SEED Subsystem: Folate Biosynthesis in Klebsiella pneumoniae MKP103

Experiments:

Role Gene Name  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) KDGMDA_13255
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) KDGMDA_04415
5-nucleotidase SurE (EC 3.1.3.5) No genes
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) KDGMDA_18710
COG0488: ATPase components of ABC transporters with duplicated ATPase domains KDGMDA_18165
Dihydrofolate reductase (EC 1.5.1.3) KDGMDA_00335
  KDGMDA_12730
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) KDGMDA_05295
Dihydroneopterin triphosphate epimerase KDGMDA_27140
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) KDGMDA_00350
  KDGMDA_05955
  KDGMDA_19825
FolM Alternative dihydrofolate reductase 1 KDGMDA_20970
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 KDGMDA_26625
GTP cyclohydrolase I (EC 3.5.4.16) type 2 No genes
Methionyl-tRNA formyltransferase (EC 2.1.2.9) KDGMDA_06545
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) KDGMDA_15035
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) KDGMDA_06835
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) KDGMDA_25150
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) KDGMDA_28355
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) KDGMDA_24490
Thymidylate synthase (EC 2.1.1.45) KDGMDA_03845
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) KDGMDA_09340
  KDGMDA_12540
  KDGMDA_27670
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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