Experiment: supernatant control, M9 with 0.1X LB 
Only strains with sufficient reads to estimate fitness are shown,
                   but the strain fitness values are still rather noisy and may be biased towards zero.
                   Strains near the edge of a gene are not shown as being associated with that
                   gene (they are in grey).
                   Strains in the central 10-90% of a gene are color coded by the insertion's strand.
                   Usually, "+" means that the selectable marker is encoded on the forward strand,
                   i.e., transcribed rightward. 
    
        
         
     
    
        
         
     
    
        
         
     
    
        
         
     
    
         
     
     
 
500 nt COO64_RS26165 and COO64_RS26170 overlap by 1 nucleotides COO64_RS26170 and bglX are separated by 182 nucleotides bglX and COO64_RS26180 are separated by 60 nucleotides  
        
        COO64_RS26165: COO64_RS26165 - YgcG family protein, at 1 to 675 
         
        _RS26165 
         
        
        COO64_RS26170: COO64_RS26170 - LemA family protein, at 675 to 1,277 
         
        _RS26170 
         
        
        COO64_RS26175: bglX - beta-glucosidase BglX, at 1,460 to 3,751 
         
        bglX 
         
        
        COO64_RS26180: COO64_RS26180 - ATP-binding protein, at 3,812 to 5,569 
         
        _RS26180 
         Position (kb)  
1 
 
2 
 
3 
 
4 Strain fitness (log2 ratio)  
-2 
 
-1 
 
0 
 
1 
 
2 at 0.630 kb on + strand at 0.631 kb on - strand at 0.751 kb on + strand, within COO64_RS26170 at 0.751 kb on + strand, within COO64_RS26170 at 0.752 kb on - strand, within COO64_RS26170 at 0.752 kb on - strand, within COO64_RS26170 at 0.785 kb on + strand, within COO64_RS26170 at 0.802 kb on + strand, within COO64_RS26170 at 0.803 kb on - strand, within COO64_RS26170 at 0.803 kb on - strand, within COO64_RS26170 at 0.857 kb on + strand, within COO64_RS26170 at 1.051 kb on - strand, within COO64_RS26170 at 1.051 kb on - strand, within COO64_RS26170 at 1.087 kb on + strand, within COO64_RS26170 at 1.170 kb on + strand, within COO64_RS26170 at 1.170 kb on + strand, within COO64_RS26170 at 1.171 kb on - strand, within COO64_RS26170 at 1.183 kb on + strand, within COO64_RS26170 at 1.183 kb on + strand, within COO64_RS26170 at 1.183 kb on + strand, within COO64_RS26170 at 1.183 kb on + strand, within COO64_RS26170 at 1.184 kb on - strand, within COO64_RS26170 at 1.184 kb on - strand, within COO64_RS26170 at 1.251 kb on + strand at 1.252 kb on - strand at 1.261 kb on + strand at 1.261 kb on + strand at 1.261 kb on + strand at 1.261 kb on + strand at 1.262 kb on - strand at 1.262 kb on - strand at 1.262 kb on - strand at 1.283 kb on + strand at 1.284 kb on - strand at 1.284 kb on - strand at 1.284 kb on - strand at 1.323 kb on - strand at 1.323 kb on - strand at 1.323 kb on - strand at 1.363 kb on - strand at 1.382 kb on + strand at 1.391 kb on - strand at 1.419 kb on + strand at 1.420 kb on - strand at 1.420 kb on - strand at 1.439 kb on + strand at 1.439 kb on + strand at 1.440 kb on - strand at 1.440 kb on - strand at 1.440 kb on - strand at 1.440 kb on - strand at 1.440 kb on - strand at 1.514 kb on + strand at 1.514 kb on + strand at 1.515 kb on - strand at 1.522 kb on + strand at 1.675 kb on + strand at 1.676 kb on - strand at 1.684 kb on + strand at 1.772 kb on + strand, within bglX at 1.979 kb on + strand, within bglX at 1.979 kb on + strand, within bglX at 1.979 kb on + strand, within bglX at 1.979 kb on + strand, within bglX at 1.980 kb on - strand, within bglX at 1.980 kb on - strand, within bglX at 1.980 kb on - strand, within bglX at 1.980 kb on - strand, within bglX at 1.980 kb on - strand, within bglX at 1.980 kb on - strand, within bglX at 1.980 kb on - strand, within bglX at 2.082 kb on - strand, within bglX at 2.108 kb on + strand, within bglX at 2.108 kb on + strand, within bglX at 2.108 kb on + strand, within bglX at 2.108 kb on + strand, within bglX at 2.108 kb on + strand, within bglX at 2.150 kb on + strand, within bglX at 2.151 kb on - strand, within bglX at 2.414 kb on + strand, within bglX at 2.504 kb on + strand, within bglX at 2.504 kb on + strand, within bglX at 2.505 kb on - strand, within bglX at 2.505 kb on - strand, within bglX at 2.505 kb on - strand, within bglX at 2.573 kb on + strand, within bglX at 2.573 kb on + strand, within bglX at 2.573 kb on + strand, within bglX at 2.573 kb on + strand, within bglX at 2.574 kb on - strand, within bglX at 2.574 kb on - strand, within bglX at 2.816 kb on + strand, within bglX at 2.816 kb on + strand, within bglX at 2.816 kb on + strand, within bglX at 2.816 kb on + strand, within bglX at 2.817 kb on - strand, within bglX at 2.976 kb on + strand, within bglX at 3.218 kb on + strand, within bglX at 3.218 kb on + strand, within bglX at 3.218 kb on + strand, within bglX at 3.218 kb on + strand, within bglX at 3.218 kb on + strand, within bglX at 3.218 kb on + strand, within bglX at 3.219 kb on - strand, within bglX at 3.219 kb on - strand, within bglX at 3.278 kb on + strand, within bglX at 3.278 kb on + strand, within bglX at 3.278 kb on + strand, within bglX at 3.278 kb on + strand, within bglX at 3.278 kb on + strand, within bglX at 3.278 kb on + strand, within bglX at 3.278 kb on + strand, within bglX at 3.278 kb on + strand, within bglX at 3.278 kb on + strand, within bglX at 3.279 kb on - strand, within bglX at 3.279 kb on - strand, within bglX at 3.279 kb on - strand, within bglX at 3.281 kb on + strand, within bglX at 3.281 kb on + strand, within bglX at 3.281 kb on + strand, within bglX at 3.281 kb on + strand, within bglX at 3.281 kb on + strand, within bglX at 3.281 kb on + strand, within bglX at 3.281 kb on + strand, within bglX at 3.281 kb on + strand, within bglX at 3.281 kb on + strand, within bglX at 3.281 kb on + strand, within bglX at 3.281 kb on + strand, within bglX at 3.281 kb on + strand, within bglX at 3.281 kb on + strand, within bglX at 3.282 kb on - strand, within bglX at 3.282 kb on - strand, within bglX at 3.282 kb on - strand, within bglX at 3.282 