SEED Subsystems in Klebsiella pneumoniae MRSN742743

Subsystems are shown if they have at least one gene assigned to them. Because many roles are assigned to more than one subsystem, the subsystem may not be present even if the gene annotation(s) are correct.

Category Subsystem #Genes
Amino Acids and Derivatives L-2-amino-thiazoline-4-carboxylic acid-Lcysteine conversion 2
Amino Acids and Derivatives : Alanine, serine, and glycine Alanine biosynthesis 7
  Glycine Biosynthesis 3
  Glycine and Serine Utilization 29
  Glycine cleavage system 6
  Serine Biosynthesis 9
Amino Acids and Derivatives : Arginine; urea cycle, polyamines Arginine Biosynthesis extended 11
  Arginine Deiminase Pathway 3
  Arginine and Ornithine Degradation 34
  Cyanophycin Metabolism 1
  Polyamine Metabolism 23
  Urea decomposition 13
Amino Acids and Derivatives : Aromatic amino acids and derivatives Aromatic amino acid degradation 14
  Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. 7
  Chorismate Synthesis 17
  Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) 16
  Phenylalanine and Tyrosine Branches from Chorismate 6
  Tryptophan synthesis 6
Amino Acids and Derivatives : Branched-chain amino acids Branched-Chain Amino Acid Biosynthesis 22
  Isoleucine degradation 5
  Ketoisovalerate oxidoreductase 1
  Leucine Biosynthesis 7
  Leucine Degradation and HMG-CoA Metabolism 3
  Valine degradation 5
Amino Acids and Derivatives : Glutamine, glutamate, aspartate, asparagine; ammonia assimilation Glutamate dehydrogenases 1
  Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 29
  Glutamine synthetases 1
Amino Acids and Derivatives : Histidine Metabolism Histidine Biosynthesis 8
  Histidine Degradation 7
Amino Acids and Derivatives : Lysine, threonine, methionine, and cysteine Cysteine Biosynthesis 20
  Lysine Biosynthesis DAP Pathway 11
  Lysine degradation 6
  Methionine Biosynthesis 33
  Methionine Degradation 23
  Methionine Salvage 5
  Threonine anaerobic catabolism gene cluster 11
  Threonine and Homoserine Biosynthesis 18
  Threonine degradation 6
Amino Acids and Derivatives : Proline and 4-hydroxyproline Proline, 4-hydroxyproline uptake and utilization 6
  Proline Synthesis 4
Carbohydrates Unknown sugar utilization (cluster yphABCDEFG) 2
Carbohydrates : Aminosugars Chitin and N-acetylglucosamine utilization 6
  N-Acetyl-Galactosamine and Galactosamine Utilization 3
Carbohydrates : CO2 fixation Calvin-Benson cycle 21
  Carboxysome 4
  Photorespiration (oxidative C2 cycle) 15
Carbohydrates : Central carbohydrate metabolism Dihydroxyacetone kinases 5
  Entner-Doudoroff Pathway 20
  Glycolate, glyoxylate interconversions 2
  Glycolysis and Gluconeogenesis 23
  Glycolysis and Gluconeogenesis, including Archaeal enzymes 16
  Methylglyoxal Metabolism 7
  Pentose phosphate pathway 18
  Pyruvate:ferredoxin oxidoreductase 1
  Pyruvate Alanine Serine Interconversions 13
  Pyruvate metabolism I: anaplerotic reactions, PEP 12
  Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 17
  TCA Cycle 19
Carbohydrates : Di- and oligosaccharides Beta-Glucoside Metabolism 30
  Fructooligosaccharides(FOS) and Raffinose Utilization 9
  Lactose and Galactose Uptake and Utilization 22
  Lactose utilization 8
  Maltose and Maltodextrin Utilization 36
  Melibiose Utilization 5
  Sucrose utilization 7
  Sucrose utilization Shewanella 2
  Trehalose Biosynthesis 5
  Trehalose Uptake and Utilization 15
Carbohydrates : Fermentation Acetoin, butanediol metabolism 11
  Acetyl-CoA fermentation to Butyrate 5
  Butanol Biosynthesis 8
  Fermentations: Lactate 5
  Fermentations: Mixed acid 18
Carbohydrates : Glycoside hydrolases Predicted carbohydrate hydrolases 2
Carbohydrates : Monosaccharides 2-Ketogluconate Utilization 5
