| Condition | Gene | Description | Fitness | Cons. |
|---|
| Acriflavine | Psyr_0284 | Electron transport protein SCO1/SenC | -2.0 | |
| Acriflavine | Psyr_1833 | amino acid ABC transporter substrate-binding protein, PAAT family | -1.4 | |
| Acriflavine | Psyr_2282 | Hydrophobe/amphiphile efflux-1 HAE1 | -2.3 | Yes |
| Acriflavine | Psyr_2283 | Secretion protein HlyD | -2.3 | Yes |
| Acriflavine | Psyr_2427 | gamma-glutamylputrescine oxidase | +1.1 | |
| Acriflavine | Psyr_4061 | imelysin, Metallo peptidase, MEROPS family M75 | -1.2 | |
| Acriflavine | Psyr_4422 | Protein of unknown function DUF461 | -1.5 | |
| Avocadyne | Psyr_3695 | RelA/SpoT protein | -1.5 | |
| Benzalkonium Chloride | Psyr_3106 | phosphate ABC transporter substrate-binding protein, PhoT family | -1.3 | |
| Berberine | Psyr_2282 | Hydrophobe/amphiphile efflux-1 HAE1 | -1.9 | Yes |
| Berberine | Psyr_2283 | Secretion protein HlyD | -1.9 | Yes |
| Berberine | Psyr_4061 | imelysin, Metallo peptidase, MEROPS family M75 | -1.3 | |
| Berberine | Psyr_5043 | Thioesterase superfamily | -2.0 | |
| Carbenicillin disodium salt | Psyr_0045 | oligopeptidase A, Metallo peptidase, MEROPS family M03A | +1.3 | |
| Carbenicillin disodium salt | Psyr_0066 | bifunctional spore maturation protein, fused SpmA/SpmB | -2.5 | Yes |
| Carbenicillin disodium salt | Psyr_0168 | Phosphoenolpyruvate carboxykinase (ATP) | +1.3 | |
| Carbenicillin disodium salt | Psyr_0265 | N-acetylmuramoyl-L-alanine amidase, family 2 | -2.7 | Yes |
| Carbenicillin disodium salt | Psyr_0291 | DedA | +1.5 | |
| Carbenicillin disodium salt | Psyr_0402 | Peptidoglycan glycosyltransferase | -1.4 | Yes |
| Carbenicillin disodium salt | Psyr_0630 | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase | -3.0 | |
| Carbenicillin disodium salt | Psyr_0726 | ribosomal large subunit pseudouridine synthase D | +1.9 | |
| Carbenicillin disodium salt | Psyr_0832 | Two-component sensor kinase CbrA | +1.7 | |
| Carbenicillin disodium salt | Psyr_0842 | Peptidoglycan glycosyltransferase | -2.1 | |
| Carbenicillin disodium salt | Psyr_0843 | TPR repeat protein | -2.2 | |
| Carbenicillin disodium salt | Psyr_0880 | MltA:3D | -1.1 | Yes |
| Carbenicillin disodium salt | Psyr_0996 | Alpha/beta hydrolase fold protein | -1.7 | |
| Carbenicillin disodium salt | Psyr_1023 | conserved hypothetical protein | -1.6 | |
| Carbenicillin disodium salt | Psyr_1550 | Beta-lactamase-like protein | +1.1 | |
| Carbenicillin disodium salt | Psyr_1867 | conserved hypothetical protein | +1.2 | |
| Carbenicillin disodium salt | Psyr_2111 | Peptidase S13, D-Ala-D-Ala carboxypeptidase C | -2.6 | Yes |
| Carbenicillin disodium salt | Psyr_3289 | 3-ketoacyl-CoA thiolase | +1.4 | |
| Carbenicillin disodium salt | Psyr_3295 | SLT | -2.3 | Yes |
| Carbenicillin disodium salt | Psyr_3364 | Beta-lactamase | -2.7 | Yes |
| Carbenicillin disodium salt | Psyr_3649 | Amidohydrolase | +1.4 | |
| Carbenicillin disodium salt | Psyr_3768 | General substrate transporter:Major facilitator superfamily | +1.2 | |
| Carbenicillin disodium salt | Psyr_4113 | LppC putative lipoprotein | -2.2 | |
| Carbenicillin disodium salt | Psyr_4122 | AFG1-like ATPase | +2.5 | |
| Carbenicillin disodium salt | Psyr_4381 | arginine decarboxylase | -1.2 | |
| Carbenicillin disodium salt | Psyr_4878 | outer membrane porin | +1.2 | |
