| Role | Gene | Name | |
| 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17) | No genes | | |
| ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) | Echvi_1629 | | |
| | Echvi_4634 | | |
| Adenine phosphoribosyltransferase (EC 2.4.2.7) | No genes | | |
| Adenylate cyclase (EC 4.6.1.1) | Echvi_0494 | | |
| Adenylate/guanylate cyclase (EC 4.6.1.2) | No genes | | |
| CAMP phosphodiesterases class-II:Metallo-beta-lactamase superfamily | No genes | | |
| Cyclic AMP receptor protein | No genes | | |
| ElaA protein | No genes | | |
| Heme-regulated cyclic AMP phosphodiesterase (EC 3.1.4.-) | No genes | | |
| Hydrolase, alpha/beta fold family functionally coupled to Phosphoribulokinase | Echvi_3337 | | |
| | Echvi_3887 | | |
| Predicted signal-transduction protein containing cAMP-binding and CBS domains | Echvi_1269 | | |
| | Echvi_2227 | | |
| Prophage Clp protease-like protein | No genes | | |
| Purine cyclase-related protein | No genes | | |
| Putative Heme-regulated two-component response regulator | No genes | | |
| Putative hemin-binding lipoprotein | No genes | | |
| Putative insecticidal toxin complex | No genes | | |
| adenylate cyclase ExoY | No genes | | |
| anthrax toxin moiety, protective antigen, pagA formerly pag, plasmid pXO1, B. anthracis (M22589, P13423) | No genes | | |
| bifunctional hemolysin-adenylate cyclase precursor | No genes | | |
| cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases | Echvi_0743 | | |
| | Echvi_0819 | | |
| | Echvi_1066 | | |
| | Echvi_1102 | | |
| | Echvi_1125 | | |
| | Echvi_2063 | | |
| | Echvi_2708 | | |
| | Echvi_3054 | | |
| | Echvi_3121 | | |
| | Echvi_4289 | | |
| cAMP-dependent Kef-type K+ transport system | No genes | | |
| calmodulin sensitive adenylate cyclase, edema factor, cya, plasmid pXO1, B. anthracis (M23179, M24074) | No genes | | |
| cyclolysin secretion ATP-binding protein | No genes | | |
| cyclolysin secretion protein | No genes | | |
| cyclolysin-activating lysine-acyltransferase | No genes | | |
| trans-acting positive regulator (Atx A) | No genes | | |
| transcriptional activator AtxA, (pXO1-119) | No genes | | |