Experiment: NL-CCM, start OD=0.1
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt MPMX19_03708 and MPMX19_03709 are separated by 48 nucleotides MPMX19_03709 and MPMX19_03710 are separated by 28 nucleotides
MPMX19_03708: MPMX19_03708 - Branched-chain-amino-acid aminotransferase, at 1,146,963 to 1,147,886
_03708
MPMX19_03709: MPMX19_03709 - Voltage-gated ClC-type chloride channel ClcB, at 1,147,935 to 1,149,713
_03709
MPMX19_03710: MPMX19_03710 - Glycine cleavage system transcriptional activator, at 1,149,742 to 1,150,680
_03710
Position (kb)
1147
1148
1149
1150 Strain fitness (log2 ratio)
-2
-1
0
1
2 at 1146.955 kb on + strand at 1146.955 kb on + strand at 1146.955 kb on + strand at 1146.955 kb on + strand at 1146.956 kb on - strand at 1146.956 kb on - strand at 1146.956 kb on - strand at 1146.956 kb on - strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.959 kb on + strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1146.960 kb on - strand at 1147.005 kb on + strand at 1147.005 kb on + strand at 1147.005 kb on + strand at 1147.005 kb on + strand at 1147.005 kb on + strand at 1147.005 kb on + strand at 1147.005 kb on + strand at 1147.006 kb on - strand at 1147.006 kb on - strand at 1147.006 kb on - strand at 1147.006 kb on - strand at 1147.006 kb on - strand at 1147.006 kb on - strand at 1147.006 kb on - strand at 1147.006 kb on - strand at 1147.006 kb on - strand at 1147.041 kb on + strand at 1147.041 kb on + strand at 1147.041 kb on + strand at 1147.041 kb on + strand at 1147.041 kb on + strand at 1147.041 kb on + strand at 1147.041 kb on + strand at 1147.041 kb on + strand at 1147.041 kb on + strand at 1147.042 kb on - strand at 1147.042 kb on - strand at 1147.042 kb on - strand at 1147.042 kb on - strand at 1147.042 kb on - strand at 1147.042 kb on - strand at 1147.042 kb on - strand at 1147.042 kb on - strand at 1147.042 kb on - strand at 1147.172 kb on + strand, within MPMX19_03708 at 1147.172 kb on + strand, within MPMX19_03708 at 1147.172 kb on + strand, within MPMX19_03708 at 1147.173 kb on - strand, within MPMX19_03708 at 1147.185 kb on + strand, within MPMX19_03708 at 1147.185 kb on + strand, within MPMX19_03708 at 1147.185 kb on + strand, within MPMX19_03708 at 1147.185 kb on + strand, within MPMX19_03708 at 1147.185 kb on + strand, within MPMX19_03708 at 1147.186 kb on - strand, within MPMX19_03708 at 1147.386 kb on + strand, within MPMX19_03708 at 1147.386 kb on + strand, within MPMX19_03708 at 1147.387 kb on - strand, within MPMX19_03708 at 1147.387 kb on - strand, within MPMX19_03708 at 1147.387 kb on - strand, within MPMX19_03708 at 1147.387 kb on - strand, within MPMX19_03708 at 1147.387 kb on - strand, within MPMX19_03708 at 1147.387 kb on - strand, within MPMX19_03708 at 1147.387 kb on - strand, within MPMX19_03708 at 1147.387 kb on - strand, within MPMX19_03708 at 1147.687 kb on - strand, within MPMX19_03708 at 1147.740 kb on + strand, within MPMX19_03708 at 1147.740 kb on + strand, within