SEED Subsystem: Folate Biosynthesis in Escherichia coli BW25113

Experiments:

Role Gene Name  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) b0142 folK
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) b2912 ygfA
5-nucleotidase SurE (EC 3.1.3.5) No genes
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) b1096 pabC
COG0488: ATPase components of ABC transporters with duplicated ATPase domains b0949 uup
Dihydrofolate reductase (EC 1.5.1.3) b0048 folA
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) b3058 ygiG
Dihydroneopterin triphosphate epimerase b2303 folX
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) b3177 folP
FolM Alternative dihydrofolate reductase 1 b1606 folM
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 b2153 folE
GTP cyclohydrolase I (EC 3.5.4.16) type 2 No genes
Methionyl-tRNA formyltransferase (EC 2.1.2.9) b3288 fmt
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) b0529 folD
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) b3360 pabA
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) b1812 pabB
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) b2551 glyA
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) b1238 tdk
Thymidylate synthase (EC 2.1.1.45) b2827 thyA
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) b0008 talB
  b0825 mipB
  b2464 talA
  b3946 fsaB
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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