  D-Galacturonate and D-Glucuronate Utilization 25
  D-Sorbitol(D-Glucitol) and L-Sorbose Utilization 6
  D-Tagatose and Galactitol Utilization 3
  D-galactarate, D-glucarate and D-glycerate catabolism 11
  D-galactonate catabolism 9
  D-gluconate and ketogluconates metabolism 12
  D-ribose utilization 28
  Deoxyribose and Deoxynucleoside Catabolism 13
  Fructose utilization 13
  Hexose Phosphate Uptake System 4
  L-Arabinose utilization 15
  L-ascorbate utilization (and related gene clusters) 10
  L-fucose utilization 9
  L-fucose utilization temp 1
  L-rhamnose utilization 22
  Mannose Metabolism 9
  Xylose utilization 15
Carbohydrates : One-carbon Metabolism One-carbon metabolism by tetrahydropterines 4
  Serine-glyoxylate cycle 27
Carbohydrates : Organic acids Alpha-acetolactate operon 2
  Isobutyryl-CoA to Propionyl-CoA Module 2
  Lactate utilization 5
  Malonate decarboxylase 15
  Propionate-CoA to Succinate Module 1
Carbohydrates : Polysaccharides Glycogen metabolism 7
Carbohydrates : Sugar alcohols Di-Inositol-Phosphate biosynthesis 3
  Ethanolamine utilization 22
  Glycerol and Glycerol-3-phosphate Uptake and Utilization 18
  Glycerol fermenation to 1,3-propanediol 7
  Inositol catabolism 20
  Mannitol Utilization 7
  Propanediol utilization 21
  Ribitol, Xylitol, Arabitol, Mannitol and Sorbitol utilization 15
Cell Division and Cell Cycle Bacterial Cytoskeleton 25
  Control of cell elongation - division cycle in Bacilli 1
  Macromolecular synthesis operon 5
  MukBEF Chromosome Condensation 5
  Two cell division clusters relating to chromosome partitioning 9
Cell Wall and Capsule Peptidoglycan Biosynthesis 27
  UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis 10
Cell Wall and Capsule : Capsular and extracellular polysacchrides Alginate metabolism 10
  CMP-N-acetylneuraminate Biosynthesis 1
  Capsular heptose biosynthesis 4
  Colanic acid biosynthesis 3
  O-Methyl Phosphoramidate Capsule Modification in Campylobacter 1
  Polysaccharide deacetylases 1
  Rhamnose containing glycans 8
  Sialic Acid Metabolism 15
  dTDP-rhamnose synthesis 7
Cell Wall and Capsule : Cell wall of Mycobacteria linker unit-arabinogalactan synthesis 7
  mycolic acid synthesis 9
Cell Wall and Capsule : Gram-Negative cell wall components KDO2-Lipid A biosynthesis 15
  LOS core oligosaccharide biosynthesis 12
  Lipid A-Ara4N pathway ( Polymyxin resistance ) 7
  Lipid A modifications 8
  Lipopolysaccharide-related cluster in Alphaproteobacteria 1
Cell Wall and Capsule : Gram-Positive cell wall components Teichoic and lipoteichoic acids biosynthesis 4
  Teichuronic acid biosynthesis 2
Clustering-based subsystems Bacterial Cell Division 25
  Bacterial RNA-metabolizing Zn-dependent hydrolases 6
  CBSS-214092.1.peg.3450 5
  CBSS-562.2.peg.5158 SK3 including 7
  Conserved gene cluster associated with Met-tRNA formyltransferase 16
  LMPTP YwlE cluster 4
  NusA-TFII Cluster 3
  PA0057 cluster 2
  Putative hemin transporter 1
  Putative sulfate assimilation cluster 3
Clustering-based subsystems : Clustering-based subsystems CBSS-262719.3.peg.410 2
Clustering-based subsystems : Lysine, threonine, methionine, and cysteine YeiH 4
Clustering-based subsystems : proteosome related Cluster-based Subsystem Grouping Hypotheticals - perhaps Proteosome Related 2
Cofactors, Vitamins, Prosthetic Groups, Pigments Thiamin biosynthesis 17
Cofactors, Vitamins, Prosthetic Groups, Pigments : Biotin Biotin biosynthesis 9
Cofactors, Vitamins, Prosthetic Groups, Pigments : Coenzyme A Coenzyme A Biosynthesis 11
Cofactors, Vitamins, Prosthetic Groups, Pigments : Folate and pterines Folate Biosynthesis 22
  Molybdenum cofactor biosynthesis 15
  Pterin biosynthesis 2
  p-Aminobenzoyl-Glutamate Utilization 7
