SEED Subsystem: Folate Biosynthesis in Klebsiella pneumoniae MRSN742743

Role	Gene	Name
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3)	KFA93_RS11700	folK;inference=COORDINATES
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2)	KFA93_RS18325
5-nucleotidase SurE (EC 3.1.3.5)	No genes
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12)	No genes
ATPase component of general energizing module of ECF transporters	No genes
Alternative Folylglutamate Synthase	No genes
Alternative dihydrofolate reductase 2	No genes
Alternative dihydrofolate reductase 3	No genes
Aminodeoxychorismate lyase (EC 4.1.3.38)	KFA93_RS00180	pabC;go_function=4-amino-4-deoxychorismate
COG0488: ATPase components of ABC transporters with duplicated ATPase domains	KFA93_RS00725
Dihydrofolate reductase (EC 1.5.1.3)	KFA93_RS11200	folA;go_function=dihydrofolate
Dihydrofolate synthase (EC 6.3.2.12)	KFA93_RS05945	folC;go_function=tetrahydrofolylpolyglutamate
Dihydroneopterin aldolase (EC 4.1.2.25)	KFA93_RS12550	folB;go_function=dihydroneopterin
Dihydroneopterin triphosphate epimerase	KFA93_RS06015	folX;go_function=dihydroneopterin
Dihydroneopterin triphosphate pyrophosphohydolase	No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2	No genes
Dihydropteroate synthase (EC 2.5.1.15)	KFA93_RS13210	folP;go_function=dihydropteroate
FolM Alternative dihydrofolate reductase 1	KFA93_RS22310	folM;go_function=oxidoreductase
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB)	No genes
Folate transporter 3	No genes
Folylpolyglutamate synthase (EC 6.3.2.17)	KFA93_RS05945	folC;go_function=tetrahydrofolylpolyglutamate
Formate--tetrahydrofolate ligase (EC 6.3.4.3)	No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1	KFA93_RS06520	folE;go_function=GTP
GTP cyclohydrolase I (EC 3.5.4.16) type 2	No genes
Methionyl-tRNA formyltransferase (EC 2.1.2.9)	KFA93_RS24760	fmt;go_component=cytoplasm|0005737||IEA;go_function=methionyl-tRNA
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5)	KFA93_RS03235	folD;go_function=methylenetetrahydrofolate
Non functional Dihydropteroate synthase 2	No genes
Nucleoside triphosphate pyrophosphohydrolase MazG	No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85)	KFA93_RS10300	pabA;inference=COORDINATES
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85)	KFA93_RS07910	pabB;go_process=folic
PqqC-like protein	No genes
Putative DHNTP pyrophosphatase	No genes
Related to Dihydropteroate synthase	No genes
Serine hydroxymethyltransferase (EC 2.1.2.1)	KFA93_RS04805	glyA;go_function=glycine
Substrate-specific component FolT of folate ECF transporter	No genes
Thymidine kinase (EC 2.7.1.21)	KFA93_RS15860	tdk;inference=COORDINATES
Thymidylate synthase (EC 2.1.1.45)	KFA93_RS17760	thyA;go_function=thymidylate
Thymidylate synthase thyX (EC 2.1.1.-)	No genes
Transaldolase (EC 2.2.1.2)	KFA93_RS00005	tal;go_component=cytoplasm|0005737||IEA;go_function=transaldolase
	KFA93_RS05460	tal;go_component=cytoplasm|0005737||IEA;go_function=transaldolase
	KFA93_RS11065	tal;go_component=cytoplasm|0005737||IEA;go_function=transaldolase
	KFA93_RS22815	fsa;go_function=aldehyde-lyase
Transmembrane component of general energizing module of ECF transporters	No genes
Xanthosine/inosine triphosphate pyrophosphatase	No genes
alternate gene name: yzbB	No genes