SEED Subsystem: Folate Biosynthesis in Variovorax sp. OAS795

Experiments:

Role Gene Name  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) ABID97_RS08715
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) ABID97_RS06600
5-nucleotidase SurE (EC 3.1.3.5) ABID97_RS10715
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 ABID97_RS00350
Aminodeoxychorismate lyase (EC 4.1.3.38) No genes
COG0488: ATPase components of ABC transporters with duplicated ATPase domains ABID97_RS00005
Dihydrofolate reductase (EC 1.5.1.3) ABID97_RS02965
  ABID97_RS10035
  ABID97_RS11755
  ABID97_RS27230
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) ABID97_RS06510
  ABID97_RS12600
Dihydroneopterin triphosphate epimerase No genes
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 ABID97_RS07295
Dihydropteroate synthase (EC 2.5.1.15) ABID97_RS17040
FolM Alternative dihydrofolate reductase 1 ABID97_RS06515
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 ABID97_RS07305
GTP cyclohydrolase I (EC 3.5.4.16) type 2 No genes
Methionyl-tRNA formyltransferase (EC 2.1.2.9) ABID97_RS01810
  ABID97_RS13595
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) ABID97_RS14085
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) ABID97_RS02320
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) No genes
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase ABID97_RS12615
Serine hydroxymethyltransferase (EC 2.1.2.1) ABID97_RS17890
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) ABID97_RS10040
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) ABID97_RS07095
  ABID97_RS07140
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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