Cofactors, Vitamins, Prosthetic Groups, Pigments : Lipoic acid Lipoic acid metabolism 6
Cofactors, Vitamins, Prosthetic Groups, Pigments : NAD and NADP NAD and NADP cofactor biosynthesis global 14
  NAD regulation 9
  PnuC-like transporters 2
Cofactors, Vitamins, Prosthetic Groups, Pigments : Pyridoxine Pyridoxin (Vitamin B6) Biosynthesis 19
Cofactors, Vitamins, Prosthetic Groups, Pigments : Quinone cofactors Coenzyme PQQ synthesis 4
  Menaquinone and Phylloquinone Biosynthesis 5
  Plastoquinone Biosynthesis 3
  Pyrroloquinoline Quinone biosynthesis 5
  Tocopherol Biosynthesis 3
  Ubiquinone Biosynthesis 11
Cofactors, Vitamins, Prosthetic Groups, Pigments : Riboflavin, FMN, FAD Flavodoxin 4
  Riboflavin, FMN and FAD metabolism 3
Cofactors, Vitamins, Prosthetic Groups, Pigments : Tetrapyrroles Cobalamin synthesis 15
  Coenzyme B12 biosynthesis 28
  Experimental tye 15
  Heme and Siroheme Biosynthesis 15
DNA Metabolism DNA structural proteins, bacterial 8
  Restriction-Modification System 2
  YcfH 3
DNA Metabolism : CRISPs CRISPRs 2
DNA Metabolism : DNA recombination RuvABC plus a hypothetical 3
DNA Metabolism : DNA repair 2-phosphoglycolate salvage 6
  DNA Repair Base Excision 12
  DNA repair, UvrABC system 4
  DNA repair, bacterial 29
  DNA repair, bacterial DinG and relatives 2
  DNA repair, bacterial MutL-MutS system 2
  DNA repair, bacterial RecFOR pathway 7
  DNA repair, bacterial UvrD and related helicases 3
DNA Metabolism : DNA replication DNA-replication 38
  DNA replication, archaeal 1
  DNA topoisomerases, Type I, ATP-independent 3
  DNA topoisomerases, Type II, ATP-dependent 4
  Plasmid replication 5
Fatty Acids, Lipids, and Isoprenoids Polyhydroxybutyrate metabolism 6
Fatty Acids, Lipids, and Isoprenoids : Fatty acids Fatty Acid Biosynthesis FASII 17
Fatty Acids, Lipids, and Isoprenoids : Isoprenoids Archaeal lipids 1
  Isoprenoid Biosynthesis 7
  polyprenyl synthesis 5
Fatty Acids, Lipids, and Isoprenoids : Phospholipids Glycerolipid and Glycerophospholipid Metabolism in Bacteria 30
Fatty Acids, Lipids, and Isoprenoids : Triacylglycerols Triacylglycerol metabolism 1
Iron acquisition and metabolism Campylobacter Iron Metabolism 7
  Heme, hemin uptake and utilization systems in GramPositives 2
  Hemin transport system 6
  Iron acquisition in Vibrio 20
  Transport of Iron 12
Iron acquisition and metabolism : Siderophores Siderophore Aerobactin 4
  Siderophore Enterobactin 11
Membrane Transport Choline Transport 1
  ECF class transporters 5
  Ton and Tol transport systems 15
  Transport of Manganese 6
  Transport of Molybdenum 4
  Transport of Nickel and Cobalt 11
  Transport of Zinc 8
Membrane Transport : ABC transporters ABC transporter alkylphosphonate (TC 3.A.1.9.1) 4
  ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 14
  ABC transporter dipeptide (TC 3.A.1.5.2) 20
  ABC transporter oligopeptide (TC 3.A.1.5.1) 15
Membrane Transport : Protein and nucleoprotein secretion system, Type IV Type IV pilus 14
  pVir Plasmid of Campylobacter 2
Membrane Transport : Protein secretion system, Type III Type III secretion system orphans 2
Membrane Transport : Protein secretion system, Type VIII (Extracellular nucleation/precipitation pathway, ENP) Curli production 1
Membrane Transport : Protein translocation across cytoplasmic membrane Twin-arginine translocation system 5
Membrane Transport : Sugar Phosphotransferase Systems, PTS Fructose and Mannose Inducible PTS 2
Membrane Transport : Uni- Sym- and Antiporters Na(+) H(+) antiporter 1
Metabolism of Aromatic Compounds Aromatic Amin Catabolism 6
  Benzoate transport and degradation cluster 3
  Gentisare degradation 4
Metabolism of Aromatic Compounds : Metabolism of central aromatic intermediates 4-Hydroxyphenylacetic acid catabolic pathway 11
  Catechol branch of beta-ketoadipate pathway 9
