SEED Subsystem: Folate Biosynthesis in Pseudomonas putida KT2440

Experiments:

Role Gene Name Betaine (N)  
⨯
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) PP_0393 -1.1
  PP_4698 N.D.
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) PP_5203 -0.7
5-nucleotidase SurE (EC 3.1.3.5) No genes
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) PP_1917 -0.3
COG0488: ATPase components of ABC transporters with duplicated ATPase domains PP_2131 -0.1
Dihydrofolate reductase (EC 1.5.1.3) PP_5132 N.D.
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) PP_0392 N.D.
Dihydroneopterin triphosphate epimerase No genes
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) PP_4717 N.D.
FolM Alternative dihydrofolate reductase 1 PP_4632 +0.1
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 PP_1823 N.D.
  PP_2512 +0.1
GTP cyclohydrolase I (EC 3.5.4.16) type 2 PP_3324 +0.1
Methionyl-tRNA formyltransferase (EC 2.1.2.9) PP_0067 N.D.
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) PP_1945 +0.2
  PP_2265 N.D.
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) PP_0727 -0.1
  PP_1842 -0.0
  PP_3598 -0.0
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) PP_2329 +0.1
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) PP_0322 -2.3
  PP_0671 N.D.
  PP_0672 -0.3
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) PP_5141 N.D.
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) PP_2168 -2.1
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

Or select organism:

Or view this subsystem at the SEED (slow)