SEED Subsystem: Coenzyme B12 biosynthesis in Sphingobium sp. HT1-2

Experiments:

Role Gene Name  
5,6-dimethylbenzimidazole synthase, flavin destructase family No genes
ATPase component CbiO of energizing module of cobalt ECF transporter No genes
Additional lipoprotein component of predicted cobalamin ECF transporter No genes
Additional substrate-specific component CbiN of cobalt ECF transporter No genes
Adenosylcobinamide amidohydrolase (EC 3.5.1.90) No genes
Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) GFF823
Adenosylcobinamide-phosphate synthase No genes
Aerobic cobaltochelatase CobS subunit (EC 6.6.1.2) GFF3334
Aerobic cobaltochelatase CobT subunit (EC 6.6.1.2) GFF3336
Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) GFF827
CblX, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase No genes
CblY, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase No genes
CblZ, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase No genes
ChlD component of cobalt chelatase involved in B12 biosynthesis No genes
ChlI component of cobalt chelatase involved in B12 biosynthesis No genes
Cob(I)alamin adenosyltransferase (EC 2.5.1.17) GFF877
Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) No genes
Cob(II)alamin reductase No genes
CobN component of cobalt chelatase involved in B12 biosynthesis GFF878
CobW GTPase involved in cobalt insertion for B12 biosynthesis GFF879
Cobalamin biosynthesis protein CbiG No genes
Cobalamin biosynthesis protein CobG GFF1860
Cobalamin synthase GFF826
Cobalamine-related hypothetical metal-binding protein CrdX No genes
Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) GFF1858
Cobalt-precorrin-3b C17-methyltransferase GFF1857
Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) GFF1853
Cobalt-precorrin-6 synthase, anaerobic No genes
Cobalt-precorrin-6x reductase (EC 1.3.1.54) GFF1856
Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) GFF1855
Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) GFF1855
Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) GFF1859
Cobyric acid synthase No genes
Cobyrinic acid A,C-diamide synthase GFF1852
Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter No genes
HoxN/HupN/NixA family cobalt transporter GFF3027
HupE-UreJ family cobalt transporter No genes
L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) GFF825
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) GFF828
Optional hypothetical component of the B12 transporter BtuM No genes
Optional hypothetical component of the B12 transporter BtuN GFF3028
Outer membrane vitamin B12 receptor BtuB GFF3029
  GFF313
  GFF830
Precorrin-6A synthase (EC 2.1.1.152) GFF1851
Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62) No genes
Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73) No genes
Predicted alpha-ribazole-5-phosphate synthase CblS for cobalamin biosynthesis No genes
Predicted cobalt ABC transporter periplasmic component No genes
Predicted cobalt transporter CbtA No genes
Predicted cobalt transporter CbtC No genes
Predicted cobalt transporter in Bacteroides_Porphyromonas No genes
Predicted cobalt transporter in Mycobacteria No genes
Predicted cobalt transporter in Thermoplasma No genes
Predicted cobalt transporter in sulfate-reducing delta-proteobacteria No genes
Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis No genes
Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) No genes
Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) No genes
Substrate-specific component CbiM of cobalt ECF transporter No genes
Substrate-specific component CblT of predicted B12-regulated ECF transporter for dimethylbenzimidazole No genes
Substrate-specific component CbrT of predicted cobalamin ECF transporter No genes
Threonine kinase in B12 biosynthesis No genes
Transmembrane component CbiQ of energizing module of cobalt ECF transporter No genes
Transmembrane component CbrV of energizing module of predicted cobalamin ECF transporter No genes
Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) GFF1180
  GFF1450
  GFF3796
Vitamin B12 ABC transporter, ATPase component BtuD GFF311
Vitamin B12 ABC transporter, B12-binding component BtuF GFF832
Vitamin B12 ABC transporter, permease component BtuC GFF312

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