Experiment: NF
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt MPMX19_02074 and MPMX19_02075 are separated by 158 nucleotides MPMX19_02075 and MPMX19_02076 are separated by 9 nucleotides MPMX19_02076 and MPMX19_02077 are separated by 274 nucleotides
MPMX19_02074: MPMX19_02074 - Homogentisate 1,2-dioxygenase, at 2,171,333 to 2,172,457
_02074
MPMX19_02075: MPMX19_02075 - hypothetical protein, at 2,172,616 to 2,173,161
_02075
MPMX19_02076: MPMX19_02076 - Carnitine operon protein CaiE, at 2,173,171 to 2,173,809
_02076
MPMX19_02077: MPMX19_02077 - 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase, at 2,174,084 to 2,175,751
_02077
Position (kb)
2172
2173
2174 Strain fitness (log2 ratio)
-2
-1
0
1
2 at 2171.652 kb on - strand, within MPMX19_02074 at 2171.715 kb on + strand, within MPMX19_02074 at 2171.715 kb on + strand, within MPMX19_02074 at 2171.716 kb on - strand, within MPMX19_02074 at 2171.716 kb on - strand, within MPMX19_02074 at 2171.811 kb on + strand, within MPMX19_02074 at 2171.812 kb on - strand, within MPMX19_02074 at 2171.812 kb on - strand, within MPMX19_02074 at 2171.812 kb on - strand, within MPMX19_02074 at 2171.812 kb on - strand, within MPMX19_02074 at 2171.967 kb on + strand, within MPMX19_02074 at 2171.968 kb on - strand, within MPMX19_02074 at 2171.968 kb on - strand, within MPMX19_02074 at 2171.968 kb on - strand, within MPMX19_02074 at 2171.987 kb on + strand, within MPMX19_02074 at 2171.987 kb on + strand, within MPMX19_02074 at 2171.987 kb on + strand, within MPMX19_02074 at 2171.988 kb on - strand, within MPMX19_02074 at 2171.988 kb on - strand, within MPMX19_02074 at 2172.054 kb on + strand, within MPMX19_02074 at 2172.054 kb on + strand, within MPMX19_02074 at 2172.054 kb on + strand, within MPMX19_02074 at 2172.054 kb on + strand, within MPMX19_02074 at 2172.054 kb on + strand, within MPMX19_02074 at 2172.054 kb on + strand, within MPMX19_02074 at 2172.054 kb on + strand, within MPMX19_02074 at 2172.054 kb on + strand, within MPMX19_02074 at 2172.054 kb on + strand, within MPMX19_02074 at 2172.054 kb on + strand, within MPMX19_02074 at 2172.054 kb on + strand, within MPMX19_02074 at 2172.054 kb on + strand, within MPMX19_02074 at 2172.055 kb on - strand, within MPMX19_02074 at 2172.055 kb on - strand, within MPMX19_02074 at 2172.055 kb on - strand, within MPMX19_02074 at 2172.055 kb on - strand, within MPMX19_02074 at 2172.055 kb on - strand, within MPMX19_02074 at 2172.055 kb on - strand, within MPMX19_02074 at 2172.055 kb on - strand, within MPMX19_02074 at 2172.055 kb on - strand, within MPMX19_02074 at 2172.055 kb on - strand, within MPMX19_02074 at 2172.055 kb on - strand, within MPMX19_02074 at 2172.055 kb on - strand, within MPMX19_02074 at 2172.055 kb on - strand, within MPMX19_02074 at 2172.055 kb on - strand, within MPMX19_02074 at 2172.055 kb on - strand, within MPMX19_02074 at 2172.084 kb on + strand, within MPMX19_02074 at 2172.084 kb on + strand, within MPMX19_02074 at 2172.084 kb on + strand, within MPMX19_02074 at 2172.085 kb on - strand, within MPMX19_02074 at 2172.085 kb on - strand, within MPMX19_02074 at 2172.085 kb on - strand, within MPMX19_02074 at 2172.085 kb on - strand, within MPMX19_02074 at 2172.085 kb on - strand, within MPMX19_02074 at 2172.085 kb on - strand, within MPMX19_02074 at 2172.085 kb on - strand, within MPMX19_02074 at 2172.085 kb on - strand, within MPMX19_02074 at 2172.244 kb on + strand, within MPMX19_02074 at 2172.244 kb on + strand, within MPMX19_02074 at 2172.245 kb on - strand, within MPMX19_02074 at 2172.245 kb on - strand, within MPMX19_02074 at 2172.245 kb on - strand, within MPMX19_02074 at 2172.378 kb on + strand at 2172.378 kb on + strand at 2172.378 kb on + strand at 2172.378 kb on + strand at 2172.378 kb on + strand at 2172.378 kb on + strand at 2172.378 kb on + strand at 2172.378 kb on + strand at 2172.378 kb on + strand at 2172.378 kb on + strand at 2172.378 kb on + strand at 2172.378 kb on + strand at 2172.379 kb on + strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.379 kb on - strand at 2172.422 kb on - strand at 2172.565 kb on - strand at 2172.565 kb on - strand at 2172.565 kb on - strand at 2172.597 kb on + strand at 2172.597 kb on + strand at 2172.597 kb on + strand at 2172.597 kb on + strand at 2172.598 kb on - strand at 2172.598 kb on - strand at 2172.598 kb on - strand at 2172.598 kb on - strand at 2172.709 kb on + strand, within MPMX19_02075 at 2172.760 kb on + strand, within MPMX19_02075 at 2172.760 kb on + strand, within MPMX19_02075 at 2172.760 kb on + strand, within MPMX19_02075 at 2172.760 kb on + strand, within MPMX19_02075 at 2172.760 kb on + strand, within MPMX19_02075 at 2172.760 kb on + strand, within MPMX19_02075 at 2172.760 kb on + strand, within MPMX19_02075 at 2172.760 kb on + strand, within MPMX19_02075 at 2172.760 kb on + strand, within MPMX19_02075 at 2172.760 kb on + strand, within MPMX19_02075 at 2172.761 kb on - strand, within MPMX19_02075 at 2172.988 kb on + strand, within MPMX19_02075 at 2172.988 kb on + strand, within MPMX19_02075 at 2172.988 kb on + strand, within MPMX19_02075 at 2172.988 kb on + strand, within MPMX19_02075 at 2172.988 kb on + strand, within MPMX19_02075 at 2172.989 kb on - strand, within MPMX19_02075 at 2172.989 kb on - strand, within MPMX19_02075 at 2172.989 kb on - strand, within MPMX19_02075 at 2172.989 kb on - strand, within MPMX19_02075 at 2172.989 kb on - strand, within MPMX19_02075 at 2172.989 kb on - strand, within MPMX19_02075 at 2172.989 kb on - strand, within MPMX19_02075 at 2172.989 kb on - strand, within MPMX19_02075 at 2172.989 kb on - strand, within MPMX19_02075 at 2173.018 kb on + strand, within MPMX19_02075 at 2173.018 kb on + strand, within MPMX19_02075 at 2173.018 kb on + strand, within MPMX19_02075 at 2173.018 kb on + strand, within MPMX19_02075 at 2173.018 kb on + strand, within MPMX19_02075 at 2173.018 kb on + strand, within MPMX19_02075 at 2173.018 kb on + strand, within MPMX19_02075 at 