Pairwise Alignments

Query, 1385 a.a., Rhs-related protein from Pseudomonas putida KT2440

Subject, 5052 a.a., Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA from Variovorax sp. SCN45

 Score = 99.0 bits (245), Expect = 1e-23
 Identities = 181/779 (23%), Positives = 296/779 (37%), Gaps = 124/779 (15%)

Query: 396  GRLTDIKRVVN-----NEAVETLTQYRYDEHGQLSAVINRNGDTVRSFSYADGLMVTHSN 450
            G +T  +R  +       A  TL   R D   Q  ++        +++S A+ L+ + +N
Sbjct: 1603 GNVTQTRRYASLARNPGSANATLASVRPDPSAQDQSI-------TQTWSAANQLL-SRTN 1654

Query: 451  ALGLGCHYRWQTLGDKPRVVEHWTSDGEH----YHFRYDLDSRTSWATDVLGRELEVQYN 506
            A G    + +   G   R+V+  T+ G         RYD+        D  G +  V  N
Sbjct: 1655 AEGTVTTFTYDVAG---RLVQTTTAAGTPDERIQRLRYDIQGHLIAELDGRGSDA-VALN 1710

Query: 507  ADHRVVASRDYGGERYAIELDEHGNMVGLTLPDGNRLQFKYDEFSRLLEETDPLGRKTQY 566
            A    +AS    G  +A   D  G   G T  +G+R  F YD F RL    + LG  T+ 
Sbjct: 1711 AP---LASWSANGSTHAY--DAAGRRTGTTDANGHRTLFFYDAFGRLAYTVNALGEVTES 1765

Query: 567  EYHHLTTLVTQVSYPDGSTWRARFDDKGNLLAEFDALGQMTEY-LNSD--DGLPHTIIDA 623
             Y+    +  Q+ Y       +R D           LG  T   LN+D    L  T+ D 
Sbjct: 1766 RYNAYGQVSEQIVYG------SRID--------LTPLGTATPGGLNTDALKALLATMADP 1811

Query: 624  TYKSKYL-WWNTLAQVERYQDCSGKSTYYRYDERQHLVAVTDALNQTTTLARKPDGEVLR 682
               +  L  +N    +    D  G  T Y Y+  +  +A     +  T L+    G+V+ 
Sbjct: 1812 AKDTHVLKTYNASGTLTSSTDAMGGVTSYAYNAFREAIA-----SSRTRLS----GQVI- 1861

Query: 683  ISHPDGTTESFTYNVYGQVLSHTD---GKGQTTRLMRTARGLPSSRQDAKGQRVRYEYDK 739
                   T + T++  G  +S T    G G T R    A G P +R D  G      YD+
Sbjct: 1862 -------TNTVTFDRRGLQVSTTSDATGAGLTRRTGYDAFGRPDTRIDGNGNTASLRYDR 1914

Query: 740  AMRLTALVNENNATYSFAYDASDRLSEEVRVDNLTRRFSYDVGGHLTRLDEIGYGENAER 799
              R+ A  +   AT +  YDA DR+  +    N    ++Y V      +         E 
Sbjct: 1915 LGRVVATTDATGATRTTTYDAFDRVLTQRDALNNVTSYAYSVANRSVTVT------TPEG 1968

Query: 800  PERHTLFERDAIGRLIAKLNSDAQQRFTYDDGDRLLSIERQPTGIGK---------QLGI 850
                TL  R      +     +    ++YD    LL  +  P G+G          +L  
Sbjct: 1969 VSVTTLHNRQGQTTSVTDGRGNTTT-YSYDKSGNLLRTQA-PEGVGTSTTYDKIGLKLST 2026

Query: 851  TEEK---LEYAYDLLGRL-TKEISPDG---TLGYEYDPLSNLTTLTLPDGRKVNHLYYGS 903
            T+ +     Y YD + RL T+ + P G      Y YD      ++T P G      Y  +
Sbjct: 2027 TDARGTVTTYGYDAVSRLLTRTVDPGGLTLVTSYLYDAKGQTISVTDPGGTVTTTAYDLN 2086

Query: 904  GHLHQLNLDG----------QVISDMERDDLHREVYRTQGKLTSCFGYDAMGRKAWQFAS 953
            G + +  LD           + +   + D     V+   G+LT  + YD  GR+  +   
Sbjct: 2087 GQVVRQTLDPSNGAYVGLKLETVYTHDSDGTALSVHGPDGRLTR-YTYDGAGRRIKEQVD 2145

Query: 954  TLPADKL-SQVHNTGINTSLLVEHAYNPIHRRYQYDPAGELVRTLDKLRGEIKYEYEANG 1012
             L  +   S  ++   N    V+ + N     + YD A  L  T+D + G  +  Y+A G
Sbjct: 2146 PLGLNLTRSYAYDAEGNVIKAVDASGNAT--LFIYDQAKRLAFTIDAMGGVQQSGYDAEG 2203

Query: 1013 QLRSRDT-----------GSLIGSEEFRYD-PAANRLDFNARQFDKVKDNRIKQWRDQ-- 1058
            +L S+ T           G+       +   P        +R++D  +D R++   D   
Sbjct: 2204 RLSSQTTYAAFVPVAAWNGTAPSLSAMQAALPTLGLAATQSRRYD--RDGRLRFAVDATG 2261

Query: 1059 ---EYRYDPWGNLIEKRSGHSKLQHFSYDCENRLVRAETLVNGKLESQGEYRYDSLGRR 1114
               EYRYD  GN++E R+   +++   +   +  +    + +   + +    YD+LGR+
Sbjct: 2262 AVVEYRYDDAGNVVESRAYAQRIELGKW---HGAIDPPVVADDAHDQRSRSVYDALGRK 2317



 Score = 83.6 bits (205), Expect = 5e-19
 Identities = 135/576 (23%), Positives = 202/576 (35%), Gaps = 94/576 (16%)

Query: 363 GHFLHFTRTPDGTLTDISATGGTRVHLHYDNPLGRLTDIKRVVNNEAVETLTQYRYDEHG 422
           G+ + ++   +GTL  +    G   +  Y      LT ++ V    A  T  +Y YD   
Sbjct: 176 GNTVSYSYNANGTLKSVVDANGEATYFDYTGT--NLTQVRTVATGGATLTRVRYAYDGAN 233

Query: 423 QLSAVIN---------RNGDT-VRSFSYADGLM-----VTHSNALGLGCHYRWQTLGDKP 467
           +LS+V            +G T V +++Y DG       VT S+   L   + +   G   
Sbjct: 234 RLSSVTVDLSPEDNSVADGKTYVTTYNY-DGTSKRVASVTQSDGTALA--FTYVLSGSSY 290

Query: 468 RVVEHWTSDGEHYHFRYDLDSRTSWATDVLGRELEVQYNADHR-------VVASRDYGGE 520
           +V     + G+   F YD  S T+  TD  G      Y+AD         V A    G  
Sbjct: 291 KVATVTDALGQITRFAYDSASSTTTVTDPQGARSTFLYDADGNLLQVRQGVTAGNAAGLS 350

Query: 521 RYAIELDEHGNMVGLTLPDGNRLQFKYDEFSRLLEETDPLGRKTQYEYHHLTTLVTQVSY 580
           + +   D  GN+ G+T  +G  L ++YD    LL+E D  G      Y+    L++   Y
Sbjct: 351 QVSYRYDAAGNVTGMTDGEGRELAYEYDANGNLLKEVDSAGNTHTRTYNSANQLLSDTIY 410

Query: 581 PDGSTWRARFDDKGNLLAEFDALGQMTEYLNSDDGLPHTIIDATYKSKYLWWNTLAQVER 640
            D S  R  F           AL + T Y+ +           T +             R
Sbjct: 411 ADASVSRGVFSKDA-------ALPETTRYVYAPGNALQLRFVVTAQGN-------VTEHR 456

Query: 641 YQDCSGKSTYYRYDERQHLVA---VTDALNQTTTLARKPDGEVLRISHPDGTTESFTYNV 697
           Y     + +  RY    + V+    TD   Q   LA     +  R    D     + Y+ 
Sbjct: 457 YDSYGQRISTIRYVGSAYGVSTLGTTDVPTQAQMLAWLGGQDPSRTERVD-----YAYDA 511