kb on - strand, within bglX at 3.282 kb on - strand, within bglX at 3.282 kb on - strand, within bglX at 3.282 kb on - strand, within bglX at 3.282 kb on - strand, within bglX at 3.282 kb on - strand, within bglX at 3.282 kb on - strand, within bglX at 3.282 kb on - strand, within bglX at 3.332 kb on + strand, within bglX at 3.332 kb on + strand, within bglX at 3.332 kb on + strand, within bglX at 3.332 kb on + strand, within bglX at 3.332 kb on + strand, within bglX at 3.333 kb on - strand, within bglX at 3.333 kb on - strand, within bglX at 3.333 kb on - strand, within bglX at 3.333 kb on - strand, within bglX at 3.333 kb on - strand, within bglX at 3.345 kb on - strand, within bglX at 3.345 kb on - strand, within bglX at 3.372 kb on - strand, within bglX at 3.372 kb on - strand, within bglX at 3.383 kb on + strand, within bglX at 3.395 kb on + strand, within bglX at 3.522 kb on - strand at 3.522 kb on - strand at 3.650 kb on + strand at 3.650 kb on + strand at 3.749 kb on + strand at 3.749 kb on + strand at 3.749 kb on + strand at 3.750 kb on - strand at 3.962 kb on + strand at 3.963 kb on - strand at 3.963 kb on - strand at 3.963 kb on - strand at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.193 kb on + strand, within COO64_RS26180 at 4.194 kb on - strand, within COO64_RS26180 at 4.194 kb on - strand, within COO64_RS26180 at 4.194 kb on - strand, within COO64_RS26180 at 4.194 kb on - strand, within COO64_RS26180 at 4.194 kb on - strand, within COO64_RS26180 at 4.194 kb on - strand, within COO64_RS26180 at 4.194 kb on - strand, within COO64_RS26180 at 4.194 kb on - strand, within COO64_RS26180 at 4.194 kb on - strand, within COO64_RS26180 at 4.194 kb on - strand, within COO64_RS26180 at 4.194 kb on - strand, within COO64_RS26180 at 4.194 kb on - strand, within COO64_RS26180 at 4.194 kb on - strand, within COO64_RS26180 at 4.208 kb on + strand, within COO64_RS26180 at 4.208 kb on + strand, within COO64_RS26180 at 4.208 kb on + strand, within COO64_RS26180 at 4.209 kb on - strand, within COO64_RS26180 at 4.209 kb on - strand, within COO64_RS26180 at 4.209 kb on - strand, within COO64_RS26180 at 4.209 kb on - strand, within COO64_RS26180 at 4.224 kb on - strand, within COO64_RS26180 at 4.262 kb on + strand, within COO64_RS26180 at 4.262 kb on + strand, within COO64_RS26180 at 4.263 kb on - strand, within COO64_RS26180 at 4.263 kb on - strand, within COO64_RS26180 at 4.296 kb on - strand, within COO64_RS26180 at 4.524 kb on - strand, within COO64_RS26180 at 4.558 kb on + strand, within COO64_RS26180 at 4.558 kb on + strand, within COO64_RS26180 at 4.558 kb on + strand, within COO64_RS26180 at 4.559 kb on - strand, within COO64_RS26180 at 4.559 kb on - strand, within COO64_RS26180 at 4.559 kb on - strand, within COO64_RS26180 at 4.625 kb on + strand, within COO64_RS26180 at 4.625 kb on + strand, within COO64_RS26180 at 4.625 kb on + strand, within COO64_RS26180 at 4.625 kb on + strand, within COO64_RS26180 at 4.626 kb on - strand, within COO64_RS26180 at 4.626 kb on - strand, within COO64_RS26180  
 