  Central meta-cleavage pathway of aromatic compound degradation 7
  Homogentisate pathway of aromatic compound degradation 4
  Protocatechuate branch of beta-ketoadipate pathway 13
  Salicylate and gentisate catabolism 5
Metabolism of Aromatic Compounds : Peripheral pathways for catabolism of aromatic compounds Benzoate degradation 5
  Biphenyl Degradation 2
  Chloroaromatic degradation pathway 3
  Phenylpropanoid compound degradation 5
  Quinate degradation 4
  Salicylate ester degradation 1
  n-Phenylalkanoic acid degradation 3
  p-Hydroxybenzoate degradation 5
Miscellaneous Muconate lactonizing enzyme family 2
  YaaA 1
  YbbK 2
  ZZ gjo need homes 17
Miscellaneous : Plant-Prokaryote DOE project Conserved gene cluster possibly involved in RNA metabolism 2
  Synechocystis experimental 1
Motility and Chemotaxis Bacterial Chemotaxis 7
Motility and Chemotaxis : Flagellar motility in Prokaryota Flagellar motility 1
  Flagellum 2
  Flagellum in Campylobacter 3
Nitrogen Metabolism Allantoin Utilization 4
  Ammonia assimilation 10
  Cyanate hydrolysis 6
  Dissimilatory nitrite reductase 3
  Nitrate and nitrite ammonification 19
  Nitric oxide synthase 1
  Nitrosative stress 6
Nucleosides and Nucleotides Adenosyl nucleosidases 2
  Hydantoin metabolism 4
  Ribonucleotide reduction 9
Nucleosides and Nucleotides : Detoxification Nudix proteins (nucleoside triphosphate hydrolases) 14
Nucleosides and Nucleotides : Purines De Novo Purine Biosynthesis 12
  Purine Utilization 9
  Purine conversions 24
  Purine nucleotide synthesis regulator 1
Nucleosides and Nucleotides : Pyrimidines De Novo Pyrimidine Synthesis 11
  Pyrimidine utilization 11
Phages, Prophages, Transposable elements, Plasmids : Pathogenicity islands Staphylococcal pathogenicity islands SaPI 9
Phages, Prophages, Transposable elements, Plasmids : Phages, Prophages IbrA and IbrB: co-activators of prophage gene expression 2
  Staphylococcal phi-Mu50B-like prophages 1
Phages, Prophages, Transposable elements, Plasmids : Transposable elements Tn552 1
Phosphorus Metabolism Alkylphosphonate utilization 14
  High affinity phosphate transporter and control of PHO regulon 9
  Phosphate metabolism 27
  Phosphonate metabolism 7
Potassium metabolism Glutathione-regulated potassium-efflux system and associated functions 6
  Potassium homeostasis 20
Protein Metabolism : Protein biosynthesis Ribosome LSU bacterial 29
  Ribosome SSU bacterial 19
  Ribosome activity modulation 3
  Ribosome biogenesis bacterial 14
  Trans-translation by stalled ribosomes 1
  Translation elongation factor G family 2
  Translation elongation factors eukaryotic and archaeal 1
  Translation initiation factors eukaryotic and archaeal 2
  Universal GTPases 14
  tRNA aminoacylation, Asp and Asn 2
  tRNA aminoacylation, Glu and Gln 2
Protein Metabolism : Protein degradation Proteasome bacterial 6
  Protein degradation 3
  Proteolysis in bacteria, ATP-dependent 15
  Putative TldE-TldD proteolytic complex 1
Protein Metabolism : Protein folding GroEL GroES 2
  Peptidyl-prolyl cis-trans isomerase 3
  Periplasmic disulfide interchange 6
  Protein chaperones 10
Protein Metabolism : Protein processing and modification Ribosomal protein S12p Asp methylthiotransferase 3
  Ribosomal protein S5p acylation 2
  Signal peptidase 2
Protein Metabolism : Selenoproteins Glycine reductase, sarcosine reductase and betaine reductase 2
  Selenocysteine metabolism 4
RNA Metabolism : RNA processing and modification ATP-dependent RNA helicases, bacterial 3
  Polyadenylation bacterial 4
  Queuosine-Archaeosine Biosynthesis 24
  RNA processing and degradation, bacterial 9
  Ribonuclease H 2
  Wyeosine-MimG Biosynthesis 3
  tRNA nucleotidyltransferase 1
  tRNA processing 10