Query: 698 YGQVLSHTD-GKGQTTRLMRTARGLPSSRQDAKGQRVRYEYDKAMRLTALVN-ENNATYS 755
            G + S T  G+   T    T          A   R +Y YD+   L   +      T +
Sbjct: 512 RGSLSSATTYGEVDATGAGTT----------ATAARTQYVYDQHGNLLQKIEPSGGGTTT 561

Query: 756 FAYDASDRL--SEEVRVDNLTRRFSYDVGGHLTRLDEIGYGENAERPERHTLFERDAIGR 813
           + YD   R+       +D +T   +      +T  D+ G                   GR
Sbjct: 562 YVYDGLGRVLSVSAPSLDGVTANTT------VTSYDDAG-------------------GR 596

Query: 814 LIAKLNSDAQQRFTYDDGDRLLSIERQPTGIGKQLGITEEKLEYAYDLLGRLTKEISPDG 873
               + S       YD   RL+S+ +Q  G G  LG T     YAYD  G L     P G
Sbjct: 597 TSVTVASGLVSISAYDKAGRLVSVTQQSAGSG-VLGTT----TYAYDKNGNLLMTQDPTG 651

Query: 874 TLGYE-YDPLSNLTTLTLPDGRKVNHLYYGSGHLHQ 908
              +  YD  +         G  V ++Y  SG L Q
Sbjct: 652 VRKWMLYDEANRKIAEIDATGALVEYVYNASGQLRQ 687



 Score = 83.6 bits (205), Expect = 5e-19
 Identities = 203/937 (21%), Positives = 343/937 (36%), Gaps = 164/937 (17%)

Query: 366  LHFTRTPDGTLTDISATGGTRVHL--HYDNPLGR--------LTDIKRVVNNEAVETLTQ 415
            L +T  P G L   S  G  R+ L   Y  P+          +  ++ + +    +   Q
Sbjct: 2604 LVYTLGPLGQLEKNSYDGAGRITLTTRYARPVSTKGLGAAPTVAQLQALASQTPGQDQQQ 2663

Query: 416  YR-YDEHGQLSAVINRNGDTVRSFSYADGLMVTHSNALGLGCHYRWQTLGDKPRVVEHWT 474
            +  YD+ G+LSA ++  G  V      +G +   +         +W    D   V +  T
Sbjct: 2664 FNVYDQGGRLSATVDAMGSVVTFKRDGNGSVSERTAWANTVDMNKWAP--DTAPVPKADT 2721

Query: 475  SDGEHYHFRYDLDSRTSWATDVLGRELEVQYNADHRVVASRDYGGERYAIELDEHGNMVG 534
            +  +H    YD   R +   D LG  ++ QY+A          G   Y +        V 
Sbjct: 2722 ARDQHTRIFYDAMGRETLTIDALGYAVQRQYDAQ---------GRPSYVVRYP-----VA 2767

Query: 535  LTLPDGNRLQFKYDEFSRLLEETDPLGRKTQYEYH---HLTTLVTQVSYPDGSTWRARFD 591
            +     N  + K D    L   +    + T Y Y    + T+    +  P+ +T +  FD
Sbjct: 2768 VPASTPNTQKAKLDAAIALASVSGRPLQITAYGYDAAGNRTSQTEALGQPEAATTQYVFD 2827

Query: 592  DKGNLLAEFDALGQMTEYLNSDDGLPHTIIDATYKSKY-------LWWNTLAQVERYQDC 644
              G L    DA G   E   SD     T      + KY       L  + L+Q +R    
Sbjct: 2828 GIGRLTRTIDARG--VELSQSDSAWALT---QRLQLKYVNAAGGALKASDLSQAQRQALA 2882

Query: 645  SGKSTYYRYDERQHLVAVTDALNQTTTLARKPDGEVLRISHPDGTTESFTYNVYGQVLSH 704
            +  +T   YD   H ++VTDAL   T      +G V+RI+ P G +  + ++  G+V   
Sbjct: 2883 ARYTTTIDYDAAGHKLSVTDALGGVTRSDYDANGRVVRITDPRGNSAFYYFDAAGRVTLS 2942

Query: 705  TDGKGQTTRLMRTARGLPSSRQDAKGQRVRYEYDKAMRLTAL--VNENNATYSFAYDASD 762
             D +G  T     A G   S +     RV   Y K  +  AL   N ++A   F YDAS 
Sbjct: 2943 VDPEGYATATTYDALGHTLSVK-RHFNRVSGTY-KIAQPPALPGANPSDALTRFEYDASG 3000

Query: 763  RLSEEVRVDNLTRRFSYDVGGHLTRL------------DEIGYGENAERPERHTLFERDA 810
            RL+  +   +   R++Y+  G    L            D++G   +   P    +  R+A
Sbjct: 3001 RLTRTIDAQSNAERYTYNALGQRETLTNKLGGLTAYTYDQLGRVASETLP----ITSRNA 3056

Query: 811  IGRLIAKLNSDAQQRFTYDDGDRLLSIERQPTGIGKQLGITEEKL-EYAYDLLGRLTKE- 868
             G+ +A  N  A   F    G+R  + E         +G+ E+++ +++YD L R  ++ 
Sbjct: 3057 AGQSVAVRNQYAYDAF----GNRATTTE--------AVGLPEQRVTQFSYDGLNREVEQR 3104

Query: 869  -----ISPDG--------TLGYEYDPLSNLTTLTLPDG-----------RKVNHL----- 899
                 I  DG        T    YD   NL  +  P+G           RKV  +     
Sbjct: 3105 QAQVRIYVDGQGWSTIAPTRTRSYDASGNLIAVVEPNGGRTRTWFDGTNRKVAEVSATGT 3164

Query: 900  -----YYGSGHLHQLNLDGQVISDMERDDLHREVYRTQGKLTS----------------- 937
                 Y  +G++    + G  +     D L   V     +LT+                 
Sbjct: 3165 LSTWSYDATGNVMAQRVYGDALILPVGDALPTPVNAANVRLTTYQVDANNRVLSSTIAGI 3224

Query: 938  -CFGYDAMGRKAWQFASTLPADKLSQVHNTGINTSLLVEHAYNPIHRRYQYDPAGELVRT 996
                YDA G    Q+   + +D +++      N +++ EH          YD  G+ +  
Sbjct: 3225 QSGNYDASGH---QYNMAVTSDLVNRSFYDA-NGNVVREHNGKDAATLTWYDRLGQKLLQ 3280

Query: 997  LDKLRGEIKYEYEANGQLRSRDT--------GSLIGSEEFRYDPAANRLDFNAR-QFDKV 1047
            +D +   +++E +ANG +  R+T        GSL  SE    D    +       Q  + 
Sbjct: 3281 VDAMGFGVRWERDANGAV-LRETRFAKEIVLGSL--SESTSVDAVLQKFTPGLNDQITEY 3337

Query: 1048 KDNRIKQWRDQEYRYDPWGNLIEKRSGHSKLQHFSYDCENRLVRAETLVNGKLESQGEYR 1107
              +R  + R +      +G +    +        +   E   +  +T        + E R
Sbjct: 3338 SYDRNARVRSESRLNVAYGRVAANGALSEGATSATQRTEYNAMGNKTATIDAQGQRSEMR 3397

Query: 1108 YDSLGRRIAKQ----AEINGEVEQK--RFLWQGLRMLRE----------ETPGQSILYLY 1151
            YD++GR ++ Q    A+ NG   ++   +   GL  +R           E+  + + Y Y
Sbjct: 3398 YDTIGRLLSVQRPGAADFNGNAVRQVTDYELNGLGNVRREIRRGTDNAVESDDEIVRYGY 3457

Query: 1152 EPGSYAPLARVDQVEGEGQKVYYFHTDQIGTPLELTD 1188
            +    A   R      +G+ V Y       T  ++TD
Sbjct: 3458 D----ATGVRTSMTTAKGETVTYGRDANGNTTAQMTD 3490



 Score = 81.6 bits (200), Expect = 2e-18
 Identities = 128/560 (22%), Positives = 207/560 (36%), Gaps = 95/560 (16%)

