SEED Subsystem: Folate Biosynthesis in Escherichia coli ECOR38

Experiments:

Role Gene Name  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) HEPCGN_08310 folK
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) HEPCGN_18775 ygfA
5-nucleotidase SurE (EC 3.1.3.5) No genes
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) HEPCGN_23920 pabC
COG0488: ATPase components of ABC transporters with duplicated ATPase domains HEPCGN_23245 uup
Dihydrofolate reductase (EC 1.5.1.3) HEPCGN_08850
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) HEPCGN_17555 folB
Dihydroneopterin triphosphate epimerase HEPCGN_21965 folX
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) HEPCGN_16940 folP_P64S
FolM Alternative dihydrofolate reductase 1 HEPCGN_06050 folM
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 HEPCGN_22785 folE
GTP cyclohydrolase I (EC 3.5.4.16) type 2 No genes
Methionyl-tRNA formyltransferase (EC 2.1.2.9) HEPCGN_16355 fmt
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) HEPCGN_06445
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) HEPCGN_16050 pabA
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) HEPCGN_04950 pabB
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) HEPCGN_20655 glyA
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) HEPCGN_25060 tdk
Thymidylate synthase (EC 2.1.1.45) HEPCGN_19270 thyA
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) HEPCGN_01905 fsa
  HEPCGN_09085
  HEPCGN_12285 fsa
  HEPCGN_21170 tal
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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