SEED Subsystem: Folate Biosynthesis in Paraburkholderia sabiae LMG 24235

Experiments:

Role Gene Name  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) QEN71_RS26470
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) QEN71_RS28640
5-nucleotidase SurE (EC 3.1.3.5) QEN71_RS22255
  QEN71_RS32145
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 QEN71_RS02395
Aminodeoxychorismate lyase (EC 4.1.3.38) QEN71_RS26485
COG0488: ATPase components of ABC transporters with duplicated ATPase domains QEN71_RS24715
Dihydrofolate reductase (EC 1.5.1.3) QEN71_RS04275
  QEN71_RS20955
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) QEN71_RS28600
  QEN71_RS32800
  QEN71_RS34075
Dihydroneopterin triphosphate epimerase No genes
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 QEN71_RS02045
Dihydropteroate synthase (EC 2.5.1.15) QEN71_RS04810
FolM Alternative dihydrofolate reductase 1 QEN71_RS28605
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 QEN71_RS18075
GTP cyclohydrolase I (EC 3.5.4.16) type 2 QEN71_RS15225
Methionyl-tRNA formyltransferase (EC 2.1.2.9) QEN71_RS00160
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) QEN71_RS05700
  QEN71_RS33970
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) QEN71_RS03945
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) QEN71_RS26485
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase QEN71_RS32785
  QEN71_RS34065
Serine hydroxymethyltransferase (EC 2.1.2.1) QEN71_RS08310
  QEN71_RS11055
  QEN71_RS26235
  QEN71_RS33600
  QEN71_RS34010
  QEN71_RS34315
  QEN71_RS35520
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) QEN71_RS00815
  QEN71_RS04325
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) QEN71_RS24595
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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