| Role | Gene | Name | |
| 4-aminobutyraldehyde dehydrogenase (EC 1.2.1.19) | HEPCGN_26255 | patD | |
| 5'-methylthioadenosine nucleosidase (EC 3.2.2.16) | No genes | | |
| ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) | HEPCGN_24060 | potD | |
| | HEPCGN_26235 | potD | |
| Agmatinase (EC 3.5.3.11) | HEPCGN_18620 | speB | |
| Agmatine deiminase (EC 3.5.3.12) | No genes | | |
| Agmatine/putrescine antiporter, associated with agmatine catabolism | No genes | | |
| Arginine decarboxylase (EC 4.1.1.19) | No genes | | |
| Arginine decarboxylase, catabolic (EC 4.1.1.19) | HEPCGN_11185 | adiA | |
| Arginine/agmatine antiporter | HEPCGN_11195 | adiC | |
| Arginine/ornithine antiporter | No genes | | |
| Arginine/ornithine antiporter ArcD | HEPCGN_06055 | ydgI | |
| | HEPCGN_10050 | yfcC | |
| Biosynthetic arginine decarboxylase (EC 4.1.1.19) | HEPCGN_18610 | speA | |
| Carbamate kinase (EC 2.7.2.2) | HEPCGN_06490 | arcC | |
| | HEPCGN_07550 | yahI | |
| | HEPCGN_10040 | arcC | |
| Carboxynorspermidine decarboxylase, putative (EC 4.1.1.-) | No genes | | |
| Carboxynorspermidine dehydrogenase, putative (EC 1.1.1.-) | No genes | | |
| DNA-binding response regulator, LuxR family, near polyamine transporter | No genes | | |
| N-carbamoylputrescine amidase (3.5.1.53) | No genes | | |
| Ornithine decarboxylase (EC 4.1.1.17) | HEPCGN_01145 | speF | |
| | HEPCGN_18450 | speC | |
| Predicted chaperone lipoprotein YacC, potentially involved in protein secretion | HEPCGN_08440 | yacC | |
| Predicted polyamine sensor NspS, involved in biofilm formation | No genes | | |
| Probable spermidine/putrescine substrate binding protein in Mollicutes | No genes | | |
| Probable two-component sensor, near polyamine transporter | No genes | | |
| Putative GntR-family regulatory protein and aminotransferase near polyamine transporter | No genes | | |
| Putrescine ABC transporter putrescine-binding protein PotF (TC 3.A.1.11.2) | HEPCGN_02070 | potF | |
| Putrescine carbamoyltransferase (EC 2.1.3.6) | No genes | | |
| Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) | HEPCGN_24075 | potA | |
| | HEPCGN_26240 | | |
| Putrescine transport ATP-binding protein PotG (TC 3.A.1.11.2) | HEPCGN_02075 | potG | |
| Putrescine transport system permease protein PotH (TC 3.A.1.11.2) | HEPCGN_02080 | potH | |
| Putrescine transport system permease protein PotI (TC 3.A.1.11.2) | HEPCGN_02085 | potI | |
| Putrescine-ornithine antiporter | No genes | | |
| Putrescine/proton symporter, putrescine/ornithine antiporter PotE | HEPCGN_01140 | potE | |
| S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50), eukaryotic | No genes | | |
| S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50), prokaryotic class 1A | HEPCGN_08450 | speD | |
| S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50), prokaryotic class 1B | No genes | | |
| Spermidine N1-acetyltransferase (EC 2.3.1.57) | HEPCGN_06170 | speG | |
| Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) | HEPCGN_24070 | potB | |
| | HEPCGN_26245 | potB | |
| Spermidine Putrescine ABC transporter permease component potC (TC_3.A.1.11.1) | HEPCGN_24065 | potC | |
| | HEPCGN_26250 | ydcV | |
| Spermidine synthase (EC 2.5.1.16) | HEPCGN_08445 | speE | |
| Transcriptional regulator of catabolic arginine decarboxylase (adiA) | HEPCGN_00555 | envY | |
| | HEPCGN_11190 | adiY | |
| Transcriptional regulator, MerR family, near polyamine transporter | No genes | | |
| Transcriptional regulator, TetR family, associated with agmatine catabolism | No genes | | |
| Transcriptional regulator, luxR family, associated with agmatine catabolism | No genes | | |