SEED Subsystem: Methionine Biosynthesis in Pseudomonas putida KT2440

Experiments:

Role Gene Name  
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) PP_4638
  PP_4977
5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) PP_2375
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) PP_2698
  PP_4637
Adenosylhomocysteinase (EC 3.3.1.1) PP_4976
Archaeal S-adenosylmethionine synthetase (EC 2.5.1.6) No genes
Betaine--homocysteine S-methyltransferase (EC 2.1.1.5) No genes
Cystathionine beta-lyase (EC 4.4.1.8) PP_4348
Cystathionine beta-lyase, type II (EC 4.4.1.8) No genes
Cystathionine beta-synthase (EC 4.2.1.22) No genes
Cystathionine gamma-lyase (EC 4.4.1.1) PP_4594
Cystathionine gamma-synthase (EC 2.5.1.48) PP_0659
Cysteine synthase (EC 2.5.1.47) PP_1113
  PP_4571
Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter No genes
Homocysteine S-methyltransferase (EC 2.1.1.10) PP_0658
  PP_2776
Homoserine O-acetyltransferase (EC 2.3.1.31) PP_5097
Homoserine O-succinyltransferase (EC 2.3.1.46) No genes
Homoserine dehydrogenase (EC 1.1.1.3) PP_0664
  PP_1470
Homoserine kinase (EC 2.7.1.39) PP_0121
Methionine ABC transporter ATP-binding protein PP_0114
  PP_0220
  PP_0507
Methionine ABC transporter permease protein PP_0113
  PP_0219
Methionine ABC transporter substrate-binding protein PP_0112
  PP_0221
  PP_5165
Methionine repressor MetJ No genes
Methionine synthase activation domain (EC 2.1.1.13) No genes
Methionine transporter MetT No genes
O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) PP_0875
  PP_2001
  PP_2528
  PP_2549
  PP_4548
O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) PP_2001
  PP_2528
Predicted regulator of methionine metabolism, ArsR family No genes
S-adenosylhomocysteine nucleosidase (EC 3.2.2.9) PP_3254
S-adenosylmethionine synthetase (EC 2.5.1.6) PP_4967
S-ribosylhomocysteine lyase (EC 4.4.1.21) No genes
SAM-dependent methlytransferase UbiG No genes
SAM-dependent methlytransferase YrrT No genes
Serine acetyltransferase (EC 2.3.1.30) PP_0228
  PP_0385
  PP_0840
  PP_3136
Substrate-specific component MtsA of methionine-regulated ECF transporter No genes
Transcriptional activator MetR PP_1063
  PP_2696
Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter No genes

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