MPMX19_03708 at 1147.740 kb on + strand, within MPMX19_03708 at 1147.740 kb on + strand, within MPMX19_03708 at 1147.740 kb on + strand, within MPMX19_03708 at 1147.740 kb on + strand, within MPMX19_03708 at 1147.740 kb on + strand, within MPMX19_03708 at 1147.740 kb on + strand, within MPMX19_03708 at 1147.740 kb on + strand, within MPMX19_03708 at 1147.740 kb on + strand, within MPMX19_03708 at 1147.740 kb on + strand, within MPMX19_03708 at 1147.740 kb on + strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.741 kb on - strand, within MPMX19_03708 at 1147.863 kb on + strand at 1147.863 kb on + strand at 1147.863 kb on + strand at 1147.863 kb on + strand at 1147.863 kb on + strand at 1147.863 kb on + strand at 1147.864 kb on - strand at 1147.864 kb on - strand at 1147.864 kb on - strand at 1147.864 kb on - strand at 1148.389 kb on - strand, within MPMX19_03709 at 1148.529 kb on + strand, within MPMX19_03709 at 1148.529 kb on + strand, within MPMX19_03709 at 1148.529 kb on + strand, within MPMX19_03709 at 1148.529 kb on + strand, within MPMX19_03709 at 1148.529 kb on + strand, within MPMX19_03709 at 1148.529 kb on + strand, within MPMX19_03709 at 1148.529 kb on + strand, within MPMX19_03709 at 1148.529 kb on + strand, within MPMX19_03709 at 1148.529 kb on + strand, within MPMX19_03709 at 1148.529 kb on + strand, within MPMX19_03709 at 1148.530 kb on - strand, within MPMX19_03709 at 1148.530 kb on - strand, within MPMX19_03709 at 1148.530 kb on - strand, within MPMX19_03709 at 1148.530 kb on - strand, within MPMX19_03709 at 1148.530 kb on - strand, within MPMX19_03709 at 1148.530 kb on - strand, within MPMX19_03709 at 1148.530 kb on - strand, within MPMX19_03709 at 1148.530 kb on - strand, within MPMX19_03709 at 1148.530 kb on - strand, within MPMX19_03709 at 1148.530 kb on - strand, within MPMX19_03709 at 1148.530 kb on - strand, within MPMX19_03709 at 1148.556 kb on + strand, within MPMX19_03709 at 1148.556 kb on + strand, within MPMX19_03709 at 1148.557 kb on - strand, within MPMX19_03709 at 1148.557 kb on - strand, within MPMX19_03709 at 1148.557 kb on - strand, within MPMX19_03709 at 1148.680 kb on - strand, within MPMX19_03709 at 1148.892 kb on + strand, within MPMX19_03709 at 1148.892 kb on + strand, within MPMX19_03709 at 1148.892 kb on + strand, within MPMX19_03709 at 1148.892 kb on + strand, within MPMX19_03709 at 1148.893 kb on - strand, within MPMX19_03709 at 1148.893 kb on - strand, within MPMX19_03709 at 1148.893 kb on - strand, within MPMX19_03709 at 1148.893 kb on - strand, within MPMX19_03709 at 1148.893 kb on - strand, within MPMX19_03709 at 1148.893 kb on - strand, within MPMX19_03709 at 1148.895 kb on + strand, within MPMX19_03709 at 1148.895 kb on + strand, within MPMX19_03709 at 1148.895 kb on + strand, within MPMX19_03709 at 1148.895 kb on + strand, within MPMX19_03709 at 1148.895 kb on + strand, within MPMX19_03709 at 1148.895 kb on + strand, within MPMX19_03709 at 1148.895 kb on + strand, within MPMX19_03709 