Pairwise Alignments

Query, 1054 a.a., Copper/silver efflux RND transporter, transmembrane protein CusA from Variovorax sp. SCN45

Subject, 1458 a.a., CusA/CzcA family heavy metal efflux RND transporter from Pontibacter actiniarum KMM 6156, DSM 19842

 Score =  622 bits (1605), Expect = 0.0
 Identities = 357/1045 (34%), Positives = 581/1045 (55%), Gaps = 21/1045 (2%)

Query: 1    MIAKLIRWSIANRFLVLLATAMLSAWGVYSVLRTPLDALPDLSDVQVIIRTSYPGQAPRI 60
            M  K+I +SI N+ ++ L    L  WG YS+ R PLDA+PD+++ QV + T  P  A + 
Sbjct: 1    MFDKIISFSIKNKLVIGLFVLALIGWGTYSLNRIPLDAVPDITNNQVQVITQAPDLATQE 60

Query: 61   VENQITYPLTTTMLSVPGAKTVRGYSFFGDSFVYVLFEDGTDLYWARSRVLEYLNQVQSR 120
            VE  ITYP+ T M  +P  + +R  S FG S + ++FE+  D Y AR  V E +      
Sbjct: 61   VEQFITYPMETAMSFIPDVEEIRSISRFGLSVITIVFEEDVDPYLARQLVSEQIKTASEN 120

Query: 121  LPAA-AKASLGPDATGVGWIYQYALVDRGG---TQDASQLRALQDWFLKYELKTVPNVAE 176
            +P       L P  TG+  IYQY LV+  G        +LR++QDW +K +L  VP VAE
Sbjct: 121  IPEGFGTPQLAPMVTGLSEIYQYTLVEEEGYDTVYSPMELRSIQDWIVKRQLAGVPGVAE 180

Query: 177  VASIGGMVRQYQVVLDPEKLAAYRIPHTKAVEAIQKANQETGGSVLELGEAEYMVRASGY 236
            V+S GG ++QY+V +DPEKL +Y +       AI + NQ TGGS +E     Y +R  G 
Sbjct: 181  VSSFGGYLKQYEVAIDPEKLRSYHLTVADVYRAIAQNNQNTGGSYIERANTAYFIRGEGM 240

Query: 237  LQGLEDFRKIPLMTTDAGVSVRLGDVARIQVGPEMRRGIGELDGEGEAVGGVIVMRSGKN 296
            +  L+D R + +   + G  + +GDVA++Q G   R G    +GEGE VGG+++M  G+N
Sbjct: 241  VSSLDDIRSVLIRNVN-GTPILVGDVAKVQFGHATRFGAITRNGEGETVGGLVLMLKGEN 299

Query: 297  ALETITAVKEKLQTLQASLPKGVEIVPTYDRSNLIERAVRNLGFKLLEEFIVVAVVCFIF 356
            + +   AVKE++  +Q SLP+G+ I P  DRS+LI+RA+  +   L+E  ++V  V  + 
Sbjct: 300  SYQVTQAVKERMAQIQKSLPEGIHIDPFLDRSSLIDRAIATVTRNLVEGGLIVVFVLVLL 359

Query: 357  LFHLRSAFVAIVSLPIGILAAFIVMRYQGVNANIMSLGGIAIAIGAMVDAAVVMIENAHK 416
            L + R+  V    +P+ +L A  +M   GV+AN+MSLG  AI  G +VD AV+++E    
Sbjct: 360  LGNWRAGLVVASVIPLSMLFALGMMHVFGVSANLMSLG--AIDFGLIVDGAVIIVEAI-- 415

Query: 417  HIEKWKHDHPDQTLRGETHWRVIADSAAEVGPALFFSLLIITLSFIPVFTLEAQEGRMFS 476
             I +       Q L        +  ++  +  +  F  +II + ++P+  L   EG+MF 
Sbjct: 416  -IHRLYGSFNGQRLTQNEMDAQVGAASRHIRKSAAFGEIIILIVYLPILALVGIEGKMFG 474

Query: 477  PLAFTKTYAMAAAAGLSVTLIPVLMGYLIRGRIPDEK--TNPLNRLLIAVYQPLLNAVLR 534
            P+A T ++A+  A  LS+T +P++   +++ +I  ++  ++ +      +Y+P++   L 
Sbjct: 475  PMAQTVSFAILGAFILSLTYVPMMSALVLKKKIVVKRNISDKIMDFFHRLYEPVIRFALG 534

Query: 535  WPKLTLAGAAVVLVLSLWPLQHIGGEFMPRLDEGDLLYMPSALPGLSTGKAGELLQQT-D 593
              K+ L  A ++   SL     +GGEF+P+LDEGD+        G S  +   + ++  D
Sbjct: 535  AKKMVLLVAVLIFAASLVVFSRMGGEFIPQLDEGDIAAHQILPTGTSIRQMVAVSKKIQD 594

Query: 594  RLIKTVPEVASVYGKAGRAESATDPAPIEMFETTIQFKPREQWRAGMTQDKLVEELDRIV 653
            RL+   PEV  V  K G +E  TDP  +E+ +  I  K +E+W +  +++++ E+++ ++
Sbjct: 595  RLMHDFPEVKEVVTKIGTSEIPTDPMAMELADIIIVMKDKEEWVSATSREEMFEKMEAVI 654