| Chaulmoogric acid | Psyr_4293 | Acyl-CoA thioesterase | -1.9 | Yes |
| Erythromycin | Psyr_0284 | Electron transport protein SCO1/SenC | -1.9 | |
| Erythromycin | Psyr_0402 | Peptidoglycan glycosyltransferase | -1.7 | |
| Erythromycin | Psyr_0525 | Lipopolysaccharide kinase | -2.5 | |
| Erythromycin | Psyr_0583 | membrane protein, putative | -1.3 | |
| Erythromycin | Psyr_0626 | DedA | +1.5 | Yes |
| Erythromycin | Psyr_0630 | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase | -1.8 | |
| Erythromycin | Psyr_0937 | mannose-6-phosphate isomerase, type 2 / mannose-1-phosphate guanylyltransferase (GDP) | +1.7 | |
| Erythromycin | Psyr_1584 | Aspartyl/Asparaginyl beta-hydroxylase | -1.4 | Yes |
| Erythromycin | Psyr_1599 | C-terminal processing peptidase-1, Serine peptidase, MEROPS family S41A | -1.8 | |
| Erythromycin | Psyr_3521 | transcriptional regulator, LysR family | -1.8 | |
| Erythromycin | Psyr_3522 | L-serine ammonia-lyase | -2.2 | |
| Erythromycin | Psyr_3616 | Heat shock protein, Metallo peptidase, MEROPS family M48B | -1.4 | |
| Erythromycin | Psyr_3658 | Rhodanese-like protein | -1.2 | |
| Erythromycin | Psyr_3831 | ATP-dependent helicase HrpA | -3.4 | Yes |
| Erythromycin | Psyr_4061 | imelysin, Metallo peptidase, MEROPS family M75 | -1.3 | Yes |
| Erythromycin | Psyr_4063 | Protein of unknown function DUF1111 | -1.6 | |
| Erythromycin | Psyr_4067 | Lipopolysaccharide kinase | -2.3 | |
| Erythromycin | Psyr_4113 | LppC putative lipoprotein | -1.9 | |
| Erythromycin | Psyr_4178 | tRNA pseudouridine synthase B | -2.6 | Yes |
| Erythromycin | Psyr_4208 | heme catalase/peroxidase | -1.0 | |
| Erythromycin | Psyr_4297 | Helicase, C-terminal:DEAD/DEAH box helicase, N-terminal | -2.1 | |
| Erythromycin | Psyr_4381 | arginine decarboxylase | -1.6 | |
| Erythromycin | Psyr_4843 | NUDIX hydrolase | -1.6 | Yes |
| Erythromycin | Psyr_4932 | agmatine deiminase | -1.7 | |
| Escin | Psyr_2109 | methyl-accepting chemotaxis sensory transducer | -1.3 | |
| Harmine | Psyr_3616 | Heat shock protein, Metallo peptidase, MEROPS family M48B | -1.4 | |
| Harmine | Psyr_4150 | Uncharacterized P-loop ATPase protein UPF0042 | -1.6 | |
| Harmine | Psyr_4357 | HopAJ2 protein | -1.7 | |
| Harmine | Psyr_4732 | choline dehydrogenase | -1.1 | |
| Harmol | Psyr_0502 | potassium/proton antiporter, CPA1 family | +1.4 | |
| Lawsone | Psyr_2586 | Drug resistance transporter EmrB/QacA subfamily | -1.4 | |
| Lawsone | Psyr_4277 | Oxidoreductase FAD/NAD(P)-binding:Oxidoreductase FAD-binding region | -2.1 | |
| Levodopa | Psyr_4837 | Heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase:Heavy metal translocating P-type ATPase | +1.5 | |
| Mitomycin C | Psyr_0533 | conserved hypothetical protein | +1.9 | |
| Mitomycin C | Psyr_0626 | DedA | +2.5 | |
| Mitomycin C | Psyr_0726 | ribosomal large subunit pseudouridine synthase D | +2.7 | Yes |
| Mitomycin C | Psyr_1974 | Excinuclease ABC subunit B | -1.5 | Yes |
| Mitomycin C | Psyr_2760 | hypothetical protein | +3.0 | Yes |
| Mitomycin C | Psyr_2761 | DNA-directed DNA polymerase | +3.0 | Yes |
| Mitomycin C | Psyr_2762 | Peptidase S24, S26A and S26B | +2.6 | Yes |
| Mitomycin C | Psyr_2763 | Protein of unknown function DUF159 | +3.0 | Yes |
| Mitomycin C | Psyr_2764 | conserved hypothetical protein | +2.8 | Yes |