 
 
Per-strain Table 
Position  Strand  Gene  LocusTag  Fraction   supernatant control, M9 with 0.1X LB             remove   630   +        +0.6   631   -        +0.3   751   +    COO64_RS26170   0.13  +0.6   751   +    COO64_RS26170   0.13  -1.2   752   -    COO64_RS26170   0.13  -0.6   752   -    COO64_RS26170   0.13  -0.9   785   +    COO64_RS26170   0.18  -0.2   802   +    COO64_RS26170   0.21  -0.3   803   -    COO64_RS26170   0.21  -0.6   803   -    COO64_RS26170   0.21  -1.2   857   +    COO64_RS26170   0.30  -0.8   1,051   -    COO64_RS26170   0.62  -0.5   1,051   -    COO64_RS26170   0.62  -0.6   1,087   +    COO64_RS26170   0.68  -0.7   1,170   +    COO64_RS26170   0.82  -0.1   1,170   +    COO64_RS26170   0.82  +0.0   1,171   -    COO64_RS26170   0.82  +0.1   1,183   +    COO64_RS26170   0.84  +1.2   1,183   +    COO64_RS26170   0.84  -0.5   1,183   +    COO64_RS26170   0.84  -0.3   1,183   +    COO64_RS26170   0.84  -0.6   1,184   -    COO64_RS26170   0.84  -0.2   1,184   -    COO64_RS26170   0.84  -0.1   1,251   +        +1.7   1,252   -        -0.2   1,261   +        -0.3   1,261   +        +0.8   1,261   +        -1.4   1,261   +        -0.0   1,262   -        -1.4   1,262   -        +0.4   1,262   -        -0.4   1,283   +        -0.6   1,284   -        -0.1   1,284   -        -0.4   1,284   -        -0.7   1,323   -        +0.2   1,323   -        -0.4   1,323   -        +2.3   1,363   -        +0.0   1,382   +        +0.4   1,391   -        -0.1   1,419   +        +0.7   1,420   -        +0.5   1,420   -        -1.6   1,439   +        -0.2   1,439   +        -1.8   1,440   -        +0.1   1,440   -        +0.9   1,440   -        +0.7   1,440   -        -0.1   1,440   -        +1.2   1,514   +        -0.2   1,514   +        -0.3   1,515   -        +0.6   1,522   +        +0.4   1,675   +        +1.0   1,676   -        -0.3   1,684   +        +0.9   1,772   +  bglX  COO64_RS26175   0.14  -0.6   1,979   +  bglX  COO64_RS26175   0.23  -0.1   1,979   +  bglX  COO64_RS26175   0.23  +0.4   1,979   +  bglX  COO64_RS26175   0.23  +0.2   1,979   +  bglX  COO64_RS26175   0.23  +0.1   1,980   -  bglX  COO64_RS26175   0.23  +0.5   1,980   -  bglX  COO64_RS26175   0.23  -0.0   1,980   -  bglX  COO64_RS26175   0.23  +0.7   1,980   -  bglX  COO64_RS26175   0.23  +0.2   1,980   -  bglX  COO64_RS26175   0.23  +0.2   1,980   -  bglX  COO64_RS26175   0.23  -0.1   1,980   -  bglX  COO64_RS26175   0.23  -0.1   2,082   -  bglX  COO64_RS26175   0.27  -0.0   2,108   +  bglX  COO64_RS26175   0.28  +0.3   2,108   +  bglX  COO64_RS26175   0.28  +0.6   2,108   +  bglX  COO64_RS26175   0.28  +1.0   2,108   +  bglX  COO64_RS26175   0.28  -0.2   2,108   +  bglX  COO64_RS26175   0.28  -0.7   2,150   +  bglX  COO64_RS26175   0.30  -0.2   2,151   -  bglX  COO64_RS26175   0.30  -0.1   2,414   +  bglX  COO64_RS26175   0.42  +0.3   2,504   +  bglX  COO64_RS26175   0.46  +0.8   2,504   +  bglX  COO64_RS26175   0.46  +0.2   2,505   -  bglX  COO64_RS26175   0.46  +0.7   2,505   -  bglX  COO64_RS26175   0.46  -0.0   2,505   -  bglX  COO64_RS26175   0.46  +1.1   2,573   +  bglX  COO64_RS26175   0.49  -0.8   2,573   +  bglX  