| Role |  Gene |  Name |  Malonic (C) 10 mM |    | 
  |   |   |  ⨯ |   | 
 | 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17) |  PFR28_05096 |   |  N.D. |   | 
 | ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) |  PFR28_01228 |   |  N.D. |   | 
 |   |  PFR28_02682 |   |  -0.2 |   | 
 | Adenine phosphoribosyltransferase (EC 2.4.2.7) |  PFR28_01078 |   |  +0.4 |   | 
 | Adenylate cyclase (EC 4.6.1.1) |  PFR28_00991 |   |  +0.1 |   | 
 |   |  PFR28_04310 |   |  -0.2 |   | 
 |   |  PFR28_04371 |   |  -0.1 |   | 
 | Adenylate/guanylate cyclase (EC 4.6.1.2) |  No genes |   |   |   | 
 | CAMP phosphodiesterases class-II:Metallo-beta-lactamase superfamily |  No genes |   |   |   | 
 | Cyclic AMP receptor protein |  PFR28_04041 |   |  +0.1 |   | 
 | ElaA protein |  PFR28_04176 |   |  +1.1 |   | 
 | Heme-regulated cyclic AMP phosphodiesterase (EC 3.1.4.-) |  No genes |   |   |   | 
 | Hydrolase, alpha/beta fold family functionally coupled to Phosphoribulokinase |  PFR28_03127 |   |  -0.3 |   | 
 |   |  PFR28_04263 |   |  -0.1 |   | 
 | Predicted signal-transduction protein containing cAMP-binding and CBS domains |  PFR28_04112 |   |  +0.1 |   | 
 | Prophage Clp protease-like protein |  No genes |   |   |   | 
 | Purine cyclase-related protein |  No genes |   |   |   | 
 | Putative Heme-regulated two-component response regulator |  No genes |   |   |   | 
 | Putative hemin-binding lipoprotein |  No genes |   |   |   | 
 | Putative insecticidal toxin complex |  PFR28_03072 |   |  +0.1 |   | 
 |   |  PFR28_03460 |   |  -0.1 |   | 
 |   |  PFR28_03567 |   |  +0.0 |   | 
 | adenylate cyclase ExoY |  No genes |   |   |   | 
 | anthrax toxin moiety, protective antigen, pagA formerly pag, plasmid pXO1, B. anthracis (M22589, P13423) |  No genes |   |   |   | 
 | bifunctional hemolysin-adenylate cyclase precursor |  No genes |   |   |   | 
 | cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases |  No genes |   |   |   | 
 | cAMP-dependent Kef-type K+ transport system |  No genes |   |   |   | 
 | calmodulin sensitive adenylate cyclase, edema factor, cya, plasmid pXO1, B. anthracis (M23179, M24074) |  No genes |   |   |   | 
 | cyclolysin secretion ATP-binding protein |  No genes |   |   |   | 
 | cyclolysin secretion protein |  No genes |   |   |   | 
 | cyclolysin-activating lysine-acyltransferase |  No genes |   |   |   | 
 | trans-acting positive regulator (Atx A) |  No genes |   |   |   | 
 | transcriptional activator AtxA, (pXO1-119) |  No genes |   |   |   |