| Mitomycin C | Psyr_2767 | Glycoside hydrolase, family 19 | +3.0 | |
| Mitomycin C | Psyr_2770 | tail fiber domain protein | +2.0 | Yes |
| Mitomycin C | Psyr_2771 | conserved domain protein | +1.7 | Yes |
| Mitomycin C | Psyr_2772 | Fibronectin, type III | +2.6 | Yes |
| Mitomycin C | Psyr_2773 | hypothetical protein | +2.8 | Yes |
| Mitomycin C | Psyr_2775 | hypothetical protein | +2.8 | Yes |
| Mitomycin C | Psyr_2776 | hypothetical protein | +2.7 | Yes |
| Mitomycin C | Psyr_2777 | NLP/P60 | +2.9 | Yes |
| Mitomycin C | Psyr_2778 | Phage minor tail protein L | +3.3 | |
| Mitomycin C | Psyr_2779 | Phage minor tail | +2.5 | |
| Mitomycin C | Psyr_2780 | Phage tail tape measure protein lambda | +2.5 | Yes |
| Mitomycin C | Psyr_2782 | hypothetical protein | +3.2 | Yes |
| Mitomycin C | Psyr_2783 | conserved hypothetical protein | +3.0 | Yes |
| Mitomycin C | Psyr_2784 | phage-related conserved hypothetical protein | +3.2 | Yes |
| Mitomycin C | Psyr_2785 | conserved hypothetical protein | +2.7 | Yes |
| Mitomycin C | Psyr_2786 | phage-related conserved hypothetical protein | +2.2 | |
| Mitomycin C | Psyr_2788 | hypothetical protein | +3.4 | |
| Mitomycin C | Psyr_2789 | conserved hypothetical protein | +2.7 | Yes |
| Mitomycin C | Psyr_2792 | Phage putative head morphogenesis protein, SPP1 gp7 | +2.1 | Yes |
| Mitomycin C | Psyr_2793 | hypothetical protein | +2.4 | Yes |
| Mitomycin C | Psyr_2794 | Protein of unknown function DUF264 | +2.3 | Yes |
| Mitomycin C | Psyr_2797 | hypothetical protein | +2.5 | |
| Mitomycin C | Psyr_2798 | hypothetical protein | +2.4 | Yes |
| Mitomycin C | Psyr_2799 | hypothetical protein | +2.4 | Yes |
| Mitomycin C | Psyr_2801 | hypothetical protein | +1.9 | Yes |
| Mitomycin C | Psyr_2805 | hypothetical protein | +4.9 | Yes |
| Mitomycin C | Psyr_2813 | conserved hypothetical protein | +2.6 | Yes |
| Mitomycin C | Psyr_2815 | conserved hypothetical protein | +2.4 | Yes |
| Mitomycin C | Psyr_2816 | hypothetical protein | +2.7 | Yes |
| Mitomycin C | Psyr_2817 | hypothetical protein | +2.3 | Yes |
| Mitomycin C | Psyr_2818 | hypothetical protein | +1.7 | |
| Mitomycin C | Psyr_2821 | conserved hypothetical protein | +2.1 | Yes |
| Mitomycin C | Psyr_2825 | DNA methylase N-4/N-6 | +2.5 | Yes |
| Mitomycin C | Psyr_2828 | C-5 cytosine-specific DNA methylase | +2.4 | Yes |
| Mitomycin C | Psyr_2830 | conserved hypothetical protein | +3.4 | |
| Mitomycin C | Psyr_2834 | hypothetical protein | +1.7 | Yes |
| Mitomycin C | Psyr_2835 | hypothetical protein | +1.6 | Yes |
| Mitomycin C | Psyr_2841 | hypothetical protein | +1.8 | |
| Mitomycin C | Psyr_2843 | C-5 cytosine-specific DNA methylase | +1.8 | Yes |
| Mitomycin C | Psyr_2846 | Phage integrase:Phage integrase, N-terminal SAM-like protein | +1.3 | Yes |
| Mitomycin C | Psyr_2896 | Excinuclease ABC subunit C | -1.4 | |
| Mitomycin C | Psyr_3003 | [Acyl-carrier protein] phosphodiesterase | +4.6 | Yes |
| Mitomycin C | Psyr_3842 | SNF2-related:Helicase, C-terminal:Type III restriction enzyme, res subunit | +1.3 | |
| Mitomycin C | Psyr_4197 | DNA replication and repair protein RecN | -3.5 | Yes |
| Mitomycin C | Psyr_4520 | Excinuclease ABC subunit A | -1.4 | Yes |
| Nalidixic acid sodium salt | Psyr_0185 | tyrosine recombinase XerC subunit | -1.5 | |
| Nalidixic acid sodium salt | Psyr_0318 | cell division protein ZapA | +1.4 | |
