SEED Subsystem: Methionine Biosynthesis in Paraburkholderia sabiae LMG 24235

Experiments:

Role Gene Name L-Histidine (C)  
⨯
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) QEN71_RS28715 -3.4
5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) QEN71_RS01190 -0.1
  QEN71_RS01195 +0.3
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) QEN71_RS19725 -2.4
Adenosylhomocysteinase (EC 3.3.1.1) QEN71_RS27895 -3.2
  QEN71_RS28725 N.D.
Archaeal S-adenosylmethionine synthetase (EC 2.5.1.6) No genes
Betaine--homocysteine S-methyltransferase (EC 2.1.1.5) No genes
Cystathionine beta-lyase (EC 4.4.1.8) QEN71_RS22165 -0.2
Cystathionine beta-lyase, type II (EC 4.4.1.8) No genes
Cystathionine beta-synthase (EC 4.2.1.22) No genes
Cystathionine gamma-lyase (EC 4.4.1.1) No genes
Cystathionine gamma-synthase (EC 2.5.1.48) QEN71_RS38310 +0.1
Cysteine synthase (EC 2.5.1.47) QEN71_RS40460 +0.2
Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter No genes
Homocysteine S-methyltransferase (EC 2.1.1.10) QEN71_RS32165 +0.1
Homoserine O-acetyltransferase (EC 2.3.1.31) QEN71_RS00285 -0.1
  QEN71_RS00290 -2.9
  QEN71_RS16300 -0.1
Homoserine O-succinyltransferase (EC 2.3.1.46) QEN71_RS42530 -0.1
Homoserine dehydrogenase (EC 1.1.1.3) QEN71_RS22405 -3.4
Homoserine kinase (EC 2.7.1.39) QEN71_RS17850 -3.6
Methionine ABC transporter ATP-binding protein QEN71_RS01270 +0.4
  QEN71_RS04160 -0.0
  QEN71_RS13685 N.D.
  QEN71_RS27920 -2.6
  QEN71_RS35070 +0.0
  QEN71_RS40240 N.D.
  QEN71_RS40290 N.D.
Methionine ABC transporter permease protein QEN71_RS04165 +0.2
Methionine ABC transporter substrate-binding protein QEN71_RS01570 +0.1
  QEN71_RS04170 -0.1
  QEN71_RS21120 -0.1
Methionine repressor MetJ No genes
Methionine synthase activation domain (EC 2.1.1.13) No genes
Methionine transporter MetT No genes
O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) QEN71_RS05200 +0.0
  QEN71_RS17685 +0.1
  QEN71_RS23590 -0.0
  QEN71_RS33705 -0.4
  QEN71_RS42510 +0.2
O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) QEN71_RS05200 +0.0
  QEN71_RS17685 +0.1
  QEN71_RS42510 +0.2
Predicted regulator of methionine metabolism, ArsR family No genes
S-adenosylhomocysteine nucleosidase (EC 3.2.2.9) No genes
S-adenosylmethionine synthetase (EC 2.5.1.6) QEN71_RS00375 N.D.
S-ribosylhomocysteine lyase (EC 4.4.1.21) No genes
SAM-dependent methlytransferase UbiG No genes
SAM-dependent methlytransferase YrrT No genes
Serine acetyltransferase (EC 2.3.1.30) QEN71_RS06105 +0.1
  QEN71_RS18060 -0.1
  QEN71_RS40700 +0.2
Substrate-specific component MtsA of methionine-regulated ECF transporter No genes
Transcriptional activator MetR QEN71_RS19730 -2.5
Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter No genes

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