RNA Metabolism : Transcription RNA polymerase bacterial 4
  Rrf2 family transcriptional regulators 3
  Transcription factors bacterial 10
  Transcription factors cyanobacterial RpoD-like sigma factors 1
  Transcription initiation, bacterial sigma factors 8
Regulation and Cell signaling CytR regulation 2
  DNA-binding regulatory proteins, strays 21
  Orphan regulatory proteins 22
  Pseudomonas quinolone signal PQS 1
  Sex pheromones in Enterococcus faecalis and other Firmicutes 6
  Stringent Response, (p)ppGpp metabolism 1
  cAMP signaling in bacteria 10
Regulation and Cell signaling : Programmed Cell Death and Toxin-antitoxin Systems Murein hydrolase regulation and cell death 11
Regulation and Cell signaling : Quorum sensing and biofilm formation Autoinducer 2 (AI-2) transport and processing (lsrACDBFGE operon) 9
  Quorum Sensing: Autoinducer-2 Synthesis 1
  Quorum sensing regulation in Pseudomonas 1
Respiration Biogenesis of c-type cytochromes 13
  Biogenesis of cytochrome c oxidases 2
  Formate hydrogenase 13
  Soluble cytochromes and functionally related electron carriers 5
Respiration : ATP synthases F0F1-type ATP synthase 6
Respiration : Electron accepting reactions Anaerobic respiratory reductases 7
  Terminal cytochrome O ubiquinol oxidase 4
  Terminal cytochrome d ubiquinol oxidases 8
  Terminal cytochrome oxidases 12
Respiration : Electron donating reactions Formate dehydrogenase 5
  Hydrogenases 1
  Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 12
  NiFe hydrogenase maturation 6
  Respiratory Complex I 12
  Respiratory dehydrogenases 1 15
  Succinate dehydrogenase 9
Secondary Metabolism : Aromatic amino acids and derivatives Cinnamic Acid Degradation 9
Secondary Metabolism : Bacterial cytostatics, differentiation factors and antibiotics Phenazine biosynthesis 1
Secondary Metabolism : Biosynthesis of phenylpropanoids Phenylpropionate Degradation 1
Secondary Metabolism : Plant Hormones Auxin biosynthesis 5
  Auxin degradation 1
Stress Response Bacterial hemoglobins 2
  Flavohaemoglobin 1
  Hfl operon 5
  Sugar-phosphate stress regulation 1
  Universal stress protein family 8
Stress Response : Acid stress Acid resistance mechanisms 1
Stress Response : Detoxification Glutathione-dependent pathway of formaldehyde detoxification 2
Stress Response : Heat shock Heat shock dnaK gene cluster extended 15
Stress Response : Osmotic stress Choline and Betaine Uptake and Betaine Biosynthesis 8
Stress Response : Oxidative stress Glutaredoxins 5
  Glutathione: Biosynthesis and gamma-glutamyl cycle 4
  Glutathione: Non-redox reactions 15
  Glutathione: Redox cycle 4
  Glutathionylspermidine and Trypanothione 2
  Oxidative stress 20
  Redox-dependent regulation of nucleus processes 5
  Rubrerythrin 1
Sulfur Metabolism Galactosylceramide and Sulfatide metabolism 6
  Sulfate reduction-associated complexes 1
  Sulfur oxidation 1
  Thioredoxin-disulfide reductase 8
Sulfur Metabolism : Organic sulfur assimilation Alkanesulfonate assimilation 14
  Alkanesulfonates Utilization 10
  Taurine Utilization 4
  Utilization of glutathione as a sulphur source 2
Virulence : Type III, Type IV, Type VI, ESAT secretion systems Type 4 secretion and conjugative transfer 3
Virulence, Disease and Defense : Detection MLST 5
Virulence, Disease and Defense : Resistance to antibiotics and toxic compounds Arsenic resistance 5
  Beta-lactamase 3
  Cobalt-zinc-cadmium resistance 14
  Copper homeostasis 7
  Copper homeostasis: copper tolerance 9
  Fosfomycin resistance 1
  Methicillin resistance in Staphylococci 4
  Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria 6
  Multidrug Resistance Efflux Pumps 20
  Multidrug efflux pump in Campylobacter jejuni (CmeABC operon) 9
  Resistance to fluoroquinolones 4
  Zinc resistance 3