SEED Subsystem: Folate Biosynthesis in Pseudomonas simiae WCS417

Experiments:

Role Gene Name root sample 6; outgrowth in LB  
⨯
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) PS417_23905 N.D.
  PS417_25850 N.D.
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) PS417_27305 -1.1
5-nucleotidase SurE (EC 3.1.3.5) PS417_06350 +0.3
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) PS417_21425 +0.6
COG0488: ATPase components of ABC transporters with duplicated ATPase domains PS417_07555 -0.0
Dihydrofolate reductase (EC 1.5.1.3) PS417_16880 -0.1
  PS417_26905 N.D.
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) PS417_25855 N.D.
Dihydroneopterin triphosphate epimerase PS417_23500 +0.4
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) PS417_24010 N.D.
FolM Alternative dihydrofolate reductase 1 PS417_23490 +1.6
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 PS417_19350 -1.3
  PS417_23495 -0.1
GTP cyclohydrolase I (EC 3.5.4.16) type 2 PS417_28305 -0.0
Methionyl-tRNA formyltransferase (EC 2.1.2.9) PS417_00090 N.D.
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) PS417_17265 N.D.
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) PS417_21210 -0.6
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) PS417_21105 -0.3
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) PS417_24275 +0.5
  PS417_24280 N.D.
  PS417_26195 -0.8
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) PS417_26965 N.D.
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) PS417_07730 N.D.
  PS417_09700 +1.5
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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