SEED Subsystem: Folate Biosynthesis in Escherichia coli ECRC98

Experiments:

Role Gene Name  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) JDDGAC_13955 folK
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) JDDGAC_23125 ygfA
5-nucleotidase SurE (EC 3.1.3.5) No genes
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) JDDGAC_07220 pabC
COG0488: ATPase components of ABC transporters with duplicated ATPase domains JDDGAC_08885 uup
Dihydrofolate reductase (EC 1.5.1.3) JDDGAC_14455
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) JDDGAC_22335 folB
Dihydroneopterin triphosphate epimerase JDDGAC_26725 folX
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) JDDGAC_21690 folP_P64S
FolM Alternative dihydrofolate reductase 1 JDDGAC_02265 folM
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 JDDGAC_27475 folE
GTP cyclohydrolase I (EC 3.5.4.16) type 2 No genes
Methionyl-tRNA formyltransferase (EC 2.1.2.9) JDDGAC_21155 fmt
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) JDDGAC_11455
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) JDDGAC_20850 pabA
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) JDDGAC_01135 pabB
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) JDDGAC_25175 glyA
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) JDDGAC_05975 tdk
Thymidylate synthase (EC 2.1.1.45) JDDGAC_23680 thyA
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) JDDGAC_09765 fsa
  JDDGAC_14675
  JDDGAC_17265 fsa
  JDDGAC_25945 tal
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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