Pairwise Alignments

Query, 1530 a.a., putative RHS family protein from Pseudomonas putida KT2440

Subject, 5052 a.a., Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA from Variovorax sp. SCN45

 Score = 99.0 bits (245), Expect = 1e-23
 Identities = 170/722 (23%), Positives = 256/722 (35%), Gaps = 162/722 (22%)

Query: 631  AGQLIKRIDPQGGEWRYSYDDIGRLIETRDPLGR-SEHIKYLRH---------------- 673
            A QL+ R + +G    ++YD  GRL++T    G   E I+ LR+                
Sbjct: 1646 ANQLLSRTNAEGTVTTFTYDVAGRLVQTTTAAGTPDERIQRLRYDIQGHLIAELDGRGSD 1705

Query: 674  -WALPIQVTDTAGRTRQYGYDSHGNLLWQQDPLGRETQYQYDPEGRVTQVTDALEKSKYL 732
              AL   +   +     + YD+ G      D  G  T + YD  GR+    +AL +    
Sbjct: 1706 AVALNAPLASWSANGSTHAYDAAGRRTGTTDANGHRTLFFYDAFGRLAYTVNALGEVTES 1765

Query: 733  SWNTCGQ--------------------------------LLSYRD-CSNAQTLYHYDAHG 759
             +N  GQ                                L +  D   +   L  Y+A G
Sbjct: 1766 RYNAYGQVSEQIVYGSRIDLTPLGTATPGGLNTDALKALLATMADPAKDTHVLKTYNASG 1825

Query: 760  RLRESINARGEHTHFRYDARGYLVESERP--DGRI-------DRYEIDVAGQLTRYIDPA 810
             L  S +A G  T + Y+A    + S R    G++       DR  + V+   T     A
Sbjct: 1826 TLTSSTDAMGGVTSYAYNAFREAIASSRTRLSGQVITNTVTFDRRGLQVS--TTSDATGA 1883

Query: 811  QKTLQFRYDPSGRLVERTDAMGYSVKFRYDAYGRLLQLTNENDESYRFGWDELDRLVAQK 870
              T +  YD  GR   R D  G +   RYD  GR++  T+    +    +D  DR++ Q+
Sbjct: 1884 GLTRRTGYDAFGRPDTRIDGNGNTASLRYDRLGRVVATTDATGATRTTTYDAFDRVLTQR 1943

Query: 871  DLDGSGRLYAYNVLDEVIRLT-----HVPSPDEQPPLSDNAPPTRTTAIRHDFER----- 920
            D   +   YAY+V +  + +T      V +   +   + +    R     + +++     
Sbjct: 1944 DALNNVTSYAYSVANRSVTVTTPEGVSVTTLHNRQGQTTSVTDGRGNTTTYSYDKSGNLL 2003

Query: 921  --------------DAIGRLVSKRTEDGT-TDYRYDAADNLLSITFTDNKGEKQQLDYTY 965
                          D IG  +S     GT T Y YDA   LL+ T  D  G      Y Y
Sbjct: 2004 RTQAPEGVGTSTTYDKIGLKLSTTDARGTVTTYGYDAVSRLLTRT-VDPGGLTLVTSYLY 2062

Query: 966  DANGQLLSETNSAGLLQYR-YDELGNLQTLVLPDQRELNHLYYGSGHLHQINLNGRVISD 1024
            DA GQ +S T+  G +    YD  G +    L      N  Y G        L    +  
Sbjct: 2063 DAKGQTISVTDPGGTVTTTAYDLNGQVVRQTLDPS---NGAYVG--------LKLETVYT 2111

Query: 1025 FERDAVHDEVLRTQGKLVTRTRYDTSGRLAGKAIHYRDAPAEVLPL---LDKAYRYDASD 1081
             + D     V    G+L TR  YD +GR   +         +V PL   L ++Y YDA  
Sbjct: 2112 HDSDGTALSVHGPDGRL-TRYTYDGAGRRIKE---------QVDPLGLNLTRSYAYDAEG 2161

Query: 1082 NLIAEVLTQTQRRGMSNAANDENANLEQII-GRFLDLPHTGKTYSGHNRYGYDLNEQL-- 1138
            N+I  V              D + N    I  +   L  T     G  + GYD   +L  
Sbjct: 2162 NVIKAV--------------DASGNATLFIYDQAKRLAFTIDAMGGVQQSGYDAEGRLSS 2207

Query: 1139 QTVHQ----------SRPNWQATQ----------VEDFKYDKAGNLFDGPKLNGLIKHNR 1178
            QT +           + P+  A Q           +  +YD+ G L       G +    
Sbjct: 2208 QTTYAAFVPVAAWNGTAPSLSAMQAALPTLGLAATQSRRYDRDGRLRFAVDATGAV---- 2263

Query: 1179 VLVYQDKRYRYDRFGRLCEKRIGSNWVQYFEYDAEQRLVCVEQYRSGERERVVFAYDPLG 1238
                    YRYD  G + E R  +  ++  ++        V      +R R V  YD LG
Sbjct: 2264 ------VEYRYDDAGNVVESRAYAQRIELGKWHGAIDPPVVADDAHDQRSRSV--YDALG 2315

Query: 1239 RR 1240
            R+
Sbjct: 2316 RK 2317



 Score = 90.1 bits (222), Expect = 5e-21
 Identities = 175/751 (23%), Positives = 275/751 (36%), Gaps = 171/751 (22%)

Query: 305 EDIDFNLPGL-LAIQWARRYDSRDMRSDGLLGMGWSVP---YEVELARVPHPQGGTLWIY 360
           +D+D  L G  L I   R Y+S+ +  D   G  W V     +V L       G TL   
Sbjct: 50  QDLDDRLVGRGLDIATVRTYNSQGLFDDDN-GDNWRVGAHGQKVVLTGTAGTAGSTL-AR 107

Query: 361 IDNDGNRLELGRLSAGDAFISAVDGLAF----FQLEDGQTVVEDINEGLYRVFDTDPLNP 416
            D DG        ++ + ++S+    AF    +   + + V  D + GL   +D      
Sbjct: 108 TDRDGATAVYAWSASRNLYVSSAGAGAFDTIAYDAANARYVWTDGSSGLVERYDASG--- 164

Query: 417 KRSRLIRLGDRNLNCLDLLYDEQGRLKALYDKYGQTVVQLHYAARHPQRVSEVSRVFLKN 476
            + RL+   D N N +   Y+  G LK++ D  G+      Y   +  +V  V+      
Sbjct: 165 -QGRLLFAVDPNGNTVSYSYNANGTLKSVVDANGEATY-FDYTGTNLTQVRTVAT----- 217

Query: 477 GGTPTVERSELLVSYRYTDNGQLHEVLDATDQRVRRFTYTPEGYLNSHQLASGAVREYEW 536
            G  T+ R    V Y Y    +L  V             +PE     + +A G       
Sbjct: 218 -GGATLTR----VRYAYDGANRLSSVT---------VDLSPE----DNSVADG------- 252

Query: 537 ARFAIPETRPTPKRLDGTPYRLPPLLEPQPDHEWRVIRHWGSDGEEYRFEYNLEAGE--- 593
                 +T  T    DGT  R+  + +              SDG    F Y L       
Sbjct: 253 ------KTYVTTYNYDGTSKRVASVTQ--------------SDGTALAFTYVLSGSSYKV 292

Query: 594 TLVTDNLGRRDHYYWGPLYEVYKHIDPQGNCWLAEVIAGQLIKRIDPQGGEWRYSYDDIG 653
             VTD LG+   + +                      A       DPQG    + YD  G
Sbjct: 293 ATVTDALGQITRFAYDS--------------------ASSTTTVTDPQGARSTFLYDADG 332

Query: 654 RLIETRDPLGRSEHIKYLRHWALPIQVTDTAGRTR-QYGYDSHGNLLWQQDPLGRETQYQ 712
            L++ R                  +   + AG ++  Y YD+ GN+    D  GRE  Y+
Sbjct: 333 NLLQVRQG----------------VTAGNAAGLSQVSYRYDAAGNVTGMTDGEGRELAYE 376

Query: 713 YDPEGRVTQVTDALEKSKYLSWNTCGQLLS---YRDCSNAQTLYHYDA------------ 757
           YD  G + +  D+   +   ++N+  QLLS   Y D S ++ ++  DA            
Sbjct: 377 YDANGNLLKEVDSAGNTHTRTYNSANQLLSDTIYADASVSRGVFSKDAALPETTRYVYAP 436

Query: 758 --HGRLRESINARGEHTHFRYDARGYLVESERPDG------RIDRYEIDVAGQLTRYI-- 807
               +LR  + A+G  T  RYD+ G  + + R  G       +   ++    Q+  ++  
Sbjct: 437 GNALQLRFVVTAQGNVTEHRYDSYGQRISTIRYVGSAYGVSTLGTTDVPTQAQMLAWLGG 496

Query: 808 -DPAQ-KTLQFRYDPSGRLVERT-----DAMGYS-------VKFRYDAYGRLLQLTNEND 853
            DP++ + + + YD  G L   T     DA G          ++ YD +G LLQ    + 
Sbjct: 497 QDPSRTERVDYAYDARGSLSSATTYGEVDATGAGTTATAARTQYVYDQHGNLLQKIEPSG 556

