SEED Subsystem: Valine degradation in Pseudomonas putida KT2440

Experiments:

Role Gene Name 2-methyl-1-butanol (C)  
⨯
3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) PP_2047 -0.0
  PP_2136 -1.3
3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) PP_4666 -0.5
3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) PP_3491 -1.6
Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12) No genes
Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4) PP_4401 +0.2
Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4) PP_4402 -0.0
Branched-chain amino acid aminotransferase (EC 2.6.1.42) PP_3511 -6.2
Butyrate kinase (EC 2.7.2.7) No genes
Butyryl-CoA dehydrogenase (EC 1.3.99.2) PP_1893 -0.0
  PP_2216 -2.2
  PP_2793 +0.8
  PP_3638 +0.1
  PP_3725 -0.1
Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168) PP_4403 +0.1
Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase (EC 1.8.1.4) PP_4404 +0.2
Enoyl-CoA hydratase (EC 4.2.1.17) PP_1412 -0.2
  PP_2047 -0.0
  PP_2136 -1.3
  PP_3726 +0.1
  PP_3732 +0.0
Enoyl-CoA hydratase [valine degradation] (EC 4.2.1.17) PP_2217 -6.3
  PP_4030 -0.0
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.-) No genes
Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27) PP_0597 -0.0
  PP_4667 -0.4
Predicted transcriptional regulator of leucine degradation pathway, MerR family No genes
Probable acyl-CoA dehydrogenase (EC 1.3.99.3) PP_2214 -6.6
Transcriptional regulator BkdR of isoleucine and valine catabolism operon PP_4400 -0.0
phosphotransbutyrylase (EC 2.3.1.19) No genes

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