SEED Subsystem: Folate Biosynthesis in Escherichia coli BW25113

Role	Gene	Name	undecene 5 vol%
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3)	b0142	folK	-0.1
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2)	b2912	ygfA	+0.4
5-nucleotidase SurE (EC 3.1.3.5)	No genes
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12)	No genes
ATPase component of general energizing module of ECF transporters	No genes
Alternative Folylglutamate Synthase	No genes
Alternative dihydrofolate reductase 2	No genes
Alternative dihydrofolate reductase 3	No genes
Aminodeoxychorismate lyase (EC 4.1.3.38)	b1096	pabC	+0.1
COG0488: ATPase components of ABC transporters with duplicated ATPase domains	b0949	uup	-0.7
Dihydrofolate reductase (EC 1.5.1.3)	b0048	folA	N.D.
Dihydrofolate synthase (EC 6.3.2.12)	No genes
Dihydroneopterin aldolase (EC 4.1.2.25)	b3058	ygiG	N.D.
Dihydroneopterin triphosphate epimerase	b2303	folX	-0.1
Dihydroneopterin triphosphate pyrophosphohydolase	No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2	No genes
Dihydropteroate synthase (EC 2.5.1.15)	b3177	folP	N.D.
FolM Alternative dihydrofolate reductase 1	b1606	folM	-0.0
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB)	No genes
Folate transporter 3	No genes
Folylpolyglutamate synthase (EC 6.3.2.17)	No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3)	No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1	b2153	folE	N.D.
GTP cyclohydrolase I (EC 3.5.4.16) type 2	No genes
Methionyl-tRNA formyltransferase (EC 2.1.2.9)	b3288	fmt	N.D.
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5)	b0529	folD	N.D.
Non functional Dihydropteroate synthase 2	No genes
Nucleoside triphosphate pyrophosphohydrolase MazG	No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85)	b3360	pabA	-0.1
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85)	b1812	pabB	+0.1
PqqC-like protein	No genes
Putative DHNTP pyrophosphatase	No genes
Related to Dihydropteroate synthase	No genes
Serine hydroxymethyltransferase (EC 2.1.2.1)	b2551	glyA	N.D.
Substrate-specific component FolT of folate ECF transporter	No genes
Thymidine kinase (EC 2.7.1.21)	b1238	tdk	+0.9
Thymidylate synthase (EC 2.1.1.45)	b2827	thyA	N.D.
Thymidylate synthase thyX (EC 2.1.1.-)	No genes
Transaldolase (EC 2.2.1.2)	b0008	talB	-1.2
	b0825	mipB	+0.2
	b2464	talA	+0.4
	b3946	fsaB	+0.0
Transmembrane component of general energizing module of ECF transporters	No genes
Xanthosine/inosine triphosphate pyrophosphatase	No genes
alternate gene name: yzbB	No genes