strand, within B158DRAFT_0261 at 267.554 kb on + strand, within B158DRAFT_0261 at 267.683 kb on + strand, within B158DRAFT_0261 at 267.691 kb on - strand, within B158DRAFT_0261 at 267.691 kb on - strand, within B158DRAFT_0261 at 267.703 kb on + strand, within B158DRAFT_0261 at 267.711 kb on - strand, within B158DRAFT_0261 at 267.729 kb on + strand, within B158DRAFT_0261 at 267.737 kb on - strand, within B158DRAFT_0261 at 267.737 kb on - strand, within B158DRAFT_0261 at 267.737 kb on - strand, within B158DRAFT_0261 at 267.737 kb on - strand, within B158DRAFT_0261 at 267.756 kb on + strand, within B158DRAFT_0261 at 267.785 kb on - strand, within B158DRAFT_0261 at 267.787 kb on + strand, within B158DRAFT_0261 at 267.797 kb on + strand, within B158DRAFT_0261 at 267.802 kb on + strand, within B158DRAFT_0261 at 267.854 kb on + strand, within B158DRAFT_0261 at 267.854 kb on + strand, within B158DRAFT_0261 at 267.900 kb on + strand, within B158DRAFT_0261 at 267.924 kb on - strand, within B158DRAFT_0261 at 267.924 kb on - strand, within B158DRAFT_0261 at 267.987 kb on - strand at 267.988 kb on + strand at 267.988 kb on + strand at 267.997 kb on - strand at 268.020 kb on + strand at 268.028 kb on - strand at 268.028 kb on - strand at 268.038 kb on + strand at 268.088 kb on + strand at 268.135 kb on + strand at 268.331 kb on + strand at 268.331 kb on + strand at 268.331 kb on + strand at 268.339 kb on - strand at 268.358 kb on + strand at 268.358 kb on + strand at 268.364 kb on + strand at 268.371 kb on - strand at 268.456 kb on + strand at 268.466 kb on + strand at 268.469 kb on - strand at 268.469 kb on - strand at 268.474 kb on - strand at 268.474 kb on - strand at 268.507 kb on + strand at 268.536 kb on - strand at 268.614 kb on + strand, within B158DRAFT_0262 at 268.615 kb on - strand, within B158DRAFT_0262 at 268.615 kb on - strand, within B158DRAFT_0262 at 268.622 kb on - strand, within B158DRAFT_0262 at 268.632 kb on - strand, within B158DRAFT_0262 at 268.646 kb on + strand, within B158DRAFT_0262 at 268.646 kb on + strand, within B158DRAFT_0262 at 268.679 kb on + strand, within B158DRAFT_0262 at 268.705 kb on + strand, within B158DRAFT_0262 at 268.710 kb on + strand, within B158DRAFT_0262 at 268.713 kb on - strand, within B158DRAFT_0262 at 268.713 kb on - strand, within B158DRAFT_0262 at 268.713 kb on - strand, within B158DRAFT_0262 at 268.713 kb on - strand, within B158DRAFT_0262 at 268.713 kb on - strand, within B158DRAFT_0262 at 268.713 kb on - strand, within B158DRAFT_0262 at 268.804 