Query: 854 ESYRFGWDELDRLVAQKDLDGSGRLYAYNV--LDEVIRLTHVPSPDEQPPLSDNAPPTRT 911
                              DG GR+ + +   LD V   T V S D+          T  
Sbjct: 557 GG-----------TTTYVYDGLGRVLSVSAPSLDGVTANTTVTSYDD---AGGRTSVTVA 602

Query: 912 TAIRHDFERDAIGRLVSKRTED------GTTDYRYDAADNLLSITFTDNKGEKQQLDYTY 965
           + +      D  GRLVS   +       GTT Y YD   NLL     D  G ++ +   Y
Sbjct: 603 SGLVSISAYDKAGRLVSVTQQSAGSGVLGTTTYAYDKNGNLLMT--QDPTGVRKWM--LY 658

Query: 966 DANGQLLSETNSAG-LLQYRYDELGNLQTLV 995
           D   + ++E ++ G L++Y Y+  G L+  V
Sbjct: 659 DEANRKIAEIDATGALVEYVYNASGQLRQSV 689



 Score = 88.6 bits (218), Expect = 2e-20
 Identities = 131/557 (23%), Positives = 207/557 (37%), Gaps = 105/557 (18%)

Query: 631  AGQLIKRIDPQGGEWRYSYDDIGRLIETRDPLGRSEHIKYLRHWALPIQVTDTAGRTRQY 690
            AG  +   D  GG  R  YD  GR++   DP G S    +     + + V D  G     
Sbjct: 2894 AGHKLSVTDALGGVTRSDYDANGRVVRITDPRGNSAFYYFDAAGRVTLSV-DPEGYATAT 2952

Query: 691  GYDSHGNLLWQQ---------------------DPLGRETQYQYDPEGRVTQVTDALEKS 729
             YD+ G+ L  +                     +P    T+++YD  GR+T+  DA   +
Sbjct: 2953 TYDALGHTLSVKRHFNRVSGTYKIAQPPALPGANPSDALTRFEYDASGRLTRTIDAQSNA 3012

Query: 730  KYLSWNTCGQLLSYRDCSNAQTLYHYDAHGRLRE------SINARGE----HTHFRYDAR 779
            +  ++N  GQ  +  +     T Y YD  GR+        S NA G+       + YDA 
Sbjct: 3013 ERYTYNALGQRETLTNKLGGLTAYTYDQLGRVASETLPITSRNAAGQSVAVRNQYAYDAF 3072

Query: 780  GYLVESERPDGRIDRYEIDVAGQLTRYIDPAQKTLQFRYDPSGRLVER--------TDAM 831
            G    +    G                  P Q+  QF YD   R VE+         D  
Sbjct: 3073 GNRATTTEAVGL-----------------PEQRVTQFSYDGLNREVEQRQAQVRIYVDGQ 3115

Query: 832  GYSV-----KFRYDAYGRLLQLTNENDESYRFGWDELDRLVAQKDLDGSGRLYAYNVLDE 886
            G+S         YDA G L+ +   N    R  +D  +R VA+    G+   ++Y+    
Sbjct: 3116 GWSTIAPTRTRSYDASGNLIAVVEPNGGRTRTWFDGTNRKVAEVSATGTLSTWSYDATGN 3175

Query: 887  VIRLTHVPSPDEQPPLSDNAP-PTRTTAIR-HDFERDAIGRLVSKRTEDGTTDYRYDAAD 944
            V+    V       P+ D  P P     +R   ++ DA  R++S  T  G     YDA+ 
Sbjct: 3176 VM-AQRVYGDALILPVGDALPTPVNAANVRLTTYQVDANNRVLSS-TIAGIQSGNYDASG 3233

Query: 945  NLLSITFTDNKGEKQQLDYTYDANGQLLSETN--SAGLLQYRYDELGNLQTLVLPD---- 998
            +  ++  T +   +      YDANG ++ E N   A  L + YD LG  Q L+  D    
Sbjct: 3234 HQYNMAVTSDLVNRS----FYDANGNVVREHNGKDAATLTW-YDRLG--QKLLQVDAMGF 3286

Query: 999  ----QRELNHLYYGSGHLHQINLNGRVISDFERDAVHDEVLRTQGKLVTRTRYDTSGRLA 1054
                +R+ N          +  + G +      DAV  +        +T   YD + R+ 
Sbjct: 3287 GVRWERDANGAVLRETRFAKEIVLGSLSESTSVDAVLQKFTPGLNDQITEYSYDRNARVR 3346

Query: 1055 GKAIHYRDAPAEVLPLLDKAYRYDASDNLIAEVLTQTQRRGMSNAANDENANLE------ 1108
             ++             L+ AY   A++  ++E  T   +R   NA  ++ A ++      
Sbjct: 3347 SES------------RLNVAYGRVAANGALSEGATSATQRTEYNAMGNKTATIDAQGQRS 3394

Query: 1109 ----QIIGRFLDLPHTG 1121
                  IGR L +   G
Sbjct: 3395 EMRYDTIGRLLSVQRPG 3411



 Score = 84.0 bits (206), Expect = 4e-19
 Identities = 128/551 (23%), Positives = 200/551 (36%), Gaps = 104/551 (18%)

Query: 631  AGQLIKRIDPQGGEWRYSYDDIGRLIETRDPLGRSEHIKYLRHWALPIQVTDTAGRTRQY 690
            AG  + R D  G    Y++     L  +    G  + I Y    A  +    ++G   +Y
Sbjct: 101  AGSTLARTDRDGATAVYAWSASRNLYVSSAGAGAFDTIAYDAANARYVWTDGSSGLVERY 160

Query: 691  GYDSHGNLLWQQDPLGRETQYQYDPEGRVTQVTDALEKSKYLSWN-----------TCGQ 739
                 G LL+  DP G    Y Y+  G +  V DA  ++ Y  +            T G 
Sbjct: 161  DASGQGRLLFAVDPNGNTVSYSYNANGTLKSVVDANGEATYFDYTGTNLTQVRTVATGGA 220

Query: 740  LL-------------------------SYRDCSNAQTLYHYDAHGRLRESI-NARGEHTH 773
             L                         S  D     T Y+YD   +   S+  + G    
Sbjct: 221  TLTRVRYAYDGANRLSSVTVDLSPEDNSVADGKTYVTTYNYDGTSKRVASVTQSDGTALA 280

Query: 774  FRYDARG--YLVESERPD-GRIDRYEIDVAGQLTRYIDPAQKTLQFRYDPSGRL------ 824
            F Y   G  Y V +     G+I R+  D A   T   DP      F YD  G L      
Sbjct: 281  FTYVLSGSSYKVATVTDALGQITRFAYDSASSTTTVTDPQGARSTFLYDADGNLLQVRQG 340

Query: 825  VERTDAMGYS-VKFRYDAYGRLLQLTNENDESYRFGWDELDRLVAQKDLDGSGRLYAYNV 883
            V   +A G S V +RYDA G +  +T+       + +D    L+ + D  G+     YN 
Sbjct: 341  VTAGNAAGLSQVSYRYDAAGNVTGMTDGEGRELAYEYDANGNLLKEVDSAGNTHTRTYNS 400

Query: 884  LDEVIRLT-HVPSPDEQPPLSDNAPPTRTT--------AIRHDFERDAIGRLVSKRTED- 933
             ++++  T +  +   +   S +A    TT        A++  F   A G +   R +  
Sbjct: 401  ANQLLSDTIYADASVSRGVFSKDAALPETTRYVYAPGNALQLRFVVTAQGNVTEHRYDSY 460

Query: 934  -------------------GTTDYRYDAADNLLSITFTDNKGEKQQLDYTYDANGQLLSE 974
                               GTTD    A   +L+     +    +++DY YDA G L S 
Sbjct: 461  GQRISTIRYVGSAYGVSTLGTTDVPTQA--QMLAWLGGQDPSRTERVDYAYDARGSLSSA 518

Query: 975  TN-------------SAGLLQYRYDELGNLQTLVLPD-QRELNHLYYGSGHLHQI---NL 1017
            T              +A   QY YD+ GNL   + P       ++Y G G +  +   +L
Sbjct: 519  TTYGEVDATGAGTTATAARTQYVYDQHGNLLQKIEPSGGGTTTYVYDGLGRVLSVSAPSL 578

Query: 1018 NG----RVISDFERDAVHDEVLRTQGKLVTRTRYDTSGRLAGKAIHYRDAPAEVLPLLDK 1073
            +G      ++ ++       V    G LV+ + YD +GRL   ++  + A + VL     
Sbjct: 579  DGVTANTTVTSYDDAGGRTSVTVASG-LVSISAYDKAGRLV--SVTQQSAGSGVLG--TT 633

Query: 1074 AYRYDASDNLI 1084
             Y YD + NL+
Sbjct: 634  TYAYDKNGNLL 644



 Score = 84.0 bits (206), Expect = 4e-19
 Identities = 119/513 (23%), Positives = 193/513 (37%), Gaps = 141/513 (27%)