Query: 654  K-VPGLTNIWVPPIRNRIDMLATGIKSPVGVKVAGTDLATIDRITGEIERVLKDVPGVSS 712
              VPG+   +  PI+ R + L TG++  + VK+ G DL  + R   E   ++  + GV  
Sbjct: 655  NSVPGVGTEFTQPIQMRFNELITGVRQDIAVKIYGEDLDVLFRKGNEANELISRIEGVGG 714

Query: 713  ALAERLTGGRYVDVNIKRDEASRFGMNIADVQSVIASAVGGENIGETVEGLQRFPINVRY 772
             + E+LTG   + +N  R + +++G+ + DV + I +A  G   G   EG +RF + VR+
Sbjct: 715  TVVEQLTGLPQIQINYDRGKMAQYGLAVEDVNTAINTAFAGGTAGVVFEGERRFDLVVRF 774

Query: 773  PREIRDSLEQLRSLPIVTERGARLVLSDVADIRITDGPPMLRSENARLSGWVYVDIRGRD 832
                R  ++ +R + I    G ++ + +VA+IR  + P  +  +NA+    V V+ R RD
Sbjct: 775  QESFRQEIDNVRDMYIPLPSGGQVPVKEVANIRFEEAPAQISRDNAQRRIVVGVNTRNRD 834

Query: 833  LRSAVQDMQRVVTKEVKLPPGYAVSWSGQFEFLERATAKLKVVVPFTLLIIFVLLYLTFK 892
            + S VQD+Q+V+ ++++LPPGY +++ GQFE L  AT +L V VP  LL+I VLL+ TF 
Sbjct: 835  VESVVQDIQQVLDEQLELPPGYYITYGGQFENLIEATQRLSVAVPAALLLILVLLFFTFG 894

Query: 893  RFDEALLIMAALPFALVGGIWLLYLLSYNLSVAGAVGFIALAGVSAEFGVIMLLYLKHAW 952
               +ALLI  A+P + +GGI  L+L     S++  VGFIAL GV+   G+++L       
Sbjct: 895  SMKQALLIFTAVPMSAIGGILALWLRGMPFSISAGVGFIALFGVAVLNGIVLL------- 947

Query: 953  DERVDEGKTSTADLLDAIREGAVLRVRPKAMTVAVILAGLFPIMWGTGTGSEVMQRIAAP 1012
             E     K    D+ + I +G   R+RP  MT +V   G  P+   T  G+EV Q +A  
Sbjct: 948  SEFNSLKKEGVKDIRERILKGTHTRLRPVIMTASVASLGFLPMALSTSAGAEVQQPLATV 1007

Query: 1013 MVGGMITAPLLSMFVIPAAYLLMRR 1037
            ++GG++TA LL++ V+P  Y  + R
Sbjct: 1008 VIGGLVTATLLTLVVLPILYYYLER 1032



 Score = 56.6 bits (135), Expect = 1e-11
 Identities = 79/361 (21%), Positives = 150/361 (41%), Gaps = 32/361 (8%)

Query: 174  VAEVASIGGMV-------RQYQVVLDPEKLAAYRIPHTKAVEAIQKANQETGGSVLELGE 226
            ++ +  +GG V        Q Q+  D  K+A Y +       AI  A       V+  GE
Sbjct: 706  ISRIEGVGGTVVEQLTGLPQIQINYDRGKMAQYGLAVEDVNTAINTAFAGGTAGVVFEGE 765

Query: 227  AEY--MVR-ASGYLQGLEDFRK--IPLMTTDAGVSVRLGDVARIQVGPEMRRGIGELDGE 281
              +  +VR    + Q +++ R   IPL    +G  V + +VA I+   E    I   + +
Sbjct: 766  RRFDLVVRFQESFRQEIDNVRDMYIPL---PSGGQVPVKEVANIRF-EEAPAQISRDNAQ 821

Query: 282  GEAVGGVIVMRSGKNALETITAVKEKLQTLQASLPKGVEIVPTYDRSNLIERAVRNLGFK 341
               V GV    +    +E++    +++   Q  LP G  I       NLIE A + L   
Sbjct: 822  RRIVVGV---NTRNRDVESVVQDIQQVLDEQLELPPGYYITYGGQFENLIE-ATQRLSVA 877

Query: 342  LLEEFIVVAVVCFIFLFHLRSAFVAIVSLPIGILAAFIVMRYQGVNANIMSLGGIAIAIG 401
            +    +++ V+ F     ++ A +   ++P+  +   + +  +G+  +I +  G     G
Sbjct: 878  VPAALLLILVLLFFTFGSMKQALLIFTAVPMSAIGGILALWLRGMPFSISAGVGFIALFG 937

Query: 402  AMVDAAVVMIENAHKHIEKWKHDHPDQTLRGETHWRVIADSAAEVGPALFFSLLIITLSF 461
              V   +V++   +   ++   D  ++ L+G TH R+           +  +  + +L F
Sbjct: 938  VAVLNGIVLLSEFNSLKKEGVKDIRERILKG-THTRL---------RPVIMTASVASLGF 987

Query: 462  IPVFTLEAQEGRMFSPLAFTKTYAMAAAAGLSVTLIPVLMGYLIRGRIPDEKTNPLNRLL 521
            +P+    +    +  PLA      +  A  L++ ++P+L  YL RG  P  K  P   LL
Sbjct: 988  LPMALSTSAGAEVQQPLATVVIGGLVTATLLTLVVLPILYYYLERGFRP--KAQPAALLL 1045

Query: 522  I 522
            +
Sbjct: 1046 L 1046