at 1148.895 kb on + strand, within MPMX19_03709 at 1148.895 kb on + strand, within MPMX19_03709 at 1148.895 kb on + strand, within MPMX19_03709 at 1148.896 kb on - strand, within MPMX19_03709 at 1148.896 kb on - strand, within MPMX19_03709 at 1148.896 kb on - strand, within MPMX19_03709 at 1148.896 kb on - strand, within MPMX19_03709 at 1148.896 kb on - strand, within MPMX19_03709 at 1148.896 kb on - strand, within MPMX19_03709 at 1148.896 kb on - strand, within MPMX19_03709 at 1148.896 kb on - strand, within MPMX19_03709 at 1148.896 kb on - strand, within MPMX19_03709 at 1148.896 kb on - strand, within MPMX19_03709 at 1149.441 kb on + strand, within MPMX19_03709 at 1149.442 kb on - strand, within MPMX19_03709 at 1149.442 kb on - strand, within MPMX19_03709 at 1149.666 kb on + strand at 1149.667 kb on - strand at 1149.667 kb on - strand at 1149.667 kb on - strand at 1149.709 kb on + strand at 1149.709 kb on + strand at 1149.709 kb on + strand at 1149.709 kb on + strand at 1149.709 kb on + strand at 1149.709 kb on + strand at 1149.709 kb on - strand at 1149.710 kb on - strand at 1149.710 kb on - strand at 1149.710 kb on - strand at 1149.710 kb on - strand at 1149.710 kb on - strand at 1149.710 kb on - strand at 1149.710 kb on - strand at 1149.710 kb on - strand at 1149.848 kb on + strand, within MPMX19_03710 at 1149.848 kb on + strand, within MPMX19_03710 at 1149.849 kb on - strand, within MPMX19_03710 at 1149.849 kb on - strand, within MPMX19_03710 at 1149.849 kb on - strand, within MPMX19_03710 at 1149.980 kb on + strand, within MPMX19_03710 at 1149.980 kb on + strand, within MPMX19_03710 at 1149.980 kb on + strand, within MPMX19_03710 at 1149.981 kb on - strand, within MPMX19_03710 at 1150.119 kb on + strand, within MPMX19_03710 at 1150.183 kb on + strand, within MPMX19_03710 at 1150.184 kb on - strand, within MPMX19_03710 at 1150.470 kb on - strand, within MPMX19_03710 at 1150.642 kb on + strand at 1150.643 kb on - strand at 1150.643 kb on - strand at 1150.643 kb on - strand
Per-strain Table
Position Strand Gene LocusTag Fraction NL-CCM, start OD=0.1 remove 1,146,955 + +0.4 1,146,955 + -0.6 1,146,955 + +1.3 1,146,955 + -0.5 1,146,956 - +0.1 1,146,956 - -2.7 1,146,956 - -0.3 1,146,956 - +0.2 1,146,959 + -0.5 1,146,959 + +0.7 1,146,959 + -1.8 1,146,959 + -0.6 1,146,959 + -0.9 1,146,959 + -1.9 1,146,959 + -0.8 1,146,959 + +0.1 1,146,959 + -0.0 1,146,959 + +0.5 1,146,959 + -0.3 1,146,959 + +0.5 1,146,959 + +0.1 1,146,959 + -1.3 1,146,959 + -0.8 1,146,959 + -1.8 1,146,959 + -0.6 1,146,959 + -0.9 1,146,959 + -1.1 1,146,959 + -0.2 1,146,959 + -0.0 1,146,959 + -1.3 1,146,959 + -0.4 1,146,959 + -2.0 1,146,959 + -0.8 1,146,959 + -0.5 1,146,959 + -0.6 1,146,959 + -0.1 1,146,959 + +1.5 1,146,959 + +1.8 1,146,959 + -0.5 1,146,959 + -0.5 1,146,959 + -0.1 1,146,960 - +0.7 1,146,960 - -1.0 1,146,960 - -0.8 1,146,960 - -0.5 1,146,960 - -0.8 1,146,960 - +1.0 1,146,960 - -1.5 1,146,960 - -0.0 1,146,960 - -0.7 1,146,960 - +0.3 1,146,960 - -0.9 1,146,960 - +0.2 1,146,960 - +0.1 1,146,960 - -0.0 1,146,960 - +1.0 1,146,960 - -2.5 1,146,960 - -0.5 1,146,960 - -0.5 1,146,960 - +1.3 1,146,960 - -0.5 1,146,960 - +0.1 1,146,960 - +1.0 1,146,960 - -1.0 1,146,960 - +0.4 1,146,960 - -1.6 1,146,960 - +2.1 1,146,960 - +0.7 1,146,960 - -0.0 1,146,960 - +0.9 1,146,960 - -0.9 1,146,960 - -0.5 1,146,960 - -0.5 1,146,960 - +2.3 1,146,960 - -0.0 1,146,960 - +1.3 1,146,960 - -0.6 1,146,960 - -0.8 1,146,960 - +1.0 1,147,005 + -1.0 1,147,005 + -0.4 1,147,005 + +0.1 1,147,005 + -0.0 1,147,005 + -0.9 1,147,005 + +1.0 1,147,005 + +0.5 1,147,006 - -1.0 1,147,006 - +0.7 1,147,006 - -1.4 1,147,006 - -0.5 1,147,006 - +2.5 1,147,006 - -0.0 1,147,006 - -2.4 1,147,006 - -0.5 1,147,006 - -0.4 1,147,041 + -0.5 1,147,041 + -0.2 1,147,041 + -0.6 1,147,041 + +0.5 1,147,041 + -0.5 1,147,041 + -0.8 1,147,041 + -0.7 1,147,041 + +0.3 1,147,041 + -0.5 1,147,042 - -0.0 1,147,042 - +1.0 1,147,042 - -0.3 1,147,042 - -1.5 1,147,042 - +0.5 1,147,042 - +0.8 1,147,042 - -0.2 1,147,042 - +0.5 1,147,042 - -1.8 1,147,172 + MPMX19_03708 0.23 +0.2 1,147,172 + MPMX19_03708 0.23 +0.5 1,147,172 + MPMX19_03708 0.23 +0.3 1,147,173 - MPMX19_03708 0.23 -0.6 1,147,185 + MPMX19_03708 0.24 -0.6 1,147,185 + MPMX19_03708 0.24 -0.0 1,147,185 + MPMX19_03708 0.24 -1.3 1,147,185 + MPMX19_03708 0.24 +0.3 1,147,185 + MPMX19_03708 0.24 +0.1 1,147,186 - MPMX19_03708 0.24 -0.9 1,147,386 + MPMX19_03708 0.46 -1.8 1,147,386 + MPMX19_03708 0.46 +1.8 1,147,387 - MPMX19_03708 0.46 +0.5 1,147,387 - MPMX19_03708 0.46 +1.1 1,147,387 - MPMX19_03708 0.46 +1.3 1,147,387 - MPMX19_03708 0.46 -0.1 1,147,387 - MPMX19_03708 0.46 +0.2 1,147,387 - MPMX19_03708 0.46 -0.5 1,147,387 - MPMX19_03708 0.46 -0.5 1,147,387 - MPMX19_03708 0.46 -1.3 1,147,687 - MPMX19_03708 0.78 -1.2 1,147,740 + MPMX19_03708 0.84 -1.0 1,147,740 + MPMX19_03708 0.84 +0.9 1,147,740 + MPMX19_03708 0.84 -1.4 1,147,740 + MPMX19_03708 0.84 -0.0 1,147,740 + MPMX19_03708 0.84 -0.5 1,147,740 + MPMX19_03708 0.84 -2.6 1,147,740 + MPMX19_03708 0.84 -0.9 1,147,740 + MPMX19_03708 0.84 +1.5 1,147,740 + MPMX19_03708 0.84 -1.9 1,147,740 + MPMX19_03708 0.84 -0.2 1,147,740 + MPMX19_03708 0.84 +0.7 1,147,740 + MPMX19_03708 0.84 -1.5 1,147,741 - MPMX19_03708 0.84 +0.5 1,147,741 - MPMX19_03708 0.84 +0.3 1,147,741 - MPMX19_03708 0.84 +0.2 1,147,741 - MPMX19_03708 0.84 -0.6 1,147,741 - MPMX19_03708 0.84 +1.0 1,147,741 - MPMX19_03708 0.84 -0.1 1,147,741 - MPMX19_03708 0.84 +0.1 1,147,741 - MPMX19_03708 0.84 +0.1 1,147,741 - MPMX19_03708 0.84 +0.1 1,147,741 - MPMX19_03708 0.84 -0.2 1,147,741 - MPMX19_03708 0.84 +0.1 1,147,741 - MPMX19_03708 0.84 +0.7 1,147,741 - MPMX19_03708 0.84 -1.8 1,147,741 - MPMX19_03708 0.84 +0.3 1,147,741 - MPMX19_03708 0.84 -2.1 1,147,741 - MPMX19_03708 0.84 -0.4 1,147,741 - MPMX19_03708 0.84 +0.8 1,147,863 + -1.6 1,147,863 + +0.5 1,147,863 + -0.8 1,147,863 + +0.4 1,147,863 + -0.5 1,147,863 + +0.3 1,147,864 - -0.5 1,147,864 - -0.3 1,147,864 - -0.5 1,147,864 - -0.1 1,148,389 - MPMX19_03709 0.26 +0.0 