2173.018 kb on + strand, within MPMX19_02075 at 2173.018 kb on + strand, within MPMX19_02075 at 2173.019 kb on - strand, within MPMX19_02075 at 2173.019 kb on - strand, within MPMX19_02075 at 2173.019 kb on - strand, within MPMX19_02075 at 2173.019 kb on - strand, within MPMX19_02075 at 2173.019 kb on - strand, within MPMX19_02075 at 2173.019 kb on - strand, within MPMX19_02075 at 2173.159 kb on + strand at 2173.159 kb on + strand at 2173.159 kb on + strand at 2173.160 kb on - strand at 2173.160 kb on - strand at 2173.160 kb on - strand at 2173.160 kb on - strand at 2173.298 kb on + strand, within MPMX19_02076 at 2173.298 kb on + strand, within MPMX19_02076 at 2173.298 kb on + strand, within MPMX19_02076 at 2173.299 kb on - strand, within MPMX19_02076 at 2173.299 kb on - strand, within MPMX19_02076 at 2173.299 kb on - strand, within MPMX19_02076 at 2173.299 kb on - strand, within MPMX19_02076 at 2173.299 kb on - strand, within MPMX19_02076 at 2173.299 kb on - strand, within MPMX19_02076 at 2173.299 kb on - strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.667 kb on + strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.668 kb on - strand, within MPMX19_02076 at 2173.763 kb on + strand at 2173.763 kb on + strand at 2173.763 kb on + strand at 2173.763 kb on + strand at 2173.763 kb on + strand at 2173.763 kb on + strand at 2173.763 kb on + strand at 2173.763 kb on + strand at 2173.764 kb on - strand at 2173.764 kb on - strand at 2173.764 kb on - strand at 2173.764 kb on - strand at 2173.883 kb on + strand at 2173.883 kb on + strand at 2173.884 kb on - strand at 2173.884 kb on - strand at 2173.932 kb on + strand at 2173.933 kb on - strand at 2173.939 kb on - strand at 2173.939 kb on - strand at 2173.939 kb on - strand at 2173.939 kb on - strand at 2173.939 kb on - strand at 2174.102 kb on + strand at 2174.111 kb on + strand at 2174.111 kb on + strand at 2174.111 kb on + strand at 2174.112 kb on - strand at 2174.112 kb on - strand at 2174.112 kb on - strand at 2174.112 kb on - strand
Per-strain Table
Position Strand Gene LocusTag Fraction NF remove 2,171,652 - MPMX19_02074 0.28 -0.0 2,171,715 + MPMX19_02074 0.34 -0.8 2,171,715 + MPMX19_02074 0.34 +0.2 2,171,716 - MPMX19_02074 0.34 +0.9 2,171,716 - MPMX19_02074 0.34 +0.8 2,171,811 + MPMX19_02074 0.42 +0.6 2,171,812 - MPMX19_02074 0.43 -0.6 2,171,812 - MPMX19_02074 0.43 -2.5 2,171,812 - MPMX19_02074 0.43 -0.7 2,171,812 - MPMX19_02074 0.43 -2.4 2,171,967 + MPMX19_02074 0.56 -0.3 2,171,968 - MPMX19_02074 0.56 -0.2 2,171,968 - MPMX19_02074 0.56 +0.2 2,171,968 - MPMX19_02074 0.56 +0.6 2,171,987 + MPMX19_02074 0.58 -0.5 2,171,987 + MPMX19_02074 0.58 -0.9 2,171,987 + MPMX19_02074 0.58 -0.2 2,171,988 - MPMX19_02074 0.58 +0.2 2,171,988 - MPMX19_02074 0.58 -1.7 2,172,054 + MPMX19_02074 0.64 +0.4 2,172,054 + MPMX19_02074 0.64 +0.7 2,172,054 + MPMX19_02074 0.64 +0.6 2,172,054 + MPMX19_02074 0.64 +0.5 2,172,054 + MPMX19_02074 0.64 -1.2 2,172,054 + MPMX19_02074 0.64 -1.2 2,172,054 + MPMX19_02074 