COO64_RS26175   0.49  -0.3   2,573   +  bglX  COO64_RS26175   0.49  -0.3   2,573   +  bglX  COO64_RS26175   0.49  +0.7   2,574   -  bglX  COO64_RS26175   0.49  +0.2   2,574   -  bglX  COO64_RS26175   0.49  +0.0   2,816   +  bglX  COO64_RS26175   0.59  -0.0   2,816   +  bglX  COO64_RS26175   0.59  -1.6   2,816   +  bglX  COO64_RS26175   0.59  +0.3   2,816   +  bglX  COO64_RS26175   0.59  +0.3   2,817   -  bglX  COO64_RS26175   0.59  +0.2   2,976   +  bglX  COO64_RS26175   0.66  -0.1   3,218   +  bglX  COO64_RS26175   0.77  -1.9   3,218   +  bglX  COO64_RS26175   0.77  +0.5   3,218   +  bglX  COO64_RS26175   0.77  -0.8   3,218   +  bglX  COO64_RS26175   0.77  -0.3   3,218   +  bglX  COO64_RS26175   0.77  -1.2   3,218   +  bglX  COO64_RS26175   0.77  +1.1   3,219   -  bglX  COO64_RS26175   0.77  -0.2   3,219   -  bglX  COO64_RS26175   0.77  +0.8   3,278   +  bglX  COO64_RS26175   0.79  +1.2   3,278   +  bglX  COO64_RS26175   0.79  +0.2   3,278   +  bglX  COO64_RS26175   0.79  +0.1   3,278   +  bglX  COO64_RS26175   0.79  -0.4   3,278   +  bglX  COO64_RS26175   0.79  -0.7   3,278   +  bglX  COO64_RS26175   0.79  -0.1   3,278   +  bglX  COO64_RS26175   0.79  -0.1   3,278   +  bglX  COO64_RS26175   0.79  -0.1   3,278   +  bglX  COO64_RS26175   0.79  -0.4   3,279   -  bglX  COO64_RS26175   0.79  +0.2   3,279   -  bglX  COO64_RS26175   0.79  +0.0   3,279   -  bglX  COO64_RS26175   0.79  +0.5   3,281   +  bglX  COO64_RS26175   0.79  -1.2   3,281   +  bglX  COO64_RS26175   0.79  -0.7   3,281   +  bglX  COO64_RS26175   0.79  -0.8   3,281   +  bglX  COO64_RS26175   0.79  +0.2   3,281   +  bglX  COO64_RS26175   0.79  +0.2   3,281   +  bglX  COO64_RS26175   0.79  +1.3   3,281   +  bglX  COO64_RS26175   0.79  +0.4   3,281   +  bglX  COO64_RS26175   0.79  +0.2   3,281   +  bglX  COO64_RS26175   0.79  +0.2   3,281   +  bglX  COO64_RS26175   0.79  -0.5   3,281   +  bglX  COO64_RS26175   0.79  -0.2   3,281   +  bglX  COO64_RS26175   0.79  -0.1   3,281   +  bglX  COO64_RS26175   0.79  +0.4   3,282   -  bglX  COO64_RS26175   0.79  -0.8   3,282   -  bglX  COO64_RS26175   0.79  +1.8   3,282   -  bglX  COO64_RS26175   0.79  +0.2   3,282   -  bglX  COO64_RS26175   0.79  +1.1   3,282   -  bglX  COO64_RS26175   0.79  +0.6   3,282   -  bglX  COO64_RS26175   0.79  +1.1   3,282   -  bglX  COO64_RS26175   0.79  +1.4   3,282   -  bglX  COO64_RS26175   0.79  +0.1   3,282   -  bglX  COO64_RS26175   0.79  -0.3   3,282   -  bglX  COO64_RS26175   0.79  +0.2   3,282   -  bglX  COO64_RS26175   0.79  +0.8   3,332   +  bglX  COO64_RS26175   0.82  +0.8   3,332   +  bglX  COO64_RS26175   0.82  -0.9   3,332   +  bglX  COO64_RS26175   0.82  -0.2   3,332   +  bglX  COO64_RS26175   0.82  +0.4   3,332   +  bglX  COO64_RS26175   0.82  -0.8   3,333   -  bglX  COO64_RS26175   0.82  +0.1   3,333   -  bglX  COO64_RS26175   0.82  +1.2   3,333   -  bglX  COO64_RS26175   0.82  +1.1   3,333   -  bglX  COO64_RS26175   0.82  +0.5   3,333   -  bglX  COO64_RS26175   0.82  +0.2   3,345   -  bglX  COO64_RS26175   0.82  +1.5   3,345   -  bglX  COO64_RS26175   0.82  +0.8   3,372   -  bglX  COO64_RS26175   0.83  -0.2   3,372   -  bglX  COO64_RS26175   0.83  +0.2   3,383   +  bglX  COO64_RS26175   0.84  +0.2   3,395   +  bglX  COO64_RS26175   0.84  -0.9   3,522   -        +0.6   3,522   -        +0.1   3,650   +        -0.5   3,650   +        -0.7   3,749   +        -1.4   3,749   +        -0.1   3,749   +        -0.9   3,750   -        -1.2   3,962   +        +0.4   3,963   -        -0.7   3,963   -        -0.5   3,963   -        +0.8   4,193   +    COO64_RS26180   0.22  -0.6   4,193   +    COO64_RS26180   0.22  +1.0   4,193   +    COO64_RS26180   0.22  -0.3   4,193   +    COO64_RS26180   0.22  -0.8   4,193   +    COO64_RS26180   0.22  -0.2   4,193   +    COO64_RS26180   0.22  -0.2   4,193   +    COO64_RS26180   0.22  +0.2   4,193   +    COO64_RS26180   0.22  +0.3   4,193   +    COO64_RS26180   0.22  +0.4   4,193   +    COO64_RS26180   0.22  -0.0   4,193   +    COO64_RS26180   0.22  -0.1   4,193   +    COO64_RS26180   0.22  +0.2   4,193   +    COO64_RS26180   0.22  -1.4   4,193   +    COO64_RS26180   0.22  +0.2   4,193   +    COO64_RS26180   0.22  -0.0   4,193   +    COO64_RS26180   0.22  +0.8   4,193   +    COO64_RS26180   0.22  -0.2   4,193   +    COO64_RS26180   0.22  -1.1   4,193   +    COO64_RS26180   0.22  -0.7   4,193   +    COO64_RS26180   0.22  +0.6   4,193   +    COO64_RS26180   0.22  -0.1   4,193   +    COO64_RS26180   0.22  +0.4   4,193   +    COO64_RS26180   0.22  -0.8   4,193   +    COO64_RS26180   0.22  +0.2   4,193   +    COO64_RS26180   0.22  +0.5   4,193   +    COO64_RS26180   0.22  -0.8   4,194   -    COO64_RS26180   0.22  +0.6   4,194   -    COO64_RS26180   0.22  +0.2   4,194   -    COO64_RS26180   0.22  -0.6   4,194   -    COO64_RS26180   0.22  -0.1   4,194   -    COO64_RS26180   0.22  -0.8   4,194   -    COO64_RS26180   0.22  -0.5   4,194   -    COO64_RS26180   0.22  +0.3   4,194   -    COO64_RS26180   0.22  -1.0   4,194   -    COO64_RS26180   0.22  -0.0   4,194   -    COO64_RS26180   0.22  +1.1   4,194   -    COO64_RS26180   0.22  -0.6   4,194   -    COO64_RS26180   0.22  +0.5   4,194   -    COO64_RS26180   0.22  +0.0   4,208   +    COO64_RS26180   0.23  -0.2   4,208   +    COO64_RS26180   0.23  +0.1   4,208   +    COO64_RS26180   0.23  +0.2   4,209   -    COO64_RS26180   0.23  +0.6   4,209   -    COO64_RS26180   0.23  +1.2   4,209   -    COO64_RS26180   0.23  +0.1   4,209   -    COO64_RS26180   0.23  -0.2   4,224   -    COO64_RS26180   0.23  +2.3   4,262   +    COO64_RS26180   0.26  -0.8   4,262   +    COO64_RS26180   0.26  +0.2   4,263   -    COO64_RS26180   0.26  +0.1   4,263   -    COO64_RS26180   0.26  -0.9   4,296   -    COO64_RS26180   0.28  +0.4   4,524   -    COO64_RS26180   0.41  +0.4   4,558   +    COO64_RS26180   0.42  -0.6   4,558   +    COO64_RS26180   0.42  -0.3   4,558   +    COO64_RS26180   0.42  +0.4   4,559   -    COO64_RS26180   0.42  -0.0   4,559   -    COO64_RS26180   0.42  +0.5   4,559   -    COO64_RS26180   0.42  +0.3   4,625   +    COO64_RS26180   0.46  -0.2   4,625   +    COO64_RS26180   0.46  -0.1   4,625   +    COO64_RS26180   0.46  -0.5   4,625   +    COO64_RS26180   0.46  +1.2   4,626   -    COO64_RS26180   0.46  -0.1   4,626   -    COO64_RS26180   0.46  +0.0 
 
Or see this region's nucleotide sequence