Pairwise Alignments

Query, 693 a.a., Topoisomerase IA from Echinicola vietnamensis KMM 6221, DSM 17526

Subject, 860 a.a., DNA topoisomerase I (EC 5.99.1.2) from Sphingobium sp. HT1-2

 Score =  136 bits (343), Expect = 4e-36
 Identities = 172/659 (26%), Positives = 273/659 (41%), Gaps = 101/659 (15%)

Query: 1   MKTVIAEKPSVAREIASLLGATEKKEGHLTGNGYFVTWAFGHLVGLGMPEDYGITGFDKA 60
           M+ VI E P+ A+ I   LG             + V  ++GH+  L  P+D  +   +  
Sbjct: 1   MQLVIVESPAKAKTIEKYLGGD-----------FHVLASYGHIRDLP-PKDGSVDPDNGF 48

Query: 61  ALPILPHPFLLAVRKVKKDKGYTTDAGAIKQLKIIEQLFNRSDGIIVATDAGREGELIFR 120
           A+    +           DKG        KQLK I     ++  +I+ATD  REGE I  
Sbjct: 49  AMSWENYG----------DKG--------KQLKAIADEAKKATRLILATDPDREGEAISW 90

Query: 121 YIYEYLKCIKPF----QRLWISSLTEKAIKQGFDNLKDGKEFD-GLYQAAQGRSRADWLV 175
           ++ E L+  K       R+  +++T+ A+    D +   +  D  L  A + R   D+LV
Sbjct: 91  HVQEVLRAKKALPQTVDRVTFNAITKAAV---LDAMAKPRALDEDLIDAYRARRALDYLV 147

Query: 176 GINATQALSIAAGNGVYSLGRVQTPTLALICRRYLENKNFSVQKYWQIQLSHTKEFIEFK 235
           G   +  L      G  S GRVQ+  L L+  R  E ++F  Q+YW I     +    F 
Sbjct: 148 GFTLSPVLWRKLP-GAKSAGRVQSVALRLVVEREREIESFVPQEYWSISAEMEQGGQGFT 206

Query: 236 SLSKNKWDNQKLAKDTLKSIERNGNTAA-----------VTSVETKNVTEQPPLLFDLTG 284
           +    +W  +K+ + T   I + G+  A           V  VETK +T  PP  F  + 
Sbjct: 207 ARLV-RWKGEKIDRLT---IGKEGDAMAAKADVEAGRFTVDKVETKPLTRNPPPPFTTST 262

Query: 285 LQKEVNKKLNLSAEETLKIAQSLYEKKFITYPRTGSKYIPEDMWTEIPNLIRALQDRDTC 344
           LQ+E  +KL  SA  T++IAQ LYE   ITY RT    +     +     I    D    
Sbjct: 263 LQQEAARKLGFSASHTMRIAQQLYEDGAITYMRTDGVQMDGSAISAARKAIAERYDGGYL 322

Query: 345 KQAVAKVKWGRFNKRIVND-LRVTDHHGLLTTDTIPSALNAKENAVYDMIAFRLLEAISG 403
            +   + +    N +  ++ +R T+ H     D +    +A+   +YD+I  R L +   
Sbjct: 323 PEKPRQYQTKAKNAQEAHEAIRPTEFH----RDKVGGGDHAR---LYDLIFKRALASQMA 375

Query: 404 ACTKEATHITL--QALHYDFTTKGCKVLEPGWRSIKGNFTDD-DAEPIEDLPDIKEGDVL 460
           +   E T I +   +  +     G  V+ PG+ ++     DD + +  + LP + EGD  
Sbjct: 376 SARLERTTIDMVDGSGSHTLRATGQVVIFPGFLALYEEGRDDAEDDDSKLLPRLSEGDAP 435

Query: 461 KIKQAAVLEKKTKPPVLYTEAGLLSAMETAGKDIKNEEERKALQNIGIGTPATRAAIIET 520
             K+ +  +  T+PP  Y+EA L+                K L+ +GIG P+T A+ ++ 
Sbjct: 436 AKKKVSAEQHFTQPPPRYSEASLV----------------KKLEELGIGRPSTYASTLQV 479

Query: 521 LFTRNYIQREKKSLIPTEKGLQVYELVKD--RKIADVAMTAEWELALQKIETSEMN---- 574
           L  R+Y++ EK      E G  V   ++    +      TA  E  L +I          
Sbjct: 480 LKDRDYVRVEKNRFFAEESGRLVTAFLERFFERYVSYDFTAGLEDELDEISGGRAQWQEV 539

Query: 575 AIAFQKE--------MEAYTKSITGEL---LQTSI---AKDNSPELVCPKCKKQKLLIR 619
             AF K+        ME     IT EL   L+  +     D S    CP C   +L +R
Sbjct: 540 LEAFWKDFKPKTAEIMEQKPSDITAELDKFLEPMLFPPKADGSNPRACPLCADGQLSLR 598