0.64 +0.2 2,172,054 + MPMX19_02074 0.64 -0.2 2,172,054 + MPMX19_02074 0.64 -0.5 2,172,054 + MPMX19_02074 0.64 -1.9 2,172,054 + MPMX19_02074 0.64 -1.0 2,172,054 + MPMX19_02074 0.64 -0.5 2,172,055 - MPMX19_02074 0.64 +0.3 2,172,055 - MPMX19_02074 0.64 -1.2 2,172,055 - MPMX19_02074 0.64 +0.0 2,172,055 - MPMX19_02074 0.64 -0.5 2,172,055 - MPMX19_02074 0.64 +0.6 2,172,055 - MPMX19_02074 0.64 -0.5 2,172,055 - MPMX19_02074 0.64 -0.1 2,172,055 - MPMX19_02074 0.64 +0.6 2,172,055 - MPMX19_02074 0.64 -0.9 2,172,055 - MPMX19_02074 0.64 +0.1 2,172,055 - MPMX19_02074 0.64 -1.8 2,172,055 - MPMX19_02074 0.64 -1.0 2,172,055 - MPMX19_02074 0.64 +0.8 2,172,055 - MPMX19_02074 0.64 +0.3 2,172,084 + MPMX19_02074 0.67 -0.6 2,172,084 + MPMX19_02074 0.67 +0.2 2,172,084 + MPMX19_02074 0.67 -1.4 2,172,085 - MPMX19_02074 0.67 -0.6 2,172,085 - MPMX19_02074 0.67 -0.2 2,172,085 - MPMX19_02074 0.67 -1.0 2,172,085 - MPMX19_02074 0.67 -1.9 2,172,085 - MPMX19_02074 0.67 -0.9 2,172,085 - MPMX19_02074 0.67 -0.7 2,172,085 - MPMX19_02074 0.67 -1.4 2,172,085 - MPMX19_02074 0.67 -0.7 2,172,244 + MPMX19_02074 0.81 +1.3 2,172,244 + MPMX19_02074 0.81 -0.0 2,172,245 - MPMX19_02074 0.81 -0.9 2,172,245 - MPMX19_02074 0.81 +0.8 2,172,245 - MPMX19_02074 0.81 +0.3 2,172,378 + -0.4 2,172,378 + -0.3 2,172,378 + +0.9 2,172,378 + +1.0 2,172,378 + +2.2 2,172,378 + -0.2 2,172,378 + +1.5 2,172,378 + -0.2 2,172,378 + -2.5 2,172,378 + -0.5 2,172,378 + +0.2 2,172,378 + -0.1 2,172,379 + -1.2 2,172,379 - -1.2 2,172,379 - -1.0 2,172,379 - +0.6 2,172,379 - -0.2 2,172,379 - -2.1 2,172,379 - -0.7 2,172,379 - -1.2 2,172,379 - +0.8 2,172,379 - -1.7 2,172,379 - -0.7 2,172,379 - -0.2 2,172,379 - +0.2 2,172,379 - -0.2 2,172,379 - -1.7 2,172,379 - -0.8 2,172,379 - -0.8 2,172,422 - -0.2 2,172,565 - -0.0 2,172,565 - -0.3 2,172,565 - +0.2 2,172,597 + -1.0 2,172,597 + -1.9 2,172,597 + +0.6 2,172,597 + -0.2 2,172,598 - +0.4 2,172,598 - -1.0 2,172,598 - +0.8 2,172,598 - -0.7 2,172,709 + MPMX19_02075 0.17 +0.9 2,172,760 + MPMX19_02075 0.26 +0.2 2,172,760 + MPMX19_02075 0.26 +0.3 2,172,760 + MPMX19_02075 0.26 -2.0 2,172,760 + MPMX19_02075 0.26 +1.4 2,172,760 + MPMX19_02075 0.26 -1.4 2,172,760 + MPMX19_02075 0.26 -0.7 2,172,760 + MPMX19_02075 0.26 +1.3 2,172,760 + MPMX19_02075 0.26 +1.4 2,172,760 + MPMX19_02075 0.26 -0.1 2,172,760 + MPMX19_02075 0.26 +0.2 2,172,761 - MPMX19_02075 0.27 -2.0 2,172,988 + MPMX19_02075 0.68 -2.5 2,172,988 + MPMX19_02075 0.68 -0.7 2,172,988 + MPMX19_02075 0.68 +0.2 2,172,988 + MPMX19_02075 0.68 -1.6 2,172,988 + MPMX19_02075 0.68 +1.5 2,172,989 - MPMX19_02075 0.68 -1.5 2,172,989 - MPMX19_02075 0.68 +0.2 2,172,989 - MPMX19_02075 0.68 -0.3 2,172,989 - MPMX19_02075 0.68 +1.7 2,172,989 - MPMX19_02075 0.68 -1.6 2,172,989 - MPMX19_02075 0.68 +1.0 2,172,989 - MPMX19_02075 0.68 +1.5 2,172,989 - MPMX19_02075 0.68 -0.1 2,172,989 - MPMX19_02075 0.68 +1.0 2,173,018 + MPMX19_02075 0.74 -2.4 2,173,018 + MPMX19_02075 0.74 +2.3 2,173,018 + MPMX19_02075 0.74 +0.1 2,173,018 + MPMX19_02075 0.74 +0.3 2,173,018 + MPMX19_02075 0.74 -0.4 2,173,018 + MPMX19_02075 0.74 -0.3 2,173,018 + MPMX19_02075 0.74 -0.5 2,173,018 + MPMX19_02075 0.74 -2.5 2,173,018 + MPMX19_02075 0.74 +0.1 2,173,019 - MPMX19_02075 0.74 +0.6 2,173,019 - MPMX19_02075 0.74 -0.4 2,173,019 - MPMX19_02075 0.74 -0.0 2,173,019 - MPMX19_02075 0.74 +0.4 2,173,019 - MPMX19_02075 0.74 +0.5 2,173,019 - MPMX19_02075 0.74 -0.4 2,173,159 + -0.5 2,173,159 + +0.9 2,173,159 + -0.7 2,173,160 - -0.1 2,173,160 - +0.2 2,173,160 - +0.4 2,173,160 - -0.3 2,173,298 + MPMX19_02076 0.20 -0.6 2,173,298 + MPMX19_02076 0.20 +0.4 2,173,298 + MPMX19_02076 0.20 -0.4 2,173,299 - MPMX19_02076 0.20 -0.4 2,173,299 - MPMX19_02076 0.20 -0.5 2,173,299 - MPMX19_02076 0.20 -0.0 2,173,299 - MPMX19_02076 0.20 -0.7 2,173,299 - MPMX19_02076 0.20 +0.9 2,173,299 - MPMX19_02076 0.20 -2.1 2,173,299 - MPMX19_02076 0.20 -1.4 2,173,667 + MPMX19_02076 0.78 -0.1 2,173,667 + MPMX19_02076 0.78 -0.7 2,173,667 + MPMX19_02076 0.78 -0.3 2,173,667 + MPMX19_02076 0.78 +0.3 2,173,667 + MPMX19_02076 0.78 +1.8 2,173,667 + MPMX19_02076 0.78 -1.2 2,173,667 + MPMX19_02076 0.78 -0.2 2,173,667 + MPMX19_02076 0.78 -0.8 2,173,667 + MPMX19_02076 0.78 -1.2 2,173,667 + MPMX19_02076 0.78 +0.6 2,173,667 + MPMX19_02076 0.78 +0.0 2,173,667 + MPMX19_02076 0.78 -0.2 2,173,667 + MPMX19_02076 0.78 -1.0 2,173,667 + MPMX19_02076 0.78 -0.2 2,173,667 + MPMX19_02076 0.78 +0.5 2,173,667 + MPMX19_02076 0.78 +0.2 2,173,667 + MPMX19_02076 0.78 -0.9 2,173,667 + MPMX19_02076 0.78 +0.1 2,173,667 + MPMX19_02076 0.78 -1.5 2,173,667 + MPMX19_02076 0.78 -1.4 2,173,667 + MPMX19_02076 0.78 +1.0 2,173,667 + MPMX19_02076 0.78 -1.8 2,173,667 + MPMX19_02076 0.78 -1.0 2,173,667 + MPMX19_02076 0.78 +0.6 2,173,667 + MPMX19_02076 0.78 -1.0 2,173,667 + MPMX19_02076 0.78 -0.2 2,173,667 + MPMX19_02076 0.78 +0.0 2,173,667 + MPMX19_02076 0.78 +0.0 2,173,668 - MPMX19_02076 0.78 -0.1 2,173,668 - MPMX19_02076 0.78 +0.6 2,173,668 - MPMX19_02076 0.78 +0.4 2,173,668 - MPMX19_02076 0.78 +1.1 2,173,668 - MPMX19_02076 0.78 +0.2 2,173,668 - MPMX19_02076 0.78 -1.5 2,173,668 - MPMX19_02076 0.78 -0.5 2,173,668 - MPMX19_02076 0.78 -0.8 2,173,668 - MPMX19_02076 0.78 +0.2 2,173,668 - MPMX19_02076 0.78 +0.0 2,173,668 - MPMX19_02076 0.78 -0.7 2,173,668 - MPMX19_02076 0.78 +0.4 2,173,668 - MPMX19_02076 0.78 +0.2 2,173,668 - MPMX19_02076 0.78 +0.6 2,173,668 - MPMX19_02076 0.78 -0.8 2,173,668 - MPMX19_02076 0.78 +0.9 2,173,668 - MPMX19_02076 0.78 +0.3 2,173,763 + -0.3 2,173,763 + -0.5 2,173,763 + +0.2 2,173,763 + +0.2 2,173,763 + -1.2 2,173,763 + +0.4 2,173,763 + +0.9 2,173,763 + -0.3 2,173,764 - +0.1 2,173,764 - +0.5 2,173,764 - +1.4 2,173,764 - -2.3 2,173,883 + -0.7 2,173,883 + +1.0 2,173,884 - -1.0 2,173,884 - -0.2 2,173,932 + -0.0 2,173,933 - +0.8 2,173,939 - -1.5 2,173,939 - -1.4 2,173,939 - +0.3 2,173,939 - -0.2 2,173,939 - -0.0 2,174,102 + +0.0 2,174,111 + +1.3 2,174,111 + -0.8 2,174,111 + -1.9 2,174,112 - -0.0 2,174,112 - +1.3 2,174,112 - -0.5 2,174,112 - -0.4
Or see this region's nucleotide sequence