Pairwise Alignments

Query, 1070 a.a., Cobalt/zinc/cadmium efflux RND transporter, transmembrane protein CzcA from Variovorax sp. SCN45

Subject, 1470 a.a., heavy metal efflux pump (cobalt-zinc-cadmium) from Echinicola vietnamensis KMM 6221, DSM 17526

 Score =  848 bits (2191), Expect = 0.0
 Identities = 457/1067 (42%), Positives = 682/1067 (63%), Gaps = 40/1067 (3%)

Query: 1    MFERIIRFSIEQRWLILLAVLGMAALGIFSYQKLPIDAVPDITNVQVQINTAAPGYSPLE 60
            M  +II FSI+ ++++ L  L +  +GI+S   + + +VPDITN QVQ+ T +P  +  +
Sbjct: 1    MINKIISFSIKNKFIVGLLTLALIGVGIYSMATVNLGSVPDITNNQVQVMTVSPNLATED 60

Query: 61   TEQRVTYPIETVMAGLPGLQQTRSLSRYGLSQVTVIFKDGTDIYFARQLVNERIQSARES 120
             EQ VTYP+E  M  LPG+ + RS+SR+GLS VT++F+D   IY  RQLV E++   +E+
Sbjct: 61   IEQFVTYPVELAMGNLPGVDEIRSISRFGLSVVTIVFEDEMGIYKPRQLVQEKLNELKET 120

Query: 121  MPRGI-SPVIGPISTGLGEIYLWTVEAEEGARKADGKPYSSTDLREIQDWIIKPQLRNVA 179
            +P    SP +GPISTGLG+IY +T++ +EG        YS  +LR IQDWI+K QL  + 
Sbjct: 121  IPEKFGSPTMGPISTGLGQIYEYTIQPKEGYEDQ----YSPMELRTIQDWIVKRQLTLLD 176

Query: 180  GVTEINSIGGYAKEFQISPDPAKLLAHGLTMTDLVTALERNNANVGAGYIEKRGEQYLIR 239
            GV E+NS GGY K+++++ +P KL A  ++++ +  AL RNN N G  YIEK      IR
Sbjct: 177  GVVEVNSFGGYIKQYEVAINPEKLNAQNVSISQVYEALARNNVNTGGAYIEKNRMSNFIR 236

Query: 240  APGQVKSVEDIGNVILGNANGIPLRVQDVAE-VGIGKELRTGAATDNGREVVLGTVFMLI 298
              G V+S++DI  +++   NGIP+ + DVAE V  G ++R GA T +G+E V G + M+ 
Sbjct: 237  GEGLVRSLDDIRKIVIKTENGIPVTIGDVAEKVHFGNQVRYGAFTQDGKEAVGGIIMMMK 296

Query: 299  GENSRTVSQAVDRKMQEINRTLPAGVKAVTVYDRTVLVDKAIATVKKNLFEGAVLVIAIL 358
            G N   V Q V  +M+E+ ++LP G+   T+ DR+ L+ +   TVK NLFEGA++VI  L
Sbjct: 297  GSNPNAVIQDVKARMEEVEKSLPEGLTINTIIDRSDLISRTTDTVKTNLFEGALIVIFAL 356

Query: 359  FLFLGNIRAALITALVIPLSMLFTFTGMVNQKVSANLMSLGALDFGIIIDGAVVIVENCV 418
             + LG++R  +ITA  IPLS+LF F  M    V ANLMSLGA+DFGIIIDGAV+I+E  V
Sbjct: 357  VILLGSLRGGIITATTIPLSLLFAFIMMKQFNVWANLMSLGAIDFGIIIDGAVIIIEGTV 416

Query: 419  RRLAHAQAHKGRPLTRSERFHEV-FAASQEARRPLLFGQLIIMIVYLPIFALTGVEGKLF 477
              +   +   G+         EV + A         FGQ+II+IV+ PI  LTGVEGK+F
Sbjct: 417  YEI-QKRIRSGKIKFNQVLMDEVAYDAGSTMMGSAFFGQIIILIVFAPILFLTGVEGKMF 475