Query: 520  ERYAIELDEHGNMVGLTLPDGNRLQFKYDEFSRLLEETDPLGRKTQYEYHHLT-TLVTQV 578
            ERY  +    G ++    P+GN + + Y+    L    D  G  T ++Y     T V  V
Sbjct: 158  ERY--DASGQGRLLFAVDPNGNTVSYSYNANGTLKSVVDANGEATYFDYTGTNLTQVRTV 215

Query: 579  SYPDGSTWRARFDDKGNLLAEFDALGQMTEYLNSDDGLPHTIIDA-TYKSKYLWWNTLAQ 637
            +    +  R R+   G      + L  +T  L+ +D   +++ D  TY + Y +  T  +
Sbjct: 216  ATGGATLTRVRYAYDGA-----NRLSSVTVDLSPED---NSVADGKTYVTTYNYDGTSKR 267

Query: 638  VERYQDCSGKS---TYYRYDERQHLVAVTDALNQTTTLARKPDGEVLRISHPDGTTESFT 694
            V       G +   TY        +  VTDAL Q T  A         ++ P G   +F 
Sbjct: 268  VASVTQSDGTALAFTYVLSGSSYKVATVTDALGQITRFAYDSASSTTTVTDPQGARSTFL 327

Query: 695  YNVYGQVLSHTDG--KGQTTRLMRT-----ARGLPSSRQDAKGQRVRYEYDKAMRLTALV 747
            Y+  G +L    G   G    L +      A G  +   D +G+ + YEYD    L   V
Sbjct: 328  YDADGNLLQVRQGVTAGNAAGLSQVSYRYDAAGNVTGMTDGEGRELAYEYDANGNLLKEV 387

Query: 748  NENNATYSFAYDASDRL----------------SEEVRVDNLTR-----------RFSYD 780
            +    T++  Y+++++L                S++  +   TR           RF   
Sbjct: 388  DSAGNTHTRTYNSANQLLSDTIYADASVSRGVFSKDAALPETTRYVYAPGNALQLRFVVT 447

Query: 781  VGGHLT---------RLDEIGYGENAERPERHTLFERDAIGRLIAKLNSDAQQR-----F 826
              G++T         R+  I Y  +A         +     +++A L      R     +
Sbjct: 448  AQGNVTEHRYDSYGQRISTIRYVGSAYGVSTLGTTDVPTQAQMLAWLGGQDPSRTERVDY 507

Query: 827  TYDDGDRLLSI----ERQPTGIGKQLGITEEKLEYAYDLLGRLTKEISPDG--TLGYEYD 880
             YD    L S     E   TG G     T  + +Y YD  G L ++I P G  T  Y YD
Sbjct: 508  AYDARGSLSSATTYGEVDATGAGTTA--TAARTQYVYDQHGNLLQKIEPSGGGTTTYVYD 565

Query: 881  PLSNLTTLTLP--DGRKVNHL---YYGSGHLHQLNLDGQVISDMERDDLHREVYRTQGKL 935
             L  + +++ P  DG   N     Y  +G    + +   ++S    D   R V  TQ   
Sbjct: 566  GLGRVLSVSAPSLDGVTANTTVTSYDDAGGRTSVTVASGLVSISAYDKAGRLVSVTQQSA 625

Query: 936  TSCFGYDAMGRKAWQFASTLPADKLSQVHNTGINTSLLVEHAYNPIHRRYQYDPAGELVR 995
                G   +G   + +      DK         N +LL+      + +   YD A   + 
Sbjct: 626  ----GSGVLGTTTYAY------DK---------NGNLLMTQDPTGVRKWMLYDEANRKIA 666

Query: 996  TLDKLRGEIKYEYEANGQLR 1015
             +D     ++Y Y A+GQLR
Sbjct: 667  EIDATGALVEYVYNASGQLR 686



 Score = 81.3 bits (199), Expect = 2e-18
 Identities = 161/686 (23%), Positives = 238/686 (34%), Gaps = 103/686 (15%)

Query: 369  TRTPDGTLTD-ISATGGTRVHLHYD-------NPLGRLTDIKRVVNNEAVETLTQYRYDE 420
            T TP G  TD + A   T      D       N  G LT      + +A+  +T Y Y+ 
Sbjct: 1790 TATPGGLNTDALKALLATMADPAKDTHVLKTYNASGTLTS-----STDAMGGVTSYAYNA 1844

Query: 421  HGQL--SAVINRNGDTVRSFSYAD--GLMV-THSNALGLGCHYR--WQTLGDKPRVVEHW 473
              +   S+    +G  + +    D  GL V T S+A G G   R  +   G     ++  
Sbjct: 1845 FREAIASSRTRLSGQVITNTVTFDRRGLQVSTTSDATGAGLTRRTGYDAFGRPDTRID-- 1902

Query: 474  TSDGEHYHFRYDLDSRTSWATDVLGRELEVQYNADHRVVASRDYGGERYAIELDEHGNMV 533
              +G     RYD   R    TD  G      Y+A  RV+  RD      +         V
Sbjct: 1903 -GNGNTASLRYDRLGRVVATTDATGATRTTTYDAFDRVLTQRDALNNVTSYAYSVANRSV 1961

Query: 534  GLTLPDGNRLQFKYDEFSRLLEETDPLGRKTQYEYHHLTTLVTQVSYPDGSTWRARFDDK 593
             +T P+G  +   ++   +    TD  G  T Y Y     L+ +   P+G      +D  
Sbjct: 1962 TVTTPEGVSVTTLHNRQGQTTSVTDGRGNTTTYSYDKSGNLL-RTQAPEGVGTSTTYDKI 2020

Query: 594  GNLLAEFDALGQMTEY-LNSDDGLPHTIIDA---TYKSKYLWWNTLAQVERYQDCSGKST 649
            G  L+  DA G +T Y  ++   L    +D    T  + YL+ +   Q     D  G  T
Sbjct: 2021 GLKLSTTDARGTVTTYGYDAVSRLLTRTVDPGGLTLVTSYLY-DAKGQTISVTDPGGTVT 2079

Query: 650  YYRYDERQHLVAVT--------DALNQTTTLARKPDGEVLRISHPDGTTESFTYNVYGQ- 700
               YD    +V  T          L   T      DG  L +  PDG    +TY+  G+ 
Sbjct: 2080 TTAYDLNGQVVRQTLDPSNGAYVGLKLETVYTHDSDGTALSVHGPDGRLTRYTYDGAGRR 2139

Query: 701  VLSHTD--GKGQTTRLMRTARGLPSSRQDAKGQRVRYEYDKAMRLTALVNENNATYSFAY 758
            +    D  G   T      A G      DA G    + YD+A RL   ++         Y
Sbjct: 2140 IKEQVDPLGLNLTRSYAYDAEGNVIKAVDASGNATLFIYDQAKRLAFTIDAMGGVQQSGY 2199

Query: 759  DASDRLSEEVRVDNLTRRFSYD-----VGGHLTRLDEIGYGENAERPERHTLFERDAIGR 813
            DA  RLS +          +++     +      L  +G      R      ++RD  GR
Sbjct: 2200 DAEGRLSSQTTYAAFVPVAAWNGTAPSLSAMQAALPTLGLAATQSR-----RYDRD--GR 2252

Query: 814  L-IAKLNSDAQQRFTYDDGDRLLSIERQPTGIGKQLGITEEKLEYAYDL-LGRLTKEISP 871
            L  A   + A   + YDD                  G   E   YA  + LG+    I P
Sbjct: 2253 LRFAVDATGAVVEYRYDDA-----------------GNVVESRAYAQRIELGKWHGAIDP 2295

Query: 872  DGTLGYEYDPLSNLTTLTLPDGRKVNHLYYGSGHLHQLNLDGQVISDMERDDLHREVYRT 931
                   +D  S      L  GRK           H ++  G V+         R+V+  
Sbjct: 2296 PVVADDAHDQRSRSVYDAL--GRKT----------HSIDGTGAVV---------RQVFDA 2334

Query: 932  QGKLTSCFGYDAMGRKAWQFASTLPADKLSQVHNTGINTSLLVEHAYNPIHRRYQYDPAG 991
             G +T  F Y          +  +PA   +         +L+ E A +P H  Y YD AG
Sbjct: 2335 SGNVTERFAY----------SKRVPAATAATTDALAAAVALVAEPARDP-HDTYVYDRAG 2383