Query: 678  IQVTDTAGRTRQ---YGYDSHGNLLWQQDPLGRE----TQYQYDPEGRVTQVTDA----L 726
            I +   +GR  Q   YGYD+ GN   Q + LG+     TQY +D  GR+T+  DA    L
Sbjct: 2784 IALASVSGRPLQITAYGYDAAGNRTSQTEALGQPEAATTQYVFDGIGRLTRTIDARGVEL 2843

Query: 727  EKS------------KYLSWNTCGQLLSYRDCSNAQTLYHYDAHGRLRESINARGEHTHF 774
             +S            KY+  N  G  L   D S AQ           R+++ AR   T  
Sbjct: 2844 SQSDSAWALTQRLQLKYV--NAAGGALKASDLSQAQ-----------RQALAARYTTT-I 2889

Query: 775  RYDARGYLVESERPDGRIDRYEIDVAGQLTRYIDPAQKTLQFRYDPSGRLVERTDAMGYS 834
             YDA G+ +      G + R + D  G++ R  DP   +  + +D +GR+    D  GY+
Sbjct: 2890 DYDAAGHKLSVTDALGGVTRSDYDANGRVVRITDPRGNSAFYYFDAAGRVTLSVDPEGYA 2949

Query: 835  VKFRYDAYGRLLQL---------------------TNENDESYRFGWDELDRLVAQKDLD 873
                YDA G  L +                      N +D   RF +D   RL    D  
Sbjct: 2950 TATTYDALGHTLSVKRHFNRVSGTYKIAQPPALPGANPSDALTRFEYDASGRLTRTIDAQ 3009

Query: 874  GSGRLYAYNVLDEVIRLTHVPS-------------PDEQPPLSDNAPPTRTTAIRHDFER 920
             +   Y YN L +   LT+                  E  P++      ++ A+R+ +  
Sbjct: 3010 SNAERYTYNALGQRETLTNKLGGLTAYTYDQLGRVASETLPITSRNAAGQSVAVRNQYAY 3069

Query: 921  DAIG-------------RLVSKRTEDG--------------------------TTDYRYD 941
            DA G             + V++ + DG                          T    YD
Sbjct: 3070 DAFGNRATTTEAVGLPEQRVTQFSYDGLNREVEQRQAQVRIYVDGQGWSTIAPTRTRSYD 3129

Query: 942  AADNLLSITFTDNKGEKQQLDYTYDANGQLLSETNSAGLLQ-YRYDELGNL-------QT 993
            A+ NL+++    N G  +     +D   + ++E ++ G L  + YD  GN+         
Sbjct: 3130 ASGNLIAVV-EPNGGRTRT---WFDGTNRKVAEVSATGTLSTWSYDATGNVMAQRVYGDA 3185

Query: 994  LVLPDQRELNHLYYGSGHLHQINLNGRVISDFERDAVHDEVLRTQGKLVTRTRYDTSGRL 1053
            L+LP          G      +N     ++ ++ DA ++ VL +    +    YD SG  
Sbjct: 3186 LILP---------VGDALPTPVNAANVRLTTYQVDA-NNRVLSSTIAGIQSGNYDASGHQ 3235

Query: 1054 AGKAIHYRDAPAEVLPLLDKAYRYDASDNLIAE 1086
               A+           L+++++ YDA+ N++ E
Sbjct: 3236 YNMAV--------TSDLVNRSF-YDANGNVVRE 3259



 Score = 79.0 bits (193), Expect = 1e-17
 Identities = 152/698 (21%), Positives = 248/698 (35%), Gaps = 150/698 (21%)

Query: 632  GQLIKRIDPQGGEWRYSYDDIGRLIETRDPLGRSEHIKYLRHWALPIQVTDTAG------ 685
            GQ+   +D +G    Y Y+  G  +++     R+ +   +    + + +   +G      
Sbjct: 1505 GQVQGTLDAEGYLTEYKYNAAGEQVQSIRYANRAANFASVSARLMAVAIARASGDLAGVR 1564

Query: 686  --------RTRQYGYDSHGNLLWQQDPLGRETQYQYDPEGRVTQVT-------------- 723
                    RT  + Y++ G  + Q D  G  T+  YD  G VTQ                
Sbjct: 1565 PAASDGDIRTYTF-YNARGQAVGQVDGEGYLTETVYDARGNVTQTRRYASLARNPGSANA 1623

Query: 724  ---------DALEKSKYLSWNTCGQLLSYRDCSNAQTLYHYDAHGRLRESINARG----E 770
                      A ++S   +W+   QLLS  +     T + YD  GRL ++  A G     
Sbjct: 1624 TLASVRPDPSAQDQSITQTWSAANQLLSRTNAEGTVTTFTYDVAGRLVQTTTAAGTPDER 1683

Query: 771  HTHFRYDARGYLVESERPDGR-----------------IDRYEIDVAGQLTRYIDPAQKT 813
                RYD +G+L+     DGR                    +  D AG+ T   D     
Sbjct: 1684 IQRLRYDIQGHLI--AELDGRGSDAVALNAPLASWSANGSTHAYDAAGRRTGTTDANGHR 1741

Query: 814  LQFRYDPSGRLVERTDAMGYSVKFRYDAYGRL---------LQLT--------------- 849
              F YD  GRL    +A+G   + RY+AYG++         + LT               
Sbjct: 1742 TLFFYDAFGRLAYTVNALGEVTESRYNAYGQVSEQIVYGSRIDLTPLGTATPGGLNTDAL 1801

Query: 850  ---------NENDESYRFGWDELDRLVAQKDLDGSGRLYAYNVLDEVIRLTHVPSPDEQP 900
                        D      ++    L +  D  G    YAYN   E I  +      +  
Sbjct: 1802 KALLATMADPAKDTHVLKTYNASGTLTSSTDAMGGVTSYAYNAFREAIASSRTRLSGQ-- 1859

Query: 901  PLSDNAPPTRTTAIRHDFERDAIGRLVSKRT---EDGTTDYRYDAADNLLSITF------ 951
             +  N        ++     DA G  +++RT     G  D R D   N  S+ +      
Sbjct: 1860 -VITNTVTFDRRGLQVSTTSDATGAGLTRRTGYDAFGRPDTRIDGNGNTASLRYDRLGRV 1918

Query: 952  ---TDNKGEKQQLDYTYDANGQLLSETNSA-GLLQYRYDELGNLQTLVLPDQRELNHLYY 1007
               TD  G  +    TYDA  ++L++ ++   +  Y Y       T+  P+   +  L+ 
Sbjct: 1919 VATTDATGATRTT--TYDAFDRVLTQRDALNNVTSYAYSVANRSVTVTTPEGVSVTTLHN 1976

Query: 1008 GSGHLHQINLNGRVISDFERDAVHDEVLRTQGK--LVTRTRYDTSGRLAGKAIHYRDAPA 1065
              G    +  +GR  +          +LRTQ    + T T YD      G  +   DA  
Sbjct: 1977 RQGQTTSVT-DGRGNTTTYSYDKSGNLLRTQAPEGVGTSTTYDK----IGLKLSTTDARG 2031

Query: 1066 EVLPLLDKAYRYDASDNLIAEVLTQTQRRGMSNAANDENANLEQIIGRFLDLPHTGKTYS 1125
             V       Y YDA    ++ +LT+T   G         + L    G+ + +   G T +
Sbjct: 2032 TV-----TTYGYDA----VSRLLTRTVDPGGLTLV---TSYLYDAKGQTISVTDPGGTVT 2079

Query: 1126 GHNRYGYDLNEQL--QTVHQSRPNWQATQVED-FKYDKAGNLFDGPKLNGLIKHNRVLVY 1182
                  YDLN Q+  QT+  S   +   ++E  + +D  G        +G +        
Sbjct: 2080 ---TTAYDLNGQVVRQTLDPSNGAYVGLKLETVYTHDSDGTALSVHGPDGRL-------- 2128

Query: 1183 QDKRYRYDRFGRLCEKRI---GSNWVQYFEYDAEQRLV 1217
               RY YD  GR  ++++   G N  + + YDAE  ++
Sbjct: 2129 --TRYTYDGAGRRIKEQVDPLGLNLTRSYAYDAEGNVI 2164



 Score = 77.0 bits (188), Expect = 5e-17
 Identities = 134/573 (23%), Positives = 203/573 (35%), Gaps = 85/573 (14%)

Query: 675  ALPIQVT-DTAGRTRQYGYDSHGNLLWQQDPLGRETQYQYDPEGRVTQVTDALEKSKYLS 733
            A P+ +   T  +  ++ YDS G L++   PLG+  +  YD  GR+T  T     ++ +S
Sbjct: 2580 ATPVLIAAKTQSQVTRFAYDSAGRLVYTLGPLGQLEKNSYDGAGRITLTT---RYARPVS 2636

Query: 734  WNTCG---------QLLSYRDCSNAQTLYHYDAHGRLRESINARGEHTHFRYDARGYLVE 784
                G          L S     + Q    YD  GRL  +++A G    F+ D  G + E
Sbjct: 2637 TKGLGAAPTVAQLQALASQTPGQDQQQFNVYDQGGRLSATVDAMGSVVTFKRDGNGSVSE 2696