Query: 478  HPMAFTVVIALLGAMILSITFIPAAVALFIGNKVSEKEN---RLMVWAKR---------- 524
             PMA+T   A++GA+IL +T++P   ALF+   +  K+N   R   W +R          
Sbjct: 476  QPMAYTFGFAMIGAIILCLTYVPMMSALFM-KPIQNKKNWFGRFERWLERVSDKIIGSIQ 534

Query: 525  -GYEPLLARVMGAKPLVITTAVVAVLLSGLLATRLGTEFVPSLSEGDFAIQALRIPGTSL 583
              Y PLL   +  K +VI  A+V +  +G + +R+G EFVP L EGD A+QAL  PG+SL
Sbjct: 535  KVYLPLLKGALRFKAIVIIVAIVLLGAAGFVFSRMGGEFVPQLDEGDIAMQALIRPGSSL 594

Query: 584  TQSVEMQKQLERTLKEKFPEIERIFARTGTAEIASDPMPPNISDGYIMLKPESEWPKPRR 643
            ++S E+  ++E  L E FPEI+ + AR G A+I +DPMP +I+D Y++L+ + +      
Sbjct: 595  SESKEVSIKIENLLLESFPEIKTVTARIGVADIPTDPMPMDIADMYLILEKDKDQWVSAE 654

Query: 644  SRAEVLAAVQEEVE-KLPGNNYEFSQPIQLRFNELISGVRSDVAVKIFGDDMDVLNKTAA 702
            ++ E++  +++++E  L G N  F+QP++LRFNEL+ GVR D+AVK++G+D++VL++   
Sbjct: 655  TKDELIEQIKDKLETHLTGVNLVFTQPVELRFNELLEGVREDIAVKLYGEDLEVLSEKVQ 714

Query: 703  EVSEALGKIAGAAEVKVEQTTGLPMLTVNIDRNKTARYGLNVGDVQEAISIAVGGREAGT 762
            E++  +  ++GA +V  E+T+GLP +TV  +R+K A+YGL +  + E +S A  G  AG 
Sbjct: 715  EMANIISTVSGAGDVNPERTSGLPQMTVRYNRDKVAQYGLVIQKLNEYVSSAFAGGVAGV 774

Query: 763  LFDGDRRFDIIVRLPENLRTDLEAIKRLPVALPKGAGAEGARTSFIPLGEVATLDIAPGP 822
            +F+G++RFD+++R  E  R  ++ ++ L + LP G        + +P+ EVA +   PGP
Sbjct: 775  IFEGEKRFDLVIRFDEAHRKSIDDLRTLYIDLPDG--------TQVPIKEVADISYMPGP 826

Query: 823  NQVSREDGKRRIVVSANVRGRDLGSFVAEAEEAM-RNVKIPTGYWTVWGGQYENLASATQ 881
             Q+SR++  RR  V  N RGRD+ S V + +E +   + +P GY+  +GG++ENL  A  
Sbjct: 827  MQISRDNTYRRTYVGVNTRGRDVESVVNDIQEKLDAELDLPPGYYITYGGEFENLQRAKS 886

Query: 882  RLQVVVPVSLLLVFTLLFAMFGNLKDGLLVFTGIPFALTGGIVALWMRGIPLSISAAVGF 941
            RLQ+VVP++L L+F LL+    +    ++++  IP A  GG+  LW+RG+P SISA VGF
Sbjct: 887  RLQIVVPIALFLIFVLLYFALKSFSQSIMIYMAIPLAAIGGVFGLWIRGMPFSISAGVGF 946

Query: 942  IALSGVAVLNGLVMISFIRNLREGGLPLDAAIREGALT----RLRPVLMTALVASLGFVP 997
            I L GVAVLNGLV+I+   +L+E G+    +IRE  LT    R+RP+++TA     GF+P
Sbjct: 947  IVLFGVAVLNGLVLINRFNSLKEEGV---TSIRERILTGTKERIRPIMLTATTDIFGFLP 1003

