SEED Subsystem: TCA Cycle in Escherichia coli ECRC101

Experiments:

Role Gene Name Sodium-DL-Lactate  
⨯
2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2) MCAODC_26145 sucA -4.1
Aconitate hydratase (EC 4.2.1.3) No genes
Aconitate hydratase 2 (EC 4.2.1.3) No genes
Aconitate hydratase X, predicted No genes
Aconitate hydratase large subunit (EC 4.2.1.3) No genes
Aconitate hydratase small subunit (EC 4.2.1.3) No genes
Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5) No genes
Archaeal succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5) No genes
Citrate lyase gamma chain, acyl carrier protein (EC 4.1.3.6) MCAODC_26665 +0.2
Citrate synthase (si) (EC 2.3.3.1) MCAODC_26180 gltA -4.4
Dihydrolipoamide dehydrogenase (EC 1.8.1.4) No genes
Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase (EC 1.8.1.4) No genes
Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex (EC 1.8.1.4) No genes
Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) MCAODC_26140 odhB -4.5
Fumarate hydratase class I (EC 4.2.1.2) MCAODC_26115 ttdA -0.1
Fumarate hydratase class I, aerobic (EC 4.2.1.2) MCAODC_17765 fumB -0.3
Fumarate hydratase class II (EC 4.2.1.2) MCAODC_17760 fumC -0.7
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) MCAODC_22325 icd N.D.
Isocitrate dehydrogenase [NAD] (EC 1.1.1.41) No genes
Malate dehydrogenase (EC 1.1.1.37) MCAODC_08315 mdh -2.7
  MCAODC_25485 hcxB -0.1
Malate:quinone oxidoreductase (EC 1.1.5.4) MCAODC_14275 mqo -0.3
Putative Dihydrolipoamide dehydrogenase (EC 1.8.1.4) No genes
Putative malate dehydrogenase (EC 1.1.1.37), similar to archaeal MJ1425 No genes
Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) MCAODC_02855 frdA -0.1
  MCAODC_26160 sdhA -2.3
Succinate dehydrogenase iron-sulfur protein (EC 1.3.99.1) MCAODC_02860 frdB -0.2
  MCAODC_26155 sdhB -1.7
Succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5) MCAODC_26130 sucD -4.3
Succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5) MCAODC_26135 sucC -4.1
Transcriptional regulator of succinyl CoA synthetase operon No genes
hypothetical protein that often co-occurs with aconitase No genes

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