Query: 785  SERPDGRID--RYEIDVAGQLTRYIDPAQKTLQFRYDPSGRLVERTDAMGYSVKFRYDAY 842
                   +D  ++  D A          Q T  F YD  GR     DA+GY+V+ +YDA 
Sbjct: 2697 RTAWANTVDMNKWAPDTAPVPKADTARDQHTRIF-YDAMGRETLTIDALGYAVQRQYDAQ 2755

Query: 843  GR----------------------------LLQLTNENDESYRFGWDELDRLVAQKDLDG 874
            GR                            L  ++    +   +G+D      +Q +  G
Sbjct: 2756 GRPSYVVRYPVAVPASTPNTQKAKLDAAIALASVSGRPLQITAYGYDAAGNRTSQTEALG 2815

Query: 875  SGRLYAYN-VLDEVIRLTHVPSPDEQPPLSDNAPPTRTTAIRHDFERDAIGRLVSKRTED 933
                     V D + RLT             ++    T  ++  +   A G L +     
Sbjct: 2816 QPEAATTQYVFDGIGRLTRTIDARGVELSQSDSAWALTQRLQLKYVNAAGGALKASDLSQ 2875

Query: 934  G---------TTDYRYDAADNLLSITFTDNKGEKQQLDYTYDANGQLLSETNSAG-LLQY 983
                      TT   YDAA + LS+  TD  G   + D  YDANG+++  T+  G    Y
Sbjct: 2876 AQRQALAARYTTTIDYDAAGHKLSV--TDALGGVTRSD--YDANGRVVRITDPRGNSAFY 2931

Query: 984  RYDELGNLQTLVLPDQRELNHLYYGSGHLHQINLNGRVISDFERDAVHDEVL-RTQGKLV 1042
             +D  G +   V P+       Y   GH   +  +   +S   + A    +        +
Sbjct: 2932 YFDAAGRVTLSVDPEGYATATTYDALGHTLSVKRHFNRVSGTYKIAQPPALPGANPSDAL 2991

Query: 1043 TRTRYDTSGRLAG-------------KAIHYRDAPAEVLPLLDKAYRYDASDNLIAEVLT 1089
            TR  YD SGRL                A+  R+     L  L  AY YD    + +E L 
Sbjct: 2992 TRFEYDASGRLTRTIDAQSNAERYTYNALGQRETLTNKLGGL-TAYTYDQLGRVASETLP 3050

Query: 1090 QTQRRGMSNAANDENANLEQIIG------RFLDLPH---TGKTYSGHNRYGYDLNEQLQT 1140
             T R     +    N       G        + LP    T  +Y G NR       Q++ 
Sbjct: 3051 ITSRNAAGQSVAVRNQYAYDAFGNRATTTEAVGLPEQRVTQFSYDGLNREVEQRQAQVR- 3109

Query: 1141 VHQSRPNWQA-TQVEDFKYDKAGNLFDGPKLNG 1172
            ++     W          YD +GNL    + NG
Sbjct: 3110 IYVDGQGWSTIAPTRTRSYDASGNLIAVVEPNG 3142



 Score = 74.3 bits (181), Expect = 3e-16
 Identities = 131/558 (23%), Positives = 186/558 (33%), Gaps = 130/558 (23%)

Query: 646  RYSYDDIGRLIETRDPLGRSEHIKY--------LRHWALPIQ----------------VT 681
            R++YD  GRL+ T  PLG+ E   Y           +A P+                  +
Sbjct: 2595 RFAYDSAGRLVYTLGPLGQLEKNSYDGAGRITLTTRYARPVSTKGLGAAPTVAQLQALAS 2654

Query: 682  DTAGRTRQY--GYDSHGNLLWQQDPLGRETQYQYDPEGRVTQVTDALEKSKYLSWNTCGQ 739
             T G+ +Q    YD  G L    D +G    ++ D  G V++ T          W     
Sbjct: 2655 QTPGQDQQQFNVYDQGGRLSATVDAMGSVVTFKRDGNGSVSERTAWANTVDMNKWAPDTA 2714

Query: 740  LLSYRDCSNAQ-TLYHYDAHGRLRESINARGEHTHFRYDARG---YLVE----------- 784
             +   D +  Q T   YDA GR   +I+A G     +YDA+G   Y+V            
Sbjct: 2715 PVPKADTARDQHTRIFYDAMGRETLTIDALGYAVQRQYDAQGRPSYVVRYPVAVPASTPN 2774

Query: 785  ---------------SERPDGRIDRYEIDVAGQLTRYID----PAQKTLQFRYDPSGRLV 825
                           S RP  +I  Y  D AG  T   +    P   T Q+ +D  GRL 
Sbjct: 2775 TQKAKLDAAIALASVSGRP-LQITAYGYDAAGNRTSQTEALGQPEAATTQYVFDGIGRLT 2833

Query: 826  ERTDAMG--------------------------------------------YSVKFRYDA 841
               DA G                                            Y+    YDA
Sbjct: 2834 RTIDARGVELSQSDSAWALTQRLQLKYVNAAGGALKASDLSQAQRQALAARYTTTIDYDA 2893

Query: 842  YGRLLQLTNENDESYRFGWDELDRLVAQKDLDGSGRLYAYNVLDEVIRLTHVPSPDEQPP 901
             G  L +T+      R  +D   R+V   D  G+   Y +   D   R+T    P+    
Sbjct: 2894 AGHKLSVTDALGGVTRSDYDANGRVVRITDPRGNSAFYYF---DAAGRVTLSVDPEGYAT 2950

Query: 902  LSDNAPPTRTTAIRHDFERDA-------IGRLVSKRTEDGTTDYRYDAADNLLSITFTDN 954
             +       T +++  F R +          L      D  T + YDA+  L       +
Sbjct: 2951 ATTYDALGHTLSVKRHFNRVSGTYKIAQPPALPGANPSDALTRFEYDASGRLTRTIDAQS 3010

Query: 955  KGEKQQLDYTYDANGQLLSETNS-AGLLQYRYDELGNLQTLVLPDQRELNHLYYGSGHLH 1013
              E+    YTY+A GQ  + TN   GL  Y YD+LG + +  LP           +G   
Sbjct: 3011 NAER----YTYNALGQRETLTNKLGGLTAYTYDQLGRVASETLPITSR-----NAAGQSV 3061

Query: 1014 QINLNGRVISDFERDAVHDEVLRTQGKLVTRTRYDTSGR----LAGKAIHYRDAPAEVLP 1069
             +  N      F   A   E +    + VT+  YD   R       +   Y D       
Sbjct: 3062 AVR-NQYAYDAFGNRATTTEAVGLPEQRVTQFSYDGLNREVEQRQAQVRIYVDGQGWSTI 3120

Query: 1070 LLDKAYRYDASDNLIAEV 1087
               +   YDAS NLIA V
Sbjct: 3121 APTRTRSYDASGNLIAVV 3138



 Score = 72.0 bits (175), Expect = 2e-15
 Identities = 133/615 (21%), Positives = 237/615 (38%), Gaps = 101/615 (16%)

Query: 631  AGQLIKRIDPQGGEWRYSYDDIGRLIETRDPLGRSEHIKY-----LRHWALPIQVTDTAG 685
            +G+L + ID Q    RY+Y+ +G+     + LG      Y     +    LPI   + AG
Sbjct: 2999 SGRLTRTIDAQSNAERYTYNALGQRETLTNKLGGLTAYTYDQLGRVASETLPITSRNAAG 3058

Query: 686  RT----RQYGYDSHGNLLWQQDPLG----RETQYQYDPEGRVTQVTDA------------ 725
            ++     QY YD+ GN     + +G    R TQ+ YD   R  +   A            
Sbjct: 3059 QSVAVRNQYAYDAFGNRATTTEAVGLPEQRVTQFSYDGLNREVEQRQAQVRIYVDGQGWS 3118

Query: 726  -LEKSKYLSWNTCGQLLSYRDCSNAQTLYHYDAHGRLRESINARGEHTHFRYDARGYLVE 784
             +  ++  S++  G L++  + +  +T   +D   R    ++A G  + + YDA G ++ 
Sbjct: 3119 TIAPTRTRSYDASGNLIAVVEPNGGRTRTWFDGTNRKVAEVSATGTLSTWSYDATGNVM- 3177

Query: 785  SERPDGRIDRYEIDVAGQLTRYIDPAQKTLQ-FRYDPSGRLVERT---------DAMGYS 834
            ++R  G  D   + V   L   ++ A   L  ++ D + R++  T         DA G+ 
Sbjct: 3178 AQRVYG--DALILPVGDALPTPVNAANVRLTTYQVDANNRVLSSTIAGIQSGNYDASGHQ 3235

Query: 835  VKFR----------YDAYGRLLQLTNENDESYRFGWDELDRLVAQKDLDGSGRLYAYNVL 884
                          YDA G +++  N  D +    +D L + + Q D  G G  +  +  
Sbjct: 3236 YNMAVTSDLVNRSFYDANGNVVREHNGKDAATLTWYDRLGQKLLQVDAMGFGVRWERDAN 3295

