SEED Subsystem: Folate Biosynthesis in Variovorax sp. SCN45

Role	Gene	Name
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3)	GFF3944
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2)	GFF5164
	GFF7649
5-nucleotidase SurE (EC 3.1.3.5)	GFF2845
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12)	No genes
ATPase component of general energizing module of ECF transporters	No genes
Alternative Folylglutamate Synthase	No genes
Alternative dihydrofolate reductase 2	No genes
Alternative dihydrofolate reductase 3	GFF3720
Aminodeoxychorismate lyase (EC 4.1.3.38)	GFF6781
COG0488: ATPase components of ABC transporters with duplicated ATPase domains	GFF3812
Dihydrofolate reductase (EC 1.5.1.3)	GFF1730
	GFF3005
	GFF4143
Dihydrofolate synthase (EC 6.3.2.12)	No genes
Dihydroneopterin aldolase (EC 4.1.2.25)	GFF7307
Dihydroneopterin triphosphate epimerase	No genes
Dihydroneopterin triphosphate pyrophosphohydolase	No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2	GFF2550
Dihydropteroate synthase (EC 2.5.1.15)	GFF368
FolM Alternative dihydrofolate reductase 1	GFF7306
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB)	No genes
Folate transporter 3	No genes
Folylpolyglutamate synthase (EC 6.3.2.17)	No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3)	No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1	GFF2552
	GFF7631
GTP cyclohydrolase I (EC 3.5.4.16) type 2	GFF7703
Methionyl-tRNA formyltransferase (EC 2.1.2.9)	GFF5493
	GFF7566
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5)	GFF964
Non functional Dihydropteroate synthase 2	No genes
Nucleoside triphosphate pyrophosphohydrolase MazG	No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85)	GFF1457
	GFF5374
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85)	GFF1457
	GFF6781
PqqC-like protein	No genes
Putative DHNTP pyrophosphatase	No genes
Related to Dihydropteroate synthase	No genes
Serine hydroxymethyltransferase (EC 2.1.2.1)	GFF4463
	GFF560
Substrate-specific component FolT of folate ECF transporter	No genes
Thymidine kinase (EC 2.7.1.21)	No genes
Thymidylate synthase (EC 2.1.1.45)	GFF3004
	GFF7987
Thymidylate synthase thyX (EC 2.1.1.-)	No genes
Transaldolase (EC 2.2.1.2)	GFF5266
	GFF5278
Transmembrane component of general energizing module of ECF transporters	No genes
Xanthosine/inosine triphosphate pyrophosphatase	No genes
alternate gene name: yzbB	No genes