Query: 992  ELVRTLDKLRGEIKYEYEANGQLRSR 1017
              +   D +       Y+ +G + SR
Sbjct: 2384 RQLLHTDGVGKVTSQNYDKSGNIISR 2409



 Score = 70.9 bits (172), Expect = 3e-15
 Identities = 156/699 (22%), Positives = 243/699 (34%), Gaps = 130/699 (18%)

Query: 408  EAVETLTQYRYDEHGQLSAVINRNGDTVRSFSYADGLMVTHSNALGLGCHYRWQTLGDKP 467
            +A+  +T+  YD +G++  + +  G++   +  A G +    +  G      +  LG   
Sbjct: 2902 DALGGVTRSDYDANGRVVRITDPRGNSAFYYFDAAGRVTLSVDPEGYATATTYDALGHTL 2961

Query: 468  RVVEHWTSDGEHY------------------HFRYDLDSRTSWATDVLGRELEVQYNA-D 508
             V  H+      Y                   F YD   R +   D         YNA  
Sbjct: 2962 SVKRHFNRVSGTYKIAQPPALPGANPSDALTRFEYDASGRLTRTIDAQSNAERYTYNALG 3021

Query: 509  HRVVASRDYGGERYAIELDEHGNMVGLTLPDGNRL----------QFKYDEFSRLLEETD 558
             R   +   GG   A   D+ G +   TLP  +R           Q+ YD F      T+
Sbjct: 3022 QRETLTNKLGGLT-AYTYDQLGRVASETLPITSRNAAGQSVAVRNQYAYDAFGNRATTTE 3080

Query: 559  PLG----RKTQYEYHHLTTLVTQVS-----YPDGSTW------RAR-FDDKGNLLAEFDA 602
             +G    R TQ+ Y  L   V Q       Y DG  W      R R +D  GNL+A  + 
Sbjct: 3081 AVGLPEQRVTQFSYDGLNREVEQRQAQVRIYVDGQGWSTIAPTRTRSYDASGNLIAVVEP 3140

Query: 603  LGQMTEYLNSDDGLPHTIIDATYKSKYLWW------NTLAQVERYQDC------------ 644
             G  T      DG    + + +       W      N +AQ   Y D             
Sbjct: 3141 NGGRTR--TWFDGTNRKVAEVSATGTLSTWSYDATGNVMAQ-RVYGDALILPVGDALPTP 3197

Query: 645  ----SGKSTYYRYDERQHLVAVTDALNQTTTLARKPDGEVLRISHPDGTTESFTYNVYGQ 700
                + + T Y+ D    +++ T A  Q+           + ++  D    SF Y+  G 
Sbjct: 3198 VNAANVRLTTYQVDANNRVLSSTIAGIQSGNYDASGHQYNMAVTS-DLVNRSF-YDANGN 3255

Query: 701  VLSHTDGKGQTTRLMRTARGLPSSRQDAKGQRVRYEYDKAMRLTALVNENNATYSFAYDA 760
            V+   +GK   T       G    + DA G  VR+E D      A++ E          +
Sbjct: 3256 VVREHNGKDAATLTWYDRLGQKLLQVDAMGFGVRWERDAN---GAVLRETRFAKEIVLGS 3312

Query: 761  SDRLSEEVRVDNLTRRFSYDVGGHLTRLD-------------EIGYG---------ENAE 798
               LSE   VD + ++F+  +   +T                 + YG         E A 
Sbjct: 3313 ---LSESTSVDAVLQKFTPGLNDQITEYSYDRNARVRSESRLNVAYGRVAANGALSEGAT 3369

Query: 799  RPERHTLFERDAIGRLIAKLNSDAQQ-RFTYDDGDRLLSIERQPTGIGKQLGITEEKLEY 857
               + T  E +A+G   A +++  Q+    YD   RLLS++R P           +  +Y
Sbjct: 3370 SATQRT--EYNAMGNKTATIDAQGQRSEMRYDTIGRLLSVQR-PGAADFNGNAVRQVTDY 3426

Query: 858  AYDLLGRLTKEI---------SPDGTLGYEYDPLSNLTTLTLPDGRKVNHLYYGSGH--- 905
              + LG + +EI         S D  + Y YD     T++T   G  V +    +G+   
Sbjct: 3427 ELNGLGNVRREIRRGTDNAVESDDEIVRYGYDATGVRTSMTTAKGETVTYGRDANGNTTA 3486

Query: 906  --LHQLNLDGQVISD---MERDDLHREVYRTQGKLTSCFGYDAMGRKAWQFASTLPADKL 960
                +++ DG V  D   +  D  +RE  R  G      G DA     +  A+T+     
Sbjct: 3487 QMTDRVDADGAVSRDIVSIAYDAANREARRFTG------GRDAADMPVFDAANTITLTYN 3540

Query: 961  SQVHNTGINTSLLVEHAYNPIHRRYQYDPAGELVRTLDK 999
            +        T     +A       Y YD AG L RT  K
Sbjct: 3541 AWGELASKRTG--SGNAQGQAQEYYDYDKAGRLWRTNSK 3577



 Score = 63.5 bits (153), Expect = 5e-13
 Identities = 101/447 (22%), Positives = 173/447 (38%), Gaps = 75/447 (16%)

Query: 505  YNADHRVVASRDYGGERYAIELDEHGNMV-----GLTLPDGNRLQFKYDEFSRLLEETDP 559
            Y+ + + V  RD  G +  ++++  G  V     G T      ++  YD F  L   TD 
Sbjct: 4306 YDLNGQFVGKRDANGNQSTVQINAAGQAVAEWHPGATAGTSAVVRKAYDVFGNLRTVTDE 4365

Query: 560  LGRKTQYEYHHLTTLVTQVSYPDGSTWRARFDDKGNLLAEFDALGQMTEYLNSDDGLPHT 619
            +GR T+ EY      + +V  P  +      D       E+D LGQ    +N+ D    T
Sbjct: 4366 IGRVTRNEY-DFNNRLKRVERPVNANGSVAVD-----AYEYDILGQRIAQVNALDYRVRT 4419

Query: 620  IIDATYKSKYLWWNTLAQVERYQDCSGKSTYYRYDERQHLVAV----TDALNQTTTLARK 675
                       +++++ +V RY    G +  Y Y     + +     T     TTT A  
Sbjct: 4420 -----------YYDSMGRVTRYISAEGATVNYGYTYDNSIGSAGGVNTGGWTNTTTDA-- 4466

Query: 676  PDGEVLRISHPDGTTESFTYNVYGQVLSHTDGKGQTTRLMRTARGLPSSRQDAKGQRVRY 735
                       +G T++   +V+G+ +   D  G          GL +++    GQ + Y
Sbjct: 4467 -----------NGRTQTLKNDVFGRTMWKQDLGGHQFTYGYNWSGLIATQTGNSGQNIAY 4515

Query: 736  EYDKAMRLTALVNENNATYS-FAYDAS-DRLSEEVR--VDNLT---RRFSYDVGGHLTRL 788
             Y     L  + +   +T S F YD + +R+ E ++    N+     R SYD    +  +
Sbjct: 4516 SYYDNGYLRKVSDAGVSTESIFEYDNNGNRIFEGLKAITGNVVFQWSRVSYDAYNRVKTI 4575

Query: 789  DEIGYGENAERPERHTLFERDAIGR----LIAKLNSDAQQRFTYDDGDRLLSIERQPTGI 844
            D+  Y  N         +E DA G     L   +N   Q++   D       + R  T +
Sbjct: 4576 DDARYMIN---------YEYDANGNRRRVLSTYINVVDQRKDVQDYWYAYDGMNRFTTTM 4626

Query: 845  GKQLGITEEKLEYAYDLLGRLTKEISPDGTLGYEYDPL-SNLTTLTLPDGRKVNHLYYGS 903
            G+ +              G++ +  S DG +  EYD        +   DG + ++ Y G+
Sbjct: 4627 GQMVN-------------GQIWRGASGDG-VTIEYDNAGQRKAAIYARDGHREDYDYDGT 4672

Query: 904  GHLHQLNLDGQVISDMERDDLHREVYR 930
            GHL  + ++G V+     +DL   V R
Sbjct: 4673 GHLTAMKMNG-VLRSRRTNDLAGRVTR 4698



