| Role | Gene | Name | |
| 4-aminobutyraldehyde dehydrogenase (EC 1.2.1.19) | HGI48_RS07415 | | |
| 5'-methylthioadenosine nucleosidase (EC 3.2.2.16) | HGI48_RS16010 | | |
| ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) | HGI48_RS11850 | | |
| Agmatinase (EC 3.5.3.11) | No genes | | |
| Agmatine deiminase (EC 3.5.3.12) | HGI48_RS20520 | | |
| Agmatine/putrescine antiporter, associated with agmatine catabolism | No genes | | |
| Arginine decarboxylase (EC 4.1.1.19) | No genes | | |
| Arginine decarboxylase, catabolic (EC 4.1.1.19) | No genes | | |
| Arginine/agmatine antiporter | No genes | | |
| Arginine/ornithine antiporter | No genes | | |
| Arginine/ornithine antiporter ArcD | HGI48_RS00745 | | |
| Biosynthetic arginine decarboxylase (EC 4.1.1.19) | HGI48_RS18460 | | |
| Carbamate kinase (EC 2.7.2.2) | No genes | | |
| Carboxynorspermidine decarboxylase, putative (EC 4.1.1.-) | No genes | | |
| Carboxynorspermidine dehydrogenase, putative (EC 1.1.1.-) | No genes | | |
| DNA-binding response regulator, LuxR family, near polyamine transporter | HGI48_RS11705 | | |
| N-carbamoylputrescine amidase (3.5.1.53) | HGI48_RS20525 | | |
| Ornithine decarboxylase (EC 4.1.1.17) | HGI48_RS04890 | | |
| Predicted chaperone lipoprotein YacC, potentially involved in protein secretion | HGI48_RS16125 | | |
| Predicted polyamine sensor NspS, involved in biofilm formation | No genes | | |
| Probable spermidine/putrescine substrate binding protein in Mollicutes | No genes | | |
| Probable two-component sensor, near polyamine transporter | No genes | | |
| Putative GntR-family regulatory protein and aminotransferase near polyamine transporter | No genes | | |
| Putrescine ABC transporter putrescine-binding protein PotF (TC 3.A.1.11.2) | HGI48_RS09480 | | |
| Putrescine carbamoyltransferase (EC 2.1.3.6) | No genes | | |
| Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) | HGI48_RS04570 | | |
| | HGI48_RS10850 | | |
| | HGI48_RS11870 | | |
| | HGI48_RS17500 | | |
| | HGI48_RS21050 | | |
| Putrescine transport ATP-binding protein PotG (TC 3.A.1.11.2) | HGI48_RS09485 | | |
| Putrescine transport system permease protein PotH (TC 3.A.1.11.2) | HGI48_RS09490 | | |
| Putrescine transport system permease protein PotI (TC 3.A.1.11.2) | HGI48_RS09495 | | |
| Putrescine-ornithine antiporter | No genes | | |
| Putrescine/proton symporter, putrescine/ornithine antiporter PotE | No genes | | |
| S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50), eukaryotic | No genes | | |
| S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50), prokaryotic class 1A | HGI48_RS16135 | | |
| S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50), prokaryotic class 1B | No genes | | |
| Spermidine N1-acetyltransferase (EC 2.3.1.57) | No genes | | |
| Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) | HGI48_RS11845 | | |
| Spermidine Putrescine ABC transporter permease component potC (TC_3.A.1.11.1) | HGI48_RS11840 | | |
| Spermidine synthase (EC 2.5.1.16) | HGI48_RS16130 | | |
| Transcriptional regulator of catabolic arginine decarboxylase (adiA) | No genes | | |
| Transcriptional regulator, MerR family, near polyamine transporter | No genes | | |
| Transcriptional regulator, TetR family, associated with agmatine catabolism | No genes | | |
| Transcriptional regulator, luxR family, associated with agmatine catabolism | No genes | | |