Query: 998  MAIATGTGAEVQRPLATVVIGGILSSTALTLLVLPLLYRIAHRRDEE 1044
            MA +   GAEVQRPLATVVIGG+L++T LTL+VLP+LY     R E+
Sbjct: 1004 MAFSASAGAEVQRPLATVVIGGMLTATLLTLVVLPVLYTFVEGRREK 1050



 Score = 41.2 bits (95), Expect = 6e-07
 Identities = 88/518 (16%), Positives = 209/518 (40%), Gaps = 34/518 (6%)

Query: 15   LILLAVLGMAALGIFSYQKLPIDAVPDITNVQVQINTAAPGYSPLETEQRVTYPIETVMA 74
            +I++A++ + A G F + ++  + VP +    + +       S L   + V+  IE ++ 
Sbjct: 551  VIIVAIVLLGAAG-FVFSRMGGEFVPQLDEGDIAMQALIRPGSSLSESKEVSIKIENLL- 608

Query: 75   GLPGLQQTRSLS-RYGLSQVTV--IFKDGTDIYFARQLVNERIQSA--RESMPRGISPVI 129
             L    + ++++ R G++ +    +  D  D+Y   +   ++  SA  ++ +   I   +
Sbjct: 609  -LESFPEIKTVTARIGVADIPTDPMPMDIADMYLILEKDKDQWVSAETKDELIEQIKDKL 667

Query: 130  GPISTGLGEIYLWTVEAE-----EGARKADGKPYSSTDLREIQDWIIKPQ--LRNVAGVT 182
                TG+  ++   VE       EG R+         DL  + + + +    +  V+G  
Sbjct: 668  ETHLTGVNLVFTQPVELRFNELLEGVREDIAVKLYGEDLEVLSEKVQEMANIISTVSGAG 727

Query: 183  EIN-SIGGYAKEFQISPDPAKLLAHGLTMTDLVTALERNNANVGAGYI---EKRGEQYLI 238
            ++N        +  +  +  K+  +GL +  L   +    A   AG I   EKR +  + 
Sbjct: 728  DVNPERTSGLPQMTVRYNRDKVAQYGLVIQKLNEYVSSAFAGGVAGVIFEGEKRFDLVIR 787

Query: 239  RAPGQVKSVEDIGNVILGNANGIPLRVQDVAEVGIGKELRTGAATDNGREVVLGTVFMLI 298
                  KS++D+  + +   +G  + +++VA++         +  +  R   +G     +
Sbjct: 788  FDEAHRKSIDDLRTLYIDLPDGTQVPIKEVADISYMPGPMQISRDNTYRRTYVG-----V 842

Query: 299  GENSRTVSQAVDRKMQEINRTL--PAGVKAVTVYDRTVLVDKAIATVKKNLFEGAVLVIA 356
                R V   V+   ++++  L  P G   +T       + +A + ++  +     L+  
Sbjct: 843  NTRGRDVESVVNDIQEKLDAELDLPPGYY-ITYGGEFENLQRAKSRLQIVVPIALFLIFV 901

Query: 357  ILFLFLGNIRAALITALVIPLSMLFTFTGMVNQKVSANLMSLGALDFGIIIDGAVVIVEN 416
            +L+  L +   +++  + IPL+ +    G+    +     S+ A    I++ G  V+   
Sbjct: 902  LLYFALKSFSQSIMIYMAIPLAAI---GGVFGLWIRGMPFSISAGVGFIVLFGVAVLNGL 958

Query: 417  CVRRLAHAQAHKGRPLTRSERFHEVFAASQEARRPLLFGQLIIMIVYLPIFALTGVEGKL 476
             +    ++   +G    R      +   ++E  RP++      +  +LP+        ++
Sbjct: 959  VLINRFNSLKEEGVTSIRER----ILTGTKERIRPIMLTATTDIFGFLPMAFSASAGAEV 1014

Query: 477  FHPMAFTVVIALLGAMILSITFIPAAVALFIGNKVSEK 514
              P+A  V+  +L A +L++  +P       G +   K
Sbjct: 1015 QRPLATVVIGGMLTATLLTLVVLPVLYTFVEGRREKGK 1052