 Score = 61.6 bits (148), Expect = 2e-12
 Identities = 116/522 (22%), Positives = 187/522 (35%), Gaps = 97/522 (18%)

Query: 649  TYYRYDERQHLVAVTDALNQTTTLARKPDGEVLRISHPDGTTESFTYNVYGQVLSHT-DG 707
            T Y+ ++      +T        +A K   +V R ++       +T    GQ+  ++ DG
Sbjct: 2562 TGYQLEQTDVASNITPTTATPVLIAAKTQSQVTRFAYDSAGRLVYTLGPLGQLEKNSYDG 2621

Query: 708  KGQTTRLMRTARGLPS----------------SRQDAKGQRVRYEYDKAMRLTALVNENN 751
             G+ T   R AR + +                S+   + Q+    YD+  RL+A V+   
Sbjct: 2622 AGRITLTTRYARPVSTKGLGAAPTVAQLQALASQTPGQDQQQFNVYDQGGRLSATVDAMG 2681

Query: 752  ATYSFAYDASDRLSEEVRVDNLTRRFSYDVGGHLTRLDEIGYGENAERPERHTLFERDAI 811
            +  +F  D +  +SE     N     + D+         +   + A   ++HT    DA+
Sbjct: 2682 SVVTFKRDGNGSVSERTAWAN-----TVDMNKWAPDTAPVPKADTAR--DQHTRIFYDAM 2734

Query: 812  GRLIAKLNS--DAQQRFTYDDGDRLLSIERQPTGIGKQLGITEE-KLEYAYDLLGRLTKE 868
            GR    +++   A QR  YD   R   + R P  +      T++ KL+ A  L     + 
Sbjct: 2735 GRETLTIDALGYAVQR-QYDAQGRPSYVVRYPVAVPASTPNTQKAKLDAAIALASVSGRP 2793

Query: 869  ISPDGTLGYEYDPLSNLTTLT----LPDGRKVNHLYYGSGHLHQLNLDGQVISDMERDDL 924
            +       Y YD   N T+ T     P+     +++ G G L +  +D + +   + D  
Sbjct: 2794 LQ---ITAYGYDAAGNRTSQTEALGQPEAATTQYVFDGIGRLTR-TIDARGVELSQSDSA 2849

Query: 925  HREVYRTQGKLTSCFGYDAMGRKAWQFASTLPADKLSQVHNTGINTSLLVEHAYNPIHRR 984
                 R Q K  +  G              L A  LSQ     +                
Sbjct: 2850 WALTQRLQLKYVNAAG------------GALKASDLSQAQRQALAARYTTT--------- 2888

Query: 985  YQYDPAGELVRTLDKLRGEIKYEYEANGQ-LRSRDTGSLIGSEEFRYDPAANRLDFNA-- 1041
              YD AG  +   D L G  + +Y+ANG+ +R  D     G+  F Y  AA R+  +   
Sbjct: 2889 IDYDAAGHKLSVTDALGGVTRSDYDANGRVVRITDPR---GNSAFYYFDAAGRVTLSVDP 2945

Query: 1042 -------------------RQFDKVKDN-RIKQWRD----------QEYRYDPWGNLIEK 1071
                               R F++V    +I Q               + YD  G L   
Sbjct: 2946 EGYATATTYDALGHTLSVKRHFNRVSGTYKIAQPPALPGANPSDALTRFEYDASGRLTRT 3005

Query: 1072 RSGHSKLQHFSYDCENRLVRAETLVNGKLESQGEYRYDSLGR 1113
                S  + ++Y   N L + ETL N KL     Y YD LGR
Sbjct: 3006 IDAQSNAERYTY---NALGQRETLTN-KLGGLTAYTYDQLGR 3043



 Score = 52.8 bits (125), Expect = 9e-10
 Identities = 114/574 (19%), Positives = 189/574 (32%), Gaps = 142/574 (24%)

Query: 418  YDEHGQLSAVINRNGDTVRSFSYADGLMVTHSNALGLGCHYRWQTLGDKPRVVEHWTSDG 477
            YD  G+    I+ NG+T        G +V  ++A G     R  T     RV+    +  
Sbjct: 1891 YDAFGRPDTRIDGNGNTASLRYDRLGRVVATTDATGAT---RTTTYDAFDRVLTQRDALN 1947

Query: 478  EHYHFRYDLDSRTSWATDVLGRELEVQYNADHRVVASRDYGGERYAIELDEHGNMVGLTL 537
                + Y + +R+   T   G  +   +N   +  +  D  G       D+ GN++    
Sbjct: 1948 NVTSYAYSVANRSVTVTTPEGVSVTTLHNRQGQTTSVTDGRGNTTTYSYDKSGNLLRTQA 2007

Query: 538  PDGNRLQFKYDEFSRLLEETDPLGRKTQYEYHHLTTLVTQVSYPDGSTWRARF--DDKGN 595
            P+G      YD+    L  TD  G  T Y Y  ++ L+T+   P G T    +  D KG 
Sbjct: 2008 PEGVGTSTTYDKIGLKLSTTDARGTVTTYGYDAVSRLLTRTVDPGGLTLVTSYLYDAKGQ 2067

Query: 596  LLA-----------EFDALGQM------------------TEYLNSDDGLPHTIIDATYK 626
             ++            +D  GQ+                  T Y +  DG   ++     +
Sbjct: 2068 TISVTDPGGTVTTTAYDLNGQVVRQTLDPSNGAYVGLKLETVYTHDSDGTALSVHGPDGR 2127

Query: 627  -SKYLW-----------------------WNTLAQVERYQDCSGKSTYYRYDERQHLVAV 662
             ++Y +                       ++    V +  D SG +T + YD+ + L   
Sbjct: 2128 LTRYTYDGAGRRIKEQVDPLGLNLTRSYAYDAEGNVIKAVDASGNATLFIYDQAKRLAFT 2187

Query: 663  TDAL---------------NQTTTLA---------RKPDGEVLRISHPD---GTTESFTY 695
             DA+               +QTT  A           P    ++ + P      T+S  Y
Sbjct: 2188 IDAMGGVQQSGYDAEGRLSSQTTYAAFVPVAAWNGTAPSLSAMQAALPTLGLAATQSRRY 2247

Query: 696  NVYGQVLSHTDGKGQTTRLMRTARGL----------------------PSSRQDAKGQRV 733
            +  G++    D  G          G                       P    DA  QR 
Sbjct: 2248 DRDGRLRFAVDATGAVVEYRYDDAGNVVESRAYAQRIELGKWHGAIDPPVVADDAHDQRS 2307

Query: 734  RYEYDKAMRLTALVNENNATYSFAYDASDRLSEEVRVDNLTRRFSYDVGGHLTRLDEIGY 793
            R  YD   R T  ++   A     +DAS          N+T RF+Y              
Sbjct: 2308 RSVYDALGRKTHSIDGTGAVVRQVFDAS---------GNVTERFAY-------------- 2344

Query: 794  GENAERPERHTLFERDAIG---RLIAKLNSDAQQRFTYDDGDRLLSIERQPTGIGKQLGI 850
               ++R    T    DA+     L+A+   D    + YD   R L       G+GK   +
Sbjct: 2345 ---SKRVPAATAATTDALAAAVALVAEPARDPHDTYVYDRAGRQL---LHTDGVGK---V 2395

Query: 851  TEEKLEYAYDLLGRLTKEISPDGTLGYEYDPLSN 884
            T +  + + +++ R      P GT  + +   +N
Sbjct: 2396 TSQNYDKSGNIISRAYINDQPAGTNLFTHSEFAN 2429



 Score = 48.9 bits (115), Expect = 1e-08
 Identities = 133/651 (20%), Positives = 230/651 (35%), Gaps = 138/651 (21%)

Query: 372  PDG--TLTDISATGGT-RVHLHYDNPLG--RLTDIKRVVNNEAVETLTQYRYDEHGQLSA 426
            P+G  T T   A G T  V  H++   G  ++     +      + LT++ YD  G+L+ 
Sbjct: 2945 PEGYATATTYDALGHTLSVKRHFNRVSGTYKIAQPPALPGANPSDALTRFEYDASGRLTR 3004

