SEED Subsystem: Folate Biosynthesis in Pseudomonas aeruginosa MRSN321

Experiments:

Role Gene Name  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) DY961_RS22940 folK;go_function=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) DY961_RS12015
5-nucleotidase SurE (EC 3.1.3.5) No genes
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) DY961_RS02155 pabC;go_function=4-amino-4-deoxychorismate
COG0488: ATPase components of ABC transporters with duplicated ATPase domains DY961_RS01865
  DY961_RS05780
Dihydrofolate reductase (EC 1.5.1.3) DY961_RS15575
  DY961_RS21720
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) DY961_RS22935 folB;go_function=dihydroneopterin
Dihydroneopterin triphosphate epimerase DY961_RS15735 folX;go_function=dihydroneopterin
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) DY961_RS09505 folP;go_function=dihydropteroate
FolM Alternative dihydrofolate reductase 1 DY961_RS15745 folM;go_function=oxidoreductase
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 DY961_RS15740 folE;go_function=GTP
  DY961_RS20035 folE;go_function=GTP
GTP cyclohydrolase I (EC 3.5.4.16) type 2 DY961_RS26000 folE2;go_function=GTP
Methionyl-tRNA formyltransferase (EC 2.1.2.9) DY961_RS26290 fmt;go_component=cytoplasm|0005737||IEA;go_function=methionyl-tRNA
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) DY961_RS20675 folD;go_function=methylenetetrahydrofolate
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) No genes
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) DY961_RS20470 pabB;go_function=4-amino-4-deoxychorismate
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) DY961_RS23420 glyA;go_function=glycine
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) DY961_RS21680
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) DY961_RS03070 tal;go_function=transaldolase
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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