SEED Subsystem: Coenzyme B12 biosynthesis in Pseudomonas simiae WCS417

Experiments:

Role Gene Name  
5,6-dimethylbenzimidazole synthase, flavin destructase family No genes
ATPase component CbiO of energizing module of cobalt ECF transporter No genes
Additional lipoprotein component of predicted cobalamin ECF transporter No genes
Additional substrate-specific component CbiN of cobalt ECF transporter No genes
Adenosylcobinamide amidohydrolase (EC 3.5.1.90) No genes
Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) PS417_20035
Adenosylcobinamide-phosphate synthase No genes
Aerobic cobaltochelatase CobS subunit (EC 6.6.1.2) No genes
Aerobic cobaltochelatase CobT subunit (EC 6.6.1.2) No genes
Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) PS417_20025
CblX, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase No genes
CblY, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase No genes
CblZ, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase No genes
ChlD component of cobalt chelatase involved in B12 biosynthesis PS417_12360
ChlI component of cobalt chelatase involved in B12 biosynthesis PS417_12355
Cob(I)alamin adenosyltransferase (EC 2.5.1.17) PS417_20065
Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) No genes
Cob(II)alamin reductase No genes
CobN component of cobalt chelatase involved in B12 biosynthesis PS417_12350
CobW GTPase involved in cobalt insertion for B12 biosynthesis PS417_12345
Cobalamin biosynthesis protein CbiG PS417_02915
Cobalamin biosynthesis protein CobG PS417_02900
Cobalamin synthase No genes
Cobalamine-related hypothetical metal-binding protein CrdX No genes
Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) PS417_02910
Cobalt-precorrin-3b C17-methyltransferase PS417_12330
  PS417_02915
Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) PS417_12325
Cobalt-precorrin-6 synthase, anaerobic No genes
Cobalt-precorrin-6x reductase (EC 1.3.1.54) PS417_02890
Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) PS417_02895
Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) PS417_02895
Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) PS417_02905
Cobyric acid synthase No genes
Cobyrinic acid A,C-diamide synthase PS417_20060
Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter No genes
HoxN/HupN/NixA family cobalt transporter No genes
HupE-UreJ family cobalt transporter No genes
L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) PS417_20045
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) PS417_20030
Optional hypothetical component of the B12 transporter BtuM No genes
Optional hypothetical component of the B12 transporter BtuN No genes
Outer membrane vitamin B12 receptor BtuB PS417_11940
  PS417_25210
Precorrin-6A synthase (EC 2.1.1.152) PS417_11405
Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62) No genes
Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73) No genes
Predicted alpha-ribazole-5-phosphate synthase CblS for cobalamin biosynthesis No genes
Predicted cobalt ABC transporter periplasmic component No genes
Predicted cobalt transporter CbtA PS417_12335
Predicted cobalt transporter CbtC No genes
Predicted cobalt transporter in Bacteroides_Porphyromonas No genes
Predicted cobalt transporter in Mycobacteria No genes
Predicted cobalt transporter in Thermoplasma No genes
Predicted cobalt transporter in sulfate-reducing delta-proteobacteria No genes
Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis No genes
Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) No genes
Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) No genes
Substrate-specific component CbiM of cobalt ECF transporter No genes
Substrate-specific component CblT of predicted B12-regulated ECF transporter for dimethylbenzimidazole No genes
Substrate-specific component CbrT of predicted cobalamin ECF transporter No genes
Threonine kinase in B12 biosynthesis No genes
Transmembrane component CbiQ of energizing module of cobalt ECF transporter No genes
Transmembrane component CbrV of energizing module of predicted cobalamin ECF transporter No genes
Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) PS417_16465
  PS417_20980
Vitamin B12 ABC transporter, ATPase component BtuD No genes
Vitamin B12 ABC transporter, B12-binding component BtuF PS417_25215
  PS417_25220
Vitamin B12 ABC transporter, permease component BtuC No genes

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