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SEED Subsystem: Methionine Biosynthesis in
Escherichia coli BW25113
Experiments:
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Role
Gene
Name
5,10-methylenetetrahydrofolate reductase (
EC 1.5.1.20
)
b3941
metF
5-methyltetrahydrofolate--homocysteine methyltransferase (
EC 2.1.1.13
)
b4019
metH
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (
EC 2.1.1.14
)
b3829
metE
Adenosylhomocysteinase (
EC 3.3.1.1
)
No genes
Archaeal S-adenosylmethionine synthetase (
EC 2.5.1.6
)
No genes
Betaine--homocysteine S-methyltransferase (
EC 2.1.1.5
)
No genes
Cystathionine beta-lyase (
EC 4.4.1.8
)
b3008
metC
Cystathionine beta-lyase, type II (
EC 4.4.1.8
)
No genes
Cystathionine beta-synthase (
EC 4.2.1.22
)
No genes
Cystathionine gamma-lyase (
EC 4.4.1.1
)
No genes
Cystathionine gamma-synthase (
EC 2.5.1.48
)
b3939
metB
Cysteine synthase (
EC 2.5.1.47
)
b2414
cysK
Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
No genes
Homocysteine S-methyltransferase (
EC 2.1.1.10
)
b0261
mmuM
Homoserine O-acetyltransferase (
EC 2.3.1.31
)
No genes
Homoserine O-succinyltransferase (
EC 2.3.1.46
)
b4013
metA
Homoserine dehydrogenase (
EC 1.1.1.3
)
b0002
thrA
b3940
metL
Homoserine kinase (
EC 2.7.1.39
)
b0003
thrB
Methionine ABC transporter ATP-binding protein
b0199
metN
Methionine ABC transporter permease protein
b0198
metI
Methionine ABC transporter substrate-binding protein
b0197
metQ
b3661
nlpA
Methionine repressor MetJ
b3938
metJ
Methionine synthase activation domain (
EC 2.1.1.13
)
No genes
Methionine transporter MetT
No genes
O-acetylhomoserine sulfhydrylase (
EC 2.5.1.49
)
No genes
O-succinylhomoserine sulfhydrylase (
EC 2.5.1.48
)
No genes
Predicted regulator of methionine metabolism, ArsR family
No genes
S-adenosylhomocysteine nucleosidase (
EC 3.2.2.9
)
No genes
S-adenosylmethionine synthetase (
EC 2.5.1.6
)
b2942
metK
S-ribosylhomocysteine lyase (
EC 4.4.1.21
)
b2687
luxS
SAM-dependent methlytransferase UbiG
No genes
SAM-dependent methlytransferase YrrT
No genes
Serine acetyltransferase (
EC 2.3.1.30
)
b3607
cysE
Substrate-specific component MtsA of methionine-regulated ECF transporter
No genes
Transcriptional activator MetR
b3828
metR
Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
No genes
Or select organism:
Acidovorax sp. GW101-3H11
Acinetobacter baumannii LAC-4
Acinetobacter radioresistens SK82
Agrobacterium fabrum C58
Alteromonas macleodii MIT1002
Azospirillum brasilense Sp245
Azospirillum sp. SherDot2
Bacteroides ovatus ATCC 8483
Bacteroides stercoris CC31F
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium breve UCC2003
Bosea sp. OAE506
Brevundimonas sp. GW460-12-10-14-LB2
Burkholderia phytofirmans PsJN
Castellaniella sp019104865 MT123
Caulobacter crescentus NA1000
Caulobacter crescentus NA1000 Δfur
Cellulophaga baltica 18
Cupriavidus basilensis FW507-4G11
Dechlorosoma suillum PS
Desulfovibrio vulgaris Hildenborough JW710
Desulfovibrio vulgaris Miyazaki F
Dickeya dadantii 3937
Dickeya dianthicola 67-19
Dickeya dianthicola ME23