Query: 427  VINRNGDTVRSFSYADGLMVTHSNALGLGCHYRWQTLGDKPRVVEHWTSDGE-------H 479
             I+   +  R    A G   T +N LG    Y +  LG         TS           
Sbjct: 3005 TIDAQSNAERYTYNALGQRETLTNKLGGLTAYTYDQLGRVASETLPITSRNAAGQSVAVR 3064

Query: 480  YHFRYDLDSRTSWATDVLG----RELEVQYNADHRVVASRD------YGGERYAI----- 524
              + YD     +  T+ +G    R  +  Y+  +R V  R         G+ ++      
Sbjct: 3065 NQYAYDAFGNRATTTEAVGLPEQRVTQFSYDGLNREVEQRQAQVRIYVDGQGWSTIAPTR 3124

Query: 525  --ELDEHGNMVGLTLPDGNRLQFKYDEFSRLLEETDPLGRKTQYEYHHLTTLVTQVSYPD 582
                D  GN++ +  P+G R +  +D  +R + E    G  + + Y     ++ Q  Y D
Sbjct: 3125 TRSYDASGNLIAVVEPNGGRTRTWFDGTNRKVAEVSATGTLSTWSYDATGNVMAQRVYGD 3184

Query: 583  G--------------------STWRARFDDK-------GNLLAEFDALGQMTEYLNSDDG 615
                                 +T++   +++       G     +DA G       + D 
Sbjct: 3185 ALILPVGDALPTPVNAANVRLTTYQVDANNRVLSSTIAGIQSGNYDASGHQYNMAVTSDL 3244

Query: 616  LPHTIIDATYK----------SKYLWWNTLAQVERYQDCSGKSTYYRYDERQHLVAVT-- 663
            +  +  DA             +   W++ L Q     D  G    +  D    ++  T  
Sbjct: 3245 VNRSFYDANGNVVREHNGKDAATLTWYDRLGQKLLQVDAMGFGVRWERDANGAVLRETRF 3304

Query: 664  ------DALNQTTT----LARKPDG---EVLRISHPDGT---TESFTYNVYGQVLSHTD- 706
                   +L+++T+    L +   G   ++   S+       +ES     YG+V ++   
Sbjct: 3305 AKEIVLGSLSESTSVDAVLQKFTPGLNDQITEYSYDRNARVRSESRLNVAYGRVAANGAL 3364

Query: 707  GKGQTTRLMRT---ARGLPSSRQDAKGQRVRYEYDKAMRLTALVNENNATYS-------- 755
             +G T+   RT   A G  ++  DA+GQR    YD   RL ++     A ++        
Sbjct: 3365 SEGATSATQRTEYNAMGNKTATIDAQGQRSEMRYDTIGRLLSVQRPGAADFNGNAVRQVT 3424

Query: 756  -FAYDASDRLSEEVR--VDNLTR------RFSYDVGGHLTRL-----DEIGYGENAERPE 801
             +  +    +  E+R   DN         R+ YD  G  T +     + + YG +A    
Sbjct: 3425 DYELNGLGNVRREIRRGTDNAVESDDEIVRYGYDATGVRTSMTTAKGETVTYGRDANGNT 3484

Query: 802  RHTLFER----DAIGRLIAKLNSDA----QQRFT----------YDDGDRLL-------S 836
               + +R     A+ R I  +  DA     +RFT          +D  + +         
Sbjct: 3485 TAQMTDRVDADGAVSRDIVSIAYDAANREARRFTGGRDAADMPVFDAANTITLTYNAWGE 3544

Query: 837  IERQPTGIGKQLGITEEKLEYAYDLLGRLTKEISPDG-TLGYEYDPLSNLT 886
            +  + TG G   G  +E   Y YD  GRL +  S  G    + YD   N T
Sbjct: 3545 LASKRTGSGNAQGQAQE--YYDYDKAGRLWRTNSKGGVNKAWMYDLAGNAT 3593



 Score = 48.1 bits (113), Expect = 2e-08
 Identities = 140/664 (21%), Positives = 230/664 (34%), Gaps = 121/664 (18%)

Query: 385  TRVHLHYDNPLGRLTDIKRVVNNEAVETLTQYRYDEHGQLSAVINRNGDTVRSFSYADGL 444
            TR    ++N   RL  ++R VN      +  Y YD  GQ  A +N     VR++  + G 
Sbjct: 4370 TRNEYDFNN---RLKRVERPVNANGSVAVDAYEYDILGQRIAQVNALDYRVRTYYDSMGR 4426

Query: 445  MVTHSNALGLGCHYRW---QTLGDKPRV-VEHWTS-----DGEHYHFRYDLDSRTSWATD 495
            +  + +A G   +Y +    ++G    V    WT+     +G     + D+  RT W  D
Sbjct: 4427 VTRYISAEGATVNYGYTYDNSIGSAGGVNTGGWTNTTTDANGRTQTLKNDVFGRTMWKQD 4486

Query: 496  VLGRELEVQYNADHRVVASRDYGGERYAIELDEHGNMVGLT-LPDGNRLQFKYD-EFSRL 553
            + G +    YN    +       G+  A    ++G +  ++         F+YD   +R+
Sbjct: 4487 LGGHQFTYGYNWSGLIATQTGNSGQNIAYSYYDNGYLRKVSDAGVSTESIFEYDNNGNRI 4546

Query: 554  LEETDPLGRKTQYEYHHLTTLVTQVSYPDGSTWRARFDDKGNLLAEFDALGQMTEYLNSD 613
             E    +     +++       ++VSY   +  +   D +  +  E+DA G     L++ 
Sbjct: 4547 FEGLKAITGNVVFQW-------SRVSYDAYNRVKTIDDARYMINYEYDANGNRRRVLST- 4598

Query: 614  DGLPHTIIDATYKSKYLWWNTLAQVERYQDCSGKSTYYRYDERQHLVAVTDALNQTTTLA 673
                             + N + Q +  QD      +Y YD              TTT+ 
Sbjct: 4599 -----------------YINVVDQRKDVQD-----YWYAYDGMNRF---------TTTMG 4627

Query: 674  RKPDGEVLRISHPDGTTESFTYNVYGQVLS------------HTDGKGQTTRLMRTARGL 721
            +  +G++ R +  DG T    Y+  GQ  +              DG G  T +       
Sbjct: 4628 QMVNGQIWRGASGDGVT--IEYDNAGQRKAAIYARDGHREDYDYDGTGHLTAMKMNGVLR 4685

Query: 722  PSSRQDAKGQRVRYEYDKAMRLTALVNEN--NATYSFAYDASDRLSEEV---RVDNLTRR 776
                 D  G+  RYE   A +  +   +   N       +   RL+E     +  + T  
Sbjct: 4686 SRRTNDLAGRVTRYEELYADQTLSSQKDRTWNKDNQLTVEVERRLTEGTNGRKWSDTTTA 4745

Query: 777  FSYDVGGHLTRLDEIGYGENAERPERHTLFERDAIGRLIAKLNSDAQQRFTYDDGDRLLS 836
            ++    G L+++D +    N   P          I R+I+         + YD  D    
Sbjct: 4746 YTLMQDGTLSKVDSLTNAFNNFNPSAQD--PAVVITRMIS--------NYAYDWWDS--- 4792

Query: 837  IERQPTGIGKQLGITEEKLEYAYDLLGRLTKEISPDGTLGYEYD---PLSNLTTLTLPDG 893
                     KQ  IT + +   YD      K   P G   + YD    L   T L     
Sbjct: 4793 --------AKQTSITLDPVSTGYD-----PKRPQPPGYSVFGYDVNGHLKTATDLNATTP 4839

Query: 894  RKVNHLYYGSGHLHQ--------LNLDGQVISDMERDDLHREVYRTQGKLTSCFGYDAMG 945
            R  ++     G + Q        +  DG V    +  D HR  Y   GK     G D + 
Sbjct: 4840 RSFSYWTNAEGQVLQRQELIGGKIGADGNVSGASKSRD-HRYFY-FDGKRVGNVGNDGVE 4897

Query: 946  RK------AWQFASTLPADKLSQVHNTGINTSLLVEHAYNPIHRRYQYD-PAGELVRTLD 998
            R+      A   A+  P DK  +   T    S   +  Y PI+  +    P    VR  D
Sbjct: 4898 REDYAQQLARSSATQSPDDKYRKFTPT---NSADFDENYQPINAGFPGPAPGSYTVREGD 4954