| Nalidixic acid sodium salt | Psyr_0626 | DedA | +1.6 | Yes |
| Nalidixic acid sodium salt | Psyr_3970 | Uracil-DNA glycosylase | -1.2 | Yes |
| Nitrofurantoin | Psyr_0003 | DNA replication and repair protein RecF | -2.3 | Yes |
| Nitrofurantoin | Psyr_1974 | Excinuclease ABC subunit B | -3.7 | Yes |
| Nitrofurantoin | Psyr_2896 | Excinuclease ABC subunit C | -3.2 | Yes |
| Nitrofurantoin | Psyr_3396 | DNA replication and repair protein RecR | -3.6 | Yes |
| Nitrofurantoin | Psyr_3949 | DNA replication and repair protein RecO | -3.2 | Yes |
| Nitrofurantoin | Psyr_4231 | ATP-binding region, ATPase-like:Histidine kinase A, N-terminal | -1.3 | Yes |
| Nitrofurantoin | Psyr_4281 | cytochrome bd quinol oxidase subunit 2 apoprotein | -1.2 | Yes |
| Nitrofurantoin | Psyr_4282 | cytochrome bd quinol oxidase subunit 1 apoprotein | -1.2 | |
| Nitrofurantoin | Psyr_4520 | Excinuclease ABC subunit A | -3.2 | Yes |
| Nonanoic acid | Psyr_3379 | membrane protein, putative | -3.2 | |
| Nonanoic acid | Psyr_3380 | Secretion protein HlyD | -3.2 | |
| Novobiocin sodium salt | Psyr_0626 | DedA | +1.7 | Yes |
| Novobiocin sodium salt | Psyr_0726 | ribosomal large subunit pseudouridine synthase D | +2.2 | Yes |
| Novobiocin sodium salt | Psyr_0841 | conserved hypothetical protein | +1.1 | |
| Novobiocin sodium salt | Psyr_0937 | mannose-6-phosphate isomerase, type 2 / mannose-1-phosphate guanylyltransferase (GDP) | +1.2 | |
| Novobiocin sodium salt | Psyr_0938 | hypothetical protein | -1.0 | Yes |
| Novobiocin sodium salt | Psyr_1599 | C-terminal processing peptidase-1, Serine peptidase, MEROPS family S41A | -1.6 | |
| Novobiocin sodium salt | Psyr_2805 | hypothetical protein | +1.4 | Yes |
| Novobiocin sodium salt | Psyr_3214 | Propeptide, PepSY amd peptidase M4 | -2.2 | Yes |
| Novobiocin sodium salt | Psyr_4159 | RNAse G | -1.5 | |
| Novobiocin sodium salt | Psyr_4749 | cell division protein FtsX | +1.4 | |
| Novobiocin sodium salt | Psyr_4750 | cell division ATP-binding protein FtsE | +1.3 | |
| Novobiocin sodium salt | Psyr_4834 | histidine:proton symporter, AAT family | +1.3 | Yes |
| Oxedrine | Psyr_2663 | hypothetical protein | -1.3 | |
| Palmatine | Psyr_1368 | Carboxylesterase | +1.0 | |
| Palmatine | Psyr_2282 | Hydrophobe/amphiphile efflux-1 HAE1 | -2.2 | |
| Palmatine | Psyr_2283 | Secretion protein HlyD | -1.7 | |
| Palmatine | Psyr_2427 | gamma-glutamylputrescine oxidase | +1.1 | |
| Palmatine | Psyr_4076 | conserved hypothetical protein | +1.6 | |
| Palmatine | Psyr_4178 | tRNA pseudouridine synthase B | -2.4 | |
| Palmatine | Psyr_4837 | Heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase:Heavy metal translocating P-type ATPase | +2.6 | |
| Palmatine | Psyr_4932 | agmatine deiminase | +1.9 | |
| Palmatine | Psyr_4933 | Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase | +1.4 | |
| Palmatine chloride | Psyr_2282 | Hydrophobe/amphiphile efflux-1 HAE1 | -2.1 | |
| Palmatine chloride | Psyr_2283 | Secretion protein HlyD | -1.9 | |
| Phloretin | Psyr_3695 | RelA/SpoT protein | -2.7 | |
| Piperic acid | Psyr_3379 | membrane protein, putative | -1.8 | |
| Piperic acid | Psyr_3380 | Secretion protein HlyD | -1.4 | |
| Quercetin | Psyr_1969 | ABC transporter:Protein of unknown function DUF214 | -1.8 | |
| Rifampicin | Psyr_0941 | Conserved hypothetical protein 92 | -1.5 | Yes |