Query: 885  DEVIRLTHVPSPDEQPPLSDNAPPTRTTAIRHDFERDAIGRLVSKRTEDGTTDYRYDA-- 942
              V+R T          LS++      T++      DA+ +  +    D  T+Y YD   
Sbjct: 3296 GAVLRETRFAKEIVLGSLSES------TSV------DAVLQKFTPGLNDQITEYSYDRNA 3343

Query: 943  ---ADNLLSITFTD-------NKGEKQQLDYT-YDANGQLLSETNSAGLL-QYRYDELGN 990
               +++ L++ +         ++G       T Y+A G   +  ++ G   + RYD +G 
Sbjct: 3344 RVRSESRLNVAYGRVAANGALSEGATSATQRTEYNAMGNKTATIDAQGQRSEMRYDTIGR 3403

Query: 991  LQTLVLPDQRELNHLYYGSGHLHQINLNGRVISDFERDAVHDEVLRTQGKLVTRTRYDTS 1050
            L ++  P   + N         +++N  G V  +  R    D  + +  ++V R  YD +
Sbjct: 3404 LLSVQRPGAADFNGNAVRQVTDYELNGLGNVRREIRRGT--DNAVESDDEIV-RYGYDAT 3460

Query: 1051 GRLAGKAIHYRDAPAEVLPLLDKAYRYDASDNLIAEVLTQTQRRG------MSNAANDEN 1104
            G           A  E +      Y  DA+ N  A++  +    G      +S A +  N
Sbjct: 3461 GVRTSMTT----AKGETV-----TYGRDANGNTTAQMTDRVDADGAVSRDIVSIAYDAAN 3511

Query: 1105 ANLEQIIGR--FLDLPHTGKTYSGHNRYGYDLNE--QLQTVHQSRPNWQATQVEDFKYDK 1160
                +  G     D+P     +   N      N   +L +      N Q    E + YDK
Sbjct: 3512 REARRFTGGRDAADMP----VFDAANTITLTYNAWGELASKRTGSGNAQGQAQEYYDYDK 3567

Query: 1161 AGNLFDGPKLNGLIK 1175
            AG L+      G+ K
Sbjct: 3568 AGRLWRTNSKGGVNK 3582



 Score = 71.6 bits (174), Expect = 2e-15
 Identities = 66/227 (29%), Positives = 93/227 (40%), Gaps = 29/227 (12%)

Query: 640  PQGGEWRYSYDDIGRLIETR-DPLGRSEHIKYLRHWALP-----IQVTDTAGRTRQYGYD 693
            P G   RY+YD  GR I+ + DPLG    +   R +A       I+  D +G    + YD
Sbjct: 2124 PDGRLTRYTYDGAGRRIKEQVDPLG----LNLTRSYAYDAEGNVIKAVDASGNATLFIYD 2179

Query: 694  SHGNLLWQQDPLGRETQYQYDPEGRVTQVTDALEKSKYLSWNTCGQLLSYRDCS------ 747
                L +  D +G   Q  YD EGR++  T         +WN     LS    +      
Sbjct: 2180 QAKRLAFTIDAMGGVQQSGYDAEGRLSSQTTYAAFVPVAAWNGTAPSLSAMQAALPTLGL 2239

Query: 748  NAQTLYHYDAHGRLRESINARGEHTHFRYDARGYLVESERPDGRIDRYEIDVAGQLTRYI 807
             A     YD  GRLR +++A G    +RYD  G +VES     RI+       G+    I
Sbjct: 2240 AATQSRRYDRDGRLRFAVDATGAVVEYRYDDAGNVVESRAYAQRIE------LGKWHGAI 2293

Query: 808  DPA-------QKTLQFRYDPSGRLVERTDAMGYSVKFRYDAYGRLLQ 847
            DP         +  +  YD  GR     D  G  V+  +DA G + +
Sbjct: 2294 DPPVVADDAHDQRSRSVYDALGRKTHSIDGTGAVVRQVFDASGNVTE 2340



 Score = 62.4 bits (150), Expect = 1e-12
 Identities = 98/460 (21%), Positives = 159/460 (34%), Gaps = 104/460 (22%)

Query: 632  GQLIKRIDPQGGEWRYSYDDIGRLIETRDPLGRSEHIKYLRHWALPIQVTDTAGR----- 686
            G+++K ID +       Y+ +G LI+   P+               + VT   G+     
Sbjct: 4255 GRVVKEIDGKENVNDLRYNTLGLLIDKIGPV---------------VDVTLANGQRQAIR 4299

Query: 687  -TRQYGYDSHGNLLWQQDPLGRETQYQYDPEGRVTQVTDALEKSKYLSWNTCGQLLSYRD 745
             T  Y YD +G  + ++D  G ++  Q +  G+          +++    T G       
Sbjct: 4300 PTEHYSYDLNGQFVGKRDANGNQSTVQINAAGQAV--------AEWHPGATAG------- 4344

Query: 746  CSNAQTLYHYDAHGRLRESINARGEHTHFRYDARGYLVESERPDGR-----IDRYEIDVA 800
             ++A     YD  G LR   +  G  T   YD    L   ERP        +D YE D+ 
Sbjct: 4345 -TSAVVRKAYDVFGNLRTVTDEIGRVTRNEYDFNNRLKRVERPVNANGSVAVDAYEYDIL 4403

Query: 801  GQ---------------------LTRYIDPAQKTLQFRY------------DPSGRLVER 827
            GQ                     +TRYI     T+ + Y            +  G     
Sbjct: 4404 GQRIAQVNALDYRVRTYYDSMGRVTRYISAEGATVNYGYTYDNSIGSAGGVNTGGWTNTT 4463

Query: 828  TDAMGYSVKFRYDAYGRLLQLTNENDESYRFGWDELDRLVAQKDLDGSGRLYAY------ 881
            TDA G +   + D +GR +   +     + +G++    +  Q    G    Y+Y      
Sbjct: 4464 TDANGRTQTLKNDVFGRTMWKQDLGGHQFTYGYNWSGLIATQTGNSGQNIAYSYYDNGYL 4523

Query: 882  -NVLDEVIRLTHVPSPDEQPPLSDNAPPTRTTAIRHDFER---DAIGRLVSKRTEDGTTD 937
              V D  +    +   D             T  +   + R   DA  R+ +        +
Sbjct: 4524 RKVSDAGVSTESIFEYDNNGNRIFEGLKAITGNVVFQWSRVSYDAYNRVKTIDDARYMIN 4583

Query: 938  YRYDAADN---LLS--ITFTDNKGEKQQLDYTYD------------ANGQLLSETNSAGL 980
            Y YDA  N   +LS  I   D + + Q   Y YD             NGQ+    +  G 
Sbjct: 4584 YEYDANGNRRRVLSTYINVVDQRKDVQDYWYAYDGMNRFTTTMGQMVNGQIWRGASGDG- 4642

Query: 981  LQYRYDELGNLQTLVLP-DQRELNHLYYGSGHLHQINLNG 1019
            +   YD  G  +  +   D    ++ Y G+GHL  + +NG
Sbjct: 4643 VTIEYDNAGQRKAAIYARDGHREDYDYDGTGHLTAMKMNG 4682



 Score = 61.6 bits (148), Expect = 2e-12
 Identities = 152/744 (20%), Positives = 249/744 (33%), Gaps = 149/744 (20%)

Query: 735  NTCGQLLSYRDCSNAQTLYHYDAHGRLRESINARGEHTHF-RYDARGYLVESERPDGRID 793
            N  GQ+    D     T Y Y+A G   +SI       +F    AR   V   R  G   
Sbjct: 1502 NRNGQVQGTLDAEGYLTEYKYNAAGEQVQSIRYANRAANFASVSARLMAVAIARASG--- 1558

Query: 794  RYEIDVAGQLTRYIDPAQKTLQFRYDPSGRLVERTDAMGYSVKFRYDAYGRLLQL----- 848
                D+AG      D   +T  F Y+  G+ V + D  GY  +  YDA G + Q      
Sbjct: 1559 ----DLAGVRPAASDGDIRTYTF-YNARGQAVGQVDGEGYLTETVYDARGNVTQTRRYAS 1613

Query: 849  ------------------TNENDESYRFGWDELDRLVAQKDLDGSGRLYAYNVLDEVIRL 890
                               +  D+S    W   ++L+++ + +G+   + Y+V   +++ 
Sbjct: 1614 LARNPGSANATLASVRPDPSAQDQSITQTWSAANQLLSRTNAEGTVTTFTYDVAGRLVQT 1673

Query: 891  THVPSPDEQPPLSDNAPPTRTTAIRHDFERDAIGRLVSKRTE-------------DGTTD 937
            T           +   P  R   +R+D +   I  L  + ++             +G+T 
Sbjct: 1674 T----------TAAGTPDERIQRLRYDIQGHLIAELDGRGSDAVALNAPLASWSANGST- 1722

Query: 938  YRYDAADNLLSITFTDNKGEKQQLDYTYDANGQLLSETNSAG-LLQYRYDELGNLQTLVL 996
            + YDAA        TD  G +    + YDA G+L    N+ G + + RY+  G +   ++
Sbjct: 1723 HAYDAAGRRTGT--TDANGHRTL--FFYDAFGRLAYTVNALGEVTESRYNAYGQVSEQIV 1778