Dinoroseobacter shibae DFL-12
Dyella japonica UNC79MFTsu3.2
Echinicola vietnamensis KMM 6221, DSM 17526
Enterobacter asburiae PDN3
Enterobacter sp. TBS_079
Erwinia amylovora T8
Erwinia tracheiphila HP pepo 2.2
Erwinia tracheiphila SCR3
Escherichia coli BL21
Escherichia coli BW25113
Escherichia coli ECOR27
Escherichia coli ECOR38
Escherichia coli ECRC100
Escherichia coli ECRC101
Escherichia coli ECRC102
Escherichia coli ECRC62
Escherichia coli ECRC98
Escherichia coli ECRC99
Escherichia coli HS(pFamp)R (ATCC 700891)
Escherichia coli Nissle 1917
Escherichia fergusonii Becca
Fusobacterium nucleatum SB010
Herbaspirillum seropedicae SmR1
Hydrogenophaga sp. GW460-11-11-14-LB1
Kangiella aquimarina DSM 16071
Klebsiella michiganensis M5al
Klebsiella pneumoniae MKP103
Klebsiella pneumoniae MRSN742743
Lysobacter sp. OAE881
Magnetospirillum magneticum AMB-1
Marinobacter adhaerens HP15
Methanococcus maripaludis JJ
Methanococcus maripaludis S2
Methylophilus sp. DMC18
Mucilaginibacter yixingensis YX-36 DSM 26809
Mycobacterium tuberculosis H37Rv
Pantoea agglomerans CFBP13505 P0401
Pantoea sp. MT58
Parabacteroides merdae CL09T00C40
Paraburkholderia bryophila 376MFSha3.1
Paraburkholderia graminis OAS925
Paraburkholderia sabiae LMG 24235
Pectobacterium carotovorum WPP14
Pedobacter sp. GW460-11-11-14-LB5
Phaeobacter inhibens DSM 17395
Phocaeicola dorei CL03T12C01
Phocaeicola vulgatus CL09T03C04
Pontibacter actiniarum KMM 6156, DSM 19842
Pseudomonas aeruginosa MRSN321
Pseudomonas aeruginosa PA14
Pseudomonas aeruginosa PUPa3
Pseudomonas fluorescens FW300-N1B4
Pseudomonas fluorescens FW300-N2C3
Pseudomonas fluorescens FW300-N2E2
Pseudomonas fluorescens FW300-N2E3
Pseudomonas fluorescens GW456-L13
Pseudomonas fluorescens SBW25
Pseudomonas fluorescens SBW25-INTG
Pseudomonas lactucae CFBP13502
Pseudomonas orientalis W4I3
Pseudomonas putida KT2440
Pseudomonas segetis P6
Pseudomonas simiae WCS417
Pseudomonas sp. BP01
Pseudomonas sp. DMC3
Pseudomonas sp. RS175
Pseudomonas sp. S08-1
Pseudomonas sp. SVBP6
Pseudomonas stutzeri RCH2
Pseudomonas syringae pv. syringae B728a
Pseudomonas syringae pv. syringae B728a ΔmexB
Rahnella sp. WP5
Ralstonia solanacearum GMI1000
Ralstonia solanacearum IBSBF1503
Ralstonia solanacearum PSI07
Ralstonia solanacearum UW163
Ralstonia sp. UNC404CL21Col
Rhizobium sp. OAE497
Rhodanobacter denitrificans FW104-10B01
Rhodanobacter denitrificans MT42
Rhodanobacter sp. FW510-T8
Rhodanobacter sp000427505 FW510-R12
Rhodopseudomonas palustris CGA009
Rhodospirillum rubrum S1H
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868
Serratia liquefaciens MT49
Shewanella amazonensis SB2B
Shewanella loihica PV-4
Shewanella oneidensis MR-1
Shewanella sp. ANA-3
Sinorhizobium meliloti 1021
Sphingobium sp. HT1-2
Sphingomonas koreensis DSMZ 15582
Synechococcus elongatus PCC 7942
Synechocystis sp000284455 PCC 6803
Variovorax sp. OAS795
Variovorax sp. SCN45
Vibrio cholerae E7946 ATCC 55056
Xanthobacter sp. DMC5
Xanthomonas campestris pv. campestris strain 8004
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