Query: 999  KLRG 1002
             L G
Sbjct: 4955 TLEG 4958



 Score = 47.8 bits (112), Expect = 3e-08
 Identities = 108/441 (24%), Positives = 165/441 (37%), Gaps = 97/441 (21%)

Query: 709  GQTTRLMRTA--RGLPSSRQDAKGQRVRYEYDKAMRLTALVNENNATYSFAYDASDRLSE 766
            GQ   L  TA   G   +R D  G    Y +  +  L        A  + AYDA++    
Sbjct: 89   GQKVVLTGTAGTAGSTLARTDRDGATAVYAWSASRNLYVSSAGAGAFDTIAYDAANA--- 145

Query: 767  EVRVDNLTRRFSYDVG--GHLTRLDEIGYGEN--AERPERHTL-FERDAIGRLIAKLNSD 821
                     R+ +  G  G + R D  G G    A  P  +T+ +  +A G L + ++++
Sbjct: 146  ---------RYVWTDGSSGLVERYDASGQGRLLFAVDPNGNTVSYSYNANGTLKSVVDAN 196

Query: 822  AQQRFTYDDGDRLLSIERQPTGIGKQLGITEEKLEYAYDLLGRL---TKEISPDGT---- 874
             +  +    G  L  +    TG     G T  ++ YAYD   RL   T ++SP+      
Sbjct: 197  GEATYFDYTGTNLTQVRTVATG-----GATLTRVRYAYDGANRLSSVTVDLSPEDNSVAD 251

Query: 875  -----LGYEYDPLSN-LTTLTLPDGRKVNHLYYGSGHLHQLNLDGQVISDMER---DDLH 925
                   Y YD  S  + ++T  DG  +   Y  SG  +++      +  + R   D   
Sbjct: 252  GKTYVTTYNYDGTSKRVASVTQSDGTALAFTYVLSGSSYKVATVTDALGQITRFAYDSAS 311

Query: 926  REVYRTQGK-LTSCFGYDAMGR--KAWQFASTLPADKLSQVHNTGINTSLLVEHAYNPIH 982
                 T  +   S F YDA G   +  Q  +   A  LSQV                   
Sbjct: 312  STTTVTDPQGARSTFLYDADGNLLQVRQGVTAGNAAGLSQVS------------------ 353

Query: 983  RRYQYDPAGELVRTLDKLRGEIKYEYEANGQLRSRDTGSLIGSEEFRYDPAANRL----- 1037
              Y+YD AG +    D    E+ YEY+ANG L      +  G+   R   +AN+L     
Sbjct: 354  --YRYDAAGNVTGMTDGEGRELAYEYDANGNLLKEVDSA--GNTHTRTYNSANQLLSDTI 409

Query: 1038 --DFNARQFDKVKDNRIKQWRDQEYRYDPWGNLIEKRSGHSKLQHFSYDCENRLVRAETL 1095
              D +  +    KD  + +     Y Y P GN ++ R                +V A+  
Sbjct: 410  YADASVSRGVFSKDAALPE--TTRYVYAP-GNALQLRF---------------VVTAQGN 451

Query: 1096 VNGKLESQGEYRYDSLGRRIA 1116
            V        E+RYDS G+RI+
Sbjct: 452  VT-------EHRYDSYGQRIS 465



 Score = 47.0 bits (110), Expect = 5e-08
 Identities = 120/556 (21%), Positives = 195/556 (35%), Gaps = 136/556 (24%)

Query: 599  EFDALGQMTEYLNSDDGLPHTIIDATYKSKYLWWNTLAQVERYQDCSGK------STYYR 652
            E DA G++ + ++  +     + D  Y +  L  + +  V      +G+      + +Y 
Sbjct: 4250 EHDAFGRVVKEIDGKEN----VNDLRYNTLGLLIDKIGPVVDVTLANGQRQAIRPTEHYS 4305

Query: 653  YDERQHLVAVTDALNQTTTLARKPDGEVLRISHPDGTTESF-----TYNVYGQVLSHTDG 707
            YD     V   DA    +T+     G+ +   HP  T  +       Y+V+G + + TD 
Sbjct: 4306 YDLNGQFVGKRDANGNQSTVQINAAGQAVAEWHPGATAGTSAVVRKAYDVFGNLRTVTDE 4365

Query: 708  KGQTTRLMRTARGLPSSRQDAKGQRVRYEYDKAMRLTALVNENNATYSFAYDA------S 761
             G+ T                     R EYD   RL  +    NA  S A DA       
Sbjct: 4366 IGRVT---------------------RNEYDFNNRLKRVERPVNANGSVAVDAYEYDILG 4404

Query: 762  DRLSEEVRVDNLTRRFSYDVGGHLTRL-----DEIGYGENAERPERHTLFERDAIGRLIA 816
             R+++   +D   R + YD  G +TR        + YG   +          ++IG    
Sbjct: 4405 QRIAQVNALDYRVRTY-YDSMGRVTRYISAEGATVNYGYTYD----------NSIGS-AG 4452

Query: 817  KLNSDAQQRFTYDDGDRLLSIERQPTGIGKQLGITEEKLEYAYDLLGRLTKEISPDGTLG 876
             +N+      T D   R  +++    G          +  +  DL G          T G
Sbjct: 4453 GVNTGGWTNTTTDANGRTQTLKNDVFG----------RTMWKQDLGGH-------QFTYG 4495

Query: 877  YEYDPLSNLTTLTLPDGRKVNHLYYGSGHLHQLNLDGQVISDMERDDLHREVYRTQGKLT 936
            Y +  L  + T T   G+ + + YY +G+L +++ D  V ++                  
Sbjct: 4496 YNWSGL--IATQTGNSGQNIAYSYYDNGYLRKVS-DAGVSTE------------------ 4534

Query: 937  SCFGYDAMGRKAWQFASTLPADKLSQVHNTGINTSLLVEHAYNPIHRRYQYDPAGELVRT 996
            S F YD  G + ++    +  + + Q                     R  YD A   V+T
Sbjct: 4535 SIFEYDNNGNRIFEGLKAITGNVVFQ-------------------WSRVSYD-AYNRVKT 4574

Query: 997  LDKLRGEIKYEYEANGQLRSRDTGSLIGSEEFRYD--------PAANRLDFNARQFDKVK 1048
            +D  R  I YEY+ANG  R R   + I   + R D           NR      Q    +
Sbjct: 4575 IDDARYMINYEYDANGN-RRRVLSTYINVVDQRKDVQDYWYAYDGMNRFTTTMGQMVNGQ 4633

Query: 1049 DNRIKQWRDQEYRYDPWGN---LIEKRSGHSKLQHFSYDCENRLVRAETLVNGKLESQGE 1105
              R          YD  G     I  R GH   + + YD    L   +  +NG L S+  
Sbjct: 4634 IWRGASGDGVTIEYDNAGQRKAAIYARDGHR--EDYDYDGTGHLTAMK--MNGVLRSR-- 4687

Query: 1106 YRYDSLGRRIAKQAEI 1121
             R + L  R+ +  E+
Sbjct: 4688 -RTNDLAGRVTRYEEL 4702



 Score = 42.7 bits (99), Expect = 9e-07
 Identities = 65/264 (24%), Positives = 94/264 (35%), Gaps = 33/264 (12%)

Query: 409 AVETLTQYRYDEHGQLSAVINRNGDTVRSFSYADGL----MVTHSNALGLGCHYRWQTLG 464
           A    TQY YD+HG L   I  +G    ++ Y DGL     V+  +  G+  +    +  
Sbjct: 533 ATAARTQYVYDQHGNLLQKIEPSGGGTTTYVY-DGLGRVLSVSAPSLDGVTANTTVTSYD 591

Query: 465 DKPRVVEHWTSDGEHYHFRYDLDSRTSWATDVLGRELEVQYNADHRVVASRDYGGERYAI 524
           D         + G      YD   R    T         Q +A   V+ +  Y       
Sbjct: 592 DAGGRTSVTVASGLVSISAYDKAGRLVSVT---------QQSAGSGVLGTTTYA------ 636