kb on - strand, within B158DRAFT_0262 at 268.829 kb on + strand, within B158DRAFT_0262 at 268.887 kb on + strand, within B158DRAFT_0262 at 268.887 kb on + strand, within B158DRAFT_0262 at 268.918 kb on + strand, within B158DRAFT_0262 at 268.918 kb on + strand, within B158DRAFT_0262 at 268.918 kb on + strand, within B158DRAFT_0262 at 268.926 kb on - strand, within B158DRAFT_0262 at 268.926 kb on - strand, within B158DRAFT_0262 at 268.926 kb on - strand, within B158DRAFT_0262 at 269.017 kb on + strand, within B158DRAFT_0262 at 269.022 kb on + strand, within B158DRAFT_0262 at 269.030 kb on - strand, within B158DRAFT_0262 at 269.030 kb on - strand, within B158DRAFT_0262 at 269.035 kb on - strand, within B158DRAFT_0262
Per-strain Table
Position Strand Gene LocusTag Fraction m.b. Paraquat dichloride 0.00390625 mg/ml remove 264,956 + B158DRAFT_0259 0.44 -2.4 264,998 + B158DRAFT_0259 0.49 -2.6 264,998 + B158DRAFT_0259 0.49 -1.0 264,998 + B158DRAFT_0259 0.49 -2.2 264,998 + B158DRAFT_0259 0.49 -2.1 264,998 + B158DRAFT_0259 0.49 -4.2 264,998 + B158DRAFT_0259 0.49 -2.2 264,998 + B158DRAFT_0259 0.49 -2.8 264,998 + B158DRAFT_0259 0.49 -1.5 265,006 - B158DRAFT_0259 0.50 -3.4 265,006 - B158DRAFT_0259 0.50 -1.8 265,006 - B158DRAFT_0259 0.50 -1.7 265,006 - B158DRAFT_0259 0.50 -1.9 265,017 + B158DRAFT_0259 0.51 -2.2 265,034 + B158DRAFT_0259 0.54 -1.7 265,056 + B158DRAFT_0259 0.56 -2.7 265,056 + B158DRAFT_0259 0.56 -1.3 265,064 - B158DRAFT_0259 0.57 -0.6 265,064 - B158DRAFT_0259 0.57 +0.6 265,064 - B158DRAFT_0259 0.57 -2.7 265,064 - B158DRAFT_0259 0.57 -1.2 265,080 - B158DRAFT_0259 0.59 -1.8 265,291 + B158DRAFT_0259 0.86 -2.4 265,299 - B158DRAFT_0259 0.87 -2.2 265,316 + B158DRAFT_0259 0.89 -2.0 265,350 + -0.4 265,351 - -0.8 265,358 - -1.3 265,493 + B158DRAFT_0260 0.14 -0.1 265,501 - B158DRAFT_0260 0.16 -0.3 265,521 + B158DRAFT_0260 0.20 -0.5 265,576 - B158DRAFT_0260 0.32 -0.4 265,623 - B158DRAFT_0260 0.42 -0.1 265,832 - B158DRAFT_0260 0.87 +0.3 265,839 + B158DRAFT_0260 0.89 +0.3 266,044 + +0.1 266,129 + -0.4 266,129 + +0.3 266,129 + +0.2 266,129 + -0.4 266,129 + -0.7 266,129 + +0.1 266,129 + +0.2 266,129 + -0.3 266,129 + -0.2 266,129 + +0.1 266,136 + +0.0 266,137 - -0.4 266,137 - +0.4 266,137 - -1.3 266,137 - -0.2 266,137 - -0.0 266,137 - -0.5 266,137 - -0.8 266,137 - +0.2 266,137 - -0.3 266,137 - -0.5 266,137 - +0.4 266,144 - -0.1 266,213 + B158DRAFT_0261 0.12 +0.2 266,221 - B158DRAFT_0261 0.12 -0.6 266,228 - B158DRAFT_0261 0.12 -0.3 266,228 - B158DRAFT_0261 0.12 -0.6 266,228 - B158DRAFT_0261 0.12 -0.1 266,248 + B158DRAFT_0261 0.13 -0.2 266,256 - B158DRAFT_0261 0.14 -0.0 266,264 + B158DRAFT_0261 0.14 -0.2 266,264 + B158DRAFT_0261 0.14 -0.7 266,269 + B158DRAFT_0261 0.14 +0.0 266,320 + B158DRAFT_0261 0.17 -0.4 266,320 + B158DRAFT_0261 0.17 +0.7 266,320 + B158DRAFT_0261 0.17 -0.2 266,320 + B158DRAFT_0261 0.17 -0.2 266,320 + B158DRAFT_0261 0.17 -0.1 266,320 + B158DRAFT_0261 0.17 -0.1 266,320 + B158DRAFT_0261 0.17 -0.5 266,320 + B158DRAFT_0261 0.17 +0.2 266,328 + B158DRAFT_0261 0.17 +0.6 266,328 - B158DRAFT_0261 0.17 +0.5 266,328 - B158DRAFT_0261 0.17 +0.0 266,328 - B158DRAFT_0261 0.17 -0.9 266,328 - B158DRAFT_0261 0.17 -0.2 266,328 - B158DRAFT_0261 0.17 -0.5 266,351 - B158DRAFT_0261 0.18 +0.2 266,351 - B158DRAFT_0261 0.18 +0.1 266,351 - B158DRAFT_0261 0.18 -0.1 266,403 + B158DRAFT_0261 0.20 -0.3 266,410 + B158DRAFT_0261 0.21 +0.2 266,477 - B158DRAFT_0261 0.24 +0.5 266,477 - B158DRAFT_0261 0.24 -0.1 266,482 - B158DRAFT_0261 0.24 +0.6 266,574 + B158DRAFT_0261 0.28 -0.0 266,576 + B158DRAFT_0261 0.28 +0.1 266,618 + B158DRAFT_0261 0.30 -0.5 266,685 - B158DRAFT_0261 0.33 -1.1 266,767 - B158DRAFT_0261 0.37 +0.1 266,861 + B158DRAFT_0261 0.41 +2.1 266,928 + B158DRAFT_0261 0.44 -0.1 266,936 - B158DRAFT_0261 0.44 -0.6 266,936 - B158DRAFT_0261 0.44 -0.2 266,985 - B158DRAFT_0261 0.46 -0.3 267,028 + B158DRAFT_0261 0.48 -0.2 267,071 - B158DRAFT_0261 0.50 -0.5 267,071 - B158DRAFT_0261 0.50 +0.1 267,071 - B158DRAFT_0261 0.50 -0.9 267,121 + B158DRAFT_0261 0.53 +0.2 267,121 + B158DRAFT_0261 0.53 +0.2 267,129 - B158DRAFT_0261 0.53 -0.7 267,143 + B158DRAFT_0261 0.53 +0.1 267,151 - B158DRAFT_0261 0.54 -1.0 267,179 + B158DRAFT_0261 0.55 -0.2 267,179 + B158DRAFT_0261 0.55 -0.2 267,187 - B158DRAFT_0261 0.55 +0.7 267,187 - B158DRAFT_0261 0.55 +0.1 267,187 - B158DRAFT_0261 0.55 -0.4 267,219 + B158DRAFT_0261 0.57 -0.4 267,219 + B158DRAFT_0261 0.57 -0.5 267,227 - B158DRAFT_0261 0.57 -0.1 267,262 - B158DRAFT_0261 0.59 -0.3 267,313 + B158DRAFT_0261 0.61 -0.1 267,318 + B158DRAFT_0261 0.61 -0.6 267,329 + B158DRAFT_0261 0.62 -0.3 267,329 - B158DRAFT_0261 0.62 +0.2 267,331 + B158DRAFT_0261 0.62 +1.5 267,331 + B158DRAFT_0261 0.62 -0.7 267,331 + B158DRAFT_0261 0.62 -0.4 267,336 + B158DRAFT_0261 0.62 -0.3 267,339 - B158DRAFT_0261 0.62 +0.1 267,339 - B158DRAFT_0261 0.62 -0.9 267,339 - B158DRAFT_0261 0.62 +0.3 267,348 - B158DRAFT_0261 0.63 -0.0 267,388 - B158DRAFT_0261 0.64 +0.1 267,412 + B158DRAFT_0261 0.66 -0.1 267,462 + B158DRAFT_0261 0.68 +0.2 267,462 + B158DRAFT_0261 0.68 +0.1 267,470 - B158DRAFT_0261 0.68 +0.6 