1,148,529 + MPMX19_03709 0.33 -1.5 1,148,529 + MPMX19_03709 0.33 -0.5 1,148,529 + MPMX19_03709 0.33 -0.3 1,148,529 + MPMX19_03709 0.33 +0.3 1,148,529 + MPMX19_03709 0.33 -1.0 1,148,529 + MPMX19_03709 0.33 -0.5 1,148,529 + MPMX19_03709 0.33 +1.0 1,148,529 + MPMX19_03709 0.33 +0.4 1,148,529 + MPMX19_03709 0.33 -0.5 1,148,529 + MPMX19_03709 0.33 -1.3 1,148,530 - MPMX19_03709 0.33 -0.3 1,148,530 - MPMX19_03709 0.33 -0.9 1,148,530 - MPMX19_03709 0.33 +0.7 1,148,530 - MPMX19_03709 0.33 +0.8 1,148,530 - MPMX19_03709 0.33 +0.7 1,148,530 - MPMX19_03709 0.33 -2.2 1,148,530 - MPMX19_03709 0.33 -0.3 1,148,530 - MPMX19_03709 0.33 +0.6 1,148,530 - MPMX19_03709 0.33 +1.7 1,148,530 - MPMX19_03709 0.33 -0.6 1,148,530 - MPMX19_03709 0.33 -0.3 1,148,556 + MPMX19_03709 0.35 -1.6 1,148,556 + MPMX19_03709 0.35 +0.5 1,148,557 - MPMX19_03709 0.35 -0.0 1,148,557 - MPMX19_03709 0.35 +0.4 1,148,557 - MPMX19_03709 0.35 +1.0 1,148,680 - MPMX19_03709 0.42 -0.6 1,148,892 + MPMX19_03709 0.54 +0.4 1,148,892 + MPMX19_03709 0.54 +1.3 1,148,892 + MPMX19_03709 0.54 -1.0 1,148,892 + MPMX19_03709 0.54 -0.5 1,148,893 - MPMX19_03709 0.54 -1.0 1,148,893 - MPMX19_03709 0.54 +0.5 1,148,893 - MPMX19_03709 0.54 -0.8 1,148,893 - MPMX19_03709 0.54 +0.5 1,148,893 - MPMX19_03709 0.54 +0.5 1,148,893 - MPMX19_03709 0.54 -0.2 1,148,895 + MPMX19_03709 0.54 +1.8 1,148,895 + MPMX19_03709 0.54 +0.4 1,148,895 + MPMX19_03709 0.54 -0.7 1,148,895 + MPMX19_03709 0.54 -1.1 1,148,895 + MPMX19_03709 0.54 -0.6 1,148,895 + MPMX19_03709 0.54 +0.1 1,148,895 + MPMX19_03709 0.54 +1.0 1,148,895 + MPMX19_03709 0.54 -1.5 1,148,895 + MPMX19_03709 0.54 -0.6 1,148,895 + MPMX19_03709 0.54 -1.3 1,148,896 - MPMX19_03709 0.54 -1.0 1,148,896 - MPMX19_03709 0.54 -1.0 1,148,896 - MPMX19_03709 0.54 +0.0 1,148,896 - MPMX19_03709 0.54 -0.5 1,148,896 - MPMX19_03709 0.54 -1.0 1,148,896 - MPMX19_03709 0.54 -1.0 1,148,896 - MPMX19_03709 0.54 +0.7 1,148,896 - MPMX19_03709 0.54 +0.9 1,148,896 - MPMX19_03709 0.54 +0.3 1,148,896 - MPMX19_03709 0.54 -2.0 1,149,441 + MPMX19_03709 0.85 +0.5 1,149,442 - MPMX19_03709 0.85 +0.4 1,149,442 - MPMX19_03709 0.85 +0.2 1,149,666 + +0.4 1,149,667 - -0.0 1,149,667 - +0.2 1,149,667 - +0.5 1,149,709 + -0.8 1,149,709 + -1.3 1,149,709 + -0.8 1,149,709 + -0.9 1,149,709 + +1.3 1,149,709 + -1.3 1,149,709 - -0.0 1,149,710 - +1.3 1,149,710 - -0.2 1,149,710 - -0.2 1,149,710 - -0.6 1,149,710 - +1.1 1,149,710 - +1.3 1,149,710 - -2.4 1,149,710 - -1.3 1,149,848 + MPMX19_03710 0.11 +0.1 1,149,848 + MPMX19_03710 0.11 +0.5 1,149,849 - MPMX19_03710 0.11 +0.0 1,149,849 - MPMX19_03710 0.11 -1.5 1,149,849 - MPMX19_03710 0.11 -0.0 1,149,980 + MPMX19_03710 0.25 -0.1 1,149,980 + MPMX19_03710 0.25 +0.7 1,149,980 + MPMX19_03710 0.25 +0.1 1,149,981 - MPMX19_03710 0.25 +0.7 1,150,119 + MPMX19_03710 0.40 +1.0 1,150,183 + MPMX19_03710 0.47 -0.3 1,150,184 - MPMX19_03710 0.47 +0.8 1,150,470 - MPMX19_03710 0.78 -0.7 1,150,642 + +0.1 1,150,643 - +1.4 1,150,643 - -1.0 1,150,643 - -1.4
Or see this region's nucleotide sequence