Query: 997  PDQRELNHLYYGSGHLHQINLNG--RVISDFERDAVHDEVLRTQGKLVTRTRYDTSGRLA 1054
               R ++    G+     +N +    +++     A    VL+T         Y+ SG L 
Sbjct: 1779 YGSR-IDLTPLGTATPGGLNTDALKALLATMADPAKDTHVLKT---------YNASGTLT 1828

Query: 1055 GKAIHYRDAPAEVLPLLDKAYRYDASDNLIAEVLTQTQRRGMSNAANDENANLEQIIGRF 1114
                   DA   V      +Y Y+A    IA   T+   + ++N    +   L+  +   
Sbjct: 1829 SST----DAMGGV-----TSYAYNAFREAIASSRTRLSGQVITNTVTFDRRGLQ--VSTT 1877

Query: 1115 LDLPHTGKTYSGHNRYGYDLNEQLQTVHQSRPNWQATQVEDFKYDKAGNLFDGPKLNGLI 1174
             D    G T     R GYD   +  T      N         +YD+ G +       G  
Sbjct: 1878 SDATGAGLT----RRTGYDAFGRPDTRIDGNGN-----TASLRYDRLGRVVATTDATGAT 1928

Query: 1175 KHNRVLVYQDKRYRYDRFGRLCEKRIGSNWVQYFEYDAEQRLVCV--------------- 1219
            +             YD F R+  +R   N V  + Y    R V V               
Sbjct: 1929 RTT----------TYDAFDRVLTQRDALNNVTSYAYSVANRSVTVTTPEGVSVTTLHNRQ 1978

Query: 1220 ---EQYRSGERERVVFAYDPLGRRISKEVYQRDYPE-PRRRVLFHWQGFRLLQEVQSGLA 1275
                    G      ++YD  G  +  +      PE       +   G +L      G  
Sbjct: 1979 GQTTSVTDGRGNTTTYSYDKSGNLLRTQA-----PEGVGTSTTYDKIGLKLSTTDARGTV 2033

Query: 1276 SLYVYATVESYDPLARVDGKPGSEAIHYFHTTLVGQPEQLTDSDGNTIWRSDHHGWGKII 1335
            + Y Y  V     L R     G   +  +     GQ   +TD  G T+  + +   G+++
Sbjct: 2034 TTYGYDAVSRL--LTRTVDPGGLTLVTSYLYDAKGQTISVTD-PGGTVTTTAYDLNGQVV 2090

Query: 1336 NEWHSQQNGREQNLRNQGQYIDRETGLHFNIFRFYDPDIGRFTTTDPLGIEGGVNLYSY- 1394
             +     NG    L+ +  Y     G   ++                 G +G +  Y+Y 
Sbjct: 2091 RQTLDPSNGAYVGLKLETVYTHDSDGTALSVH----------------GPDGRLTRYTYD 2134

Query: 1395 --APNIVNYSDPLGLCPENVKEYD 1416
                 I    DPLGL       YD
Sbjct: 2135 GAGRRIKEQVDPLGLNLTRSYAYD 2158



 Score = 60.5 bits (145), Expect = 5e-12
 Identities = 69/290 (23%), Positives = 105/290 (36%), Gaps = 36/290 (12%)

Query: 601  GRRDHY-YWGPLYEVYKHIDPQG---NCWLAEVIAGQLIKRIDPQGGEWRYSYDDIGRLI 656
            GR   Y Y G    + + +DP G       A    G +IK +D  G    + YD   RL 
Sbjct: 2126 GRLTRYTYDGAGRRIKEQVDPLGLNLTRSYAYDAEGNVIKAVDASGNATLFIYDQAKRLA 2185

Query: 657  ETRDPLGRSEHIKYLRHWALPIQVTDTA--------------------------GRTRQY 690
             T D +G  +   Y     L  Q T  A                            T+  
Sbjct: 2186 FTIDAMGGVQQSGYDAEGRLSSQTTYAAFVPVAAWNGTAPSLSAMQAALPTLGLAATQSR 2245

Query: 691  GYDSHGNLLWQQDPLGRETQYQYDPEGRVTQVTDALEKSKYLSWN-TCGQLLSYRDCSNA 749
             YD  G L +  D  G   +Y+YD  G V +     ++ +   W+      +   D  + 
Sbjct: 2246 RYDRDGRLRFAVDATGAVVEYRYDDAGNVVESRAYAQRIELGKWHGAIDPPVVADDAHDQ 2305

Query: 750  QTLYHYDAHGRLRESINARGEHTHFRYDARGYLVE----SERPDGRIDRYEIDVAGQLTR 805
            ++   YDA GR   SI+  G      +DA G + E    S+R           +A  +  
Sbjct: 2306 RSRSVYDALGRKTHSIDGTGAVVRQVFDASGNVTERFAYSKRVPAATAATTDALAAAVAL 2365

Query: 806  YIDPAQKTLQ-FRYDPSGRLVERTDAMGYSVKFRYDAYGRLLQLTNENDE 854
              +PA+     + YD +GR +  TD +G      YD  G ++     ND+
Sbjct: 2366 VAEPARDPHDTYVYDRAGRQLLHTDGVGKVTSQNYDKSGNIISRAYINDQ 2415



 Score = 58.2 bits (139), Expect = 2e-11
 Identities = 130/623 (20%), Positives = 211/623 (33%), Gaps = 108/623 (17%)

Query: 420  RLIRLGDRNLNCLDLLYDEQGRLKALYDKYGQTVVQLHYAARHPQRVSEVSRVFLKNGGT 479
            R++R+ D   N     +D  GR+    D  G      + A  H      V R F +  GT
Sbjct: 2917 RVVRITDPRGNSAFYYFDAAGRVTLSVDPEGYATATTYDALGH---TLSVKRHFNRVSGT 2973

Query: 480  ---------PTVERSELLVSYRYTDNGQLHEVLDATDQRVRRFTYTPEGYLNSHQLASGA 530
                     P    S+ L  + Y  +G+L   +DA      R+TY   G   +     G 
Sbjct: 2974 YKIAQPPALPGANPSDALTRFEYDASGRLTRTIDA-QSNAERYTYNALGQRETLTNKLGG 3032

Query: 531  VREYEWARFAIPETRPTPKRLDGTPYRLPPLLEPQPDHEWRVIRHWGSDGEEYRFEYNLE 590
            +  Y            T  +L        P+       +   +R+        ++ Y+  
Sbjct: 3033 LTAY------------TYDQLGRVASETLPITSRNAAGQSVAVRN--------QYAYDAF 3072

Query: 591  AGETLVTDNLGRRDHYYWGPLYEVYKHIDPQGNCWLAEVIAGQLIKRIDPQGGEWRYSYD 650
                  T+ +G  +       Y+       Q    +   + GQ    I P       SYD
Sbjct: 3073 GNRATTTEAVGLPEQRVTQFSYDGLNREVEQRQAQVRIYVDGQGWSTIAPTRTR---SYD 3129

Query: 651  DIGRLIETRDPLGRSEHIKYLRHWALPIQVTDTAGRTRQYGYDSHGNLLWQQDPLGRETQ 710
              G LI   +P G      +        +V+ T G    + YD+ GN++ Q         
Sbjct: 3130 ASGNLIAVVEPNGGRTRTWFDGTNRKVAEVSAT-GTLSTWSYDATGNVMAQ--------- 3179

Query: 711  YQYDPEGRVTQVTDALEKSKYLSWNTCGQLLSYRDCSNAQ-TLYHYDAHGRLRESINARG 769
             +   +  +  V DAL                  + +N + T Y  DA+ R+  S  A  
Sbjct: 3180 -RVYGDALILPVGDALPTPV--------------NAANVRLTTYQVDANNRVLSSTIAGI 3224

Query: 770  EHTHFRYDARGYLVESERPDGRIDRYEIDVAGQLTRYIDPAQKTLQFRYDPSGRLVERTD 829
            +  +  YDA G+          ++R   D  G + R  +         YD  G+ + + D
Sbjct: 3225 QSGN--YDASGHQYNMAVTSDLVNRSFYDANGNVVREHNGKDAATLTWYDRLGQKLLQVD 3282

Query: 830  AMGYSVKFRYDAYGRLLQLT--------------------------NENDESYRFGWDEL 863
            AMG+ V++  DA G +L+ T                            ND+   + +D  
Sbjct: 3283 AMGFGVRWERDANGAVLRETRFAKEIVLGSLSESTSVDAVLQKFTPGLNDQITEYSYDRN 3342

Query: 864  DRLVAQKDLD-GSGRLYAYNVLDEVIRLTHVPSPDEQPPLSDNAPPTRTTAIRHDFERDA 922
             R+ ++  L+   GR+ A   L E    T      E   + +          R +   D 
Sbjct: 3343 ARVRSESRLNVAYGRVAANGALSE--GATSATQRTEYNAMGNKTATIDAQGQRSEMRYDT 3400

Query: 923  IGRLVSKRTEDG----------TTDYRYDAADNLLS--ITFTDN--KGEKQQLDYTYDAN 968
            IGRL+S +               TDY  +   N+       TDN  + + + + Y YDA 
Sbjct: 3401 IGRLLSVQRPGAADFNGNAVRQVTDYELNGLGNVRREIRRGTDNAVESDDEIVRYGYDAT 3460

