SEED Subsystem: Folate Biosynthesis in Methylophilus sp. DMC18

Experiments:

Role Gene Name  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) GFF2605
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) No genes
5-nucleotidase SurE (EC 3.1.3.5) GFF450
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) GFF627
COG0488: ATPase components of ABC transporters with duplicated ATPase domains GFF567
Dihydrofolate reductase (EC 1.5.1.3) GFF1061
Dihydrofolate synthase (EC 6.3.2.12) GFF659
Dihydroneopterin aldolase (EC 4.1.2.25) GFF2343
Dihydroneopterin triphosphate epimerase No genes
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 GFF2203
Dihydropteroate synthase (EC 2.5.1.15) GFF318
FolM Alternative dihydrofolate reductase 1 GFF1543
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) GFF659
Formate--tetrahydrofolate ligase (EC 6.3.4.3) GFF1024
GTP cyclohydrolase I (EC 3.5.4.16) type 1 No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 2 GFF1698
Methionyl-tRNA formyltransferase (EC 2.1.2.9) GFF1497
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) No genes
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) No genes
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) GFF1295
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase GFF1229
Serine hydroxymethyltransferase (EC 2.1.2.1) GFF72
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) GFF1165
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) GFF1289
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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