Pairwise Alignments

Query, 1235 a.a., cobalamin-dependent methionine synthase from Pseudomonas putida KT2440

Subject, 1227 a.a., homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent from Escherichia coli BL21

 Score = 1608 bits (4163), Expect = 0.0
 Identities = 822/1235 (66%), Positives = 978/1235 (79%), Gaps = 14/1235 (1%)

Query: 5    SARLQALQNALKERILILDGGMGTMIQSYRLEEHDYRGTRFADWPSDVKGNNDLLLLSRP 64
            S++++ L+  L ERIL+LDGGMGTMIQSYRL E D+RG RFADWP D+KGNNDLL+LS+P
Sbjct: 2    SSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKP 61

Query: 65   DVIAAIEKAYLDAGADILETNTFNATQISQADYGMESLVYELNVEGARIARQVADAKTLE 124
            +VIAAI  AY +AGADI+ETNTFN+T I+ ADY MESL  E+N   A++AR  AD  T  
Sbjct: 62   EVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTAR 121

Query: 125  TPDKPRFVAGVLGPTSRTCSISPDVNDPGFRNVTFDELVENYIEATRGLIEGGADLILIE 184
            TP+KPR+VAGVLGPT+RT SISPDVNDP FRN+TFD LV  Y E+T+ L+EGGADLILIE
Sbjct: 122  TPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLVAAYRESTKALVEGGADLILIE 181

Query: 185  TIFDTLNAKAAIFAVQQVFEDDNVELPIMISGTITDASGRTLSGQTTEAFWNSVRHAKPI 244
            T+FDTLNAKAA+FAV+  FE   VELPIMISGTITDASGRTLSGQTTEAF+NS+RHA+ +
Sbjct: 182  TVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEAL 241

Query: 245  SVGLNCALGAKDLRPYLEELATKADTHVSAHPNAGLPNAFGEYDETPAEMAAVVEEFAAS 304
            S GLNCALG  +LR Y++EL+  A+ +V+AHPNAGLPNAFGEYD     MA  + E+A +
Sbjct: 242  SFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQA 301

Query: 305  GFLNIIGGCCGTTPGHIQAIAEAVAKYKPREIPEIAKACRLSGLEPFTIDRQSLFVNVGE 364
            GFLNI+GGCCGTTP HI A++ AV    PR++PEI  ACRLSGLEP  I   SLFVNVGE
Sbjct: 302  GFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGE 361

Query: 365  RTNITGSAKFARLIREENYTEALEVALQQVEAGAQVIDINMDEGMLDSQAAMVRFLNLIA 424
            RTN+TGSAKF RLI+EE Y+EAL+VA QQVE GAQ+IDINMDEGMLD++AAMVRFLNLIA
Sbjct: 362  RTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIA 421

Query: 425  GEPDISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISMKEGVEQFKHHARLCKRYGAAVV 484
            GEPDI+RVPIMIDSSKW+VIE GLKCIQGKGIVNSISMKEGV+ F HHA+L +RYGAAVV
Sbjct: 422  GEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVV 481

Query: 485  VMAFDEVGQADTAARKKEICQRSYDILVNEVGFPPEDIIFDPNIFAVATGIEEHNNYAVD 544
            VMAFDE GQADT ARK EIC+R+Y IL  EVGFPPEDIIFDPNIFAVATGIEEHNNYA D
Sbjct: 482  VMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQD 541

Query: 545  FIEACAYIRDHLPHALSSGGVSNVSFSFRGNNPVREAIHSVFLYHAIQNGLTMGIVNAGQ 604
            FI AC  I+  LPHAL SGGVSNVSFSFRGN+PVREAIH+VFLY+AI+NG+ MGIVNAGQ
Sbjct: 542  FIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQ 601

Query: 605  LEIYDEIPAQLREKVEDVVLNRTPHGTDALLAIADDYKGGGA--TKEVENEEWRSLPVEK 662
            L IYD++PA+LR+ VEDV+LNR   GT+ LL +A+ Y+G     T   +  EWRS  V K
Sbjct: 602  LAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWEVNK 661

Query: 663  RLEHALVKGITAFIVEDTEACRQQCARPIEVIEGPLMNGMNVVGDLFGAGKMFLPQVVKS 722
            RLE++LVKGIT FI +DTE  RQQ  RPIEVIEGPLM+GMNVVGDLFG GKMFLPQVVKS
Sbjct: 662  RLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKS 721

Query: 723  ARVMKQAVAHLIPFIEAEKGDKPEAKGKILMATVKGDVHDIGKNIVGVVLGCNGYDIVDL 782
            ARVMKQAVA+L PFIEA K ++ +  GK+++ATVKGDVHDIGKNIVGVVL CN Y+IVDL
Sbjct: 722  ARVMKQAVAYLEPFIEASK-EQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL 780

Query: 783  GVMVPAEKILQTAREQKCDIIGLSGLITPSLDEMVHVAREMQRQGFELPLMIGGATTSKA 842
            GVMVPAEKIL+TA+E   D+IGLSGLITPSLDEMV+VA+EM+RQGF +PL+IGGATTSKA
Sbjct: 781  GVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA 840

Query: 843  HTAVKIEPKYSNDAVIYVTDASRAVGVATQLLSKELKPGFVEKTRLEYVDVRERTANRSA 902
            HTAVKIE  YS   V YV +ASR VGV   LLS   +  FV +TR EY  VR +   +  
Sbjct: 841  HTAVKIEQNYSGPTV-YVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKP 899

Query: 903  RTERLSYAQAIAAKPQYDWAGYQPTAPSFTGVKVLEDIDLRTLAEYIDWTPFFISWDLAG 962
            RT  ++   A      +DW  Y P      GV+ +E   + TL  YIDWTPFF++W LAG
Sbjct: 900  RTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVE-ASIETLRNYIDWTPFFMTWSLAG 958

Query: 963  KFPRILTDEVVGEAATALYKDAREMLDKLIDEKLISARAVFGFWPANQVDDDDIEVYGED 1022
            K+PRIL DEVVG  A  L+KDA +MLDKL  EK ++ R V G +PAN+V  DDIE+Y ++
Sbjct: 959  KYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRV-GDDIEIYRDE 1017

Query: 1023 GQ--ALATLHHLRQQTIKPDGKPNWSLADFVAPKDSGVTDYVGGFITTAGIGAEEVAKAY 1080
             +   +   HHLRQQT K  G  N+ LADFVAPK SG  DY+G F  T G+  + +A A+
Sbjct: 1018 TRTHVINVSHHLRQQTEK-TGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAF 1076

Query: 1081 QDKGDDYSSIMVKALADRLAEACAEWLHEQVRKEHWGYARDEHLDNEALIKEQYSGIRPA 1140
            + + DDY+ IMVKALADRLAEA AE+LHE+VRK +WGYA +E+L NE LI+E Y GIRPA
Sbjct: 1077 EAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPA 1136

Query: 1141 PGYPACPDHTEKETLFRLLDGTAIGETGPSGVYLTEHFAMFPAAAVSGWYFAHPQAKYFA 1200
            PGYPACP+HTEK T++ LL+         +G+ LTE FAM+P A+VSGWYF+HP +KY+A
Sbjct: 1137 PGYPACPEHTEKATIWELLE-----VEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYA 1191

Query: 1201 VGKVDKDQIERYSARKGQDISVSERWLAPNLGYDS 1235
            V ++ +DQ+E Y+ RKG  ++  ERWLAPNLGYD+
Sbjct: 1192 VAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDA 1226