SEED Subsystem: Methionine Biosynthesis in Pseudomonas putida KT2440

Experiments:

Role Gene Name carbon source 2-Deoxy-D-glucose 50 mM  
⨯
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) PP_4638 +0.1
  PP_4977 -0.7
5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) PP_2375 -0.4
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) PP_2698 +0.1
  PP_4637 -0.1
Adenosylhomocysteinase (EC 3.3.1.1) PP_4976 N.D.
Archaeal S-adenosylmethionine synthetase (EC 2.5.1.6) No genes
Betaine--homocysteine S-methyltransferase (EC 2.1.1.5) No genes
Cystathionine beta-lyase (EC 4.4.1.8) PP_4348 -0.4
Cystathionine beta-lyase, type II (EC 4.4.1.8) No genes
Cystathionine beta-synthase (EC 4.2.1.22) No genes
Cystathionine gamma-lyase (EC 4.4.1.1) PP_4594 -0.1
Cystathionine gamma-synthase (EC 2.5.1.48) PP_0659 -0.3
Cysteine synthase (EC 2.5.1.47) PP_1113 +1.7
  PP_4571 -0.6
Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter No genes
Homocysteine S-methyltransferase (EC 2.1.1.10) PP_0658 +0.1
  PP_2776 -0.4
Homoserine O-acetyltransferase (EC 2.3.1.31) PP_5097 -4.6
Homoserine O-succinyltransferase (EC 2.3.1.46) No genes
Homoserine dehydrogenase (EC 1.1.1.3) PP_0664 +0.0
  PP_1470 N.D.
Homoserine kinase (EC 2.7.1.39) PP_0121 N.D.
Methionine ABC transporter ATP-binding protein PP_0114 -0.3
  PP_0220 +0.5
  PP_0507 -1.2
Methionine ABC transporter permease protein PP_0113 +0.1
  PP_0219 -0.1
Methionine ABC transporter substrate-binding protein PP_0112 +0.3
  PP_0221 -0.1
  PP_5165 +0.0
Methionine repressor MetJ No genes
Methionine synthase activation domain (EC 2.1.1.13) No genes
Methionine transporter MetT No genes
O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) PP_0875 -0.1
  PP_2001 -3.5
  PP_2528 -0.2
  PP_2549 +1.0
  PP_4548 -0.1
O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) PP_2001 -3.5
  PP_2528 -0.2
Predicted regulator of methionine metabolism, ArsR family No genes
S-adenosylhomocysteine nucleosidase (EC 3.2.2.9) PP_3254 +0.2
S-adenosylmethionine synthetase (EC 2.5.1.6) PP_4967 N.D.
S-ribosylhomocysteine lyase (EC 4.4.1.21) No genes
SAM-dependent methlytransferase UbiG No genes
SAM-dependent methlytransferase YrrT No genes
Serine acetyltransferase (EC 2.3.1.30) PP_0228 +0.0
  PP_0385 +0.9
  PP_0840 -0.9
  PP_3136 +0.3
Substrate-specific component MtsA of methionine-regulated ECF transporter No genes
Transcriptional activator MetR PP_1063 -1.7
  PP_2696 +0.2
Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter No genes

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