267,477 - B158DRAFT_0261 0.68 -0.2 267,502 - B158DRAFT_0261 0.70 -0.0 267,502 - B158DRAFT_0261 0.70 +0.1 267,502 - B158DRAFT_0261 0.70 -0.4 267,503 + B158DRAFT_0261 0.70 -0.4 267,511 - B158DRAFT_0261 0.70 -0.6 267,530 - B158DRAFT_0261 0.71 -0.6 267,543 + B158DRAFT_0261 0.71 -0.8 267,554 + B158DRAFT_0261 0.72 +0.5 267,683 + B158DRAFT_0261 0.78 -0.2 267,691 - B158DRAFT_0261 0.78 +0.4 267,691 - B158DRAFT_0261 0.78 +0.0 267,703 + B158DRAFT_0261 0.79 -0.0 267,711 - B158DRAFT_0261 0.79 +2.9 267,729 + B158DRAFT_0261 0.80 +0.4 267,737 - B158DRAFT_0261 0.80 +0.0 267,737 - B158DRAFT_0261 0.80 +0.1 267,737 - B158DRAFT_0261 0.80 +0.0 267,737 - B158DRAFT_0261 0.80 -0.6 267,756 + B158DRAFT_0261 0.81 -0.2 267,785 - B158DRAFT_0261 0.82 -0.3 267,787 + B158DRAFT_0261 0.82 -0.0 267,797 + B158DRAFT_0261 0.83 -0.0 267,802 + B158DRAFT_0261 0.83 -0.1 267,854 + B158DRAFT_0261 0.85 +0.0 267,854 + B158DRAFT_0261 0.85 +0.1 267,900 + B158DRAFT_0261 0.87 -0.3 267,924 - B158DRAFT_0261 0.88 -0.9 267,924 - B158DRAFT_0261 0.88 -0.1 267,987 - -0.7 267,988 + +0.3 267,988 + -0.1 267,997 - -0.0 268,020 + +0.1 268,028 - +0.4 268,028 - -0.2 268,038 + +0.3 268,088 + -0.3 268,135 + -0.0 268,331 + +0.6 268,331 + -0.2 268,331 + +0.3 268,339 - -0.1 268,358 + -0.4 268,358 + -0.3 268,364 + -0.0 268,371 - +0.2 268,456 + -0.1 268,466 + +0.4 268,469 - -1.1 268,469 - -0.8 268,474 - -0.0 268,474 - +0.1 268,507 + -1.4 268,536 - +0.4 268,614 + B158DRAFT_0262 0.12 -1.3 268,615 - B158DRAFT_0262 0.12 +0.0 268,615 - B158DRAFT_0262 0.12 +0.3 268,622 - B158DRAFT_0262 0.13 +0.0 268,632 - B158DRAFT_0262 0.15 -0.4 268,646 + B158DRAFT_0262 0.17 -0.3 268,646 + B158DRAFT_0262 0.17 -0.4 268,679 + B158DRAFT_0262 0.22 -0.4 268,705 + B158DRAFT_0262 0.27 +0.2 268,710 + B158DRAFT_0262 0.27 -0.6 268,713 - B158DRAFT_0262 0.28 -0.3 268,713 - B158DRAFT_0262 0.28 +0.1 268,713 - B158DRAFT_0262 0.28 -0.5 268,713 - B158DRAFT_0262 0.28 -0.8 268,713 - B158DRAFT_0262 0.28 +0.4 268,713 - B158DRAFT_0262 0.28 +0.7 268,804 - B158DRAFT_0262 0.43 -0.2 268,829 + B158DRAFT_0262 0.47 -0.7 268,887 + B158DRAFT_0262 0.57 -0.2 268,887 + B158DRAFT_0262 0.57 -0.1 268,918 + B158DRAFT_0262 0.62 +0.3 268,918 + B158DRAFT_0262 0.62 -0.6 268,918 + B158DRAFT_0262 0.62 -0.3 268,926 - B158DRAFT_0262 0.63 +0.1 268,926 - B158DRAFT_0262 0.63 -0.4 268,926 - B158DRAFT_0262 0.63 +0.1 269,017 + B158DRAFT_0262 0.78 -0.3 269,022 + B158DRAFT_0262 0.79 +0.1 269,030 - B158DRAFT_0262 0.80 -0.0 269,030 - B158DRAFT_0262 0.80 +0.7 269,035 - B158DRAFT_0262 0.81 +0.1
Or see this region's nucleotide sequence