Query: 969  GQLLSETNSAG-LLQYRYDELGN 990
            G   S T + G  + Y  D  GN
Sbjct: 3461 GVRTSMTTAKGETVTYGRDANGN 3483



 Score = 57.0 bits (136), Expect = 5e-11
 Identities = 85/358 (23%), Positives = 130/358 (36%), Gaps = 76/358 (21%)

Query: 736  TCGQLLSYRDCSNAQTLYHYDAHGRLRESINARGEHTHFRYDA-RGYLVESERPDGRIDR 794
            T G  L+  D   A  +Y + A   L  S    G      YDA     V ++   G ++R
Sbjct: 100  TAGSTLARTDRDGATAVYAWSASRNLYVSSAGAGAFDTIAYDAANARYVWTDGSSGLVER 159

Query: 795  YEIDVAGQLTRYIDPAQKTLQFRYDPSGRLVERTDAMGYSVKFRYDAYGRLLQLTNENDE 854
            Y+    G+L   +DP   T+ + Y+ +G L    DA G +  F Y     L Q+      
Sbjct: 160  YDASGQGRLLFAVDPNGNTVSYSYNANGTLKSVVDANGEATYFDYTGTN-LTQV------ 212

Query: 855  SYRFGWDELDRLVAQKDLDGSGRLYAYNVLDEVIRLTHVPSPDEQPPLSDNAPPTRTTAI 914
                      R VA      +   YAY+  + +  +T   SP+      DN+     T +
Sbjct: 213  ----------RTVATGGATLTRVRYAYDGANRLSSVTVDLSPE------DNSVADGKTYV 256

Query: 915  RHDFERDAIGRLVSKRTEDGTTDYRYDAADN-LLSITFTDNKGEKQQLDYTYDANG---Q 970
                                 T Y YD     + S+T +D       L +TY  +G   +
Sbjct: 257  ---------------------TTYNYDGTSKRVASVTQSDGTA----LAFTYVLSGSSYK 291

Query: 971  LLSETNSAG-LLQYRYDELGNLQTLVLPDQRELNHLYYGSGHLHQINLNGRVISDFERDA 1029
            + + T++ G + ++ YD   +  T+  P       LY   G+L Q+           R  
Sbjct: 292  VATVTDALGQITRFAYDSASSTTTVTDPQGARSTFLYDADGNLLQV-----------RQG 340

Query: 1030 VHDEVLRTQGKLVTRTRYDTSGRLAGKAIHYRDAPAEVLPLLDKAYRYDASDNLIAEV 1087
            V        G      RYD +G + G      D     L     AY YDA+ NL+ EV
Sbjct: 341  V--TAGNAAGLSQVSYRYDAAGNVTGMT----DGEGREL-----AYEYDANGNLLKEV 387



 Score = 57.0 bits (136), Expect = 5e-11
 Identities = 58/229 (25%), Positives = 94/229 (41%), Gaps = 13/229 (5%)

Query: 632 GQLIKRIDPQGG-EWRYSYDDIGRLIETRDP----LGRSEHIKYLRHWALPIQVTDTAGR 686
           G L+++I+P GG    Y YD +GR++    P    +  +  +           VT  +G 
Sbjct: 546 GNLLQKIEPSGGGTTTYVYDGLGRVLSVSAPSLDGVTANTTVTSYDDAGGRTSVTVASGL 605

Query: 687 TRQYGYDSHGNLLW-QQDPLGR----ETQYQYDPEGRVTQVTDALEKSKYLSWNTCGQLL 741
                YD  G L+   Q   G      T Y YD  G +    D     K++ ++   + +
Sbjct: 606 VSISAYDKAGRLVSVTQQSAGSGVLGTTTYAYDKNGNLLMTQDPTGVRKWMLYDEANRKI 665

Query: 742 SYRDCSNAQTLYHYDAHGRLRESINARGEHTHFRYDARGYLVESERPDGRIDRYEIDVAG 801
           +  D + A   Y Y+A G+LR+S+    + T  +      L  + +P           + 
Sbjct: 666 AEIDATGALVEYVYNASGQLRQSVAYATKLTAQKLAQ--LLDGAGKPTTAWAADNTTTSL 723

Query: 802 QLTRYIDPAQKTLQFR-YDPSGRLVERTDAMGYSVKFRYDAYGRLLQLT 849
              R    AQ    +R YD  GRL  + DA+GY  +  YD   R+L +T
Sbjct: 724 ATLRPATAAQDQRVWRFYDNVGRLTWQVDALGYVTQTTYDGASRILAVT 772



 Score = 56.2 bits (134), Expect = 9e-11
 Identities = 74/308 (24%), Positives = 116/308 (37%), Gaps = 34/308 (11%)

Query: 708  ETQYQYDPEGRVTQVTDALEKSKYLSWNTCGQLL-------------SYRDCSNAQTLYH 754
            + + ++D  GRV +  D  E    L +NT G L+               R        Y 
Sbjct: 4246 QRRQEHDAFGRVVKEIDGKENVNDLRYNTLGLLIDKIGPVVDVTLANGQRQAIRPTEHYS 4305

Query: 755  YDAHGRLRESINARGEHTHFRYDARGYLVESERP-----DGRIDRYEIDVAGQLTRYIDP 809
            YD +G+     +A G  +  + +A G  V    P        + R   DV G L    D 
Sbjct: 4306 YDLNGQFVGKRDANGNQSTVQINAAGQAVAEWHPGATAGTSAVVRKAYDVFGNLRTVTDE 4365

Query: 810  AQKTLQFRYDPSGRL--VERTDAMGYSV---KFRYDAYGRLLQLTNENDESYRFGWDELD 864
              +  +  YD + RL  VER      SV    + YD  G+ +   N  D   R  +D + 
Sbjct: 4366 IGRVTRNEYDFNNRLKRVERPVNANGSVAVDAYEYDILGQRIAQVNALDYRVRTYYDSMG 4425

Query: 865  RLVAQKDLDGSGRLYAYNVLDEVIRLTHVPSPDEQPPLSDNAPPTRTTAIRHDFERDAIG 924
            R+      +G+   Y Y   + +     V +       +D    T+T       + D  G
Sbjct: 4426 RVTRYISAEGATVNYGYTYDNSIGSAGGVNTGGWTNTTTDANGRTQT------LKNDVFG 4479

Query: 925  RLVSKRTEDGTTDYRYDAADNLLSITFTDNKGEKQQLDYTYDANGQL--LSETNSAGLLQ 982
            R + K+ + G   + Y    + L  T T N G  Q + Y+Y  NG L  +S+   +    
Sbjct: 4480 RTMWKQ-DLGGHQFTYGYNWSGLIATQTGNSG--QNIAYSYYDNGYLRKVSDAGVSTESI 4536

Query: 983  YRYDELGN 990
            + YD  GN
Sbjct: 4537 FEYDNNGN 4544



 Score = 50.1 bits (118), Expect = 6e-09
 Identities = 80/311 (25%), Positives = 117/311 (37%), Gaps = 64/311 (20%)

Query: 709  TQYQYDPEGRVTQVTDALEKSKYLSWNTCGQLLSYRDCSNAQTLYHYDAHGRLRESINAR 768
            T+Y YD   RV   +++     Y      G L      +  +T   Y+A G    +I+A+
Sbjct: 3335 TEYSYDRNARVR--SESRLNVAYGRVAANGALSEGATSATQRT--EYNAMGNKTATIDAQ 3390

Query: 769  GEHTHFRYDARGYLVESERPDG---------RIDRYEIDVAGQLTRYIDPAQKTLQFRYD 819
            G+ +  RYD  G L+  +RP           ++  YE++  G + R I            
Sbjct: 3391 GQRSEMRYDTIGRLLSVQRPGAADFNGNAVRQVTDYELNGLGNVRREIRRG--------- 3441

Query: 820  PSGRLVERTDAMGYSVKFRYDAYGRLLQLTNENDESYRFGWDELDRLVAQK----DLDGS 875
             +   VE  D +   V++ YDA G    +T    E+  +G D      AQ     D DG+
Sbjct: 3442 -TDNAVESDDEI---VRYGYDATGVRTSMTTAKGETVTYGRDANGNTTAQMTDRVDADGA 3497

Query: 876  GR----LYAYNVLDEVIRLTHVPSPDEQPPLSDNAPPTRTTAIRHDFERDAIGRLVSKRT 931
                    AY+  +   R           P+ D A     T        +A G L SKRT
Sbjct: 3498 VSRDIVSIAYDAANREARRFTGGRDAADMPVFDAANTITLT-------YNAWGELASKRT 3550

Query: 932  EDGTTDYRYDAADNLLSITFTDNKGEKQQLDYTYDANGQLLSETNSAGLLQ--YRYDELG 989
              G                    +G+ Q+  Y YD  G+L   TNS G +   + YD  G
Sbjct: 3551 GSGNA------------------QGQAQEY-YDYDKAGRLW-RTNSKGGVNKAWMYDLAG 3590

Query: 990  NLQTLVLPDQR 1000
            N  TL L  QR
Sbjct: 3591 N-ATLQLESQR 3600



