SEED Subsystem: KDO2-Lipid A biosynthesis in Escherichia coli BW25113

Role	Gene	Name	Nalidixic 0.006 mg/ml
2-Keto-3-deoxy-D-manno-octulosonate-8-phosphate synthase (EC 2.5.1.55)	b1215	kdsA	N.D.
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (EC 3.1.3.45)	b3198	kdsC	-1.7
3-deoxy-D-manno-octulosonic-acid transferase (EC 2.-.-.-)	No genes
3-deoxy-manno-octulosonate cytidylyltransferase (EC 2.7.7.38)	b0918	kdsB	N.D.
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129)	b0181	lpxA	N.D.
Arabinose 5-phosphate isomerase (EC 5.3.1.13)	b3197	kdsD	-1.3
LPS-assembly lipoprotein RlpB precursor (Rare lipoprotein B)	b0641	rlpB	-0.1
Lipid A biosynthesis (KDO) 2-(lauroyl)-lipid IVA acyltransferase (EC 2.3.1.-)	b1855	lpxM	-3.8
Lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-)	No genes
Lipid A export ATP-binding/permease protein MsbA (EC 3.6.3.25)	No genes
Lipid-A-disaccharide synthase (EC 2.4.1.182)	b0182	lpxB	N.D.
Lipopolysaccharide ABC transporter, ATP-binding protein LptB	b3201	yhbG	N.D.
LptA, protein essential for LPS transport across the periplasm	b3200	yhbN	N.D.
O-antigen flippase Wzx	No genes
Oligosaccharide repeat unit polymerase Wzy	b2035	wbbH	-0.1
Predicted hydrolase of the metallo-beta-lactamase superfamily, clustered with KDO2-Lipid A biosynthesis genes	No genes
Protein of unknown function DUF1009 clustered with KDO2-Lipid A biosynthesis genes	No genes
Tetraacyldisaccharide 4'-kinase (EC 2.7.1.130)	b0915	lpxK	N.D.
UDP-2,3-diacylglucosamine hydrolase (EC 3.6.1.-)	No genes
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (EC 3.5.1.-)	No genes
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase (EC 2.3.1.-)	No genes
UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7)	b0759	galE	-1.0
regulator of length of O-antigen component of lipopolysaccharide chains	b2027	wzzB	-0.2
	b3785	wzzE	-0.1