SEED Subsystem: Leucine Degradation and HMG-CoA Metabolism in Hydrogenophaga sp. GW460-11-11-14-LB1

Experiments:

Role Gene Name  
Acetoacetyl-CoA synthetase (EC 6.2.1.16) GFF1990
  GFF4967
  GFF884
Acetoacetyl-CoA synthetase [leucine] (EC 6.2.1.16) GFF3724
  GFF4131
Biotin carboxyl carrier protein of methylcrotonyl-CoA carboxylase No genes
Biotin carboxylase of methylcrotonyl-CoA carboxylase (EC 6.3.4.14) No genes
Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12) No genes
Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4) No genes
Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4) No genes
Branched-chain amino acid aminotransferase (EC 2.6.1.42) GFF1835
Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168) GFF611
Dihydrolipoamide dehydrogenase (EC 1.8.1.4) No genes
Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase (EC 1.8.1.4) No genes
Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) GFF1709
  GFF3043
  GFF3044
  GFF3083
  GFF3084
  GFF982
Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.34) No genes
Hydroxymethylglutaryl-CoA synthase (EC 2.3.3.10) GFF5666
Isovaleryl-CoA dehydrogenase (EC 1.3.99.10) No genes
Leucine dehydrogenase (EC 1.4.1.9) No genes
Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4) GFF1711
  GFF483
  GFF873
  GFF917
  GFF945
  GFF946
  GFF981
  GFF987
Methylcrotonyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.4) GFF1715
  GFF874
  GFF922
  GFF944
  GFF980
  GFF985
Methylglutaconyl-CoA hydratase (EC 4.2.1.18) GFF1713
  GFF986
Predicted transcriptional regulator of leucine degradation pathway, MerR family No genes
Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A (EC 2.8.3.5) GFF5197
Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B (EC 2.8.3.5) GFF5196

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