Query: 525 ELDEHGNMVGLTLPDGNRLQFKYDEFSRLLEETDPLGRKTQYEYHHLTTLVTQVSYPDGS 584
             D++GN++    P G R    YDE +R + E D  G   +Y Y+    L   V+Y    
Sbjct: 637 -YDKNGNLLMTQDPTGVRKWMLYDEANRKIAEIDATGALVEYVYNASGQLRQSVAYATKL 695

Query: 585 TWRARFDDKGNLLAEFDALGQMTEYLNSDDGLPH--TIIDATYKSKYLWWNTLAQVERYQ 642
           T +        L    D  G+ T    +D+      T+  AT       W     V R  
Sbjct: 696 TAQ-------KLAQLLDGAGKPTTAWAADNTTTSLATLRPATAAQDQRVWRFYDNVGRLT 748

Query: 643 ---DCSGKSTYYRYDERQHLVAVT 663
              D  G  T   YD    ++AVT
Sbjct: 749 WQVDALGYVTQTTYDGASRILAVT 772



 Score = 40.8 bits (94), Expect = 3e-06
 Identities = 91/386 (23%), Positives = 145/386 (37%), Gaps = 48/386 (12%)

Query: 542 RLQFKYDEFSRLLEETDPLGRKTQYEYHHLTTLVTQVSYP--DG---STWRARFDDKGNL 596
           R Q+ YD+   LL++ +P G  T    +     V  VS P  DG   +T    +DD G  
Sbjct: 537 RTQYVYDQHGNLLQKIEPSGGGTTTYVYDGLGRVLSVSAPSLDGVTANTTVTSYDDAGGR 596

Query: 597 LAEFDALGQMTEYLNSDDGLPHTIIDATYKSKYLWWNTLAQVER-----YQDCSGKSTYY 651
            +   A G ++       G   ++   +  S  L   T A  +       QD +G   + 
Sbjct: 597 TSVTVASGLVSISAYDKAGRLVSVTQQSAGSGVLGTTTYAYDKNGNLLMTQDPTGVRKWM 656

Query: 652 RYDERQHLVAVTDALNQTTTLARKPDGEVLRISHPDGTTESFTYNVYGQVLSHTDGKGQT 711
            YDE    +A  DA            G+ LR S    T    T     Q+L   DG G+ 
Sbjct: 657 LYDEANRKIAEIDATGALVEYVYNASGQ-LRQSVAYAT--KLTAQKLAQLL---DGAGKP 710

Query: 712 TRLM---RTARGLPSSRQD--AKGQRVRYEYDKAMRLTALVNENNATYSFAYDASDR--- 763
           T       T   L + R    A+ QRV   YD   RLT  V+         YD + R   
Sbjct: 711 TTAWAADNTTTSLATLRPATAAQDQRVWRFYDNVGRLTWQVDALGYVTQTTYDGASRILA 770

Query: 764 ---LSEEVRVDNLTRRFSYDVGGHLTRLDEIGYGENAERPERHTLFERDAIGRLIAKLN- 819
              L++ + V  L +  + D+G   + L  I    N      + L     I  L A ++ 
Sbjct: 771 VTQLAKPIDVAPLLKGANIDLGVDPSTLGGISLSVNNAESTSYGL-----IAVLTASVDG 825

Query: 820 SDAQQRFTYDDGDRLLS----IERQPTGIGKQLGITEEKLEYAY--------DLLGRLTK 867
           +  +   T+ DG+ ++     ++ + T    ++ I    L  AY         +   + K
Sbjct: 826 AGLRGMVTFFDGETVIGSAVVVDGKATLATDRMSIGTHNLRVAYSGDDLRPASVSKAVKK 885

Query: 868 EISP---DGTLGYEYDPLSNLTTLTL 890
            I+P     TLG + +P +   ++ L
Sbjct: 886 TITPILTTATLGVQRNPSAGSRSVIL 911



 Score = 38.5 bits (88), Expect = 2e-05
 Identities = 52/243 (21%), Positives = 94/243 (38%), Gaps = 35/243 (14%)

Query: 984  RYQYDPAGELVRTLDKLRGEIKYEYEANGQLRSRDTGSLIGSEEFRYDPAANRLDFNARQ 1043
            R  YD  G L    D++    + EY+ N +L+  +          R   A   +  +A +
Sbjct: 4350 RKAYDVFGNLRTVTDEIGRVTRNEYDFNNRLKRVE----------RPVNANGSVAVDAYE 4399

Query: 1044 FDKVKDNRIKQWRDQEYR----YDPWGNLIEKRSGHSKLQHFSYDCENRLVRA------- 1092
            +D +   RI Q    +YR    YD  G +    S      ++ Y  +N +  A       
Sbjct: 4400 YD-ILGQRIAQVNALDYRVRTYYDSMGRVTRYISAEGATVNYGYTYDNSIGSAGGVNTGG 4458

Query: 1093 ----ETLVNGKLESQGEYRYDSLGRRIAKQAEINGEVEQKRFLWQGLRMLREETPGQSIL 1148
                 T  NG+ ++    + D  GR + KQ ++ G      + W GL   +    GQ+I 
Sbjct: 4459 WTNTTTDANGRTQT---LKNDVFGRTMWKQ-DLGGHQFTYGYNWSGLIATQTGNSGQNIA 4514

Query: 1149 YLYEPGSYAPLARVDQVEGEGQKVYYFHTDQIGTPLELTDSEGEIVWQ---ATYRSWGTI 1205
            Y Y    Y  L +V       + ++ +  +       L    G +V+Q    +Y ++  +
Sbjct: 4515 YSYYDNGY--LRKVSDAGVSTESIFEYDNNGNRIFEGLKAITGNVVFQWSRVSYDAYNRV 4572

Query: 1206 ETL 1208
            +T+
Sbjct: 4573 KTI 4575



 Score = 37.4 bits (85), Expect = 4e-05
 Identities = 73/361 (20%), Positives = 127/361 (35%), Gaps = 68/361 (18%)

Query: 822  AQQRFTYDDGDRLLSIERQPTGIGKQLGITEEK---LEYAYDLLGRLTKEISPDGTLGYE 878
            A  R+ + DG   L      +G G+ L   +     + Y+Y+  G L   +  +G   Y 
Sbjct: 143  ANARYVWTDGSSGLVERYDASGQGRLLFAVDPNGNTVSYSYNANGTLKSVVDANGEATYF 202

Query: 879  YDPLSNLTTL-TLPDG----RKVNHLYYGSGHLHQLNLDGQVISDMERDDLHREVYRTQG 933
                +NLT + T+  G     +V + Y G+  L  + +D   +S  +      + Y T  
Sbjct: 203  DYTGTNLTQVRTVATGGATLTRVRYAYDGANRLSSVTVD---LSPEDNSVADGKTYVTT- 258

Query: 934  KLTSCFGYDAMGRKAWQFASTLPADKLSQVHNTGINTS----LLVEHAYNPIHRRYQYDP 989
                 + YD   ++    AS   +D  +      ++ S      V  A   I  R+ YD 
Sbjct: 259  -----YNYDGTSKRV---ASVTQSDGTALAFTYVLSGSSYKVATVTDALGQI-TRFAYDS 309

Query: 990  AGELVRTLDKLRGEIKYEYEANGQLRSRDTGSLIGSEEFRYDPAANRLDFNARQFDKVKD 1049
            A       D       + Y+A+G L     G   G               NA    +V  
Sbjct: 310  ASSTTTVTDPQGARSTFLYDADGNLLQVRQGVTAG---------------NAAGLSQVS- 353

Query: 1050 NRIKQWRDQEYRYDPWGNLIEKRSGHSKLQHFSYDCENRLVRAETLVNGKLESQGEYR-- 1107
                      YRYD  GN+     G  +   + YD    L++       +++S G     
Sbjct: 354  ----------YRYDAAGNVTGMTDGEGRELAYEYDANGNLLK-------EVDSAGNTHTR 396

Query: 1108 -YDSLGRRIAKQAEINGEVEQKRFLWQGLRMLREETPGQSILYLYEPGSYAPLARVDQVE 1166
             Y+S  + ++     +  V +  F        ++    ++  Y+Y PG+   L  V   +
Sbjct: 397  TYNSANQLLSDTIYADASVSRGVF-------SKDAALPETTRYVYAPGNALQLRFVVTAQ 449

Query: 1167 G 1167
            G
Sbjct: 450  G 450