 Score = 47.8 bits (112), Expect = 3e-08
 Identities = 112/511 (21%), Positives = 197/511 (38%), Gaps = 126/511 (24%)

Query: 750  QTLYHYDAHGRLRESINARGEHTHFRYDARGYLVESERPDGRIDRYEIDVAGQLTRYIDP 809
            Q    +DA GR+ + I+ +      RY+  G L++   P       ++ +A    + I P
Sbjct: 4246 QRRQEHDAFGRVVKEIDGKENVNDLRYNTLGLLIDKIGP-----VVDVTLANGQRQAIRP 4300

Query: 810  AQKTLQFRYDPSGRLVERTDAMGYS--------------------------VKFRYDAYG 843
               T  + YD +G+ V + DA G                            V+  YD +G
Sbjct: 4301 ---TEHYSYDLNGQFVGKRDANGNQSTVQINAAGQAVAEWHPGATAGTSAVVRKAYDVFG 4357

Query: 844  RLLQLTNENDESYRFGWDELDRLV-AQKDLDGSGRL----YAYNVLDEVIRLTHVPSPDE 898
             L  +T+E     R  +D  +RL   ++ ++ +G +    Y Y++L +  R+  V + D 
Sbjct: 4358 NLRTVTDEIGRVTRNEYDFNNRLKRVERPVNANGSVAVDAYEYDILGQ--RIAQVNALDY 4415

Query: 899  QPPLSDNAPPTRTTAIRHDFERDAIGRLVSKRTEDG-TTDYRYDAADNLLSI-------- 949
            +          RT         D++GR+    + +G T +Y Y   +++ S         
Sbjct: 4416 R---------VRT-------YYDSMGRVTRYISAEGATVNYGYTYDNSIGSAGGVNTGGW 4459

Query: 950  --TFTDNKGEKQQLDYTYDANGQLLSETNSAG-LLQYRYDELGNLQTLVLPDQRELNHLY 1006
              T TD  G  Q L    D  G+ + + +  G    Y Y+  G + T      + + + Y
Sbjct: 4460 TNTTTDANGRTQTL--KNDVFGRTMWKQDLGGHQFTYGYNWSGLIATQTGNSGQNIAYSY 4517

Query: 1007 YGSGHLHQINLNG-RVISDFERD----AVHDEVLRTQGKLV---TRTRYDTSGRLAGKAI 1058
            Y +G+L +++  G    S FE D     + + +    G +V   +R  YD   R+  K I
Sbjct: 4518 YDNGYLRKVSDAGVSTESIFEYDNNGNRIFEGLKAITGNVVFQWSRVSYDAYNRV--KTI 4575

Query: 1059 HYRDAPAEVLPLLDKAYRYDASDNLIAEVLTQTQRRGMSNAANDENANLEQIIGRFLDLP 1118
               DA   +       Y YDA+ N         +RR +S   N        ++ +  D+ 
Sbjct: 4576 D--DARYMI------NYEYDANGN---------RRRVLSTYIN--------VVDQRKDVQ 4610

Query: 1119 HTGKTYSGHNRY----GYDLNEQL--------QTVHQSRPNWQATQV-------EDFKYD 1159
                 Y G NR+    G  +N Q+         T+       +   +       ED+ YD
Sbjct: 4611 DYWYAYDGMNRFTTTMGQMVNGQIWRGASGDGVTIEYDNAGQRKAAIYARDGHREDYDYD 4670

Query: 1160 KAGNLFDGPKLNGLIKHNRVLVYQDKRYRYD 1190
              G+L    K+NG+++  R      +  RY+
Sbjct: 4671 GTGHL-TAMKMNGVLRSRRTNDLAGRVTRYE 4700



 Score = 46.2 bits (108), Expect = 9e-08
 Identities = 58/258 (22%), Positives = 102/258 (39%), Gaps = 36/258 (13%)

Query: 584  RFEYNLEAGETLVTDNLGR--RDHY-YWGPLYEVYKHIDPQGNCWLAEV---IAGQLIKR 637
            R  Y++      VTD +GR  R+ Y +   L  V + ++  G+  +      I GQ I +
Sbjct: 4350 RKAYDVFGNLRTVTDEIGRVTRNEYDFNNRLKRVERPVNANGSVAVDAYEYDILGQRIAQ 4409

Query: 638  IDPQGGEWRYSYDDIGRLIETRDPLGRSEHIKYLRHWALPIQ-----------VTDTAGR 686
            ++      R  YD +GR+       G + +  Y    ++               TD  GR
Sbjct: 4410 VNALDYRVRTYYDSMGRVTRYISAEGATVNYGYTYDNSIGSAGGVNTGGWTNTTTDANGR 4469

Query: 687  TRQYGYDSHGNLLWQQDPLGRETQYQYDPEGRVTQVTDALEKSKYLSWNTCGQLLSYRDC 746
            T+    D  G  +W+QD  G +  Y Y+  G +   T    ++   S+   G L    D 
Sbjct: 4470 TQTLKNDVFGRTMWKQDLGGHQFTYGYNWSGLIATQTGNSGQNIAYSYYDNGYLRKVSDA 4529

Query: 747  S-NAQTLYHYDAHG-RLRESINARGEHTHFRYDARGYLVESERPDGRIDRYEIDVAGQLT 804
              + ++++ YD +G R+ E + A   +  F++    Y           D Y         
Sbjct: 4530 GVSTESIFEYDNNGNRIFEGLKAITGNVVFQWSRVSY-----------DAY------NRV 4572

Query: 805  RYIDPAQKTLQFRYDPSG 822
            + ID A+  + + YD +G
Sbjct: 4573 KTIDDARYMINYEYDANG 4590



 Score = 39.7 bits (91), Expect = 8e-06
 Identities = 75/313 (23%), Positives = 123/313 (39%), Gaps = 49/313 (15%)

Query: 924  GRLVSKRTEDGTTD-YRYDAADNLLSITFTDNKGEKQQLDYTYDA-NGQLLSETNSAGLL 981
            G  +++   DG T  Y + A+ NL    +  + G        YDA N + +    S+GL+
Sbjct: 102  GSTLARTDRDGATAVYAWSASRNL----YVSSAGAGAFDTIAYDAANARYVWTDGSSGLV 157

Query: 982  QYRYDELGNLQTL--VLPDQRELNHLYYGSGHLHQI-NLNGRVIS-DFE-RDAVHDEVLR 1036
            + RYD  G  + L  V P+   +++ Y  +G L  + + NG     D+   +      + 
Sbjct: 158  E-RYDASGQGRLLFAVDPNGNTVSYSYNANGTLKSVVDANGEATYFDYTGTNLTQVRTVA 216

Query: 1037 TQGKLVTRTRY--DTSGRLAGKAIHYRDAPAEVLPLLD-----KAYRYDASDNLIAEVLT 1089
            T G  +TR RY  D + RL+   +   D   E   + D       Y YD +   +A V T
Sbjct: 217  TGGATLTRVRYAYDGANRLSSVTV---DLSPEDNSVADGKTYVTTYNYDGTSKRVASV-T 272

Query: 1090 QTQRRGMS-----NAANDENANLEQIIGRFLDLPHTGKTYSGHNRYGYDLNEQLQTVHQS 1144
            Q+    ++     + ++ + A +   +G+               R+ YD      TV   
Sbjct: 273  QSDGTALAFTYVLSGSSYKVATVTDALGQI-------------TRFAYDSASSTTTVTDP 319

Query: 1145 RPNWQATQVEDFKYDKAGNLFDGPKLNGLIKHNRVLVYQDKRYRYDRFGRLCEKRIGSNW 1204
            +          F YD  GNL    +  G+   N   + Q   YRYD  G +     G   
Sbjct: 320  QGARST-----FLYDADGNLLQVRQ--GVTAGNAAGLSQVS-YRYDAAGNVTGMTDGEGR 371

Query: 1205 VQYFEYDAEQRLV 1217
               +EYDA   L+
Sbjct: 372  ELAYEYDANGNLL 384



 Score = 35.8 bits (81), Expect = 1e-04
 Identities = 40/156 (25%), Positives = 63/156 (40%), Gaps = 28/156 (17%)

Query: 678  IQVTDTAGRTRQYGYDSHGNL---------LWQQDPLGRETQYQYDPEGRVTQVTDALEK 728
            ++  D A     Y YD++GN          +  Q    ++  Y YD   R T        
Sbjct: 4572 VKTIDDARYMINYEYDANGNRRRVLSTYINVVDQRKDVQDYWYAYDGMNRFT-------- 4623

Query: 729  SKYLSWNTCGQLLS---YRDCSNAQTLYHYDAHGRLRESINARGEHTH-FRYDARGYLVE 784
                   T GQ+++   +R  S       YD  G+ + +I AR  H   + YD  G+L  
Sbjct: 4624 ------TTMGQMVNGQIWRGASGDGVTIEYDNAGQRKAAIYARDGHREDYDYDGTGHLTA 4677

Query: 785  SERPDGRIDRYEIDVAGQLTRYID-PAQKTLQFRYD 819
             +       R   D+AG++TRY +  A +TL  + D
Sbjct: 4678 MKMNGVLRSRRTNDLAGRVTRYEELYADQTLSSQKD 4713